Detailed information for compound 1414758

Basic information

Technical information
  • TDR Targets ID: 1414758
  • Name: N,N'-bis(2-fluorophenyl)-2-[(2-morpholin-4-yl -4-phenyl-1,3-thiazol-5-yl)methylidene]propan ediamide
  • MW: 546.588 | Formula: C29H24F2N4O3S
  • H donors: 2 H acceptors: 3 LogP: 6.34 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(C(=Cc1sc(nc1c1ccccc1)N1CCOCC1)C(=O)Nc1ccccc1F)Nc1ccccc1F
  • InChi: 1S/C29H24F2N4O3S/c30-21-10-4-6-12-23(21)32-27(36)20(28(37)33-24-13-7-5-11-22(24)31)18-25-26(19-8-2-1-3-9-19)34-29(39-25)35-14-16-38-17-15-35/h1-13,18H,14-17H2,(H,32,36)(H,33,37)
  • InChiKey: RZKIQSAFDPZKKZ-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N,N'-bis(2-fluorophenyl)-2-[(2-morpholino-4-phenyl-thiazol-5-yl)methylene]propanediamide
  • N,N'-bis(2-fluorophenyl)-2-[(2-morpholino-4-phenyl-5-thiazolyl)methylene]propanediamide
  • N,N'-bis(2-fluorophenyl)-2-[(2-morpholino-4-phenyl-thiazol-5-yl)methylene]malonamide
  • MLS000334864
  • SMR000249622
  • T5223301

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Human herpesvirus 8 ORF 73 Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens tumor susceptibility 101 Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126560 All targets in OG5_126560
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica cysteine surface protein, putative Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus multilocularis fibrillin 1 Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis conserved hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica cysteine surface protein, putative Get druggable targets OG5_126560 All targets in OG5_126560
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K01931 tumor suppressor protein 101 [EC:6.3.2.19], putative Get druggable targets OG5_128950 All targets in OG5_128950
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica CXXC-rich protein Get druggable targets OG5_126560 All targets in OG5_126560
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica pro protein convertase subtilisin/kexinType 5 precursor, putative Get druggable targets OG5_126560 All targets in OG5_126560
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126560 All targets in OG5_126560
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma mansoni notch Get druggable targets OG5_126560 All targets in OG5_126560
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) TK/FER protein kinase Get druggable targets OG5_126560 All targets in OG5_126560
Candida albicans weak similarity to S. cerevisiae STP22 putative ubiquitin receptor, and to mouse tumor susceiptibility protein TSG101 Get druggable targets OG5_128950 All targets in OG5_128950
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis conserved hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126560 All targets in OG5_126560
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni tsg101-related Get druggable targets OG5_128950 All targets in OG5_128950
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Trypanosoma cruzi hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica tumor susceptibility gene 101 protein, putative Get druggable targets OG5_128950 All targets in OG5_128950
Leishmania infantum surface antigen-like protein Get druggable targets OG5_126560 All targets in OG5_126560
Leishmania braziliensis surface antigen-like protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum IPR006209,EGF-like;IPR013091,EGF calcium-binding;IPR001881,EGF-like calcium-binding;IPR006210,EGF;IPR000152,Aspartic acid and as Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus granulosus tumor susceptibility gene 101 protein Get druggable targets OG5_128950 All targets in OG5_128950
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_126560 All targets in OG5_126560
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis coiled coil domain containing protein 41 Get druggable targets OG5_126560 All targets in OG5_126560
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Giardia lamblia High cysteine non-variant cyst protein Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma japonicum IPR013091,EGF calcium-binding;IPR013111,EGF, extracellular;IPR001881,EGF-like calcium-binding;IPR006210,EGF;IPR000152,Aspartic a Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis surface antigen-like protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126560 All targets in OG5_126560
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica cysteine surface protein, putative Get druggable targets OG5_126560 All targets in OG5_126560
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128950 All targets in OG5_128950
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Onchocerca volvulus Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana surface antigen-like protein Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma mansoni tsg101-related Get druggable targets OG5_128950 All targets in OG5_128950
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Giardia lamblia High cysteine membrane protein Group 1 Get druggable targets OG5_126560 All targets in OG5_126560
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Trichomonas vaginalis Involucrin, putative Get druggable targets OG5_126560 All targets in OG5_126560
Brugia malayi hypothetical protein Get druggable targets OG5_128950 All targets in OG5_128950
Schistosoma mansoni tsg101-related Get druggable targets OG5_128950 All targets in OG5_128950
Trichomonas vaginalis DNA double-strand break repair Rad50 ATPase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans weak similarity to S. cerevisiae STP22 putative ubiquitin receptor, and to mouse tumor susceiptibility protein TSG101 Get druggable targets OG5_128950 All targets in OG5_128950
Leishmania major surface antigen-like protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus granulosus fibrillin 1 Get druggable targets OG5_126560 All targets in OG5_126560
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Echinococcus multilocularis microtubule associated protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_128950 All targets in OG5_128950
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_126560 All targets in OG5_126560
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis surface antigen-like protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Giardia lamblia High cysteine membrane protein TMK-like Get druggable targets OG5_126560 All targets in OG5_126560
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica cysteine surface protein, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica hypothetical protein, conserved Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis tumor susceptibility gene 101 protein Get druggable targets OG5_128950 All targets in OG5_128950
Echinococcus granulosus coiled coil domain containing protein 41 Get druggable targets OG5_126560 All targets in OG5_126560
Giardia lamblia High cysteine membrane protein TMK-like Get druggable targets OG5_126560 All targets in OG5_126560
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus granulosus microtubule associated protein Get druggable targets OG5_126560 All targets in OG5_126560
Giardia lamblia High cysteine membrane protein TMK-like Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Tumor susceptibility gene 101 protein, putative Get druggable targets OG5_128950 All targets in OG5_128950
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis conserved hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma japonicum Neurogenic locus notch protein homolog precursor, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Trypanosoma cruzi hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1086 0.2603
Echinococcus granulosus geminin 0.0205 0.2019 0.4039
Loa Loa (eye worm) hypothetical protein 0.0365 0.3671 0.914
Echinococcus granulosus dnaJ subfamily B 0.0494 0.5 1
Trichomonas vaginalis ran, putative 0.0026 0.0175 0.0301
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0084 0.0776 0.1553
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0398 0.4015 0.8029
Schistosoma mansoni cpg binding protein 0.0035 0.0269 0.0537
Loa Loa (eye worm) hypothetical protein 0.0015 0.0067 0.0113
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0073 0.0146
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.3741 0.9314
Schistosoma mansoni cpg binding protein 0.0037 0.0289 0.0578
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0398 0.4015 0.4015
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0225 0.0129
Plasmodium vivax importin-beta 2, putative 0.0035 0.027 0.0247
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0202 0.0369
Schistosoma mansoni hypothetical protein 0.0019 0.0107 0.0215
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.027 0.0541
Plasmodium falciparum importin beta, putative 0.0035 0.027 0.0247
Schistosoma mansoni hypothetical protein 0.0372 0.3741 0.7482
Schistosoma mansoni tsg101-related 0.007 0.0632 0.1263
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0107 0.0218
Schistosoma mansoni hypothetical protein 0.0014 0.0052 0.0104
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0022 0.0044
Schistosoma mansoni importin beta-1 0.0035 0.027 0.054
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0107 0.0107
Echinococcus granulosus lamin 0.0033 0.0247 0.0493
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.027 0.0247
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.0052 0.0052
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0202 0.0369
Schistosoma mansoni tsg101-related 0.007 0.0632 0.1263
Schistosoma mansoni lamin 0.0033 0.0247 0.0493
Loa Loa (eye worm) hypothetical protein 0.0084 0.0776 0.189
Brugia malayi hypothetical protein 0.0365 0.3671 0.914
Brugia malayi eukaryotic initiation factor 4A 0.0398 0.4015 1
Echinococcus multilocularis GPCR, family 2 0.0019 0.0107 0.0107
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.1086 0.2666
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.1086 0.2603
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0398 0.4015 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.027 0.0622
Echinococcus granulosus cpg binding protein 0.0037 0.0289 0.0578
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1086 0.2603
Loa Loa (eye worm) hypothetical protein 0.003 0.0225 0.0509
Brugia malayi Importin beta-1 subunit 0.0035 0.027 0.0625
Leishmania major hypothetical protein, conserved 0.003 0.0225 0.0129
Trypanosoma brucei polo-like protein kinase 0.0114 0.1086 0.2603
Schistosoma mansoni hypothetical protein 0.0019 0.0107 0.0215
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0269 0.0618
Plasmodium vivax RNA helicase-1, putative 0.0398 0.4015 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.1086 0.2173
Schistosoma mansoni hypothetical protein 0.0205 0.2019 0.4039
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0398 0.4015 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0202 0.0369
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0531 0.128
Schistosoma mansoni hypothetical protein 0.0041 0.0335 0.067
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0493 0.1104
Schistosoma mansoni tsg101-related 0.0057 0.05 0.0999
Schistosoma mansoni hypothetical protein 0.0205 0.2019 0.4039
Echinococcus multilocularis musashi 0.0033 0.0247 0.0247
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0493 0.1104
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0225 0.0129
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1086 0.2603
Schistosoma mansoni hypothetical protein 0.0494 0.5 1
Echinococcus multilocularis cpg binding protein 0.0037 0.0289 0.0289
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0398 0.4015 0.4015
Entamoeba histolytica hypothetical protein 0.0028 0.0202 0.0369
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0175 0.0175
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0225 0.0129
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0225 0.0129
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0202 0.0369
Brugia malayi intermediate filament protein 0.0033 0.0247 0.0567
Loa Loa (eye worm) hypothetical protein 0.0015 0.0067 0.0113
Schistosoma mansoni cpg binding protein 0.0037 0.0289 0.0578
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0084 0.0776 0.0776
Echinococcus multilocularis lamin 0.0033 0.0247 0.0247
Loa Loa (eye worm) hypothetical protein 0.0016 0.0073 0.0129
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0091 0.0173
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0225 0.0427
Echinococcus granulosus lamin dm0 0.0033 0.0247 0.0493
Plasmodium falciparum eukaryotic initiation factor 4A 0.0398 0.4015 1
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1086 0.2603
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.1086 0.2603
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0398 0.4015 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0175 0.0301
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0247 0.0567
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.1086 0.2603
Leishmania major eukaryotic initiation factor 4a, putative 0.0398 0.4015 1
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0057 0.05 0.1121
Schistosoma mansoni kinase 0.0058 0.0509 0.1017
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0531 0.1276
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0175 0.0301
Leishmania major eukaryotic initiation factor 4a, putative 0.0398 0.4015 1
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1086 0.2603
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0398 0.4015 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0669 0.1338
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0107 0.0215
Entamoeba histolytica Ran family GTPase 0.0026 0.0175 0.0301
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0588 0.1075
Brugia malayi CXXC zinc finger family protein 0.0035 0.0269 0.0621
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0107 0.0215
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0335 0.0788
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.0052 0.0104
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0107 0.0218
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0398 0.4015 0.8029
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0225 0.0427
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1086 0.2603
Schistosoma mansoni hypothetical protein 0.0019 0.0107 0.0215
Loa Loa (eye worm) hypothetical protein 0.006 0.0531 0.1276
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0225 0.0427
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0073 0.0073
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0247 0.0563
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0398 0.4015 1
Schistosoma mansoni hypothetical protein 0.0019 0.0107 0.0215
Echinococcus multilocularis geminin 0.0205 0.2019 0.2019
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0175 0.0384
Onchocerca volvulus 0.0035 0.0269 0.0058
Echinococcus granulosus importin subunit beta 1 0.0035 0.027 0.054
Loa Loa (eye worm) hypothetical protein 0.0019 0.0107 0.0215
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.1086 0.2173
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0398 0.4015 1
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0398 0.4015 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.1086 0.2373
Echinococcus multilocularis importin subunit beta 1 0.0035 0.027 0.027
Giardia lamblia Kinase, PLK 0.0114 0.1086 0.2373
Schistosoma mansoni lamin 0.0033 0.0247 0.0493
Echinococcus multilocularis snurportin 1 0.0372 0.3741 0.3741
Brugia malayi hypothetical protein 0.002 0.0114 0.0234
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0022 0.0022
Trichomonas vaginalis hypothetical protein 0.0041 0.0333 0.0699
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0247 0.0563
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0175 0.0388
Echinococcus granulosus eukaryotic initiation factor 4A 0.0398 0.4015 0.8029
Onchocerca volvulus 0.0365 0.3671 0.9088
Loa Loa (eye worm) hypothetical protein 0.0032 0.0241 0.0548
Echinococcus granulosus GPCR family 2 0.0019 0.0107 0.0215
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0107 0.0107
Brugia malayi RNA, U transporter 1 0.0099 0.0931 0.2281
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0175 0.0301
Brugia malayi hypothetical protein 0.003 0.0225 0.0512
Loa Loa (eye worm) hypothetical protein 0.0041 0.0335 0.0785
Leishmania major hypothetical protein, conserved 0.0027 0.0188 0.0033
Leishmania major importin beta-1 subunit, putative 0.0028 0.0202 0.007
Loa Loa (eye worm) hypothetical protein 0.0398 0.4015 1
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0027 0.0188 0.0333
Schistosoma mansoni ran 0.0026 0.0175 0.0351
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1086 0.2603
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0091 0.0177
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.5 0.5
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0398 0.4015 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.1086 0.1086
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0398 0.4015 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0107 0.0215
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.1086 0.2229
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0398 0.4015 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.027 0.0541
Schistosoma mansoni ran 0.0026 0.0175 0.0351
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.1086 0.2669
Echinococcus granulosus snurportin 1 0.0372 0.3741 0.7482
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0398 0.4015 0.5
Schistosoma mansoni intermediate filament proteins 0.0033 0.0247 0.0493
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0027 0.0188 0.0333
Brugia malayi hypothetical protein 0.0084 0.0776 0.1893
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0175 0.0351
Echinococcus multilocularis lamin dm0 0.0033 0.0247 0.0247
Treponema pallidum ATP-dependent RNA helicase 0.0398 0.4015 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0531 0.128
Echinococcus granulosus intermediate filament protein 0.0033 0.0247 0.0493
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0398 0.4015 0.8029
Loa Loa (eye worm) hypothetical protein 0.0033 0.0247 0.0563

Activities

Activity type Activity value Assay description Source Reference
AC50 (binding) = 16.438 uM PUBCHEM_BIOASSAY: C-LANA FP assay Measured in Biochemical System Using Plate Reader - 2117-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504431] ChEMBL. No reference
AC50 (functional) = 292.356 uM PUBCHEM_BIOASSAY: 24 hour HeLa Cytotox assay Measured in Cell-Based System Using Plate Reader - 2117-03_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504431] ChEMBL. No reference
EC50 (functional) > 260 uM PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493224] ChEMBL. No reference
Potency (functional) 1.5849 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.6169 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.2643 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.6626 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.4668 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 5.0119 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 8.191 uM PubChem BioAssay. qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101: Hit Validation. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.1995 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.8336 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485342, AID485388] ChEMBL. No reference
Potency (functional) 63.0957 uM PubChem BioAssay. qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 4 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 75.6863 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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