Detailed information for compound 1443139

Basic information

Technical information
  • TDR Targets ID: 1443139
  • Name: 1-[ethyl-(4-methoxyphenyl)sulfamoyl]-N-[(3-me thylphenyl)methyl]piperidine-3-carboxamide
  • MW: 445.575 | Formula: C23H31N3O4S
  • H donors: 1 H acceptors: 3 LogP: 2.95 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(S(=O)(=O)N1CCCC(C1)C(=O)NCc1cccc(c1)C)c1ccc(cc1)OC
  • InChi: 1S/C23H31N3O4S/c1-4-26(21-10-12-22(30-3)13-11-21)31(28,29)25-14-6-9-20(17-25)23(27)24-16-19-8-5-7-18(2)15-19/h5,7-8,10-13,15,20H,4,6,9,14,16-17H2,1-3H3,(H,24,27)
  • InChiKey: LDIQVUSSSHHIIX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-[ethyl-(4-methoxyphenyl)sulfamoyl]-N-[(3-methylphenyl)methyl]-3-piperidinecarboxamide
  • 1-[ethyl-(4-methoxyphenyl)sulfamoyl]-N-(3-methylbenzyl)nipecotamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens snurportin 1 No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus importin subunit beta 1 0.0035 0.0102 0.0162
Loa Loa (eye worm) hypothetical protein 0.0027 0.0001 0.0003
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0057 0.0394 0.0627
Schistosoma mansoni tyrosinase precursor 0.0426 0.5199 0.5617
Brugia malayi ecdysteroid receptor 0.0057 0.0394 0.1255
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0057 0.0394 0.1255
Schistosoma mansoni glutaminase 0.0268 0.3138 0.339
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0433 0.1378
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0057 0.0394 0.0877
Onchocerca volvulus 0.0057 0.0394 0.4822
Brugia malayi photoreceptor-specific nuclear receptor 0.0057 0.0394 0.1255
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.019 0.05
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0057 0.0394 0.0394
Loa Loa (eye worm) ShTK domain-containing protein 0.009 0.0817 0.1819
Leishmania major DNA polymerase eta, putative 0.0031 0.005 0.0097
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0184 0.0588
Onchocerca volvulus 0.009 0.0817 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0057 0.0394 0.0877
Loa Loa (eye worm) hypothetical protein 0.0035 0.0102 0.0227
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0057 0.0394 0.1255
Loa Loa (eye worm) hypothetical protein 0.003 0.0042 0.0094
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0057 0.0394 0.1255
Loa Loa (eye worm) steroid hormone receptor 0.0057 0.0394 0.0877
Loa Loa (eye worm) tyrosinase 1 0.009 0.0817 0.1819
Echinococcus granulosus lamin dm0 0.0027 0.0001 0.0002
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0042 0.0134
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0057 0.0394 0.0426
Schistosoma mansoni hypothetical protein 0.0041 0.0184 0.0199
Brugia malayi nuclear hormone receptor 0.0057 0.0394 0.1255
Loa Loa (eye worm) hypothetical protein 0.0057 0.0394 0.0877
Echinococcus multilocularis dna polymerase eta 0.0044 0.022 0.022
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.019 0.05
Echinococcus multilocularis thyroid hormone receptor alpha 0.0057 0.0394 0.0394
Echinococcus multilocularis ecdysone induced protein 78C 0.0057 0.0394 0.0394
Echinococcus granulosus lamin 0.0027 0.0001 0.0002
Plasmodium falciparum importin beta, putative 0.0035 0.0102 0.5
Echinococcus multilocularis FTZ F1 alpha 0.0057 0.0394 0.0394
Onchocerca volvulus 0.0027 0.0001 0.0015
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.014 0.1473 0.4177
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0057 0.0394 0.1255
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.019 0.05
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0296 0.3504 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0057 0.0394 0.0426
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0057 0.0394 0.0627
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0057 0.0394 0.1255
Schistosoma mansoni hypothetical protein 0.0048 0.028 0.0302
Mycobacterium tuberculosis Conserved hypothetical protein 0.0156 0.1679 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0057 0.0394 0.1255
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0296 0.3504 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0057 0.0394 0.1255
Loa Loa (eye worm) ShTK domain-containing protein 0.009 0.0817 0.1819
Schistosoma mansoni coup transcription factor 0.0057 0.0394 0.0426
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0057 0.0394 0.1255
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0296 0.3504 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0394 0.0877
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0057 0.0394 0.0394
Brugia malayi intermediate filament protein 0.0027 0.0001 0.0004
Echinococcus granulosus intermediate filament protein 0.0027 0.0001 0.0002
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0102 0.236
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0057 0.0394 0.1255
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0057 0.0394 0.4822
Schistosoma mansoni importin beta-1 0.0035 0.0102 0.011
Echinococcus multilocularis musashi 0.0027 0.0001 0.0001
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0001 0.0004
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0057 0.0394 0.0394
Schistosoma mansoni steroid hormone receptor ad4bp 0.0057 0.0394 0.0426
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0042 0.0046
Brugia malayi nuclear receptor NHR-88 0.0057 0.0394 0.1255
Trypanosoma brucei DNA polymerase eta, putative 0.0044 0.022 0.0347
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.4491 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0057 0.0394 0.0426
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.014 0.1473 0.4177
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.003 0.0042 0.0094
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0057 0.0394 0.0877
Plasmodium vivax importin-beta 2, putative 0.0035 0.0102 0.5
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0057 0.0394 0.0627
Onchocerca volvulus Bile acid receptor homolog 0.0057 0.0394 0.4822
Loa Loa (eye worm) hypothetical protein 0.009 0.0817 0.1819
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0057 0.0394 0.1255
Brugia malayi Importin beta-1 subunit 0.0035 0.0102 0.0325
Schistosoma mansoni survival motor neuron protein 0.0048 0.028 0.0302
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.005 0.0097
Loa Loa (eye worm) hypothetical protein 0.0057 0.0394 0.0877
Schistosoma mansoni nuclear hormone receptor 0.0057 0.0394 0.0426
Brugia malayi ShTK domain containing protein 0.009 0.0817 0.2603
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0057 0.0394 0.1255
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0001 0.0003
Echinococcus multilocularis lamin 0.0027 0.0001 0.0001
Leishmania major mitochondrial DNA polymerase beta 0.0296 0.3504 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.022 0.049
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0057 0.0394 0.1255
Echinococcus multilocularis survival motor neuron protein 1 0.0238 0.2743 0.2743
Brugia malayi hypothetical protein 0.003 0.0042 0.0134
Brugia malayi hypothetical protein 0.003 0.0042 0.0134
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0057 0.0394 0.0394
Schistosoma mansoni intermediate filament proteins 0.0027 0.0001 0.0001
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.028 0.0891
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0001 0.0003
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0057 0.0394 0.0426
Leishmania major DNA polymerase eta, putative 0.0044 0.022 0.0584
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0057 0.0394 0.0877
Loa Loa (eye worm) hypothetical protein 0.006 0.0433 0.0963
Mycobacterium ulcerans glutaminase 0.0268 0.3138 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0394 0.0877
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.003 0.0042 0.0067
Loa Loa (eye worm) glutaminase 2 0.0268 0.3138 0.6988
Brugia malayi nuclear receptor RXR 0.003 0.0042 0.0134
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.014 0.1473 0.403
Echinococcus granulosus snurportin 1 0.0372 0.4491 0.7151
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.019 0.026
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0057 0.0394 0.0877
Brugia malayi Nuclear hormone receptor-like 1 0.0057 0.0394 0.1255
Loa Loa (eye worm) hypothetical protein 0.0057 0.0394 0.0877
Echinococcus granulosus geminin 0.0509 0.628 1
Brugia malayi Common central domain of tyrosinase family protein 0.009 0.0817 0.2603
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.009 0.0817 0.2603
Onchocerca volvulus 0.009 0.0817 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0394 0.0877
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.009 0.0817 0.2603
Echinococcus granulosus survival motor neuron protein 1 0.0238 0.2743 0.4368
Echinococcus multilocularis geminin 0.0509 0.628 0.628
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0057 0.0394 0.0877
Schistosoma mansoni lamin 0.0027 0.0001 0.0001
Onchocerca volvulus 0.009 0.0817 1
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0042 0.0134
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0057 0.0394 0.0426
Loa Loa (eye worm) hypothetical protein 0.003 0.0042 0.0094
Schistosoma mansoni thyroid hormone receptor 0.0057 0.0394 0.0426
Entamoeba histolytica hypothetical protein 0.0028 0.0016 0.5
Schistosoma mansoni hypothetical protein 0.0509 0.628 0.6784
Onchocerca volvulus Protein ultraspiracle homolog 0.0057 0.0394 0.4822
Schistosoma mansoni hypothetical protein 0.0509 0.628 0.6784
Schistosoma mansoni hypothetical protein 0.0372 0.4491 0.4852
Loa Loa (eye worm) glutaminase 0.0268 0.3138 0.6988
Loa Loa (eye worm) hypothetical protein 0.003 0.0042 0.0094
Echinococcus multilocularis snurportin 1 0.0372 0.4491 0.4491
Brugia malayi steroid hormone receptor 0.0057 0.0394 0.1255
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.022 0.0584
Schistosoma mansoni retinoic acid receptor RXR 0.0057 0.0394 0.0426
Echinococcus granulosus dna polymerase eta 0.0044 0.022 0.035
Loa Loa (eye worm) hypothetical protein 0.003 0.0042 0.0094
Toxoplasma gondii hypothetical protein 0.0048 0.027 1
Schistosoma mansoni thyroid hormone receptor 0.0057 0.0394 0.0426
Loa Loa (eye worm) hypothetical protein 0.0057 0.0394 0.0877
Loa Loa (eye worm) hypothetical protein 0.009 0.0817 0.1819
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0309 0.084
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0057 0.0394 0.1255
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0057 0.0394 0.0877
Brugia malayi RNA, U transporter 1 0.0099 0.0938 0.299
Echinococcus multilocularis lamin dm0 0.0027 0.0001 0.0001
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0057 0.0394 0.0426
Schistosoma mansoni RAR-like nuclear receptor 0.0057 0.0394 0.0426
Loa Loa (eye worm) hypothetical protein 0.0057 0.0394 0.0877
Brugia malayi Steroid receptor seven-up type 2 0.0057 0.0394 0.1255
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.009 0.0817 0.2603
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.003 0.0042 0.0042
Brugia malayi glutaminase DH11.1 0.0268 0.3138 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0433 0.0963
Onchocerca volvulus 0.0027 0.0001 0.0015
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0057 0.0394 0.0394
Loa Loa (eye worm) hypothetical protein 0.0238 0.2743 0.6108
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0433 0.1378
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0057 0.0394 0.0627
Trichomonas vaginalis glutaminase, putative 0.0268 0.3138 1
Brugia malayi hypothetical protein 0.0238 0.2743 0.8742
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.009 0.0817 0.2603
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0102 0.0102
Echinococcus granulosus ecdysone induced protein 78C 0.0057 0.0394 0.0627
Onchocerca volvulus 0.009 0.0817 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0738 0.9256 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.003 0.0042 0.0046
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0057 0.0394 0.0394
Loa Loa (eye worm) hypothetical protein 0.0041 0.0184 0.0411
Schistosoma mansoni lamin 0.0027 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.003 0.0042 0.0094
Schistosoma mansoni tyrosinase precursor 0.0426 0.5199 0.5617
Brugia malayi ImpB/MucB/SamB family protein 0.0044 0.022 0.0701
Schistosoma mansoni DNA polymerase eta 0.0044 0.022 0.0238
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0057 0.0394 0.0627
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0057 0.0394 0.0627
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0057 0.0394 0.0627
Echinococcus granulosus FTZ F1 alpha 0.0057 0.0394 0.0627
Onchocerca volvulus 0.0048 0.028 0.3422

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0059 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 4.6109 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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