TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 599.592 | Formula: C27H33N7O9
H donors: 6 H acceptors: 9 LogP: -1.04 Rotable bonds: 15
Rule of 5 violations (Lipinski): 3
SMILES: O=C(c1ccn(c(=O)c1O)C)NCCN(CCNC(=O)c1ccn(c(=O)c1O)C)CCNC(=O)c1ccn(c(=O)c1O)C
InChi: 1S/C27H33N7O9/c1-31-10-4-16(19(35)25(31)41)22(38)28-7-13-34(14-8-29-23(39)17-5-11-32(2)26(42)20(17)36)15-9-30-24(40)18-6-12-33(3)27(43)21(18)37/h4-6,10-12,35-37H,7-9,13-15H2,1-3H3,(H,28,38)(H,29,39)(H,30,40)
InChiKey: LXPKFUINXTWKHP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0121	0.109
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0042	0.015	0.015
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0012	0.0016	0.0016
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0141	0.06	0.0596
Trichomonas vaginalis	ABC transporter, putative	0.0012	0.0016	0.0599
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0016	0.0003
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0011	0.0013	0.0478
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0044	0.004
Echinococcus granulosus	lamin	0.0029	0.0092	0.0092
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0012	0.0016	0.0599
Mycobacterium ulcerans	lipase LipD	0.0035	0.0121	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0044	0.1615
Brugia malayi	cytoplasmic intermediate filament protein	0.0015	0.0032	0.0027
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0071	0.0284	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0121	0.0116
Echinococcus granulosus	cathepsin l1	0.0012	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0089	0.0076
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0149	0.5481
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0273	0.9614
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0012	0.0017	0.0013
Onchocerca volvulus		0.0035	0.0121	0.1771
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0085	0.3133
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0044	0.004
Trypanosoma cruzi	major cysteine proteinase, putative	0.0054	0.0206	0.7234
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0121	0.4163
Entamoeba histolytica	cysteine protease, putative	0.0018	0.0044	0.1415
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0149	0.5481
Onchocerca volvulus		0.0018	0.0044	0.0508
Schistosoma mansoni	hypothetical protein	0.018	0.0775	0.0771
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0044	0.1615
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.0121	0.5
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0012	0.0016	0.0016
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0012	0.0016	0.0599
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0044	0.1615
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0071	0.0284	0.0284
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0044	0.1615
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0071	0.0284	0.0271
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0011	0.0013	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0017	0.0004
Schistosoma mansoni	multidrug resistance protein	0.0012	0.0016	0.0012
Entamoeba histolytica	P-glycoprotein 5, putative	0.0012	0.0016	0.0427
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.0121	0.109
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0011	0.0013	0.0309
Echinococcus multilocularis	cathepsin L cysteine protease	0.0018	0.0044	0.0044
Echinococcus granulosus	multidrug resistance protein 1	0.0012	0.0016	0.0016
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0273	0.9614
Echinococcus granulosus	Chromobox protein 3	0.0011	0.0013	0.0013
Echinococcus granulosus	chromobox protein 1	0.0069	0.0272	0.0272
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0011	0.0013	0.0309
Brugia malayi	SET domain containing protein	0.0011	0.0013	0.0009
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0044	0.004
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0012	0.0016	0.0016
Entamoeba histolytica	cysteine proteinase, putative	0.0018	0.0044	0.1415
Loa Loa (eye worm)	hypothetical protein	0.0148	0.063	0.0617
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0121	0.4163
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0044	0.1615
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0012	0.0016	0.0016
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0044	0.1615
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0012	0.0016	0.0241
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0012	0.0016	0.0016
Brugia malayi	Papain family cysteine protease containing protein	0.0018	0.0044	0.004
Echinococcus multilocularis	muscleblind protein	0.0148	0.063	0.063
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0044	0.1615
Entamoeba histolytica	P-glycoprotein-5	0.0012	0.0016	0.0427
Schistosoma mansoni	serine/threonine protein kinase	0.2225	1	1
Onchocerca volvulus		0.0012	0.0017	0.0065
Onchocerca volvulus		0.0018	0.0044	0.0508
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0071	0.0284	1
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0013	0.0478
Onchocerca volvulus	Cathepsin L homolog	0.0018	0.0044	0.0508
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0011	0.0013	0.0478
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.0032	0.0019
Onchocerca volvulus		0.0018	0.0044	0.0508
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0011	0.0013	0.0478
Trichomonas vaginalis	esterase, putative	0.0035	0.0121	0.4442
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0167	0.0167
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0167	0.0167
Echinococcus granulosus	cysteine protease	0.0009	0.0004	0.0004
Brugia malayi	Intermediate filament tail domain containing protein	0.0029	0.0092	0.0087
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0018	0.0044	0.1615
Echinococcus granulosus	multidrug resistance protein 1	0.0012	0.0016	0.0016
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0071	0.0284	0.0284
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0013	0.0478
Echinococcus granulosus	multidrug resistance protein 1	0.0012	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0017	0.0004
Schistosoma mansoni	cathepsin F (C01 family)	0.0018	0.0044	0.004
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0273	0.9614
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0273	0.9614
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0121	0.4442
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0042	0.015	0.5519
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0012	0.0016	0.0016
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0013	0.0478
Echinococcus multilocularis	lamin	0.0029	0.0092	0.0092
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0012	0.0016	0.0599
Echinococcus granulosus	chromodomain helicase DNA binding protein 1	0.0011	0.0013	0.0013
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0273	0.9614
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0121	0.109
Brugia malayi	Type III restriction enzyme, res subunit family protein	0.0011	0.0013	0.0009
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0018	0.0044	0.0044
Schistosoma mansoni	lamin	0.0029	0.0092	0.0087
Echinococcus multilocularis	multidrug resistance protein 1	0.0012	0.0016	0.0016
Onchocerca volvulus		0.0012	0.0016	0.0054
Echinococcus granulosus	transcription factor Dp 1	0.0041	0.0148	0.0148
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0011	0.0013	0.0009
Onchocerca volvulus		0.0146	0.0621	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0121	0.0121
Echinococcus granulosus	cathepsin L	0.0009	0.0004	0.0004
Leishmania major	cathepsin L-like protease	0.0018	0.0044	0.1032
Giardia lamblia	Histone acetyltransferase GCN5	0.0038	0.0134	0.5
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0141	0.06	0.06
Loa Loa (eye worm)	ctsf protein	0.0018	0.0044	0.0031
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0012	0.0017	0.0623
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0044	0.1615
Loa Loa (eye worm)	multidrug resistance protein 3	0.0012	0.0016	0.0003
Echinococcus multilocularis	cathepsin L cysteine protease	0.0018	0.0044	0.0044
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0013	0.0478
Trichomonas vaginalis	taga, putative	0.0012	0.0016	0.0599
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0167	0.0167
Loa Loa (eye worm)	hypothetical protein	0.003	0.0098	0.0085
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0012	0.0016	0.0599
Echinococcus multilocularis	chromodomain helicase DNA binding protein 1	0.0011	0.0013	0.0013
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0044	0.1615
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0018	0.0044	0.3042
Entamoeba histolytica	cysteine proteinase, putative	0.0012	0.0017	0.045
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0273	0.9614
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0071	0.0284	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0022	0.0009
Echinococcus multilocularis	cysteine protease	0.0018	0.0044	0.0044
Onchocerca volvulus		0.0035	0.0121	0.1771
Echinococcus granulosus	chromobox protein 2	0.0011	0.0013	0.0013
Plasmodium vivax	multidrug resistance protein 1, putative	0.0012	0.0016	0.082
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0273	0.9614
Echinococcus granulosus	cathepsin L cysteine protease	0.0009	0.0004	0.0004
Loa Loa (eye worm)	fibroinase	0.0018	0.0044	0.0031
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0011	0.0013	0.0478
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0136	0.0123
Echinococcus multilocularis	cysteine protease	0.0018	0.0044	0.0044
Echinococcus multilocularis	survival motor neuron protein 1	0.0716	0.3192	0.3192
Brugia malayi	Cathepsin L-like precursor	0.0012	0.0017	0.0013
Entamoeba histolytica	hypothetical protein	0.0011	0.0013	0.0309
Schistosoma mansoni	lamin	0.0029	0.0092	0.0087
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0044	0.1615
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0016	0.0003
Entamoeba histolytica	acetyltransferase, GNAT family	0.0038	0.0134	0.4651
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0044	0.1615
Brugia malayi	hypothetical protein	0.0011	0.0013	0.0009
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0011	0.0013	0.0664
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0167	0.0154
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0224	0.0974	1
Echinococcus granulosus	5'partial\|ATP binding cassette sub family B	0.0012	0.0016	0.0016
Trichomonas vaginalis	chromobox protein, putative	0.0011	0.0013	0.0478
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0092	0.0079
Entamoeba histolytica	P-glycoprotein-1	0.0012	0.0016	0.0427
Trypanosoma cruzi	cysteine peptidase, putative	0.0069	0.0273	0.9614
Leishmania major	cathepsin L-like protease	0.0018	0.0044	0.1032
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0044	0.1615
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0044	0.1615
Mycobacterium ulcerans	beta-lactamase	0.0035	0.0121	0.5
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0121	0.0108
Schistosoma mansoni	multidrug resistance protein	0.0012	0.0016	0.0012
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0273	0.9614
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0121	0.4442
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0012	0.0016	0.0599
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0041	0.0149	0.2235
Brugia malayi	Cathepsin L-like precursor	0.0012	0.0017	0.0013
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0042	0.015	0.5519
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.0121	0.109
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0012	0.0016	0.0599
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0014	0.0025	0.0025
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0012	0.0016	0.0599
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0011	0.0013	0.0478
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0012	0.0016	0.0599
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0167	0.0162
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0011	0.0013	0.0478
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0004	0.016
Schistosoma mansoni	smdr2	0.0012	0.0016	0.0012
Entamoeba histolytica	P-glycoprotein-2, putative	0.0012	0.0016	0.0427
Brugia malayi	CHD4 protein	0.0011	0.0013	0.0009
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0167	0.0162
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0044	0.1615
Echinococcus granulosus	muscleblind protein	0.0148	0.063	0.063
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0011	0.0013	0.0478
Brugia malayi	Valyl-tRNA synthetase	0.0011	0.0013	0.0009
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0042	0.015	1
Trichomonas vaginalis	Heterochromatin protein, putative	0.0011	0.0013	0.0478
Entamoeba histolytica	P-glyco protein 6, putative	0.0012	0.0016	0.0427
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0013	0.0478
Mycobacterium leprae	Probable lipase LipE	0.0035	0.0121	0.5
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0121	0.0108
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0012	0.0016	0.0599
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.0121	0.109
Onchocerca volvulus	Cathepsin F homolog	0.0018	0.0044	0.0508
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0044	0.1615
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0025	0.0012
Plasmodium vivax	vivapain-2	0.0018	0.0044	0.2715
Schistosoma mansoni	survival motor neuron protein	0.0146	0.0621	0.0617
Trichomonas vaginalis	ABC transporter, putative	0.0012	0.0016	0.0599
Echinococcus granulosus	MAP kinase activated protein kinase 2	0.2225	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0273	0.9614
Trichomonas vaginalis	abcb9, putative	0.0012	0.0016	0.0599
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	0.0012	0.0016	0.0003
Trichomonas vaginalis	ABC transporter, putative	0.0012	0.0016	0.0599
Onchocerca volvulus		0.0018	0.0044	0.0508
Brugia malayi	chromobox protein homolog 3	0.0038	0.0136	0.0131
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0012	0.0016	0.0599
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0136	0.4997
Echinococcus multilocularis	cathepsin L	0.0009	0.0004	0.0004
Loa Loa (eye worm)	heterochromatin protein 1	0.0069	0.0272	0.0259
Echinococcus multilocularis	muscleblind protein 1	0.0148	0.063	0.063
Onchocerca volvulus		0.0018	0.0044	0.0508
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0011	0.0013	0.0009
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0011	0.0013	0.0478
Loa Loa (eye worm)	hypothetical protein	0.0716	0.3192	0.3183
Onchocerca volvulus		0.0029	0.0092	0.1294
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.0121	0.109
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0273	0.9614
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.0011	0.0013	0.0013
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0018	0.0044	0.3042
Trypanosoma cruzi	cysteine peptidase, putative	0.0069	0.0273	0.9614
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.0121	0.5
Echinococcus multilocularis	chromobox protein 1	0.0069	0.0272	0.0272
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0071	0.0284	1
Echinococcus granulosus	lamin dm0	0.0029	0.0092	0.0092
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0012	0.0016	0.0016
Entamoeba histolytica	hypothetical protein	0.0011	0.0013	0.0309
Echinococcus granulosus	cathepsin l1	0.0018	0.0044	0.0044
Brugia malayi	beta-lactamase	0.0035	0.0121	0.0116
Echinococcus multilocularis	musashi	0.0029	0.0092	0.0092
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0121	0.0116
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0044	0.004
Plasmodium vivax	vivapain-2	0.0018	0.0044	0.2715
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0018	0.0044	0.3042
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.0121	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0273	0.9614
Brugia malayi	ABC transporter family protein	0.0012	0.0016	0.0012
Brugia malayi	multidrug resistance protein 3	0.0012	0.0016	0.0012
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0042	0.015	1
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0121	0.0121
Brugia malayi	Heterochromatin protein 1	0.0069	0.0272	0.0267
Loa Loa (eye worm)	camk/mapkapk/mapkapk protein kinase	0.2225	1	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0063	0.0246	0.8649
Brugia malayi	Associated with TFs and helicases family protein	0.0011	0.0013	0.0009
Brugia malayi	cathepsin L-like precursor	0.0012	0.0017	0.0013
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0044	0.1615
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0012	0.0016	0.0599
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0121	0.109
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0012	0.0017	0.0623
Brugia malayi	hypothetical protein	0.0716	0.3192	0.3189
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0136	0.4997
Echinococcus multilocularis	transcription factor Dp 1	0.0041	0.0148	0.0148
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0121	0.5
Plasmodium falciparum	histone acetyltransferase GCN5	0.0038	0.0134	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0012	0.0016	0.0599
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0121	0.0108
Onchocerca volvulus	Cathepsin L homolog	0.0018	0.0044	0.0508
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0167	0.0162
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0012	0.0016	0.0016
Trichomonas vaginalis	chromobox protein, putative	0.0011	0.0013	0.0478
Leishmania major	cathepsin L-like protease	0.0069	0.0273	0.9596
Onchocerca volvulus		0.003	0.0098	0.1402
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0011	0.0013	0.0009
Trichomonas vaginalis	ABC transporter, putative	0.0012	0.0016	0.0599
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0012	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0148	0.063	0.0617
Schistosoma mansoni	chromobox protein	0.0011	0.0013	0.0009
Brugia malayi	Protein cec-1.	0.0011	0.0013	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0121	0.0108
Schistosoma mansoni	intermediate filament proteins	0.0029	0.0092	0.0087
Loa Loa (eye worm)	acetyltransferase	0.0141	0.06	0.0588
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0017	0.0004
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0013	0.0478
Entamoeba histolytica	hypothetical protein	0.0011	0.0013	0.0309
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0071	0.0284	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0167	0.0162
Brugia malayi	acetyltransferase, GNAT family protein	0.0141	0.06	0.0596
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0121	0.0108
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0044	0.1615
Plasmodium falciparum	heterochromatin protein 1	0.0011	0.0013	0.0664
Brugia malayi	beta-lactamase family protein	0.0035	0.0121	0.0116
Echinococcus granulosus	geminin	0.018	0.0775	0.0775
Brugia malayi	M-phase phosphoprotein, mpp8	0.0011	0.0013	0.0009
Plasmodium vivax	hypothetical protein, conserved	0.0011	0.0013	0.0593
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0167	0.0167
Leishmania major	cysteine peptidase A (CPA)	0.0018	0.0044	0.1032
Echinococcus granulosus	Chromo domain	0.0011	0.0013	0.0013
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.0121	0.109
Plasmodium vivax	heterochromatin protein 1, putative	0.0011	0.0013	0.0593
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0146	0.0621	0.0617
Entamoeba histolytica	P-glycoprotein-2	0.0012	0.0016	0.0427
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0137	0.0582	0.0582
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0012	0.0016	0.0599
Plasmodium vivax	hypothetical protein, conserved	0.0011	0.0013	0.0593
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0044	0.1615
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0121	0.4442
Trichomonas vaginalis	chromobox protein, putative	0.0069	0.0272	1
Trichomonas vaginalis	chromobox protein, putative	0.0069	0.0272	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0011	0.0013	0.0478
Echinococcus multilocularis	multidrug resistance protein 1	0.0012	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0121	0.0108
Echinococcus multilocularis	lamin dm0	0.0029	0.0092	0.0092
Echinococcus multilocularis	Chromobox protein 3	0.0011	0.0013	0.0013
Leishmania major	cathepsin L-like protease	0.0018	0.0044	0.1032
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0012	0.0016	0.0599
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0038	0.0136	0.2018
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0042	0.015	1
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0012	0.0016	0.0599
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0012	0.0016	0.0599
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0022	0.0009
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0011	0.0013	0.0478
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0121	0.0108
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0085	0.3133
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0121	0.4442
Entamoeba histolytica	P-glycoprotein-2	0.0012	0.0016	0.0427
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0018	0.0044	0.0044
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0012	0.0016	0.0599
Trypanosoma cruzi	cysteine peptidase, putative	0.0018	0.0044	0.1415
Plasmodium falciparum	chromodomain-helicase-DNA-binding protein 1 homolog, putative	0.0011	0.0013	0.0664
Echinococcus multilocularis	Chromo domain	0.0011	0.0013	0.0013
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0044	0.1615
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0011	0.0013	0.0009
Leishmania major	hypothetical protein, conserved	0.0035	0.0121	0.3902
Toxoplasma gondii	ATP-binding cassette transporter ABC.B1	0.0012	0.0016	0.0241
Schistosoma mansoni	hypothetical protein	0.0146	0.0621	0.0617
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0012	0.0016	0.0599
Schistosoma mansoni	chromobox protein	0.0011	0.0013	0.0009
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0013	0.0478
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0044	0.004
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0018	0.0044	0.0031
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0011	0.0013	0.0478
Leishmania major	cathepsin L-like protease	0.0018	0.0044	0.1032
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0018	0.0044	0.1615
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0044	0.1615
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0018	0.0044	0.0031
Schistosoma mansoni	cathepsin F (C01 family)	0.0012	0.0017	0.0013
Trichomonas vaginalis	abcb9, putative	0.0012	0.0016	0.0599
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0014	0.0025	0.0025
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0121	0.0116
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0071	0.0284	0.0279
Trichomonas vaginalis	abcb9, putative	0.0012	0.0016	0.0599
Plasmodium falciparum	multidrug resistance protein 1	0.0012	0.0016	0.0918
Entamoeba histolytica	cysteine proteinase, putative	0.0018	0.0044	0.1415
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0011	0.0013	0.0478
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0016	0.0003
Echinococcus multilocularis	chromobox protein 1	0.0069	0.0272	0.0272
Leishmania major	cathepsin L-like protease	0.0018	0.0044	0.1032
Trichomonas vaginalis	hypothetical protein	0.0011	0.0013	0.0478
Trypanosoma cruzi	cysteine peptidase, putative	0.0069	0.0273	0.9614
Toxoplasma gondii	ABC1 family protein	0.0035	0.0121	0.7863
Trichomonas vaginalis	chromobox protein, putative	0.0011	0.0013	0.0478
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.0011	0.0013	0.0013
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0121	0.0108
Loa Loa (eye worm)	cysteine protease	0.0018	0.0044	0.0031
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0044	0.1615
Echinococcus granulosus	intermediate filament protein	0.0029	0.0092	0.0092
Brugia malayi	intermediate filament protein	0.0029	0.0092	0.0087
Leishmania major	cathepsin L-like protease	0.0069	0.0273	0.9596
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.0121	0.109
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0044	0.0031
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0011	0.0013	0.0009
Leishmania major	cathepsin L-like protease	0.0069	0.0273	0.9596
Echinococcus granulosus	survival motor neuron protein 1	0.0716	0.3192	0.3192
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0012	0.0016	0.0599
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0029	0.0092	0.0079
Schistosoma mansoni	hypothetical protein	0.0011	0.0013	0.0009
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0011	0.0013	0.0478
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0004	0.016
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0044	0.004
Echinococcus multilocularis	chromobox protein 2	0.0011	0.0013	0.0013
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0121	0.4442
Schistosoma mansoni	chromobox protein	0.0069	0.0272	0.0267
Onchocerca volvulus		0.0035	0.0121	0.1771
Brugia malayi	Muscleblind-like protein	0.0148	0.063	0.0626
Schistosoma mansoni	chromobox protein	0.0069	0.0272	0.0267
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0012	0.0016	0.0599
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0121	0.799
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0044	0.1615
Chlamydia trachomatis	ABC transporter ATP binding protein/permease	0.0012	0.0016	0.5
Echinococcus multilocularis	ATP binding cassette sub family B	0.0012	0.0016	0.0016
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0018	0.0044	0.0044
Echinococcus multilocularis	geminin	0.018	0.0775	0.0775
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0044	0.1615
Echinococcus multilocularis	MAP kinase activated protein kinase 2	0.2225	1	1
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0012	0.0016	0.0599
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0071	0.0284	1
Schistosoma mansoni	peptidase	0.0012	0.0015	0.001
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.0121	0.109
Trypanosoma cruzi	cruzipain precursor, putative	0.0069	0.0273	0.9614
Onchocerca volvulus		0.0029	0.0092	0.1294
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0013	0.0478
Schistosoma mansoni	cathepsin F (C01 family)	0.0018	0.0044	0.004
Loa Loa (eye worm)	intermediate filament protein	0.0029	0.0092	0.0079
Brugia malayi	beta-lactamase family protein	0.0035	0.0121	0.0116
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0121	0.4163
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0013	0.0478
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0012	0.0016	0.0599
Onchocerca volvulus		0.0018	0.0044	0.0508
Echinococcus granulosus	chromobox protein 1	0.0069	0.0272	0.0272
Toxoplasma gondii	cathepsin CPL	0.0018	0.0044	0.2256
Onchocerca volvulus		0.0018	0.0044	0.0508
Schistosoma mansoni	hypothetical protein	0.018	0.0775	0.0771
Schistosoma mansoni	multidrug resistance protein	0.0012	0.0016	0.0012
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0018	0.0044	0.0044

Activities

Activity type	Activity value	Assay description	Source	Reference
GI50 (functional)	-4.127	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
ID (functional)	= 0.7 %	Percent of Pu(IV) retained after 24 hours in kidneys of mice under the effect of 30 umol/kg (i.p.) of ligand administered 1 hr after iv injection of Pu(IV) citrate	ChEMBL.	7629800
ID (functional)	= 0.7 %	% Pu(IV) retained after 24 hours in kidneys of mice under the effect of 30microM/kg(po, gastric intubation) of ligand administered 3 min after iv injection of Pu(IV) citrate	ChEMBL.	7629800
ID (functional)	= 0.7 %	Percent of Pu(IV) retained after 24 hours in kidneys of mice under the effect of 30 umol/kg (i.p.) of ligand administered 1 hr after iv injection of Pu(IV) citrate	ChEMBL.	7629800
ID (functional)	= 0.7 %	% Pu(IV) retained after 24 hours in kidneys of mice under the effect of 30microM/kg(po, gastric intubation) of ligand administered 3 min after iv injection of Pu(IV) citrate	ChEMBL.	7629800
ID (functional)	= 1.9 %	% Pu(IV) retained after 24 hours in soft tissue of mice under the effect of 30microM/kg(po, gastric intubation) of ligand administered 3 min after iv injection of Pu(IV) citrate	ChEMBL.	7629800
ID (functional)	= 1.9 %	% Pu(IV) retained after 24 hours in soft tissue of mice under the effect of 30microM/kg(po, gastric intubation) of ligand administered 3 min after iv injection of Pu(IV) citrate	ChEMBL.	7629800
ID (functional)	= 2.7 %	Percent of Pu(IV) retained after 24 hours in soft tissue of mice under the effect of 30 umol/kg (i.p.) of ligand administered 1 hr after iv injection of Pu(IV) citrate	ChEMBL.	7629800
ID (functional)	= 2.7 %	Percent of Pu(IV) retained after 24 hours in soft tissue of mice under the effect of 30 umol/kg (i.p.) of ligand administered 1 hr after iv injection of Pu(IV) citrate	ChEMBL.	7629800
ID (functional)	= 5.5 %	Percent of Pu(IV) retained after 24 hours in liver of mice under the effect of 30 umol/kg (i.p.) of ligand administered 1 hr after iv injection of Pu(IV) citrate	ChEMBL.	7629800
ID (functional)	= 5.5 %	Percent of Pu(IV) retained after 24 hours in liver of mice under the effect of 30 umol/kg (i.p.) of ligand administered 1 hr after iv injection of Pu(IV) citrate	ChEMBL.	7629800
ID (functional)	= 8.5 %	% Pu(IV) retained after 24 hours in liver of mice under the effect of 30microM/kg(po, gastric intubation) of ligand administered 3 min after iv injection of Pu(IV) citrate	ChEMBL.	7629800
ID (functional)	= 8.5 %	% Pu(IV) retained after 24 hours in liver of mice under the effect of 30microM/kg(po, gastric intubation) of ligand administered 3 min after iv injection of Pu(IV) citrate	ChEMBL.	7629800
ID (functional)	= 11 %	Percent of Pu(IV) retained after 24 hours in skeleton of mice under the effect of 30 umol/kg (i.p.) of ligand administered 1 hr after iv injection of Pu(IV) citrate	ChEMBL.	7629800
ID (functional)	= 11 %	Percent of Pu(IV) retained after 24 hours in skeleton of mice under the effect of 30 umol/kg (i.p.) of ligand administered 1 hr after iv injection of Pu(IV) citrate	ChEMBL.	7629800
ID (functional)	= 13 %	% Pu(IV) retained after 24 hours in skeleton of mice under the effect of 30microM/kg(po, gastric intubation) of ligand administered 3 min after iv injection of Pu(IV) citrate	ChEMBL.	7629800
ID (functional)	= 13 %	% Pu(IV) retained after 24 hours in skeleton of mice under the effect of 30microM/kg(po, gastric intubation) of ligand administered 3 min after iv injection of Pu(IV) citrate	ChEMBL.	7629800
ID (functional)	= 20 %	Percent of Pu(IV) retained after 24 hours in whole body of mice under the effect of 30 umol/kg (i.p.) of ligand administered 1 hr after iv injection of Pu(IV) citrate	ChEMBL.	7629800
ID (functional)	= 20 %	Percent of Pu(IV) retained after 24 hours in whole body of mice under the effect of 30 umol/kg (i.p.) of ligand administered 1 hr after iv injection of Pu(IV) citrate	ChEMBL.	7629800
ID (functional)	= 21 %	% Pu(IV) excreted at 0-4 hr in urine under the effect of 30microM/kg(po, gastric intubation) of ligand administered 3 min after iv injection of Pu(IV) citrate	ChEMBL.	7629800
ID (functional)	= 21 %	% Pu(IV) excreted at 0-24 hr in urine under the effect of 30microM/kg(po, gastric intubation) of ligand administered 3 min after iv injection of Pu(IV) citrate	ChEMBL.	7629800
ID (functional)	= 21 %	% Pu(IV) excreted at 0-4 hr in urine under the effect of 30microM/kg(po, gastric intubation) of ligand administered 3 min after iv injection of Pu(IV) citrate	ChEMBL.	7629800
ID (functional)	= 21 %	% Pu(IV) excreted at 0-24 hr in urine under the effect of 30microM/kg(po, gastric intubation) of ligand administered 3 min after iv injection of Pu(IV) citrate	ChEMBL.	7629800
ID (functional)	= 25 %	% Pu(IV) retained after 24 hr in whole body of mice under the effect of 30microM/kg(po, gastric intubation) of ligand administered 3 min after iv injection of Pu(IV) citrate	ChEMBL.	7629800
ID (functional)	= 25 %	% Pu(IV) retained after 24 hr in whole body of mice under the effect of 30microM/kg(po, gastric intubation) of ligand administered 3 min after iv injection of Pu(IV) citrate	ChEMBL.	7629800
ID (functional)	= 34 %	%Pu(IV) excreted after 24 hr in GI contents and feces under the effect of 30microM/kg(po, gastric intubation) of ligand administered 3 min after iv injection of Pu(IV) citrate	ChEMBL.	7629800
ID (functional)	= 34 %	%Pu(IV) excreted after 24 hr in GI contents and feces under the effect of 30microM/kg(po, gastric intubation) of ligand administered 3 min after iv injection of Pu(IV) citrate	ChEMBL.	7629800
ID (functional)	= 35 %	Percent of Pu(IV) excreted after 24 hours in urine under the effect of 30 umol/kg (i.p.) of ligand administered 1 hr after iv injection of Pu(IV) citrate	ChEMBL.	7629800
ID (functional)	= 35 %	Percent of Pu(IV) excreted after 24 hours in urine under the effect of 30 umol/kg (i.p.) of ligand administered 1 hr after iv injection of Pu(IV) citrate	ChEMBL.	7629800
ID (functional)	= 45 %	Percent of Pu(IV) excreted after 24 hours in GI contents and feces under the effect of 30 umol/kg (i.p.) of ligand administered 1 hr after iv injection of Pu(IV) citrate	ChEMBL.	7629800
ID (functional)	= 45 %	Percent of Pu(IV) excreted after 24 hours in GI contents and feces under the effect of 30 umol/kg (i.p.) of ligand administered 1 hr after iv injection of Pu(IV) citrate	ChEMBL.	7629800

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL87054

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 144499