Detailed information for compound 1441921

Basic information

Technical information
  • TDR Targets ID: 1441921
  • Name: 4-amino-2-[(4-chloro-3-methylphenyl)amino]-5- (4-fluorobenzoyl)-N-(4-fluorophenyl)thiophene -3-carboxamide
  • MW: 497.944 | Formula: C25H18ClF2N3O2S
  • H donors: 3 H acceptors: 2 LogP: 7.6 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)NC(=O)c1c(Nc2ccc(c(c2)C)Cl)sc(c1N)C(=O)c1ccc(cc1)F
  • InChi: 1S/C25H18ClF2N3O2S/c1-13-12-18(10-11-19(13)26)31-25-20(24(33)30-17-8-6-16(28)7-9-17)21(29)23(34-25)22(32)14-2-4-15(27)5-3-14/h2-12,31H,29H2,1H3,(H,30,33)
  • InChiKey: YKLHKXURLMYSQP-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 4-amino-2-[(4-chloro-3-methyl-phenyl)amino]-5-(4-fluorobenzoyl)-N-(4-fluorophenyl)thiophene-3-carboxamide
  • 4-amino-2-[(4-chloro-3-methylphenyl)amino]-N-(4-fluorophenyl)-5-[(4-fluorophenyl)-oxomethyl]-3-thiophenecarboxamide
  • 4-amino-2-[(4-chloro-3-methyl-phenyl)amino]-N-(4-fluorophenyl)-5-(4-fluorophenyl)carbonyl-thiophene-3-carboxamide
  • NCGC00138324-01
  • K264-0079

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0038 0.0122 0.0119
Loa Loa (eye worm) hypothetical protein 0.0147 0.0841 0.0838
Mycobacterium ulcerans polyprenyl synthetase IdsB 0.0533 0.3405 0.3164
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0147 0.0841 0.0841
Brugia malayi intermediate filament protein 0.0033 0.0086 0.0086
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0293 0.1813 0.181
Plasmodium falciparum octaprenyl pyrophosphate synthase 0.0447 0.2832 0.2829
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0072 0.0068
Echinococcus granulosus lamin dm0 0.0033 0.0086 0.0082
Plasmodium falciparum carbonic anhydrase 0.0147 0.0841 0.0838
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0271 0.0267
Loa Loa (eye worm) hypothetical protein 0.012 0.0668 0.0664
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.038 0.0377
Loa Loa (eye worm) matrixin family protein 0.0133 0.0748 0.0745
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.012 0.0668 0.0668
Onchocerca volvulus Matrilysin homolog 0.006 0.0266 0.1487
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.038 0.0311
Echinococcus multilocularis carbonic anhydrase 0.0147 0.0841 0.0838
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0147 0.0841 0.0841
Onchocerca volvulus 0.0085 0.0431 0.2426
Giardia lamblia Farnesyl diphosphate synthase 0.1528 1 0.5
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0072 0.0068
Loa Loa (eye worm) matrix metalloproteinase 0.006 0.0266 0.0262
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0109 0.0105
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0073 0.0352 0.0352
Onchocerca volvulus 0.0033 0.0086 0.0464
Echinococcus multilocularis carbonic anhydrase 0.0147 0.0841 0.0838
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.038 0.0311
Loa Loa (eye worm) hypothetical protein 0.006 0.0266 0.0262
Brugia malayi geranylgeranyl pyrophosphate synthetase 0.0615 0.3945 0.3945
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0147 0.0841 0.0841
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0147 0.0841 0.0841
Echinococcus granulosus carbonic anhydrase 0.0147 0.0841 0.0838
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0246 0.1499 0.1496
Treponema pallidum octaprenyl-diphosphate synthase 0.0615 0.3945 0.5
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0147 0.0841 0.0838
Loa Loa (eye worm) pigment dispersing factor receptor c 0.012 0.0668 0.0664
Brugia malayi Cathepsin L-like precursor 0.002 0.0004 0.0004
Loa Loa (eye worm) polyprenyl synthetase 0.1528 1 1
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0072 0.0068
Plasmodium vivax SET domain protein, putative 0.0036 0.0109 0.0105
Brugia malayi Cathepsin L-like precursor 0.002 0.0004 0.0004
Brugia malayi Cathepsin L-like precursor 0.002 0.0004 0.0004
Brugia malayi Matrixin family protein 0.022 0.1331 0.1331
Schistosoma mansoni trans-prenyltransferase 0.0447 0.2832 0.2829
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.1536 0.1533
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.1528 1 1
Mycobacterium tuberculosis Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate 0.0533 0.3405 0.3164
Leishmania major cathepsin L-like protease 0.0077 0.038 0.0377
Brugia malayi Matrixin family protein 0.006 0.0266 0.0266
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.038 0.0377
Mycobacterium tuberculosis Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) 0.0447 0.2832 0.257
Echinococcus multilocularis prenyl (decaprenyl) diphosphate synthase 0.0447 0.2832 0.2829
Echinococcus granulosus microtubule associated protein 2 0.0833 0.5394 0.5392
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0072 0.0068
Brugia malayi Cathepsin L-like precursor 0.002 0.0004 0.0004
Trypanosoma cruzi polyprenyl synthase, putative 0.0615 0.3945 0.3943
Schistosoma mansoni hypothetical protein 0.0147 0.0841 0.0838
Loa Loa (eye worm) hypothetical protein 0.0036 0.0109 0.0105
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.038 0.0311
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0038 0.0122 0.0122
Entamoeba histolytica geranylgeranyl pyrophosphate synthase, putative 0.0447 0.2832 1
Leishmania major cathepsin L-like protease 0.0077 0.038 0.0377
Echinococcus multilocularis lamin dm0 0.0033 0.0086 0.0082
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0293 0.1813 0.181
Schistosoma mansoni intermediate filament proteins 0.0033 0.0086 0.0082
Echinococcus granulosus GPCR family 2 0.0038 0.0122 0.0119
Echinococcus granulosus geranylgeranyl pyrophosphate synthase 0.0615 0.3945 0.3943
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.038 0.0311
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.038 0.0377
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) 0.1528 1 1
Echinococcus multilocularis carbonic anhydrase II 0.0246 0.1499 0.1496
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0078
Echinococcus granulosus decaprenyl diphosphate synthase subunit 1 0.0447 0.2832 0.2829
Schistosoma mansoni hypothetical protein 0.0082 0.0415 0.0412
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.01 0.0096
Trypanosoma cruzi solanesyl-diphosphate synthase 0.0447 0.2832 0.2829
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0246 0.1499 0.1496
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0109 0.0105
Onchocerca volvulus 0.0286 0.1766 1
Schistosoma mansoni hypothetical protein 0.0038 0.0122 0.0119
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0246 0.1499 0.1499
Schistosoma mansoni lamin 0.0033 0.0086 0.0082
Loa Loa (eye worm) hypothetical protein 0.0147 0.0841 0.0838
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0336 0.0332
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative 0.1528 1 1
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0086 0.0082
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0825 0.0822
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.038 0.0311
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.1528 1 1
Brugia malayi Matrixin family protein 0.006 0.0266 0.0266
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.1528 1 1
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0447 0.2832 0.2829
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.038 0.0311
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0109 0.0105
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0038 0.0122 0.0119
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.038 0.0311
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.5394 0.5392
Loa Loa (eye worm) hypothetical protein 0.0033 0.0086 0.0082
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.038 0.0311
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0086 0.0082
Schistosoma mansoni glutathione synthetase 0.0447 0.2832 0.2829
Loa Loa (eye worm) matrixin family protein 0.022 0.1331 0.1327
Mycobacterium leprae PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) 0.0447 0.2832 1
Loa Loa (eye worm) carbonic anhydrase 3 0.0246 0.1499 0.1496
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.5394 0.5392
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0109 0.0105
Brugia malayi Cathepsin L-like precursor 0.002 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0136 0.0769 0.0766
Trypanosoma cruzi polyprenyl synthase, putative 0.0615 0.3945 0.3943
Echinococcus granulosus farnesyl pyrophosphate synthase 0.1528 1 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0038 0.0122 0.0119
Schistosoma mansoni hypothetical protein 0.0038 0.0122 0.0119
Echinococcus multilocularis lamin 0.0033 0.0086 0.0082
Loa Loa (eye worm) hypothetical protein 0.0147 0.0841 0.0838
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.038 0.0377
Loa Loa (eye worm) hypothetical protein 0.0038 0.0122 0.0119
Leishmania major cathepsin L-like protease 0.0077 0.038 0.0377
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.038 0.0311
Loa Loa (eye worm) latrophilin receptor protein 2 0.0038 0.0122 0.0119
Toxoplasma gondii hypothetical protein 0.0147 0.0841 0.0838
Leishmania major polyprenyl synthase, putative 0.0615 0.3945 0.3943
Echinococcus multilocularis decaprenyl diphosphate synthase subunit 1 0.0447 0.2832 0.2829
Echinococcus granulosus lamin 0.0033 0.0086 0.0082
Trichomonas vaginalis set domain proteins, putative 0.0286 0.1766 0.1763
Brugia malayi Hemopexin family protein 0.0085 0.0431 0.0431
Leishmania major farnesyl pyrophosphate synthase 0.1528 1 1
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase 0.0615 0.3945 0.3943
Loa Loa (eye worm) hypothetical protein 0.0082 0.0415 0.0412
Schistosoma mansoni carbonic anhydrase-related 0.0147 0.0841 0.0838
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0072 0.0068
Schistosoma mansoni geranylgeranyl pyrophosphate synthase 0.0615 0.3945 0.3943
Loa Loa (eye worm) polyprenyl synthetase 0.0447 0.2832 0.2829
Schistosoma mansoni carbonic anhydrase-related 0.0147 0.0841 0.0838
Mycobacterium ulcerans polyprenyl diphosphate synthetase, GrcC1 0.0447 0.2832 0.257
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.1528 1 1
Schistosoma mansoni hypothetical protein 0.0038 0.0122 0.0119
Loa Loa (eye worm) hypothetical protein 0.0073 0.0352 0.0348
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0147 0.0841 0.0841
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0072 0.0068
Brugia malayi hypothetical protein 0.003 0.0072 0.0072
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative 0.1528 1 1
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0246 0.1499 0.1496
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0246 0.1499 0.1496
Brugia malayi latrophilin 2 splice variant baaae 0.0082 0.0415 0.0415
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0447 0.2832 0.2829
Schistosoma mansoni carbonic anhydrase-related 0.0147 0.0841 0.0838
Loa Loa (eye worm) hypothetical protein 0.003 0.0072 0.0068
Echinococcus multilocularis musashi 0.0033 0.0086 0.0082
Brugia malayi Pre-SET motif family protein 0.0251 0.1536 0.1536
Entamoeba histolytica geranylgeranyl pyrophosphate synthetase, putative 0.0447 0.2832 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0004 0.0004
Echinococcus multilocularis GPCR, family 2 0.0038 0.0122 0.0119
Mycobacterium tuberculosis Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase) 0.0533 0.3405 0.3164
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0246 0.1499 0.1496
Schistosoma mansoni farnesyl pyrophosphate synthase 0.1528 1 1
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.1528 1 1
Trypanosoma brucei solanesyl-diphosphate synthase, putative 0.0447 0.2832 0.278
Loa Loa (eye worm) hypothetical protein 0.006 0.0266 0.0262
Onchocerca volvulus Matrix metalloproteinase homolog 0.0133 0.0748 0.4224
Trypanosoma cruzi farnesyl pyrophosphate synthase 0.1528 1 1
Brugia malayi Latrophilin receptor protein 2 0.0038 0.0122 0.0122
Schistosoma mansoni hypothetical protein 0.0085 0.0431 0.0428
Plasmodium vivax geranylgeranyl pyrophosphate synthase 0.1528 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.038 0.0311
Onchocerca volvulus 0.0033 0.0086 0.0464
Brugia malayi Matrixin family protein 0.006 0.0266 0.0266
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0246 0.1499 0.1499
Echinococcus multilocularis carbonic anhydrase 0.0147 0.0841 0.0838
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0136 0.0769 0.0766
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0109 0.0105
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0086 0.0086
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0109 0.0105
Schistosoma mansoni hypothetical protein 0.0038 0.0122 0.0119
Onchocerca volvulus 0.006 0.0266 0.1487
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0109 0.0105
Brugia malayi MH2 domain containing protein 0.0144 0.0825 0.0825
Schistosoma mansoni lamin 0.0033 0.0086 0.0082
Brugia malayi Calcitonin receptor-like protein seb-1 0.012 0.0668 0.0668
Schistosoma mansoni carbonic anhydrase 0.0147 0.0841 0.0838
Echinococcus granulosus carbonic anhydrase 0.0147 0.0841 0.0838
Trypanosoma brucei farnesyl pyrophosphate synthase 0.1528 1 1
Trypanosoma brucei carbonic anhydrase-like protein 0.0246 0.1499 0.1438
Leishmania major carbonic anhydrase-like protein 0.0246 0.1499 0.1496
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.038 0.0311
Echinococcus granulosus intermediate filament protein 0.0033 0.0086 0.0082
Brugia malayi Polyprenyl synthetase family protein 0.0447 0.2832 0.2832
Plasmodium vivax octaprenyl pyrophosphate synthase, putative 0.0447 0.2832 0.2829
Echinococcus granulosus carbonic anhydrase II 0.0246 0.1499 0.1496
Brugia malayi Pre-SET motif family protein 0.0036 0.0109 0.0109
Echinococcus granulosus carbonic anhydrase 0.0147 0.0841 0.0838
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0038 0.0122 0.0119
Chlamydia trachomatis geranylgeranyl pyrophosphate synthase 0.0533 0.3405 0.5
Leishmania major hypothetical protein, conserved 0.003 0.0072 0.0068
Leishmania major solanesyl-diphosphate synthase, putative 0.0447 0.2832 0.2829
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative 0.1528 1 1
Onchocerca volvulus Matrilysin homolog 0.0208 0.1252 0.7081
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase 0.0615 0.3945 0.3943
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0533 0.3405 1
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0004 0.0004
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0044 0.0159 0.0155
Brugia malayi Matrixin family protein 0.006 0.0266 0.0266
Echinococcus multilocularis farnesyl pyrophosphate synthase 0.1528 1 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0109 0.0105
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0825 0.0822
Echinococcus granulosus prenyl decaprenyl diphosphate synthase 0.0447 0.2832 0.2829
Entamoeba histolytica bifunctional short chain isoprenyl diphosphate synthase, putative 0.0447 0.2832 1
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0447 0.2832 0.2829
Onchocerca volvulus 0.0036 0.0109 0.0595

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.9811 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 19.9526 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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