Detailed information for compound 1429179

Basic information

Technical information
  • TDR Targets ID: 1429179
  • Name: 2-[(Z)-2-(4-chlorophenyl)ethenyl]-3-(3-methox yphenyl)quinazolin-4-one
  • MW: 388.846 | Formula: C23H17ClN2O2
  • H donors: 0 H acceptors: 1 LogP: 5.12 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)n1c(/C=C\c2ccc(cc2)Cl)nc2c(c1=O)cccc2
  • InChi: 1S/C23H17ClN2O2/c1-28-19-6-4-5-18(15-19)26-22(14-11-16-9-12-17(24)13-10-16)25-21-8-3-2-7-20(21)23(26)27/h2-15H,1H3/b14-11-
  • InChiKey: MRJAVPSFUVLGQR-KAMYIIQDSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[(Z)-2-(4-chlorophenyl)vinyl]-3-(3-methoxyphenyl)quinazolin-4-one
  • 2-[(Z)-2-(4-chlorophenyl)vinyl]-3-(3-methoxyphenyl)-4-quinazolinone
  • NCGC00098740-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens galactosylceramidase No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0111 0.1344 0.1279
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0039 0.0075 0.0052
Loa Loa (eye worm) hypothetical protein 0.0088 0.0942 0.0921
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0203 0.2948 0.2895
Trichomonas vaginalis PIKK family atypical protein kinase 0.0604 1 1
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0038 0.006 0.0037
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0039 0.0075 0.0059
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0111 0.1344 0.1279
Trichomonas vaginalis PIKK family atypical protein kinase 0.0326 0.5119 0.5111
Loa Loa (eye worm) phosphatidylinositol 3 0.0039 0.0075 0.0052
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0023 0.0023
Loa Loa (eye worm) phosphatidylinositol 3 0.0203 0.2948 0.2932
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0203 0.2948 0.2895
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0712 0.0697
Loa Loa (eye worm) hypothetical protein 0.0114 0.1397 0.1377
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0942 0.0927
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0075 0.5
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0439 0.0417
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0604 1 1
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0039 0.0075 0.0052
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0203 0.2948 0.2895
Echinococcus granulosus serine protein kinase ATM 0.0114 0.1397 0.1397
Trichomonas vaginalis PIKK family atypical protein kinase 0.0203 0.2948 0.2937
Entamoeba histolytica protein kinase rad3, putative 0.0114 0.1397 0.1332
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0039 0.0075 0.0075
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0039 0.0075 0.0052
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0039 0.0075 0.0052
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0604 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0326 0.5119 0.5111
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0039 0.0075 0.0052
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0075 0.039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0326 0.5119 0.5111
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0039 0.0075 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0481 0.7829 0.7826
Echinococcus multilocularis fk506 binding protein 0.0111 0.1344 0.1324
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0039 0.0075 0.0059
Echinococcus multilocularis serine protein kinase ATM 0.0114 0.1397 0.1377
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0039 0.0075 0.0059
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0111 0.1344 0.5
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0111 0.1344 0.1324
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0039 0.0075 0.0052
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0111 0.1344 0.1279
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0039 0.0075 0.0071
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0039 0.0075 0.039
Toxoplasma gondii target of rapamycin (TOR), putative 0.0449 0.7281 1
Schistosoma mansoni fkbp-rapamycin associated protein 0.0114 0.1397 0.1377
Trichomonas vaginalis conserved hypothetical protein 0.0075 0.0712 0.0697
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0039 0.0075 0.039
Loa Loa (eye worm) cytochrome P450 family protein 0.0078 0.0761 0.074
Loa Loa (eye worm) FKBP5 protein 0.0111 0.1344 0.1324
Trichomonas vaginalis PIKK family atypical protein kinase 0.0449 0.7281 0.7277
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0039 0.0075 0.0075
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0039 0.0075 0.039
Schistosoma mansoni hypothetical protein 0.0039 0.0075 0.0052
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0039 0.0075 0.0071
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0114 0.1397 0.1332
Trichomonas vaginalis PIKK family atypical protein kinase 0.0481 0.7829 0.7826
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0039 0.0075 0.039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0114 0.1397 0.1383
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0039 0.0075 0.0052
Echinococcus multilocularis tumor protein p63 0.0408 0.6555 0.6547
Trichomonas vaginalis PIKK family atypical protein kinase 0.0449 0.7281 0.7277
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0039 0.0075 0.0052
Toxoplasma gondii FATC domain-containing protein 0.0114 0.1397 0.1893
Plasmodium vivax hypothetical protein 0.0039 0.0075 0.039
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0203 0.2948 0.2895
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0604 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0162 0.2237 0.2224
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0111 0.1344 0.1279
Loa Loa (eye worm) phosphatidylinositol 3 0.0039 0.0075 0.0052
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0039 0.0075 0.0059
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0038 0.006 0.0037
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0111 0.1344 0.1324
Loa Loa (eye worm) phosphatidylinositol 3 0.0039 0.0075 0.0052
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0111 0.1344 0.1279
Loa Loa (eye worm) phosphatidylinositol 3 0.0039 0.0075 0.0052
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0604 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0604 1 1
Echinococcus multilocularis Zinc finger, PHD finger 0.0039 0.0075 0.0052
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0111 0.1344 0.1279
Loa Loa (eye worm) hypothetical protein 0.0127 0.1626 0.1607
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0039 0.0075 0.0075
Trichomonas vaginalis fk506-binding protein, putative 0.0111 0.1344 0.133
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0039 0.0075 0.0059
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0111 0.1344 0.1279
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0039 0.0075 0.0059
Leishmania major phosphatidylinositol 3-kinase, putative 0.0203 0.2948 0.2895
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0604 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0481 0.7829 0.7826
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0039 0.0075 0.0071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0326 0.511 0.5103
Loa Loa (eye worm) hypothetical protein 0.0039 0.0075 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0405 0.6507 0.6501
Trichomonas vaginalis PIKK family atypical protein kinase 0.0449 0.7281 0.7277
Trichomonas vaginalis PIKK family atypical protein kinase 0.0449 0.7281 0.7277
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0039 0.0075 0.0052
Onchocerca volvulus 0.006 0.0439 0.0947
Trypanosoma cruzi cytochrome P450, putative 0.0078 0.0761 0.0691
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0039 0.0075 0.0059
Onchocerca volvulus 0.0039 0.0075 0.0117
Trichomonas vaginalis PIKK family atypical protein kinase 0.0449 0.7281 0.7277
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0114 0.1397 0.1377
Trichomonas vaginalis set domain proteins, putative 0.0286 0.4413 0.4404
Schistosoma mansoni hypothetical protein 0.0088 0.0942 0.0921
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0039 0.0075 0.0052
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0604 1 1
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0088 0.0942 0.0942
Echinococcus multilocularis 0.0039 0.0075 0.0052
Entamoeba histolytica hypothetical protein 0.0114 0.1397 0.1332
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0481 0.7838 0.7822
Trichomonas vaginalis PIKK family atypical protein kinase 0.0604 1 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0203 0.2948 0.2932
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0114 0.1397 0.1332
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.3803 0.3789
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0039 0.0075 0.0052
Trypanosoma brucei cytochrome P450, putative 0.0078 0.0761 0.0691
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0111 0.1344 1
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0039 0.0075 0.0052
Brugia malayi Pre-SET motif family protein 0.0251 0.3803 0.3789
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0286 0.4408 0.4366
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0114 0.1397 0.1332
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0111 0.1344 0.1344
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0075 0.0059
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.0075 0.5
Leishmania major fk506-binding protein 1-like protein 0.0111 0.1344 0.1279
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0203 0.2948 0.2895
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0039 0.0075 0.0052
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0604 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0203 0.2948 0.2937
Trichomonas vaginalis PIKK family atypical protein kinase 0.0392 0.6278 0.6272
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0251 0.3797 0.375
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0039 0.0075 0.0052
Onchocerca volvulus 0.0286 0.4413 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.1075 0.1054
Loa Loa (eye worm) phosphatidylinositol 3 0.0604 1 1
Schistosoma mansoni immunophilin 0.0096 0.1075 0.1054
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0114 0.1397 0.1332
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0039 0.0075 0.0071
Loa Loa (eye worm) phosphatidylinositol 3 0.0039 0.0075 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0361 0.573 0.5723
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0039 0.0075 0.0075
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0038 0.006 0.006
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0088 0.0942 0.0921
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0111 0.1344 0.1324
Schistosoma mansoni immunophilin 0.0111 0.1344 0.1324
Trichomonas vaginalis PIKK family atypical protein kinase 0.0326 0.511 0.5103
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0039 0.0075 0.0052
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0111 0.1344 1
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0122 0.0099
Leishmania major cytochrome p450-like protein 0.0078 0.0761 0.0691
Trichomonas vaginalis PIKK family atypical protein kinase 0.0361 0.573 0.5723
Trichomonas vaginalis PIKK family atypical protein kinase 0.0114 0.1397 0.1383
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0111 0.1344 0.1279
Trichomonas vaginalis PIKK family atypical protein kinase 0.0481 0.7829 0.7826
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0039 0.0075 0.0052
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0114 0.1397 0.1377
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0039 0.0075 0.0075
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0481 0.7838 0.7822
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0039 0.0075 0.0059
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0039 0.0075 0.0059
Trichomonas vaginalis PIKK family atypical protein kinase 0.0114 0.1397 0.1383
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0111 0.1344 0.1344
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0111 0.1344 0.1279
Trichomonas vaginalis immunophilin, putative 0.0111 0.1344 0.133
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0039 0.0075 0.0075
Trichomonas vaginalis PIKK family atypical protein kinase 0.0357 0.5667 0.566
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0114 0.1397 0.1377
Trichomonas vaginalis PIKK family atypical protein kinase 0.0449 0.7281 0.7277
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0039 0.0075 0.0052
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0111 0.1344 0.1324
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0039 0.0075 0.0071
Giardia lamblia GTOR 0.0604 1 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0078 0.0761 0.074
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0039 0.0075 0.0052
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0127 0.1626 0.2208
Loa Loa (eye worm) hypothetical protein 0.0123 0.1552 0.1533
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0039 0.0075 0.0052
Brugia malayi Cytochrome P450 family protein 0.0078 0.0761 0.074
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0039 0.0075 0.0052
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0096 0.1075 0.1075
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0604 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0449 0.7281 0.7277
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0111 0.1344 0.1279
Trichomonas vaginalis PIKK family atypical protein kinase 0.0357 0.5667 0.566
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0114 0.1397 0.1397
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0039 0.0075 0.0075
Trichomonas vaginalis PIKK family atypical protein kinase 0.0203 0.2948 0.2937
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0114 0.1397 0.1377
Trichomonas vaginalis PIKK family atypical protein kinase 0.0326 0.5119 0.5111
Loa Loa (eye worm) hypothetical protein 0.006 0.0439 0.0417
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0096 0.1075 0.1054
Trypanosoma cruzi target of rapamycin kinase 3 0.0481 0.7838 0.7822
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0039 0.0075 0.0059
Trichomonas vaginalis PIKK family atypical protein kinase 0.0203 0.2948 0.2937
Loa Loa (eye worm) CYP4Cod1 0.0078 0.0761 0.074
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0604 1 1
Trypanosoma cruzi cytochrome P450, putative 0.0078 0.0761 0.0691
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0038 0.006 0.0037
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0039 0.0075 0.0075
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0122 0.0099
Loa Loa (eye worm) hypothetical protein 0.0075 0.0712 0.0691
Trichomonas vaginalis PIKK family atypical protein kinase 0.0516 0.8449 0.8446
Trichomonas vaginalis PIKK family atypical protein kinase 0.0481 0.7829 0.7826
Onchocerca volvulus 0.0039 0.0075 0.0117
Trichomonas vaginalis PIKK family atypical protein kinase 0.0326 0.511 0.5103
Brugia malayi Cytochrome P450 family protein 0.0078 0.0761 0.074
Loa Loa (eye worm) phosphatidylinositol kinase 0.0039 0.0075 0.0052
Leishmania major peptidylprolyl isomerase-like protein 0.0111 0.1344 0.1279
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0111 0.1344 1
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0111 0.1344 0.1324
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0203 0.2948 0.2932
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0604 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0127 0.1626 0.1613
Brugia malayi FAT domain containing protein 0.0088 0.0942 0.0921
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0604 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0361 0.573 0.5723
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0039 0.0075 0.0059
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0203 0.2948 0.2932
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0075 0.0712 0.0642
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0039 0.0075 0.0059
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0111 0.1344 0.133
Loa Loa (eye worm) hypothetical protein 0.0056 0.0367 0.0344
Loa Loa (eye worm) hypothetical protein 0.0039 0.0075 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0075 0.0059
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0111 0.1344 0.133
Echinococcus granulosus tumor protein p63 0.0408 0.6555 0.6555
Trichomonas vaginalis PIKK family atypical protein kinase 0.0203 0.2948 0.2937
Schistosoma mansoni immunophilin 0.0111 0.1344 0.1324
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0039 0.0075 0.0059
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0203 0.2948 0.2948

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1.2589 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. A Novel Cell-Based Assay to Identify Small Molecules for B -Galactocerebrosidase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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