TDR Targets

Basic information

Technical information

TDR Targets ID: 143270
Name: 4-amino-N-cyclopropyl-1-pentylpyrazolo[3,4-b] pyridine-5-carboxamide
MW: 287.36 | Formula: C15H21N5O
H donors: 2 H acceptors: 3 LogP: 2.26 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCCCCn1ncc2c1ncc(c2N)C(=O)NC1CC1
InChi: 1S/C15H21N5O/c1-2-3-4-7-20-14-11(9-18-20)13(16)12(8-17-14)15(21)19-10-5-6-10/h8-10H,2-7H2,1H3,(H2,16,17)(H,19,21)
InChiKey: JQKRNYRISDVWSM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-amino-N-cyclopropyl-1-pentyl-pyrazolo[3,4-b]pyridine-5-carboxamide
4-amino-N-cyclopropyl-1-pentyl-5-pyrazolo[3,4-b]pyridinecarboxamide
4-azanyl-N-cyclopropyl-1-pentyl-pyrazolo[3,4-b]pyridine-5-carboxamide
4-amino-1-amyl-N-cyclopropyl-pyrazolo[3,4-b]pyridine-5-carboxamide
4-amino-N-cyclopropyl-1-pentylpyrazolo[4,5-e]pyridine-5-carboxamide
4-amino-N-cyclopropyl-1-pentyl-pyrazolo[4,5-e]pyridine-5-carboxamide
4-amino-N-cyclopropyl-1-pentyl-5-pyrazolo[4,5-e]pyridinecarboxamide
4-amino-1-amyl-N-cyclopropyl-pyrazolo[4,5-e]pyridine-5-carboxamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	GABA-A receptor; anion channel	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Onchocerca volvulus	Large subunit GTPase 1 homolog	GABA-A receptor; anion channel	467 aa	496 aa	26.0 %
Echinococcus granulosus	glycine receptor subunit alpha 1	GABA-A receptor; anion channel	467 aa	430 aa	32.3 %
Onchocerca volvulus		GABA-A receptor; anion channel	467 aa	447 aa	25.7 %
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	GABA-A receptor; anion channel	467 aa	479 aa	29.2 %
Brugia malayi	Cation transporter family protein	GABA-A receptor; anion channel	467 aa	453 aa	28.5 %
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	GABA-A receptor; anion channel	467 aa	375 aa	21.9 %
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	GABA-A receptor; anion channel	467 aa	384 aa	19.5 %
Echinococcus multilocularis	glycine receptor subunit beta	GABA-A receptor; anion channel	467 aa	478 aa	28.7 %
Onchocerca volvulus		GABA-A receptor; anion channel	467 aa	454 aa	30.4 %
Loa Loa (eye worm)	hypothetical protein	GABA-A receptor; anion channel	467 aa	446 aa	29.1 %
Onchocerca volvulus		GABA-A receptor; anion channel	467 aa	446 aa	28.0 %
Loa Loa (eye worm)	hypothetical protein	GABA-A receptor; anion channel	467 aa	441 aa	33.8 %
Loa Loa (eye worm)	hypothetical protein	GABA-A receptor; anion channel	467 aa	461 aa	27.8 %
Onchocerca volvulus		GABA-A receptor; anion channel	467 aa	435 aa	29.7 %
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	GABA-A receptor; anion channel	467 aa	379 aa	19.3 %
Onchocerca volvulus		GABA-A receptor; anion channel	467 aa	468 aa	28.6 %
Loa Loa (eye worm)	hypothetical protein	GABA-A receptor; anion channel	467 aa	494 aa	25.5 %
Echinococcus multilocularis	glycine receptor subunit alpha 1	GABA-A receptor; anion channel	467 aa	430 aa	32.3 %
Onchocerca volvulus	Acetylcholine receptor subunit alpha-type homolog	GABA-A receptor; anion channel	467 aa	418 aa	19.6 %
Onchocerca volvulus		GABA-A receptor; anion channel	467 aa	434 aa	26.7 %
Onchocerca volvulus	Eukaryotic initiation factor 4A-III homolog	GABA-A receptor; anion channel	467 aa	453 aa	26.9 %
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	GABA-A receptor; anion channel	467 aa	454 aa	29.5 %
Onchocerca volvulus	Gamma-aminobutyric acid receptor subunit beta homolog	GABA-A receptor; anion channel	467 aa	433 aa	34.6 %
Echinococcus granulosus	glycine receptor subunit beta	GABA-A receptor; anion channel	467 aa	439 aa	29.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0079	0.097	0.097
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0089	0.1118	0.1118
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0151	0.0151
Loa Loa (eye worm)	oxidoreductase	0.0089	0.1118	0.1118
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0089	0.1118	0.1118
Loa Loa (eye worm)	hypothetical protein	0.0702	1	1
Entamoeba histolytica	aldose reductase, putative	0.0089	0.1118	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.097	0.097
Mycobacterium ulcerans	oxidoreductase	0.0089	0.1118	0.4045
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0023	0.0151	0.0151
Echinococcus multilocularis	aldo keto reductase	0.0089	0.1118	0.1118
Loa Loa (eye worm)	Notch2	0.0079	0.097	0.097
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0023	0.0151	0.0151
Loa Loa (eye worm)	animal heme peroxidase	0.0702	1	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0089	0.1118	0.1118
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0023	0.0151	0.0151
Echinococcus multilocularis	fibropellin Ia	0.0079	0.097	0.097
Loa Loa (eye worm)	hypothetical protein	0.0702	1	1
Echinococcus multilocularis	lipoxygenase domain containing protein	0.002	0.0113	0.0113
Trypanosoma brucei	prostaglandin f synthase	0.0089	0.1118	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.097	0.097
Plasmodium falciparum	aldehyde reductase, putative	0.0089	0.1118	1
Trypanosoma cruzi	aldo/keto reductase, putative	0.0089	0.1118	1
Echinococcus multilocularis	neurogenic locus protein delta	0.0079	0.097	0.097
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.012	0.1557	0.1557
Loa Loa (eye worm)	animal heme peroxidase	0.0702	1	1
Echinococcus multilocularis	neural cadherin	0.0079	0.097	0.097
Trypanosoma brucei	aldo/keto reductase, putative	0.0089	0.1118	1
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0089	0.1118	1
Leishmania major	aldo-keto reductase-like protein	0.0089	0.1118	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0089	0.1118	1
Schistosoma mansoni	nAChR subunit	0.0023	0.0151	0.0151
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0089	0.1118	0.1118
Trichomonas vaginalis	aldo-keto reductase, putative	0.0089	0.1118	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.097	0.097
Loa Loa (eye worm)	oxidoreductase	0.0089	0.1118	0.1118
Echinococcus granulosus	lipoxygenase domain containing protein	0.002	0.0113	0.0113
Onchocerca volvulus		0.0023	0.0151	0.0151
Plasmodium vivax	oxidoreductase, aldo/keto reductase domain containing protein	0.0089	0.1118	1
Trichomonas vaginalis	alcohol dehydrogenase, putative	0.0089	0.1118	1
Onchocerca volvulus		0.002	0.0113	0.0113
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0023	0.0151	0.0151
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0089	0.1118	0.1118
Schistosoma mansoni	hypothetical protein	0.0079	0.097	0.097
Brugia malayi	Cation transporter family protein	0.0023	0.0151	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0151	0.0151
Brugia malayi	EGF-like domain containing protein	0.0079	0.097	0.097
Loa Loa (eye worm)	hypothetical protein	0.0702	1	1
Brugia malayi	Peroxidasin	0.0702	1	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.097	0.097
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0151	0.0151
Schistosoma mansoni	rab6-interacting	0.002	0.0113	0.0113
Echinococcus granulosus	aldo keto reductase	0.0089	0.1118	0.1118
Brugia malayi	hypothetical protein	0.002	0.0113	0.0113
Brugia malayi	EGF-like domain containing protein	0.0079	0.097	0.097
Echinococcus granulosus	aldo keto reductase family 1, member B4	0.0089	0.1118	0.1118
Loa Loa (eye worm)	LGC-31 protein	0.0023	0.0151	0.0151
Echinococcus multilocularis	notch	0.0079	0.097	0.097
Schistosoma mansoni	nAChR subunit	0.0023	0.0151	0.0151
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0089	0.1118	0.1118
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0151	0.0151
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0089	0.1118	0.1118
Onchocerca volvulus		0.0089	0.1118	0.1118
Onchocerca volvulus	Peroxidasin homolog	0.0702	1	1
Brugia malayi	EGF-like domain containing protein	0.0079	0.097	0.097
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0023	0.0151	0.0151
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0079	0.097	0.097
Brugia malayi	excitatory GABA receptor EXP-1A	0.0023	0.0151	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0079	0.097	0.097
Loa Loa (eye worm)	glutamate-cysteine ligase modifier subunit	0.0089	0.1118	0.1118
Schistosoma mansoni	cell polarity protein	0.0079	0.097	0.097
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0151	0.0151
Brugia malayi	notch-like transmembrane receptor	0.0079	0.097	0.097
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0079	0.097	0.097
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0023	0.0151	0.0151
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0089	0.1118	0.1118
Schistosoma mansoni	loxhd1	0.002	0.0113	0.0113
Brugia malayi	Calcium binding EGF domain containing protein	0.0079	0.097	0.097
Echinococcus multilocularis	aldo keto reductase	0.0089	0.1118	0.1118
Echinococcus multilocularis	peroxidasin	0.0702	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0089	0.1118	1
Echinococcus granulosus	protein jagged 1	0.0079	0.097	0.097
Toxoplasma gondii	aldose reductase, putative	0.0089	0.1118	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0151	0.0151
Brugia malayi	Animal haem peroxidase family protein	0.0702	1	1
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0079	0.097	0.097
Schistosoma mansoni	inositol monophosphatase	0.0037	0.0366	0.0366
Trypanosoma cruzi	aldo-keto reductase	0.0089	0.1118	1
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0062	0.0716	0.4647
Plasmodium falciparum	aldo-keto reductase, putative	0.0089	0.1118	1
Onchocerca volvulus	Putative cubilin	0.0079	0.097	0.097
Echinococcus granulosus	nAChR subunit	0.0023	0.0151	0.0151
Trichomonas vaginalis	aldo-keto reductase, putative	0.0089	0.1118	1
Echinococcus multilocularis	slit 2 protein	0.0079	0.097	0.097
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0089	0.1118	0.1118
Onchocerca volvulus		0.0023	0.0151	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0151	0.0151
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.012	0.1557	0.1557
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0037	0.0366	0.3275
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0089	0.1118	0.1118
Onchocerca volvulus		0.0023	0.0151	0.0151
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0023	0.0151	0.0151
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0023	0.0151	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0079	0.097	0.097
Schistosoma mansoni	notch	0.0079	0.097	0.097
Onchocerca volvulus		0.0089	0.1118	0.1118
Trichomonas vaginalis	aldo-keto reductase, putative	0.0089	0.1118	1
Schistosoma mansoni	potassium channel beta	0.0089	0.1118	0.1118
Echinococcus granulosus	protein jagged 2	0.0079	0.097	0.097
Onchocerca volvulus		0.0702	1	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0151	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0702	1	1
Loa Loa (eye worm)	blistered cuticle protein 3	0.0702	1	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.097	0.097
Giardia lamblia	Aldose reductase	0.0089	0.1118	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0089	0.1118	1
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0023	0.0151	0.0151
Onchocerca volvulus		0.0089	0.1118	0.1118
Trichomonas vaginalis	aldo-keto reductase, putative	0.0089	0.1118	1
Onchocerca volvulus		0.0023	0.0151	0.0151
Trichomonas vaginalis	aldo/keto reductase, putative	0.0089	0.1118	1
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0023	0.0151	0.0151
Schistosoma mansoni	nAChR subunit	0.0023	0.0151	0.0151
Brugia malayi	Doublecortin family protein	0.002	0.0113	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0079	0.097	0.097
Loa Loa (eye worm)	hypothetical protein	0.0089	0.1118	0.1118
Brugia malayi	Delta serrate ligand family protein	0.0079	0.097	0.097
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0089	0.1118	1
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0023	0.0151	0.0151
Trichomonas vaginalis	aldo-keto reductase, putative	0.0089	0.1118	1
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0062	0.0716	0.0716
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0023	0.0151	0.0151
Onchocerca volvulus	Putative nachr subunit	0.0023	0.0151	0.0151
Schistosoma mansoni	nAChR subunit	0.0023	0.0151	0.0151
Schistosoma mansoni	pol-related	0.0089	0.1118	0.1118
Onchocerca volvulus		0.0079	0.097	0.097
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0089	0.1118	0.1118
Brugia malayi	Animal haem peroxidase family protein	0.0702	1	1
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0023	0.0151	0.0151
Trichomonas vaginalis	aldo-keto reductase, putative	0.0089	0.1118	1
Echinococcus granulosus	fibropellin Ia	0.0079	0.097	0.097
Toxoplasma gondii	aldo-keto reductase	0.0089	0.1118	1
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0023	0.0151	0.0151
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0023	0.0151	0.0151
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0023	0.0151	0.0151
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0023	0.0151	0.0151
Onchocerca volvulus		0.0079	0.097	0.097
Echinococcus granulosus	protein jagged 1	0.0079	0.097	0.097
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0151	0.0151
Echinococcus granulosus	peroxidasin	0.0702	1	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0151	0.0151
Loa Loa (eye worm)	animal heme peroxidase	0.0702	1	1
Echinococcus granulosus	glycine receptor subunit beta	0.0023	0.0151	0.0151
Entamoeba histolytica	aldose reductase, putative	0.0089	0.1118	1
Onchocerca volvulus	Peroxidase homolog	0.0702	1	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.097	0.097
Schistosoma mansoni	polycystin 1-related	0.002	0.0113	0.0113
Onchocerca volvulus		0.0089	0.1118	0.1118
Schistosoma mansoni	hypothetical protein	0.0079	0.097	0.097
Schistosoma mansoni	nAChR subunit	0.0023	0.0151	0.0151
Brugia malayi	EGF-like domain containing protein	0.0079	0.097	0.097
Echinococcus multilocularis	neurogenic locus notch protein	0.0079	0.097	0.097
Loa Loa (eye worm)	doublecortin family protein	0.002	0.0113	0.0113
Echinococcus granulosus	protein jagged 2	0.0079	0.097	0.097
Loa Loa (eye worm)	hypothetical protein	0.0702	1	1
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.0089	0.1118	1
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0023	0.0151	0.0151
Loa Loa (eye worm)	inositol-1	0.0037	0.0366	0.0366
Loa Loa (eye worm)	oxidoreductase	0.0089	0.1118	0.1118
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0151	0.0151
Schistosoma mansoni	lipoxygenase	0.0084	0.1035	0.1035
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0062	0.0716	0.0716
Echinococcus multilocularis	glycine receptor subunit beta	0.0023	0.0151	0.0151
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0023	0.0151	0.0151
Loa Loa (eye worm)	hypothetical protein	0.002	0.0113	0.0113
Brugia malayi	Animal haem peroxidase family protein	0.0702	1	1
Brugia malayi	Cadherin domain containing protein	0.0079	0.097	0.097
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0023	0.0151	0.0151
Entamoeba histolytica	alcohol dehydrogenase, putative	0.0089	0.1118	1
Schistosoma mansoni	hypothetical protein	0.0079	0.097	0.097
Echinococcus multilocularis	protein jagged 2	0.0079	0.097	0.097
Onchocerca volvulus	Neurogenic locus notch homolog	0.0079	0.097	0.097
Onchocerca volvulus		0.0079	0.097	0.097
Loa Loa (eye worm)	hypothetical protein	0.0079	0.097	0.097
Echinococcus multilocularis	Polycystic kidney disease protein	0.002	0.0113	0.0113
Trichomonas vaginalis	aldo-keto reductase, putative	0.0089	0.1118	1
Echinococcus multilocularis	lipoxygenase domain containing protein	0.002	0.0113	0.0113
Echinococcus multilocularis	voltage gated potassium channel subunit	0.0089	0.1118	0.1118
Echinococcus granulosus	delta-like protein 1	0.0079	0.097	0.097
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0023	0.0151	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0079	0.097	0.097
Echinococcus multilocularis	glycine receptor subunit beta	0.0023	0.0151	0.0151
Echinococcus granulosus	lipoxygenase domain containing protein	0.002	0.0113	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0079	0.097	0.097
Trichomonas vaginalis	aldo/keto reductase, putative	0.0089	0.1118	1
Echinococcus granulosus	notch	0.0079	0.097	0.097
Schistosoma mansoni	inositol monophosphatase	0.0037	0.0366	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0702	1	1
Mycobacterium ulcerans	epoxide hydrolase EphA	0.0166	0.2226	1
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0023	0.0151	0.0151
Onchocerca volvulus		0.0702	1	1
Entamoeba histolytica	aldose reductase, putative	0.0089	0.1118	1
Mycobacterium tuberculosis	Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase)	0.0166	0.2226	1
Brugia malayi	Animal haem peroxidase family protein	0.0702	1	1
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0023	0.0151	0.0151
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0089	0.1118	0.1118
Echinococcus granulosus	neurogenic locus notch protein	0.0079	0.097	0.097
Loa Loa (eye worm)	hypothetical protein	0.0079	0.097	0.097
Schistosoma mansoni	notch	0.0079	0.097	0.097
Loa Loa (eye worm)	hypothetical protein	0.0079	0.097	0.097
Giardia lamblia	Aldose reductase	0.0089	0.1118	1
Trypanosoma cruzi	aldo/keto reductase, putative	0.0089	0.1118	1
Echinococcus granulosus	glycine receptor subunit beta	0.0023	0.0151	0.0151
Brugia malayi	GCC2 and GCC3 family protein	0.0079	0.097	0.097
Schistosoma mansoni	septate junction protein	0.0079	0.097	0.097
Loa Loa (eye worm)	hypothetical protein	0.0702	1	1
Schistosoma mansoni	rab6-interacting	0.002	0.0113	0.0113
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0089	0.1118	0.1118
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0062	0.0716	0.188
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0037	0.0366	0.5
Schistosoma mansoni	notch	0.0079	0.097	0.097
Brugia malayi	glutamate-cysteine ligase modifier subunit	0.0089	0.1118	0.1118
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0023	0.0151	0.0151
Schistosoma mansoni	aldehyde dehydrogenase	0.0062	0.0716	0.0716
Schistosoma mansoni	nAChR subunit	0.0023	0.0151	0.0151
Loa Loa (eye worm)	notch protein	0.0079	0.097	0.097
Echinococcus multilocularis	aldo keto reductase	0.0089	0.1118	0.1118
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0023	0.0151	0.0151
Leishmania major	prostaglandin f synthase, putative	0.0089	0.1118	1
Onchocerca volvulus		0.0089	0.1118	0.1118
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0089	0.1118	0.1118
Brugia malayi	EGF-like domain containing protein	0.0079	0.097	0.097
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0089	0.1118	0.1118
Loa Loa (eye worm)	hypothetical protein	0.0702	1	1
Onchocerca volvulus	Slit protein homolog	0.0079	0.097	0.097
Schistosoma mansoni	slit	0.0079	0.097	0.097
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0151	0.0151
Echinococcus multilocularis	protein jagged 1	0.0079	0.097	0.097
Trichomonas vaginalis	aldo-keto reductase, putative	0.0089	0.1118	1
Echinococcus granulosus	neurogenic locus protein delta	0.0079	0.097	0.097
Schistosoma mansoni	laminin gamma-3 chain	0.0079	0.097	0.097
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0089	0.1118	1
Schistosoma mansoni	notch	0.0079	0.097	0.097
Echinococcus multilocularis	protein jagged 1	0.0079	0.097	0.097
Brugia malayi	EGF-like domain containing protein	0.0079	0.097	0.097
Loa Loa (eye worm)	hypothetical protein	0.0079	0.097	0.097
Mycobacterium tuberculosis	Probable oxidoreductase	0.0089	0.1118	0.4222
Echinococcus granulosus	slit 2 protein	0.0079	0.097	0.097
Loa Loa (eye worm)	ACC-1 protein	0.0023	0.0151	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0151	0.0151
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0089	0.1118	0.1118
Loa Loa (eye worm)	hypothetical protein	0.002	0.0113	0.0113
Schistosoma mansoni	peroxidasin	0.0702	1	1
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0023	0.0151	0.0151
Toxoplasma gondii	oxidoreductase, aldo/keto reductase family protein	0.0089	0.1118	1
Echinococcus granulosus	RUN	0.002	0.0113	0.0113
Onchocerca volvulus	Dual oxidase homolog	0.0702	1	1
Mycobacterium tuberculosis	Conserved protein	0.0089	0.1118	0.4222
Toxoplasma gondii	aldo/keto reductase family oxidoreductase	0.0089	0.1118	1
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0023	0.0151	0.0151
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0023	0.0151	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0079	0.097	0.097
Onchocerca volvulus	Peroxidase homolog	0.0702	1	1
Schistosoma mansoni	peroxidasin	0.0702	1	1
Brugia malayi	Inositol-1	0.0037	0.0366	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0151	0.0151
Trichomonas vaginalis	aldo-keto reductase, putative	0.0089	0.1118	1
Loa Loa (eye worm)	oxidoreductase	0.0089	0.1118	0.1118
Echinococcus granulosus	aldo keto reductase	0.0089	0.1118	0.1118
Mycobacterium ulcerans	hypothetical protein	0.0089	0.1118	0.4045
Schistosoma mansoni	lipoxygenase	0.012	0.1557	0.1557
Leishmania major	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	0.0089	0.1118	1
Schistosoma mansoni	nAChR subunit	0.0023	0.0151	0.0151
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0023	0.0151	0.0151
Onchocerca volvulus		0.0079	0.097	0.097
Schistosoma mansoni	aldo-keto reductase	0.0089	0.1118	0.1118
Schistosoma mansoni	hypothetical protein	0.002	0.0113	0.0113
Toxoplasma gondii	aldehyde dehydrogenase	0.0062	0.0716	0.4647
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0023	0.0151	0.0151
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0023	0.0151	0.0151
Brugia malayi	Cation transporter family protein	0.0023	0.0151	0.0151
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0089	0.1118	0.1118
Echinococcus granulosus	hypothetical protein	0.0089	0.1118	0.1118
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0023	0.0151	0.0151
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0023	0.0151	0.0151
Echinococcus granulosus	aldo keto reductase	0.0089	0.1118	0.1118
Schistosoma mansoni	hypothetical protein	0.0079	0.097	0.097
Echinococcus granulosus	voltage gated potassium channel subunit	0.0089	0.1118	0.1118
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0023	0.0151	0.0151
Echinococcus multilocularis	inositol monophosphatase 1	0.0037	0.0366	0.0366
Brugia malayi	Cation transporter family protein	0.0023	0.0151	0.0151
Brugia malayi	Animal haem peroxidase family protein	0.0702	1	1
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0089	0.1118	0.1118
Brugia malayi	Calcium binding EGF domain containing protein	0.0079	0.097	0.097
Onchocerca volvulus	Chorion peroxidase homolog	0.0702	1	1
Loa Loa (eye worm)	hypothetical protein	0.0702	1	1
Brugia malayi	hypothetical protein	0.002	0.0113	0.0113
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0089	0.1118	0.1118
Onchocerca volvulus		0.0089	0.1118	0.1118
Loa Loa (eye worm)	hypothetical protein	0.0079	0.097	0.097
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0079	0.097	0.097
Onchocerca volvulus	Peroxidasin homolog	0.0702	1	1
Leishmania major	aldehyde reductase, putative,oxidoreductase, putative	0.0089	0.1118	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0089	0.1118	0.1118
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0089	0.1118	0.1118
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0062	0.0716	0.188
Brugia malayi	Muscle positioning protein 4	0.0079	0.097	0.097
Onchocerca volvulus		0.0079	0.097	0.097
Loa Loa (eye worm)	hypothetical protein	0.0702	1	1
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0023	0.0151	0.0151
Onchocerca volvulus		0.0089	0.1118	0.1118
Echinococcus granulosus	neurogenic locus notch protein 4	0.0079	0.097	0.097
Onchocerca volvulus		0.002	0.0113	0.0113
Mycobacterium leprae	Possible oxidoreductase	0.0089	0.1118	1
Trypanosoma brucei	aldo-keto reductase, putative	0.0089	0.1118	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0151	0.0151
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0023	0.0151	0.0151
Echinococcus multilocularis	aldo keto reductase	0.0089	0.1118	0.1118
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0023	0.0151	0.0151
Onchocerca volvulus		0.0702	1	1
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0023	0.0151	0.0151
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0023	0.0151	0.0151
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0079	0.097	0.097
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0023	0.0151	0.0151
Trichomonas vaginalis	aldo-keto reductase, putative	0.0089	0.1118	1
Echinococcus multilocularis	nAChR subunit	0.0023	0.0151	0.0151
Loa Loa (eye worm)	ACC-1 protein	0.0023	0.0151	0.0151
Plasmodium vivax	aldehyde reductase, putative	0.0089	0.1118	1
Brugia malayi	EGF-like domain containing protein	0.0079	0.097	0.097
Loa Loa (eye worm)	hypothetical protein	0.0702	1	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.097	0.097
Schistosoma mansoni	hypothetical protein	0.0079	0.097	0.097
Leishmania major	aldo/keto reductase, putative,aldo/keto reductase family-like protein	0.0089	0.1118	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0151	0.0151
Onchocerca volvulus		0.0023	0.0151	0.0151
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0023	0.0151	0.0151
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0023	0.0151	0.0151
Loa Loa (eye worm)	animal heme peroxidase	0.0702	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0089	0.1118	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0151	0.0151
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0023	0.0151	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0151	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0151	0.0151
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0089	0.1118	0.1118
Loa Loa (eye worm)	hypothetical protein	0.0702	1	1
Onchocerca volvulus		0.0023	0.0151	0.0151
Toxoplasma gondii	EGF family domain-containing protein	0.0079	0.097	0.8024
Schistosoma mansoni	notch	0.0079	0.097	0.097
Loa Loa (eye worm)	hypothetical protein	0.0702	1	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.097	0.097
Loa Loa (eye worm)	oxidoreductase	0.0089	0.1118	0.1118
Loa Loa (eye worm)	hypothetical protein	0.0702	1	1
Schistosoma mansoni	notch	0.0079	0.097	0.097
Schistosoma mansoni	aldehyde dehydrogenase	0.0062	0.0716	0.0716
Brugia malayi	NADH-dependent xylose reductase	0.0089	0.1118	0.1118
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0023	0.0151	0.0151
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0062	0.0716	0.2121
Entamoeba histolytica	alcohol dehydrogenase, putative	0.0089	0.1118	1
Echinococcus multilocularis	RUN	0.002	0.0113	0.0113
Trichomonas vaginalis	aldo/keto reductase, putative	0.0089	0.1118	1
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0023	0.0151	0.0151
Brugia malayi	Blistered cuticle protein 3	0.0702	1	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.097	0.097
Schistosoma mansoni	hypothetical protein	0.0079	0.097	0.097
Schistosoma mansoni	aldo-keto reductase	0.0089	0.1118	0.1118
Echinococcus multilocularis	neurogenic locus notch protein	0.0079	0.097	0.097
Brugia malayi	Cadherin domain containing protein	0.0079	0.097	0.097
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0062	0.0716	0.188
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0023	0.0151	0.0151
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0023	0.0151	0.0151
Echinococcus granulosus	neural cadherin	0.0079	0.097	0.097
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0089	0.1118	0.1118
Trichomonas vaginalis	conserved hypothetical protein	0.0089	0.1118	1
Schistosoma mansoni	hypothetical protein	0.0079	0.097	0.097
Loa Loa (eye worm)	hypothetical protein	0.0079	0.097	0.097
Echinococcus granulosus	neurogenic locus notch protein	0.0079	0.097	0.097
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0023	0.0151	0.0151
Echinococcus multilocularis	neurogenic locus protein delta	0.0079	0.097	0.097
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0023	0.0151	0.0151
Echinococcus granulosus	inositol monophosphatase 1	0.0037	0.0366	0.0366
Trichomonas vaginalis	aldo-keto reductase, putative	0.0089	0.1118	1
Brugia malayi	Calcium binding EGF domain containing protein	0.0079	0.097	0.097
Echinococcus granulosus	Polycystic kidney disease protein	0.002	0.0113	0.0113
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0089	0.1118	0.1118

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 312 nM	Inhibition of [3H]-flunitrazepam binding to GABA-A benzodiazepine receptor of rat cerebral cortex	ChEMBL.	2573731
IC50 (binding)	= 312 nM	Inhibition of [3H]-flunitrazepam binding to GABA-A benzodiazepine receptor of rat cerebral cortex	ChEMBL.	2573731
MED (functional)	= 12.5 mg kg-1	Minimum effective dose (po) tested for its anxiolytic activity in rat using the shock-induced suppression of drinking (SSD) test.	ChEMBL.	2573731

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL315080
PubChem: 11818535

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 143270