Detailed information for compound 1416492

Basic information

Technical information
  • TDR Targets ID: 1416492
  • Name: (3-methyl-5-oxo-[1,3]thiazolo[3,2-a]pyrimidin -7-yl)methyl 3-fluoro-4-methoxybenzoate
  • MW: 348.349 | Formula: C16H13FN2O4S
  • H donors: 0 H acceptors: 2 LogP: 1.98 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1F)C(=O)OCc1cc(=O)n2c(n1)scc2C
  • InChi: 1S/C16H13FN2O4S/c1-9-8-24-16-18-11(6-14(20)19(9)16)7-23-15(21)10-3-4-13(22-2)12(17)5-10/h3-6,8H,7H2,1-2H3
  • InChiKey: XDARZTBAYIMBJX-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • (3-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-7-yl)methyl 3-fluoro-4-methoxy-benzoate
  • 3-fluoro-4-methoxybenzoic acid (3-methyl-5-oxo-7-thiazolo[3,2-a]pyrimidinyl)methyl ester
  • 3-fluoro-4-methoxy-benzoic acid (5-keto-3-methyl-thiazolo[3,2-a]pyrimidin-7-yl)methyl ester
  • (3-methyl-5-oxo-[1,3]thiazolo[3,2-a]pyrimidin-7-yl)methyl 3-fluoro-4-methoxy-benzoate
  • ZINC06538616
  • Z88184245

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi PAN domain containing protein 0.0224 0.0503 0.527
Toxoplasma gondii PAN/Apple domain-containing protein 0.0224 0.0503 0.063
Loa Loa (eye worm) PAN domain-containing protein 0.0224 0.0503 0.527
Onchocerca volvulus 0.0224 0.0503 0.527
Onchocerca volvulus 0.0249 0.0566 0.5927
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0104 0.0193 0.2024
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.0232 0.0897
Schistosoma mansoni cercarial elastase (S01 family) 0.0104 0.0193 0.0179
Schistosoma mansoni hypothetical protein 0.0049 0.0053 0.0039
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0104 0.0193 0.0179
Schistosoma mansoni cercarial elastase (S01 family) 0.0104 0.0193 0.0179
Schistosoma mansoni serine-type protease inhibitor 0.3918 1 1
Onchocerca volvulus 0.0224 0.0503 0.527
Brugia malayi PAN domain containing protein 0.0224 0.0503 0.527
Mycobacterium leprae Conserved hypothetical protein 0.0035 0.0017 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0104 0.0193 0.0179
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0104 0.0193 0.185
Onchocerca volvulus 0.0224 0.0503 0.527
Onchocerca volvulus 0.0104 0.0193 0.2024
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.0232 1
Toxoplasma gondii PAN domain-containing protein 0.0224 0.0503 0.063
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0058 0.0178
Onchocerca volvulus 0.0224 0.0503 0.527
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.2444 1
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0117 0.0226 0.384
Echinococcus granulosus Transglutaminase 0.0035 0.0017 0.0032
Brugia malayi PAN domain containing protein 0.0224 0.0503 0.527
Loa Loa (eye worm) trypsin family protein 0.0104 0.0193 0.2024
Loa Loa (eye worm) hypothetical protein 0.0224 0.0503 0.527
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0117 0.0226 0.0872
Brugia malayi Protein kinase domain containing protein 0.0249 0.0566 0.5927
Echinococcus multilocularis transmembrane protease serine 3 0.0104 0.0193 0.0737
Toxoplasma gondii microneme protein MIC17A 0.0224 0.0503 0.063
Echinococcus granulosus glycoprotein Antigen 5 0.0104 0.0193 0.185
Schistosoma mansoni hypothetical protein 0.0035 0.0017 0.0003
Mycobacterium ulcerans transglutaminase family protein 0.0035 0.0017 0.0894
Leishmania major developmentally regulated phosphoprotein-like protein 0.0117 0.0226 0.3994
Mycobacterium ulcerans hypothetical protein 0.0035 0.0017 0.0894
Trypanosoma cruzi hypothetical protein, conserved 0.0249 0.0566 1
Onchocerca volvulus 0.0104 0.0193 0.2024
Loa Loa (eye worm) hypothetical protein 0.0117 0.0226 0.2368
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0104 0.0193 0.0179
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0058 0.0448
Loa Loa (eye worm) hypothetical protein 0.0104 0.0193 0.2024
Schistosoma mansoni pyruvate dehydrogenase 0.011 0.021 0.0196
Loa Loa (eye worm) PAN domain-containing protein 0.0224 0.0503 0.527
Echinococcus granulosus transmembrane protease serine 3 0.0104 0.0193 0.185
Loa Loa (eye worm) hypothetical protein 0.0249 0.0566 0.5927
Echinococcus multilocularis Mastin 0.0104 0.0193 0.0737
Mycobacterium tuberculosis Conserved hypothetical protein 0.0035 0.0017 1
Loa Loa (eye worm) hypothetical protein 0.0224 0.0503 0.527
Loa Loa (eye worm) translation initiation factor 4E 0.0034 0.0014 0.0149
Brugia malayi Trypsin family protein 0.0104 0.0193 0.2024
Echinococcus multilocularis enteropeptidase 0.0104 0.0193 0.0737
Echinococcus multilocularis glycoprotein Antigen 5 0.0104 0.0193 0.0737
Loa Loa (eye worm) hypothetical protein 0.0224 0.0503 0.527
Schistosoma mansoni patched 1 0.0051 0.0058 0.0043
Toxoplasma gondii PAN domain-containing protein 0.0224 0.0503 0.063
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0104 0.0193 0.185
Onchocerca volvulus 0.0224 0.0503 0.527
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0104 0.0193 0.0179
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0041 0.0031 0.0308
Loa Loa (eye worm) hypothetical protein 0.0104 0.0193 0.2024
Schistosoma mansoni cercarial elastase (S01 family) 0.0104 0.0193 0.0179
Onchocerca volvulus 0.0224 0.0503 0.527
Schistosoma mansoni cercarial elastase (S01 family) 0.0104 0.0193 0.0179
Echinococcus granulosus neuropeptides capa receptor 0.0411 0.0983 1
Schistosoma mansoni hypothetical protein 0.0104 0.0193 0.0179
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0058 0.0603
Mycobacterium tuberculosis Hypothetical protein 0.0035 0.0017 1
Plasmodium falciparum cysteine repeat modular protein 1 0.0249 0.0566 0.5
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0034 0.0014 0.0613
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0117 0.0226 0.2188
Onchocerca volvulus 0.0224 0.0503 0.527
Loa Loa (eye worm) hypothetical protein 0.0224 0.0503 0.527
Echinococcus multilocularis expressed conserved protein 0.0112 0.0214 0.082
Brugia malayi Trypsin family protein 0.0104 0.0193 0.2024
Loa Loa (eye worm) hypothetical protein 0.0062 0.0087 0.0912
Leishmania major hypothetical protein, conserved 0.0249 0.0566 1
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.0232 0.2249
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0058 0.0448
Brugia malayi MH2 domain containing protein 0.0144 0.0297 0.311
Mycobacterium tuberculosis Conserved protein 0.0035 0.0017 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0104 0.0193 0.0179
Echinococcus multilocularis neuropeptides capa receptor 0.0411 0.0983 0.3986
Schistosoma mansoni hypothetical protein 0.0049 0.0053 0.0039
Echinococcus granulosus enteropeptidase 0.0104 0.0193 0.185
Onchocerca volvulus 0.0104 0.0193 0.2024
Toxoplasma gondii PAN domain-containing protein 0.0224 0.0503 0.063
Loa Loa (eye worm) hypothetical protein 0.0224 0.0503 0.527
Loa Loa (eye worm) hypothetical protein 0.0104 0.0193 0.2024
Brugia malayi PAN domain containing protein 0.0224 0.0503 0.527
Loa Loa (eye worm) hypothetical protein 0.0104 0.0193 0.2024
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.0363 0.1436
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0058 1
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0041 0.0031 0.0551
Loa Loa (eye worm) hypothetical protein 0.0104 0.0193 0.2024
Onchocerca volvulus 0.0224 0.0503 0.527
Loa Loa (eye worm) hypothetical protein 0.0224 0.0503 0.527
Schistosoma mansoni cercarial elastase (S01 family) 0.0104 0.0193 0.0179
Brugia malayi PAN domain containing protein 0.0224 0.0503 0.527
Brugia malayi hypothetical protein 0.0104 0.0193 0.2024
Toxoplasma gondii PAN domain-containing protein 0.3055 0.7782 1
Brugia malayi PAN domain containing protein 0.0224 0.0503 0.527
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0104 0.0193 0.0179
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0297 0.311
Onchocerca volvulus 0.04 0.0955 1
Brugia malayi Trypsin-like protease protein 5 0.0104 0.0193 0.2024
Loa Loa (eye worm) hypothetical protein 0.0051 0.0058 0.0603
Echinococcus multilocularis protein dispatched 1 0.0058 0.0076 0.0255
Toxoplasma gondii PAN domain-containing protein 0.3055 0.7782 1
Brugia malayi Trypsin family protein 0.0104 0.0193 0.2024
Mycobacterium tuberculosis Conserved hypothetical protein 0.0035 0.0017 1
Brugia malayi PAN domain containing protein 0.0224 0.0503 0.527
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0106 0.0199 0.0185
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0104 0.0193 0.0179
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.0363 0.3603
Brugia malayi PAN domain containing protein 0.0224 0.0503 0.527
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0041 0.0031 0.0801
Loa Loa (eye worm) hypothetical protein 0.0104 0.0193 0.2024
Schistosoma mansoni cercarial elastase (S01 family) 0.0104 0.0193 0.0179
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0047 0.0048 0.0043
Echinococcus multilocularis tissue type plasminogen activator 0.0249 0.0566 0.2272
Toxoplasma gondii PAN domain-containing protein 0.0224 0.0503 0.063
Toxoplasma gondii microneme protein MIC17B 0.0224 0.0503 0.063
Schistosoma mansoni pyruvate dehydrogenase 0.0117 0.0226 0.0212
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0104 0.0193 0.0179
Schistosoma mansoni cercarial elastase (S01 family) 0.0104 0.0193 0.0179
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0104 0.0193 0.0737
Loa Loa (eye worm) hypothetical protein 0.0119 0.0232 0.2429
Onchocerca volvulus 0.0104 0.0193 0.2024
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0104 0.0193 0.0179
Schistosoma mansoni cercarial elastase (S01 family) 0.0104 0.0193 0.0179
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0041 0.0031 0.0022
Toxoplasma gondii hypothetical protein 0.0224 0.0503 0.063
Giardia lamblia Hypothetical protein 0.0035 0.0017 0.5
Loa Loa (eye worm) hypothetical protein 0.04 0.0955 1
Loa Loa (eye worm) hypothetical protein 0.0224 0.0503 0.527
Mycobacterium leprae Conserved hypothetical protein 0.0035 0.0017 1
Toxoplasma gondii microneme protein, putative 0.0224 0.0503 0.063
Mycobacterium tuberculosis Long conserved protein 0.0035 0.0017 1
Onchocerca volvulus 0.0104 0.0193 0.2024
Brugia malayi PAN domain containing protein 0.0224 0.0503 0.527
Echinococcus multilocularis Transglutaminase 0.0035 0.0017 0.0013
Onchocerca volvulus 0.0224 0.0503 0.527
Brugia malayi kinase, mitochondrial precursor 0.0117 0.0226 0.2368
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0034 0.0014 0.0613
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.0232 0.2429
Brugia malayi translation initiation factor 4E 0.0034 0.0014 0.0149
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0104 0.0193 0.0179
Schistosoma mansoni cercarial elastase (S01 family) 0.0104 0.0193 0.0179
Brugia malayi CHE-14 protein 0.0051 0.0058 0.0603
Trichomonas vaginalis peptide N-glycanase, putative 0.0035 0.0017 0.0708
Loa Loa (eye worm) TK/ROR protein kinase 0.0249 0.0566 0.5927
Brugia malayi Kringle domain containing protein 0.0249 0.0566 0.5927
Echinococcus granulosus expressed conserved protein 0.0112 0.0214 0.2058
Leishmania major eukaryotic translation initiation factor-like 0.0034 0.0014 0.0251
Brugia malayi solute carrier family 40, member 1 0.04 0.0955 1
Onchocerca volvulus 0.0224 0.0503 0.527
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0297 0.311
Mycobacterium ulcerans hypothetical protein 0.0035 0.0017 0.0894
Brugia malayi Thioredoxin family protein 0.0035 0.0017 0.0181
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0104 0.0193 0.0737
Leishmania major eukaryotic translation initiation factor eIF-4E, putative 0.0034 0.0014 0.0251
Schistosoma mansoni pyruvate dehydrogenase 0.011 0.021 0.0196
Echinococcus granulosus tissue type plasminogen activator 0.0249 0.0566 0.5699
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0117 0.0226 0.0872
Loa Loa (eye worm) PAN domain-containing protein 0.0224 0.0503 0.527
Loa Loa (eye worm) PAN domain-containing protein 0.0224 0.0503 0.527
Toxoplasma gondii subtilisin SUB12 0.0224 0.0503 0.063
Leishmania major eukaryotic translation initiation factor-like protein 0.0034 0.0014 0.0251
Echinococcus multilocularis protein patched 0.0051 0.0058 0.0178
Echinococcus granulosus Mastin 0.0104 0.0193 0.185
Brugia malayi Trypsin family protein 0.0104 0.0193 0.2024
Onchocerca volvulus 0.0224 0.0503 0.527
Schistosoma mansoni hypothetical protein 0.0049 0.0053 0.0039
Toxoplasma gondii microneme protein MIC4 0.0224 0.0503 0.063
Trypanosoma brucei developmentally regulated phosphoprotein 0.0117 0.0226 1
Schistosoma mansoni hypothetical protein 0.0249 0.0566 0.0553
Schistosoma mansoni hypothetical protein 0.0104 0.0193 0.0179
Giardia lamblia Transglutaminase/protease, putative 0.0035 0.0017 0.5
Toxoplasma gondii hypothetical protein 0.0224 0.0503 0.063
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0224 0.0503 0.063
Schistosoma mansoni hypothetical protein 0.0049 0.0053 0.0039
Loa Loa (eye worm) PAN domain-containing protein 0.0224 0.0503 0.527
Toxoplasma gondii microneme protein MIC17C 0.0224 0.0503 0.063
Mycobacterium ulcerans putative transglutaminase-like protein 0.0035 0.0017 0.0894
Brugia malayi PAN domain containing protein 0.0224 0.0503 0.527
Toxoplasma gondii kringle domain-containing protein 0.0249 0.0566 0.0711
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0249 0.0566 0.5
Onchocerca volvulus 0.0104 0.0193 0.2024
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.0237 0.0223
Onchocerca volvulus 0.0035 0.0017 0.0181
Loa Loa (eye worm) hypothetical protein 0.0104 0.0193 0.2024
Mycobacterium ulcerans hypothetical protein 0.0104 0.0193 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1.7783 um PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.2387 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.3934 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 2.8184 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.1475 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 6.5104 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10.3183 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Saccharomyces cerevisiae ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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