Detailed information for compound 1423548

Basic information

Technical information
  • TDR Targets ID: 1423548
  • Name: N-(2-methoxy-5-methylphenyl)-N'-1,3,5-triazat ricyclo[3.3.1.1~3,7~]dec-7-ylthiourea
  • MW: 333.452 | Formula: C16H23N5OS
  • H donors: 1 H acceptors: 0 LogP: 1.91 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1N=C(NC12CN3CN(C2)CN(C1)C3)S)C
  • InChi: 1S/C16H23N5OS/c1-12-3-4-14(22-2)13(5-12)17-15(23)18-16-6-19-9-20(7-16)11-21(8-16)10-19/h3-5H,6-11H2,1-2H3,(H2,17,18,23)
  • InChiKey: NPHBZAICMZCHGO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • SMR000306355
  • ChemDiv3_006038
  • IDI1_023948
  • MLS000727658

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens l(3)mbt-like 1 (Drosophila) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Lethal(3)malignant brain tumor-like 3 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus granulosus endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Schistosoma japonicum Lethal(3)malignant brain tumor-like 4 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus multilocularis endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130415 All targets in OG5_130415
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.1136 0.1109
Schistosoma mansoni hypothetical protein 0.0369 1 1
Schistosoma mansoni intermediate filament proteins 0.0028 0.0622 0.0593
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0044 0.1063 0.1035
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0016 0.0291 0.0826
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0084 0.0053
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0084 0.0084
Echinococcus multilocularis snurportin 1 0.0369 1 1
Brugia malayi calpain 5 0.0011 0.0159 0.016
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.3266 0.3245
Echinococcus granulosus cathepsin b 0.0133 0.3523 0.3523
Echinococcus multilocularis importin 5 0.0007 0.0031 0.0031
Schistosoma mansoni calpain C (C02 family) 0.0016 0.0291 0.0261
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0084 0.0084
Schistosoma mansoni calpain (C02 family) 0.0016 0.0291 0.0261
Loa Loa (eye worm) calpain family protein 1 0.0031 0.0709 0.068
Loa Loa (eye worm) calpain 0.0016 0.0291 0.0261
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0802 0.6252
Brugia malayi MH2 domain containing protein 0.0124 0.3266 0.4041
Brugia malayi intermediate filament protein 0.0028 0.0622 0.0739
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0058 0.1437 1
Brugia malayi calpain family protein 1 0.0042 0.1017 0.1232
Brugia malayi mbt repeat family protein 0.0058 0.1437 0.1757
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0622 0.485
Plasmodium vivax calpain, putative 0.0016 0.0291 0.3371
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0551 0.1564
Brugia malayi cathepsin B-like cysteine proteinase 0.0133 0.3523 0.4362
Echinococcus multilocularis translational activator gcn1 0.0007 0.0031 0.0031
Brugia malayi hypothetical protein 0.0036 0.0843 0.1015
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0369 1 1
Echinococcus multilocularis lamin 0.0028 0.0622 0.0622
Brugia malayi Muscleblind-like protein 0.0297 0.8035 1
Echinococcus granulosus lamin dm0 0.0028 0.0622 0.0622
Schistosoma mansoni Mername-AA248 (C02 family) 0.0016 0.0291 0.0261
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0025 0.0551 0.0551
Schistosoma mansoni lamin 0.0028 0.0622 0.0593
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0044 0.1069 0.1042
Loa Loa (eye worm) hypothetical protein 0.0026 0.0577 0.0548
Loa Loa (eye worm) hypothetical protein 0.0031 0.0709 0.068
Echinococcus multilocularis cathepsin b 0.0133 0.3523 0.3523
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.1437 0.141
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0044 0.1069 0.1042
Entamoeba histolytica hypothetical protein 0.0028 0.0622 0.7377
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.1282 1
Trypanosoma brucei calpain-like protein, putative 0.0016 0.0291 0.2268
Echinococcus granulosus calpain 7 C02 family 0.0016 0.0291 0.0291
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0016 0.0291 0.0826
Trichomonas vaginalis ran, putative 0.0025 0.0551 0.4295
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.1656 0.1656
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0016 0.0291 0.0826
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.1437 0.1437
Loa Loa (eye worm) hypothetical protein 0.0013 0.0209 0.0179
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0802 0.0802
Trypanosoma brucei protein kinase, putative 0.0052 0.1282 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.0044 0.1063 0.8287
Brugia malayi MH2 domain containing protein 0.0008 0.0084 0.0066
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0044 0.1063 0.8244
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.1136 0.1381
Trichomonas vaginalis hypothetical protein 0.0007 0.0031 0.0241
Schistosoma mansoni smad1 5 8 and 0.0008 0.0084 0.0053
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.1656 0.1656
Echinococcus granulosus translational activator gcn1 0.0007 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0038 0.0885 0.0856
Schistosoma mansoni smad1 5 8 and 0.0008 0.0084 0.0053
Echinococcus multilocularis transportin 1 0.0007 0.0031 0.0031
Echinococcus multilocularis calpain family protein 1, d 0.0031 0.0709 0.0709
Echinococcus multilocularis lamin dm0 0.0028 0.0622 0.0622
Loa Loa (eye worm) hypothetical protein 0.0013 0.0209 0.0179
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0016 0.0291 0.2268
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.1656 0.1656
Loa Loa (eye worm) Smad1 0.0008 0.0084 0.0053
Loa Loa (eye worm) hypothetical protein 0.0028 0.0608 0.0579
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.1282 1
Brugia malayi RNA, U transporter 1 0.0098 0.2555 0.3153
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.1282 0.1282
Brugia malayi mbt repeat family protein 0.0058 0.1437 0.1757
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0016 0.0291 0.0826
Onchocerca volvulus 0.0058 0.1437 1
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0044 0.1069 0.1069
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0223 0.0223
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0622 0.0593
Entamoeba histolytica hypothetical protein 0.0036 0.0843 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.1136 0.1109
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.1282 0.1282
Loa Loa (eye worm) calpain 5 0.0011 0.0159 0.0128
Loa Loa (eye worm) hypothetical protein 0.0014 0.0223 0.0193
Loa Loa (eye worm) calpain family protein 1 0.0042 0.1017 0.0989
Loa Loa (eye worm) hypothetical protein 0.0058 0.1437 0.141
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.1136 0.1109
Loa Loa (eye worm) hypothetical protein 0.0042 0.1017 0.0989
Entamoeba histolytica Ran family GTPase 0.0025 0.0551 0.6532
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0025 0.0551 0.065
Trypanosoma brucei calpain-like protein, putative 0.0016 0.0291 0.2268
Schistosoma mansoni calpain-7 (C02 family) 0.0016 0.0291 0.0261
Echinococcus granulosus GTP binding nuclear protein Ran 0.0025 0.0551 0.0551
Brugia malayi calpain 7 0.0016 0.0291 0.0325
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0044 0.1069 0.1069
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0084 0.0053
Brugia malayi MH1 domain containing protein 0.0008 0.0084 0.0066
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.1282 0.1282
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0133 0.3523 0.3503
Echinococcus granulosus calpain 0.0016 0.0291 0.0291
Echinococcus granulosus smad 0.0008 0.0084 0.0084
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0802 0.6159
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.1282 1
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.1437 0.141
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0802 0.6252
Echinococcus multilocularis Smad4 0.0008 0.0084 0.0084
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0264 0.0234
Trypanosoma brucei calpain-like protein, putative 0.0016 0.0291 0.2268
Onchocerca volvulus 0.0028 0.0622 0.0528
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0622 0.485
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0016 0.0291 0.0826
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0084 0.0084
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.1656 0.163
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0133 0.3523 0.3503
Echinococcus granulosus calpain A 0.0044 0.1069 0.1069
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.1282 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.1136 0.1136
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.1282 0.3641
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.1656 0.2031
Entamoeba histolytica hypothetical protein 0.0036 0.0843 1
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0025 0.0551 0.6744
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0622 0.1766
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.1282 0.3641
Echinococcus multilocularis muscleblind protein 1 0.0297 0.8035 0.8035
Echinococcus multilocularis hypothetical protein 0.0016 0.0291 0.0291
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0084 0.0053
Plasmodium vivax importin-beta 2, putative 0.0035 0.0802 1
Schistosoma mansoni smad1 5 8 and 0.0008 0.0084 0.0053
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0133 0.3523 0.3503
Loa Loa (eye worm) MBCTL1 0.0066 0.1656 0.163
Brugia malayi MAP kinase sur-1 0.0052 0.1282 0.1564
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0622 0.0739
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.1282 1
Trypanosoma brucei Importin-beta N-terminal domain/HEAT-like repeat, putative 0.0007 0.0031 0.0241
Schistosoma mansoni ran 0.0025 0.0551 0.0521
Echinococcus granulosus importin 5 0.0007 0.0031 0.0031
Echinococcus multilocularis calpain 0.0016 0.0291 0.0291
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0016 0.0291 0.2268
Entamoeba histolytica hypothetical protein 0.0036 0.0843 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0084 0.0084
Echinococcus granulosus calpain 5 0.0016 0.0291 0.0291
Echinococcus multilocularis muscleblind protein 0.0297 0.8035 0.8035
Brugia malayi calpain family protein 1 0.0042 0.1017 0.1232
Echinococcus multilocularis musashi 0.0028 0.0622 0.0622
Echinococcus granulosus muscleblind protein 0.0297 0.8035 0.8035
Schistosoma mansoni hypothetical protein 0.035 0.9491 0.9489
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0025 0.0551 0.6744
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.1136 0.1136
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.1437 0.141
Echinococcus granulosus transportin 1 0.0007 0.0031 0.0031
Giardia lamblia Cathepsin B precursor 0.0044 0.1063 0.6997
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.1282 1
Echinococcus multilocularis calpain 7 (C02 family) 0.0016 0.0291 0.0291
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0016 0.0291 0.0826
Schistosoma mansoni hypothetical protein 0.0036 0.0843 0.0815
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.1282 0.3641
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0264 0.0292
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.1136 0.1109
Entamoeba histolytica HEAT repeat domain containing protein 0.0007 0.0031 0.0367
Brugia malayi Importin beta-1 subunit 0.0035 0.0802 0.0963
Echinococcus granulosus lamin 0.0028 0.0622 0.0622
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0622 0.485
Echinococcus granulosus calpain A 0.0016 0.0291 0.0291
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.1437 0.141
Schistosoma mansoni smad 0.0008 0.0084 0.0053
Trypanosoma cruzi kinesin, putative 0.0011 0.0159 0.045
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0133 0.3523 0.3503
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0223 0.0223
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.1282 0.1282
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.1136 0.1136
Entamoeba histolytica hypothetical protein 0.0036 0.0843 1
Loa Loa (eye worm) hypothetical protein 0.0297 0.8035 0.8029
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0016 0.0291 0.0826
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.1656 0.1656
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0025 0.0551 0.4295
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0042 0.1017 0.0989
Schistosoma mansoni Smad4 0.0008 0.0084 0.0053
Trypanosoma brucei antigen, putative 0.0016 0.0291 0.2268
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0227 0.61 0.61
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0044 0.1063 0.3017
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0016 0.0291 0.0826
Trypanosoma brucei calpain-like protein, putative 0.0016 0.0291 0.2268
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0016 0.0291 0.0826
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0044 0.1063 0.8287
Leishmania major kinesin, putative 0.0011 0.0159 0.102
Echinococcus multilocularis cathepsin b 0.0133 0.3523 0.3523
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.1282 0.3641
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0025 0.0551 0.0521
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0016 0.0291 0.2076
Echinococcus multilocularis calpain 5 0.0016 0.0291 0.0291
Loa Loa (eye worm) hypothetical protein 0.0035 0.0802 0.0773
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0016 0.0291 0.2076
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0133 0.3523 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0622 0.0593
Echinococcus granulosus intermediate filament protein 0.0028 0.0622 0.0622
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0843 0.0815
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.1136 0.1136
Leishmania major importin beta-1 subunit, putative 0.0028 0.0622 0.4723
Trypanosoma brucei kinesin, putative 0.0011 0.0159 0.1237
Echinococcus granulosus Smad4 0.0008 0.0084 0.0084
Schistosoma mansoni importin beta-1 0.0035 0.0802 0.0773
Giardia lamblia Cathepsin B precursor 0.0044 0.1063 0.6997
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0843 0.0843
Schistosoma mansoni calpain-7 (C02 family) 0.0016 0.0291 0.0261
Brugia malayi Smad1 0.0008 0.0084 0.0066
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.1282 1
Brugia malayi MH2 domain containing protein 0.0008 0.0084 0.0066
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0007 0.0044 0.0342
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0016 0.0291 0.2076
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0622 0.0593
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.1282 1
Leishmania major GTP-binding protein, putative 0.0025 0.0551 0.4154
Echinococcus granulosus cathepsin b 0.0133 0.3523 0.3523
Loa Loa (eye worm) hypothetical protein 0.0133 0.3523 0.3503
Trypanosoma cruzi kinesin, putative 0.0011 0.0159 0.045
Echinococcus multilocularis smad 0.0008 0.0084 0.0084
Schistosoma mansoni ran 0.0025 0.0551 0.0521
Onchocerca volvulus 0.0028 0.0622 0.0528
Echinococcus granulosus importin subunit beta 1 0.0035 0.0802 0.0802
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.3266 0.3245
Toxoplasma gondii cathepsin B 0.0044 0.1063 0.8244
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0227 0.61 0.61
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0025 0.0551 0.4154
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.1282 0.1255
Plasmodium falciparum importin beta, putative 0.0035 0.0802 1
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.1437 0.1437
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.1437 0.1437
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0016 0.0291 0.0826
Giardia lamblia Cathepsin B precursor 0.0044 0.1063 0.6997
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.1282 0.1255
Brugia malayi MH1 domain containing protein 0.0008 0.0084 0.0066
Loa Loa (eye worm) cathepsin B 0.0044 0.1063 0.1035
Echinococcus multilocularis calpain A 0.0044 0.1069 0.1069
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.1282 1
Entamoeba histolytica protein kinase, putative 0.0012 0.0172 0.2035
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0843 0.0843
Entamoeba histolytica calpain large subunit domain III containing protein 0.0011 0.0159 0.1881
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.1437 0.1437
Loa Loa (eye worm) hypothetical protein 0.0066 0.1656 0.163
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0551 0.1564
Schistosoma mansoni lamin 0.0028 0.0622 0.0593
Loa Loa (eye worm) hypothetical protein 0.0297 0.8035 0.8029

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1.122 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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