Detailed information for compound 1420704

Basic information

Technical information
  • TDR Targets ID: 1420704
  • Name: N-[5-(ethyl-phenylsulfamoyl)-2-methoxyphenyl] -2,3,4,5-tetrafluorobenzamide
  • MW: 482.448 | Formula: C22H18F4N2O4S
  • H donors: 1 H acceptors: 3 LogP: 4.2 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1NC(=O)c1cc(F)c(c(c1F)F)F)S(=O)(=O)N(c1ccccc1)CC
  • InChi: 1S/C22H18F4N2O4S/c1-3-28(13-7-5-4-6-8-13)33(30,31)14-9-10-18(32-2)17(11-14)27-22(29)15-12-16(23)20(25)21(26)19(15)24/h4-12H,3H2,1-2H3,(H,27,29)
  • InChiKey: OELNBYBZGXWBIS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[5-(ethyl-phenyl-sulfamoyl)-2-methoxy-phenyl]-2,3,4,5-tetrafluoro-benzamide
  • T0511-5361

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATM serine/threonine kinase Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Bacillus subtilis (strain 168) ATP-dependent Clp protease proteolytic subunit Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Entamoeba histolytica hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K01358 ATP-dependent Clp protease, protease subunit [EC3.4.21.92], putative Get druggable targets OG5_127187 All targets in OG5_127187
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus peptidase Clp S14 family Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Trypanosoma brucei gambiense phosphatidylinositol kinase domain protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Plasmodium yoelii ATP-dependent Clp protease, proteolytic subunit ClpP, putative Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127187 All targets in OG5_127187
Neospora caninum phosphatidylinositol 3- and 4-kinase domain- containing protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_128955 All targets in OG5_128955
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania braziliensis phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans identical to the C terminus of CaP19.5580 potential phosphatidylinositol kinase Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Trypanosoma brucei phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii FATC domain-containing protein Get druggable targets OG5_128955 All targets in OG5_128955
Treponema pallidum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis serine protein kinase ATM Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma japonicum IPR000971,Globin;IPR012292,Globin-related;IPR009050,Globin-like,domain-containing Get druggable targets OG5_128955 All targets in OG5_128955
Leishmania donovani phosphatidylinositol 3-kinase-like protein Get druggable targets OG5_128955 All targets in OG5_128955
Leishmania mexicana phosphatidylinositol 3-kinase-like protein Get druggable targets OG5_128955 All targets in OG5_128955
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania major phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma japonicum ko:K04728 ataxia telangectasia mutated family protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Candida albicans similar to putative phosphatidylinositol kinase involved in telomere length regulation Get druggable targets OG5_128955 All targets in OG5_128955
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Babesia bovis ATP-dependent Clp protease proteolytic subunit 1, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K06275 parvin, putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Neospora caninum ATP-dependent Clp protease proteolytic subunit, related Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus serine protein kinase ATM Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma mansoni ataxia telangiectasia mutated (atm) Get druggable targets OG5_128955 All targets in OG5_128955
Leishmania infantum phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Candida albicans similar to putative phosphatidylinositol kinase involved in telomere length regulation Get druggable targets OG5_128955 All targets in OG5_128955
Brugia malayi Probable ClpP-like protease Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_128955 All targets in OG5_128955
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 ATP-dependent Clp protease proteolytic subunit   197 aa 172 aa 57.0 %
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 180 aa 36.7 %
Schistosoma mansoni neuropeptide receptor ATP-dependent Clp protease proteolytic subunit   197 aa 174 aa 20.1 %
Treponema pallidum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 186 aa 40.3 %
Onchocerca volvulus Putative V-type proton ATPase subunit F ATP-dependent Clp protease proteolytic subunit   197 aa 194 aa 54.1 %
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 36.0 %
Plasmodium yoelii Clp protease ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.6 %
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.1 %
Chlamydia trachomatis hypothetical protein ATP-dependent Clp protease proteolytic subunit   197 aa 171 aa 22.8 %
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 35.5 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1551 0.5264
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.2881 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0022 0.0418 0.2325
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0143 0.0853
Mycobacterium ulcerans hypothetical protein 0.0027 0.0607 0.1181
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0062 0.1777 0.5775
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0022 0.0418 0.6675
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1551 0.5264
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.2881 1
Mycobacterium tuberculosis Conserved protein TB27.3 0.0027 0.0607 0.2065
Echinococcus granulosus beta catenin 0.0034 0.0847 0.0847
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0022 0.0418 0.5785
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0095 0.0567
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0419 0.3946
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0019 0.0329 0.0178
Schistosoma mansoni hypothetical protein 0.0084 0.2525 0.8566
Mycobacterium tuberculosis Conserved protein 0.0027 0.0607 0.2065
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0033 0.0781 0.1771
Schistosoma mansoni fkbp-rapamycin associated protein 0.0012 0.0095 0.0322
Mycobacterium tuberculosis Conserved hypothetical protein 0.0027 0.0607 0.2065
Loa Loa (eye worm) hypothetical protein 0.0026 0.0552 0.0918
Echinococcus multilocularis protein pangolin J 0.0085 0.257 0.8721
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0011 0.0038 0.0038
Mycobacterium tuberculosis Conserved protein 0.0027 0.0607 0.2065
Echinococcus granulosus hypothetical protein 0.0084 0.2525 0.2525
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0022 0.0418 0.1418
Echinococcus granulosus proteasome assembly chaperone 2 0.0059 0.1672 0.1672
Loa Loa (eye worm) phosphatidylinositol 3 0.0022 0.0418 0.0695
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0418 0.25
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0011 0.0038 0.0063
Onchocerca volvulus Cirhin homolog 0.0034 0.0839 0.134
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0418 0.25
Leishmania major phosphatidylinositol kinase related protein, putative 0.0022 0.0419 0.67
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0022 0.0418 0.0695
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.003 0.0695 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0022 0.0418 0.5785
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0095 0.0567
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0418 0.25
Schistosoma mansoni peptidase Clp (S14 family) 0.0094 0.2881 0.9777
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0095 0.0567
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0022 0.0418 0.5785
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0022 0.0418 0.6675
Echinococcus granulosus expressed conserved protein 0.0039 0.1004 0.1004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0418 0.25
Onchocerca volvulus Putative protein 0.0187 0.6014 1
Schistosoma mansoni hypothetical protein 0.0096 0.2947 1
Brugia malayi hypothetical protein 0.0039 0.1004 0.167
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0094 0.2881 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.1551 0.2579
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0022 0.0418 0.1418
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0012 0.0095 0.0322
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0095 0.0567
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0014 0.0143 0.1591
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0033 0.0781 0.2613
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0418 0.25
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0012 0.0095 0.0587
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0418 0.25
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0418 0.25
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.2881 1
Schistosoma mansoni 4-hydroxyphenylpyruvate dioxygenase 0.0027 0.0607 0.206
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1551 0.5264
Leishmania major phosphatidylinositol 3-kinase, putative 0.0022 0.0418 0.6675
Loa Loa (eye worm) hypothetical protein 0.0027 0.0607 0.101
Trypanosoma cruzi lactoylglutathione lyase-like protein, putative 0.0027 0.0607 0.5889
Toxoplasma gondii target of rapamycin (TOR), putative 0.0022 0.0418 0.1336
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein 0.0037 0.0917 0.3093
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.2881 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0094 0.2881 1
Mycobacterium ulcerans DNA gyrase subunit A 0.0037 0.0917 0.2384
Mycobacterium ulcerans glyoxalase GloA 0.0027 0.0607 0.1181
Trichomonas vaginalis DNA topoisomerase II, putative 0.0011 0.0038 0.0228
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.1004 1
Schistosoma mansoni hypothetical protein 0.0018 0.0303 0.1027
Toxoplasma gondii glyoxalase family protein 0.0027 0.0607 0.2002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0418 0.25
Echinococcus multilocularis peptidase Clp (S14 family) 0.0062 0.1777 0.6031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0418 0.25
Plasmodium falciparum glyoxalase I 0.0027 0.0607 0.2002
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0062 0.1777 1
Entamoeba histolytica hypothetical protein 0.003 0.0695 0.4019
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.003 0.0695 0.1155
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1551 0.1551
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.003 0.0695 0.2357
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0022 0.0418 0.5785
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0062 0.1777 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0094 0.2881 0.9777
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0418 0.25
Brugia malayi Armadillo/beta-catenin-like repeat family protein 0.0034 0.0847 0.1408
Mycobacterium ulcerans DNA gyrase subunit B 0.0019 0.0329 0.0102
Trypanosoma cruzi target of rapamycin kinase 3 0.0022 0.0418 0.3931
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0095 0.0567
Toxoplasma gondii hypothetical protein 0.0033 0.0781 0.2613
Trypanosoma cruzi lactoylglutathione lyase-like protein, putative 0.0027 0.0607 0.5889
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0418 0.25
Mycobacterium ulcerans hypothetical protein 0.0027 0.0607 0.1181
Mycobacterium leprae conserved hypothetical protein 0.0018 0.0303 0.0132
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0022 0.0418 0.0418
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.2881 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0418 0.25
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0022 0.0418 0.0695
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0014 0.0143 0.0368
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0022 0.0418 0.6675
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0418 0.25
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0418 0.25
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0418 0.25
Mycobacterium tuberculosis Cadmium inducible protein CadI 0.0027 0.0607 0.2065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0418 0.25
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0607 0.3631
Giardia lamblia GTOR 0.0022 0.0418 1
Loa Loa (eye worm) HMP-2 protein 0.0034 0.0847 0.1408
Schistosoma mansoni gynecophoral canal protein 0.0027 0.0607 0.206
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0418 0.25
Loa Loa (eye worm) TOPoisomerase family member 0.0011 0.0038 0.0063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0095 0.0567
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0012 0.0095 0.0158
Loa Loa (eye worm) phosphatidylinositol 3 0.0022 0.0418 0.0695
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0418 0.25
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0026 0.0552 0.532
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0094 0.2881 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0143 0.0237
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0012 0.0095 0.0095
Plasmodium vivax DNA gyrase subunit A, putative 0.0037 0.0917 0.3093
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A 0.0037 0.0917 0.2306
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.2881 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0022 0.0418 0.6675
Plasmodium falciparum glyoxalase I 0.0027 0.0607 0.2002
Toxoplasma gondii hypothetical protein 0.0039 0.1004 0.3399
Brugia malayi Probable ClpP-like protease 0.0094 0.2881 0.4791
Mycobacterium ulcerans hypothetical protein 0.0027 0.0607 0.1181
Mycobacterium ulcerans glyoxalase GloA 0.0027 0.0607 0.1181
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1551 0.5264
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0418 0.25
Plasmodium vivax glyoxalase I, putative 0.0027 0.0607 0.2002
Entamoeba histolytica protein kinase rad3, putative 0.0012 0.0095 0.0347
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0418 0.25
Plasmodium falciparum DNA gyrase subunit A 0.0037 0.0917 0.3093
Plasmodium vivax DNA gyrase subunit B, putative 0.0019 0.0329 0.1023
Mycobacterium ulcerans hypothetical protein 0.0027 0.0607 0.1181
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0143 0.0853
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0022 0.0418 0.2325
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0094 0.2881 1
Plasmodium falciparum DNA gyrase subunit B 0.0019 0.0329 0.1023
Echinococcus multilocularis proteasome assembly chaperone 2 0.0059 0.1672 0.5674
Loa Loa (eye worm) hypothetical protein 0.0094 0.2881 0.4791
Chlamydia trachomatis DNA gyrase subunit A 0.0037 0.0917 0.2306
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0418 0.25
Echinococcus granulosus serine protein kinase ATM 0.003 0.0695 0.0695
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.003 0.0695 0.6795
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0695 0.4155
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.1551 0.2579
Toxoplasma gondii FATC domain-containing protein 0.003 0.0695 0.231
Echinococcus multilocularis serine protein kinase ATM 0.003 0.0695 0.2357
Mycobacterium leprae conserved hypothetical protein 0.0027 0.0607 0.1297
Schistosoma mansoni DNA topoisomerase II 0.0011 0.0038 0.0129
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0095 0.0567
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0022 0.0418 0.1418
Treponema pallidum DNA gyrase, subunit A (gyrA) 0.0037 0.0917 0.2306
Loa Loa (eye worm) 4-hydroxyphenylpyruvate dioxygenase 0.0187 0.6014 1
Mycobacterium ulcerans hypothetical protein 0.0027 0.0607 0.1181
Echinococcus granulosus protein pangolin J 0.0085 0.257 0.257
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0022 0.0418 0.5785
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0022 0.0418 0.3931
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0418 0.25
Brugia malayi Probable DNA topoisomerase II 0.0011 0.0038 0.0063
Brugia malayi lactoylglutathione lyase 0.0027 0.0607 0.101
Toxoplasma gondii glyoxalase I, putative 0.0027 0.0607 0.2002
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0012 0.0095 0.0347
Echinococcus granulosus peptidase Clp S14 family 0.0062 0.1777 0.1777
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0033 0.0781 0.1962
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0418 0.25
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0418 0.25
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0418 0.25
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0418 0.25
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0607 0.3631
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0418 0.25
Onchocerca volvulus Lactoylglutathione lyase homolog 0.0027 0.0607 0.0952
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0418 0.25
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0022 0.0418 0.3931
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0033 0.0781 0.2613
Plasmodium vivax glyoxalase I, putative 0.0027 0.0607 0.2002
Echinococcus multilocularis beta catenin 0.0034 0.0847 0.2873
Entamoeba histolytica hypothetical protein 0.0059 0.1672 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0094 0.2881 1
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0037 0.0917 0.4168
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0022 0.0418 0.1418
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1551 0.1551
Echinococcus multilocularis expressed conserved protein 0.0039 0.1004 0.3408
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1551 0.5264
Trichomonas vaginalis hypothetical protein 0.0059 0.1672 1
Brugia malayi 4-hydroxyphenylpyruvate dioxygenase family protein 0.0187 0.6014 1
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0011 0.0038 0.0063
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0022 0.0418 0.3931
Schistosoma mansoni beta-catenin 0.0034 0.0847 0.2873
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0094 0.2881 0.2881
Leishmania major glyoxalase I,trypanothione-dependent glyoxalase I 0.0027 0.0607 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0418 0.25
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0022 0.0418 0.0418
Schistosoma mansoni hypothetical protein 0.0059 0.1672 0.5674
Mycobacterium ulcerans hypothetical protein 0.0027 0.0607 0.1181
Echinococcus multilocularis expressed conserved protein 0.0096 0.2947 1
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0011 0.0038 0.0129
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0022 0.0418 0.3931
Mycobacterium leprae conserved hypothetical protein 0.0018 0.0303 0.0132
Loa Loa (eye worm) hypothetical protein 0.0012 0.0095 0.0158
Mycobacterium ulcerans biphenyl-2,3-diol 1,2-dioxygenase 0.0027 0.0607 0.1181

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying a Potential Treatment of Ataxia-Telangiectasia. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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