Detailed information for compound 1445962

Basic information

Technical information
  • TDR Targets ID: 1445962
  • Name: (4-methoxyphenyl)-[4-[3-(4-pyrrolidin-1-ylsul fonylphenyl)-1,2,4-oxadiazol-5-yl]piperidin-1 -yl]methanone
  • MW: 496.579 | Formula: C25H28N4O5S
  • H donors: 0 H acceptors: 5 LogP: 3.14 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C(=O)N1CCC(CC1)c1onc(n1)c1ccc(cc1)S(=O)(=O)N1CCCC1
  • InChi: 1S/C25H28N4O5S/c1-33-21-8-4-20(5-9-21)25(30)28-16-12-19(13-17-28)24-26-23(27-34-24)18-6-10-22(11-7-18)35(31,32)29-14-2-3-15-29/h4-11,19H,2-3,12-17H2,1H3
  • InChiKey: VPPTUBOWLXGKSB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (4-methoxyphenyl)-[4-[3-(4-pyrrolidin-1-ylsulfonylphenyl)-1,2,4-oxadiazol-5-yl]-1-piperidyl]methanone
  • (4-methoxyphenyl)-[4-[3-(4-1-pyrrolidinylsulfonylphenyl)-1,2,4-oxadiazol-5-yl]-1-piperidinyl]methanone
  • D203-0003
  • NCGC00116953-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Protein kinase domain containing protein 0.0016 0.0167 0.0548
Onchocerca volvulus 0.0122 0.2884 0.8487
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0025 0.0395 0.0344
Schistosoma mansoni hypothetical protein 0.0041 0.0818 0.077
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0016 0.0173 0.051
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.002 0.0265 0.1529
Trichomonas vaginalis adenylate cyclase, putative 0.0017 0.0202 0.0976
Brugia malayi Death domain containing protein 0.0016 0.0162 0.0533
Toxoplasma gondii heat shock protein HSP90 0.0071 0.1585 0.2027
Schistosoma mansoni hypothetical protein 0.0019 0.0251 0.02
Brugia malayi Endochitinase 0.0011 0.0052 0.0172
Schistosoma mansoni heat shock protein 0.0071 0.1585 0.1541
Loa Loa (eye worm) hypothetical protein 0.0012 0.0083 0.0243
Plasmodium falciparum heat shock protein 90, putative 0.0026 0.0442 0.1376
Brugia malayi PAN domain containing protein 0.002 0.0264 0.0865
Onchocerca volvulus 0.0142 0.3399 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0012 0.0083 0.003
Loa Loa (eye worm) hypothetical protein 0.0012 0.0069 0.0203
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0251 0.02
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.004 0.0794 0.0969
Echinococcus granulosus potassium large conductance calcium activated 0.0045 0.0915 0.0867
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0012 0.0083 0.003
Echinococcus granulosus protein kinase c epsilon type 0.0015 0.016 0.0108
Trichomonas vaginalis DNA topoisomerase II, putative 0.002 0.0265 0.1384
Loa Loa (eye worm) RGC/RGC protein kinase 0.0016 0.0173 0.051
Schistosoma mansoni hypothetical protein 0.0028 0.0472 0.0421
Toxoplasma gondii microneme protein MIC17C 0.002 0.0264 0.026
Plasmodium vivax DNA gyrase subunit B, putative 0.002 0.0265 0.0749
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.002 0.0265 0.0709
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.0166 0.0114
Brugia malayi Doublecortin family protein 0.0019 0.0256 0.0841
Entamoeba histolytica hypothetical protein 0.0039 0.0763 0.4237
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0016 0.0173 0.0122
Echinococcus multilocularis glutamate receptor 2 0.0016 0.0173 0.0122
Trypanosoma brucei heat shock protein, putative 0.0071 0.1585 0.5087
Brugia malayi Trypsin family protein 0.0012 0.0083 0.0271
Toxoplasma gondii microneme protein, putative 0.002 0.0264 0.026
Echinococcus granulosus enteropeptidase 0.0012 0.0083 0.003
Toxoplasma gondii PAN domain-containing protein 0.002 0.0264 0.026
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0251 0.074
Toxoplasma gondii hypothetical protein 0.002 0.0264 0.026
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0256 0.0205
Loa Loa (eye worm) hypothetical protein 0.0122 0.2884 0.8487
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0083 0.003
Trypanosoma cruzi heat shock protein 85, putative 0.0071 0.1585 0.5087
Mycobacterium ulcerans two component sensor kinase MprB 0.002 0.0265 0.1529
Brugia malayi Nuclear hormone receptor-like 1 0.0013 0.0097 0.0317
Onchocerca volvulus Putative endochitinase 0.0077 0.1729 0.5088
Echinococcus multilocularis heat shock protein 90 0.0071 0.1585 0.1541
Brugia malayi endochitinase 0.0086 0.1966 0.6449
Brugia malayi Endochitinase 0.0086 0.1966 0.6449
Echinococcus multilocularis calcium activated potassium channel variant 0.0042 0.0834 0.0786
Schistosoma mansoni RAR-like nuclear receptor 0.0025 0.0395 0.0344
Onchocerca volvulus 0.0028 0.0482 0.1417
Trypanosoma cruzi heat shock protein, putative 0.0026 0.0442 0.1252
Plasmodium vivax hypothetical protein, conserved 0.002 0.0265 0.0749
Onchocerca volvulus DNA topoisomerase 2 homolog 0.002 0.0265 0.0778
Loa Loa (eye worm) hypothetical protein 0.0012 0.0061 0.0179
Trypanosoma brucei heat shock protein, putative 0.0071 0.1585 0.5087
Mycobacterium ulcerans hypothetical protein 0.0012 0.0083 0.0217
Brugia malayi bHLH-PAS transcription factor 0.0049 0.1014 0.3325
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0017 0.0202 0.0976
Brugia malayi hypothetical protein 0.0012 0.0083 0.0271
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0013 0.0097 0.0045
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.0395 0.0344
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0012 0.0083 0.003
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0025 0.0395 0.0344
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0017 0.0202 0.0976
Loa Loa (eye worm) heat shock protein 75 0.0026 0.0442 0.1301
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0025 0.0395 0.1162
Plasmodium falciparum potassium channel 0.0012 0.0069 0.0059
Loa Loa (eye worm) PAN domain-containing protein 0.002 0.0264 0.0776
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0251 0.02
Brugia malayi nuclear hormone receptor family member nhr-6 0.0012 0.0061 0.02
Trypanosoma cruzi heat shock protein 90, putative 0.0051 0.1083 0.3404
Onchocerca volvulus 0.002 0.0264 0.0776
Entamoeba histolytica hypothetical protein 0.0039 0.0763 0.4237
Loa Loa (eye worm) DR-78 0.0012 0.0061 0.0179
Plasmodium vivax potassium channel, putative 0.0012 0.0069 0.0059
Loa Loa (eye worm) steroid hormone receptor 0.0025 0.0395 0.1162
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0026 0.0442 0.1301
Trichomonas vaginalis heat shock protein, putative 0.0051 0.1083 0.6726
Loa Loa (eye worm) hypothetical protein 0.003 0.0528 0.1554
Schistosoma mansoni protein kinase 0.0016 0.0173 0.0122
Onchocerca volvulus 0.0012 0.0083 0.0243
Schistosoma mansoni hypothetical protein 0.0019 0.0256 0.0205
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0017 0.0207 0.0462
Loa Loa (eye worm) hypothetical protein 0.002 0.0264 0.0776
Loa Loa (eye worm) hypothetical protein 0.0065 0.144 0.4236
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0256 0.0205
Schistosoma mansoni aryl hydrocarbon receptor 0.0191 0.4664 0.4636
Echinococcus granulosus Nuclear hormone receptor HR96 0.0012 0.0061 0.0009
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.002 0.0265 0.0656
Brugia malayi hypothetical protein 0.0012 0.0061 0.02
Loa Loa (eye worm) hypothetical protein 0.0025 0.0395 0.1162
Brugia malayi PAN domain containing protein 0.002 0.0264 0.0865
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0202 0.0976
Brugia malayi hypothetical protein 0.0017 0.0202 0.0663
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0012 0.0061 0.0009
Toxoplasma gondii microneme protein MIC17A 0.002 0.0264 0.026
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0256 0.0205
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0083 0.003
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0012 0.0061 0.02
Trichomonas vaginalis heat shock protein, putative 0.0051 0.1083 0.6726
Brugia malayi PAN domain containing protein 0.002 0.0264 0.0865
Echinococcus multilocularis netrin receptor unc 5 0.0016 0.0162 0.0111
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0125 0.2959 0.9707
Loa Loa (eye worm) glutamate receptor 0.0067 0.1481 0.4357
Onchocerca volvulus Protein ultraspiracle homolog 0.0025 0.0395 0.1162
Schistosoma mansoni calcium-activated potassium channel 0.0045 0.0915 0.0867
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0016 0.0173 0.0122
Onchocerca volvulus 0.0019 0.0256 0.0754
Toxoplasma gondii PAN domain-containing protein 0.0303 0.7546 1
Entamoeba histolytica chitinase, putative 0.0077 0.1729 1
Echinococcus granulosus tyrosine kinase 0.0016 0.0173 0.0122
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0025 0.0395 0.1295
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.006 0.1295 0.164
Brugia malayi Cytochrome P450 family protein 0.0044 0.0895 0.2936
Brugia malayi Receptor family ligand binding region containing protein 0.0044 0.0882 0.2894
Schistosoma mansoni pyruvate dehydrogenase 0.0128 0.3049 0.3012
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0013 0.0097 0.0045
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0083 0.003
Schistosoma mansoni glutamate receptor NMDA 0.0016 0.0173 0.0122
Leishmania major heat shock protein 83-1 0.0071 0.1585 0.5087
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.003 0.0528 0.1732
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0256 0.0754
Schistosoma mansoni ankyrin 23/unc44 0.0016 0.0162 0.0111
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0025 0.0395 0.0344
Loa Loa (eye worm) hypothetical protein 0.0025 0.0395 0.1162
Trichomonas vaginalis receptor histidine kinase, putative 0.002 0.0265 0.1384
Loa Loa (eye worm) endoplasmin 0.0071 0.1585 0.4664
Echinococcus granulosus Nuclear hormone receptor HR96 0.0012 0.0061 0.0009
Brugia malayi PAN domain containing protein 0.002 0.0264 0.0865
Schistosoma mansoni nuclear hormone receptor 0.0025 0.0395 0.0344
Loa Loa (eye worm) hypothetical protein 0.0012 0.0061 0.0179
Onchocerca volvulus 0.0019 0.0256 0.0754
Echinococcus multilocularis FTZ F1 alpha 0.0025 0.0395 0.0344
Schistosoma mansoni hypothetical protein 0.0399 1 1
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0038 0.075 0.0701
Echinococcus granulosus nmda type glutamate receptor 0.0016 0.0173 0.0122
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0083 0.003
Trypanosoma brucei heat shock protein 84, putative 0.0026 0.0442 0.1252
Loa Loa (eye worm) hypothetical protein 0.0012 0.0061 0.0179
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0083 0.003
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0118 0.2801 0.2763
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0016 0.0173 0.0122
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0083 0.003
Trypanosoma cruzi extracellular receptor, putative 0.0016 0.0173 0.035
Loa Loa (eye worm) hypothetical protein 0.0128 0.3049 0.8971
Toxoplasma gondii PAN domain-containing protein 0.002 0.0264 0.026
Loa Loa (eye worm) hypothetical protein 0.0019 0.0256 0.0754
Loa Loa (eye worm) hypothetical protein 0.0012 0.0061 0.0179
Onchocerca volvulus 0.0049 0.1028 0.3026
Onchocerca volvulus 0.0012 0.0083 0.0243
Toxoplasma gondii heat shock protein 75, putative 0.0026 0.0442 0.0499
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0025 0.0395 0.1295
Plasmodium falciparum DNA topoisomerase 2 0.002 0.0265 0.0749
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.0395 0.0344
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0016 0.0173 0.0569
Echinococcus granulosus glutamate receptor 2 0.0016 0.0173 0.0122
Echinococcus multilocularis Hepatocellular carcinoma associated antigen 59 0.0122 0.2884 0.2847
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0012 0.0061 0.0009
Onchocerca volvulus Putative endochitinase 0.0086 0.1966 0.5785
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.002 0.0265 0.1529
Schistosoma mansoni serine/threonine protein kinase 0.0015 0.016 0.0108
Echinococcus multilocularis transmembrane protease serine 3 0.0012 0.0083 0.003
Leishmania major protein kinase, putative 0.0017 0.0207 0.0462
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0083 0.1891 0.1848
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.1146 0.11
Echinococcus multilocularis nuclear receptor nhr 48 0.0012 0.0061 0.0009
Leishmania major heat shock protein 83-1 0.0071 0.1585 0.5087
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0016 0.0173 0.0122
Brugia malayi Trypsin family protein 0.0012 0.0083 0.0271
Leishmania major heat shock protein 83-1 0.0071 0.1585 0.5087
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.002 0.0265 0.1529
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0017 0.0207 0.0462
Plasmodium falciparum heat shock protein 90, putative 0.0026 0.0442 0.1376
Loa Loa (eye worm) PAN domain-containing protein 0.002 0.0264 0.0776
Leishmania major DNA topoisomerase ii 0.002 0.0265 0.0656
Loa Loa (eye worm) hypothetical protein 0.0016 0.0173 0.051
Onchocerca volvulus Poor gastrulation protein homolog 0.0028 0.0472 0.1388
Plasmodium vivax DNA topoisomerase II, putative 0.002 0.0265 0.0749
Loa Loa (eye worm) hypothetical protein 0.002 0.0264 0.0776
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0025 0.0395 0.1295
Onchocerca volvulus 0.002 0.0264 0.0776
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0251 0.02
Loa Loa (eye worm) hypothetical protein 0.0016 0.0173 0.051
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0025 0.0395 0.0344
Echinococcus granulosus RUN 0.0019 0.0256 0.0205
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0251 0.02
Schistosoma mansoni polycystin 1-related 0.0019 0.0256 0.0205
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0016 0.0162 0.0111
Schistosoma mansoni retinoic acid receptor RXR 0.0131 0.3135 0.3099
Loa Loa (eye worm) hypothetical protein 0.0012 0.0061 0.0179
Plasmodium falciparum conserved protein, unknown function 0.0122 0.2884 1
Onchocerca volvulus 0.002 0.0264 0.0776
Loa Loa (eye worm) hypothetical protein 0.0016 0.0173 0.051
Brugia malayi Nuclear hormone receptor E75 0.0012 0.0061 0.02
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0012 0.0061 0.0009
Loa Loa (eye worm) hypothetical protein 0.0041 0.0818 0.2408
Echinococcus multilocularis protein kinase c iota type 0.0014 0.0128 0.0076
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0025 0.0395 0.0344
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0025 0.0395 0.1295
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.002 0.0265 0.0656
Brugia malayi photoreceptor-specific nuclear receptor 0.0025 0.0395 0.1295
Brugia malayi ecdysone receptor 0.0012 0.0061 0.02
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0482 0.1417
Brugia malayi PAN domain containing protein 0.002 0.0264 0.0865
Brugia malayi conserved hypotetical protein 0.0012 0.0061 0.02
Entamoeba histolytica hypothetical protein 0.0039 0.0763 0.4237
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.002 0.0265 0.1529
Echinococcus granulosus GPCR family 3 C terminal 0.0028 0.0472 0.0421
Echinococcus multilocularis receptor type guanylyl cyclase 0.0016 0.0173 0.0122
Brugia malayi nuclear receptor NHR-67 0.0012 0.0061 0.02
Loa Loa (eye worm) hypothetical protein 0.0016 0.0173 0.051
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0256 0.072
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0025 0.0395 0.0344
Loa Loa (eye worm) hypothetical protein 0.0012 0.0083 0.0243
Echinococcus multilocularis glutamate receptor 2 0.0016 0.0173 0.0122
Onchocerca volvulus 0.002 0.0264 0.0776
Loa Loa (eye worm) hypothetical protein 0.0142 0.3399 1
Schistosoma mansoni hypothetical protein 0.0019 0.0251 0.02
Trichomonas vaginalis endoplasmin, putative 0.0046 0.0944 0.5817
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0025 0.0395 0.1295
Trypanosoma brucei DNA topoisomerase ii 0.002 0.0265 0.0656
Loa Loa (eye worm) hypothetical protein 0.0016 0.0166 0.0488
Toxoplasma gondii 1,3(4)-beta-glucanase 0.002 0.0264 0.026
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.002 0.0265 0.1384
Loa Loa (eye worm) hypothetical protein 0.0083 0.1891 0.5565
Echinococcus granulosus FTZ F1 alpha 0.0025 0.0395 0.0344
Echinococcus granulosus Protein kinase C brain isozyme 0.0054 0.1146 0.11
Brugia malayi hypothetical protein 0.0011 0.0052 0.0172
Schistosoma mansoni hypothetical protein 0.0019 0.0251 0.02
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0017 0.0202 0.0446
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0083 0.003
Schistosoma mansoni endoplasmin 0.0071 0.1585 0.1541
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0131 0.3135 0.3099
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0012 0.0083 0.003
Loa Loa (eye worm) microfilarial chitinase 0.0075 0.1677 0.4933
Schistosoma mansoni cellular tumor antigen P53 0.0054 0.1137 0.1091
Mycobacterium leprae Probable two-component sensor kinase 0.002 0.0265 0.0709
Loa Loa (eye worm) hypothetical protein 0.002 0.0265 0.0778
Brugia malayi nuclear receptor RXR 0.0012 0.0061 0.02
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.002 0.0265 0.0749
Schistosoma mansoni zinc finger protein 0.0012 0.0061 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0202 0.0976
Loa Loa (eye worm) hypothetical protein 0.0028 0.0472 0.1388
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0025 0.0395 0.0344
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0017 0.0202 0.0446
Trypanosoma brucei heat shock protein, putative 0.0071 0.1585 0.5087
Echinococcus granulosus heat shock protein 0.0071 0.1585 0.1541
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0025 0.0395 0.1295
Onchocerca volvulus Netrin receptor homolog 0.0016 0.0162 0.0478
Onchocerca volvulus 0.0012 0.0083 0.0243
Leishmania major heat shock protein 83-1 0.0071 0.1585 0.5087
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0012 0.0083 0.003
Mycobacterium ulcerans two component regulator - sensor kinase 0.002 0.0265 0.1529
Onchocerca volvulus 0.002 0.0264 0.0776
Leishmania major heat shock protein 83-1 0.0071 0.1585 0.5087
Onchocerca volvulus Bile acid receptor homolog 0.0025 0.0395 0.1162
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0025 0.0395 0.0344
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.002 0.0265 0.0778
Brugia malayi nuclear receptor NHR-88 0.0025 0.0395 0.1295
Echinococcus granulosus DNA topoisomerase 2 alpha 0.002 0.0265 0.0213
Onchocerca volvulus 0.0054 0.1137 0.3347
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0017 0.0202 0.0976
Brugia malayi hypothetical protein 0.0016 0.0173 0.0569
Brugia malayi kinase, mitochondrial precursor 0.0128 0.3049 1
Onchocerca volvulus 0.0016 0.0173 0.051
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0012 0.0061 0.0179
Echinococcus multilocularis endoplasmin 0.0051 0.1083 0.1036
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0028 0.0472 0.1547
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.002 0.0265 0.0261
Entamoeba histolytica hypothetical protein 0.0016 0.0173 0.0722
Echinococcus granulosus heat shock protein 90 0.0051 0.1083 0.1036
Echinococcus multilocularis heat shock protein 0.0071 0.1585 0.1541
Toxoplasma gondii hypothetical protein 0.002 0.0264 0.026
Brugia malayi Protein kinase c protein 2 0.0046 0.0937 0.3074
Loa Loa (eye worm) nuclear receptor NHR-67 0.0012 0.0061 0.0179
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0061 0.0009
Plasmodium vivax heat shock protein 86, putative 0.0071 0.1585 0.5411
Trypanosoma cruzi heat shock protein 90, putative 0.0071 0.1585 0.5087
Schistosoma mansoni pyruvate dehydrogenase 0.0109 0.2547 0.2508
Onchocerca volvulus 0.0122 0.2884 0.8487
Echinococcus granulosus RNA directed DNA polymerase 0.0038 0.075 0.0701
Brugia malayi PAN domain containing protein 0.002 0.0264 0.0865
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0051 0.1083 0.3404
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0128 0.3049 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0901 0.2651
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0256 0.0205
Onchocerca volvulus Putative chitinase 0.0011 0.0052 0.0154
Loa Loa (eye worm) hypothetical protein 0.0025 0.0395 0.1162
Brugia malayi PAN domain containing protein 0.002 0.0264 0.0865
Echinococcus granulosus Mastin 0.0012 0.0083 0.003
Leishmania major heat shock protein 83-1 0.0071 0.1585 0.5087
Trypanosoma brucei heat shock protein, putative 0.0071 0.1585 0.5087
Loa Loa (eye worm) PAN domain-containing protein 0.002 0.0264 0.0776
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0128 0.3049 0.3012
Loa Loa (eye worm) hypothetical protein 0.0038 0.075 0.2206
Plasmodium vivax heat shock protein, putative 0.0026 0.0442 0.1376
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0025 0.0395 0.1162
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0016 0.0162 0.0478
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.1287 0.1242
Echinococcus granulosus calcium activated potassium channel 0.0045 0.092 0.0872
Schistosoma mansoni cpg binding protein 0.0028 0.0482 0.0431
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0115 0.2715 0.2676
Schistosoma mansoni metabotropic glutamate receptor 0.0016 0.0173 0.0122
Echinococcus granulosus Ankyrin 0.0016 0.0166 0.0114
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0026 0.0442 0.0392
Schistosoma mansoni endoplasmin 0.0071 0.1585 0.1541
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0115 0.2715 0.2676
Brugia malayi PAN domain containing protein 0.002 0.0264 0.0865
Trypanosoma brucei heat shock protein, putative 0.0071 0.1585 0.5087
Loa Loa (eye worm) hypothetical protein 0.002 0.0265 0.0778
Toxoplasma gondii PAN domain-containing protein 0.002 0.0264 0.026
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0025 0.0395 0.0344
Schistosoma mansoni hypothetical protein 0.0012 0.0083 0.003
Schistosoma mansoni heat shock protein 0.0026 0.0442 0.0392
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0025 0.0395 0.0344
Trichomonas vaginalis guanylate cyclase, putative 0.0017 0.0202 0.0976
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0012 0.0083 0.003
Echinococcus multilocularis transfer RNA-Lys 0.0049 0.1014 0.0966
Schistosoma mansoni cpg binding protein 0.003 0.0523 0.0473
Mycobacterium ulcerans chitinase/cellulase 0.0065 0.144 1
Trichomonas vaginalis sensor histidine kinase, putative 0.002 0.0265 0.1384
Onchocerca volvulus 0.002 0.0264 0.0776
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0162 0.0533
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0016 0.0173 0.051
Entamoeba histolytica heat shock protein 90, putative 0.0071 0.1585 0.914
Loa Loa (eye worm) nuclear hormone receptor 0.0012 0.0061 0.0179
Leishmania major heat shock protein, putative 0.0026 0.0442 0.1252
Mycobacterium leprae Probable two component sensor kinase MprB 0.002 0.0265 0.0709
Loa Loa (eye worm) RGC/RGC protein kinase 0.0016 0.0173 0.051
Loa Loa (eye worm) cuticular endochitinase 0.0077 0.1729 0.5088
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0013 0.0097 0.0285
Brugia malayi DNA topoisomerase II, alpha isozyme 0.002 0.0265 0.0868
Echinococcus multilocularis tumor protein p63 0.0366 0.9154 0.915
Leishmania major heat shock protein 83-1 0.0071 0.1585 0.5087
Brugia malayi hypothetical protein 0.0013 0.0097 0.0317
Schistosoma mansoni lipoxygenase 0.008 0.1826 0.1783
Trypanosoma brucei heat shock protein 90, putative 0.0071 0.1585 0.5087
Loa Loa (eye worm) cytochrome P450 family protein 0.0044 0.0895 0.2634
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.0395 0.0344
Toxoplasma gondii PAN/Apple domain-containing protein 0.002 0.0264 0.026
Brugia malayi nuclear hormone receptor 0.0025 0.0395 0.1295
Plasmodium vivax hypothetical protein, conserved 0.0122 0.2884 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0763 0.0714
Echinococcus granulosus ecdysone induced protein 78C 0.0025 0.0395 0.0344
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0044 0.0882 0.2596
Echinococcus granulosus receptor type guanylyl cyclase 0.0016 0.0173 0.0122
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0017 0.0202 0.0446
Trypanosoma cruzi heat shock protein 85, putative 0.0051 0.1083 0.3404
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0016 0.0173 0.0122
Echinococcus granulosus endoplasmin 0.0051 0.1083 0.1036
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.002 0.0265 0.0709
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0256 0.0205
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0012 0.0061 0.0009
Echinococcus granulosus Hepatocellular carcinoma associated antigen 59 0.0122 0.2884 0.2847
Echinococcus granulosus single minded 2 0.0049 0.1014 0.0966
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0025 0.0395 0.1295
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0202 0.0976
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0763 0.0714
Loa Loa (eye worm) TOPoisomerase family member 0.002 0.0265 0.0778
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0025 0.0395 0.1162
Echinococcus multilocularis RNA directed DNA polymerase 0.0038 0.075 0.0701
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.002 0.0265 0.0656
Loa Loa (eye worm) hypothetical protein 0.0011 0.0052 0.0154
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0012 0.0083 0.003
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0012 0.0083 0.003
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0026 0.0442 0.0392
Leishmania major mitochondrial DNA topoisomerase II 0.002 0.0265 0.0656
Brugia malayi Trypsin family protein 0.0012 0.0083 0.0271
Leishmania major heat shock protein 83-1 0.0071 0.1585 0.5087
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0016 0.0173 0.0122
Brugia malayi Uncoordinated protein 44 0.0016 0.0162 0.0533
Echinococcus multilocularis ecdysone induced protein 78C 0.0025 0.0395 0.0344
Leishmania major heat shock protein 83-1 0.0071 0.1585 0.5087
Loa Loa (eye worm) hypothetical protein 0.0025 0.0395 0.1162
Giardia lamblia Heat shock protein HSP 90-alpha 0.0071 0.1585 1
Brugia malayi Guanylyl cyclase protein 23 0.0016 0.0173 0.0569
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0044 0.0882 0.2596
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0012 0.0083 0.003
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0016 0.0173 0.0122
Schistosoma mansoni heat shock protein 0.0071 0.1585 0.1541
Trypanosoma brucei heat shock protein, putative 0.0071 0.1585 0.5087
Schistosoma mansoni hypothetical protein 0.0019 0.0251 0.02
Brugia malayi nuclear receptor RXR 0.0013 0.0097 0.0317
Schistosoma mansoni nuclear receptor 0.0012 0.0061 0.0009
Echinococcus granulosus aryl hydrocarbon receptor 0.0142 0.3413 0.3378
Loa Loa (eye worm) hypothetical protein 0.0019 0.0251 0.074
Toxoplasma gondii hypothetical protein 0.0122 0.2884 0.3765
Brugia malayi Hepatocellular carcinoma-associated antigen 59 family protein 0.0122 0.2884 0.9461
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0763 0.0714
Echinococcus multilocularis cpg binding protein 0.003 0.0523 0.0473
Plasmodium vivax endoplasmin, putative 0.0071 0.1585 0.5411
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0028 0.0472 0.1388
Schistosoma mansoni single-minded 0.0066 0.1453 0.1408
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0012 0.0083 0.0271
Toxoplasma gondii Hsp90 domain-containing protein 0.0026 0.0442 0.0499
Mycobacterium ulcerans chitinase/cellulase 0.0065 0.144 1
Trichomonas vaginalis heat shock protein, putative 0.0071 0.1585 1
Entamoeba histolytica DNA topoisomerase II, putative 0.002 0.0265 0.1265
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.002 0.0265 0.1529
Loa Loa (eye worm) hypothetical protein 0.0012 0.0083 0.0243
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.1125 0.1412
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0025 0.0395 0.0344
Loa Loa (eye worm) glutamate receptor 0.0044 0.0882 0.2596
Brugia malayi hypothetical protein 0.0019 0.0256 0.0841
Schistosoma mansoni thyroid hormone receptor 0.0025 0.0395 0.0344
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0017 0.0202 0.0976
Echinococcus granulosus calcium activated potassium channel variant 0.0042 0.0834 0.0786
Schistosoma mansoni calcium-activated potassium channel 0.0012 0.0069 0.0017
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0012 0.0083 0.003
Loa Loa (eye worm) hypothetical protein 0.0125 0.2959 0.8708
Brugia malayi PAN domain containing protein 0.002 0.0264 0.0865
Schistosoma mansoni loxhd1 0.0019 0.0256 0.0205
Trypanosoma brucei heat shock protein, putative 0.0071 0.1585 0.5087
Brugia malayi Glycosyl hydrolases family 18 protein 0.0011 0.0052 0.0172
Brugia malayi Probable DNA topoisomerase II 0.002 0.0265 0.0868
Trypanosoma cruzi heat shock protein 85, putative 0.0071 0.1585 0.5087
Schistosoma mansoni DNA topoisomerase II 0.002 0.0265 0.0213
Schistosoma mansoni hypothetical protein 0.0012 0.0083 0.003
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.002 0.0265 0.1384
Onchocerca volvulus 0.0012 0.0083 0.0243
Brugia malayi hypothetical protein 0.0013 0.0097 0.0317
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0025 0.0395 0.1295
Loa Loa (eye worm) RGC/RGC protein kinase 0.0016 0.0173 0.051
Onchocerca volvulus 0.0012 0.0061 0.0179
Brugia malayi tailless protein 0.0012 0.0061 0.02
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0025 0.0395 0.1162
Leishmania major extracellular receptor, putative 0.0016 0.0173 0.035
Plasmodium falciparum endoplasmin, putative 0.0046 0.0944 0.3148
Loa Loa (eye worm) hypothetical protein 0.0012 0.0061 0.0179
Echinococcus granulosus GPCR family 2 0.0019 0.0251 0.02
Echinococcus granulosus metabotropic glutamate receptor 2 0.0016 0.0173 0.0122
Echinococcus multilocularis protein kinase c epsilon type 0.0015 0.016 0.0108
Loa Loa (eye worm) hypothetical protein 0.0017 0.0202 0.0595
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0017 0.0207 0.0462
Onchocerca volvulus 0.0016 0.0173 0.051
Loa Loa (eye worm) hypothetical protein 0.0122 0.2884 0.8487
Trichomonas vaginalis heat shock protein, putative 0.0046 0.0944 0.5817
Loa Loa (eye worm) chitinase I 0.0077 0.1729 0.5088
Loa Loa (eye worm) hypothetical protein 0.0025 0.0395 0.1162
Echinococcus multilocularis tyrosine kinase 0.0016 0.0173 0.0122
Brugia malayi endochitinase 0.0077 0.1729 0.5671
Loa Loa (eye worm) hypothetical protein 0.0012 0.0061 0.0179
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0017 0.0207 0.0462
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0025 0.0395 0.1162
Brugia malayi Nuclear hormone receptor-like 1 0.0025 0.0395 0.1295
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0061 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.0264 0.0776
Echinococcus granulosus tumor protein p63 0.0366 0.9154 0.915
Onchocerca volvulus 0.0012 0.0061 0.0179
Trypanosoma cruzi DNA topoisomerase II, putative 0.002 0.0265 0.0656
Onchocerca volvulus 0.002 0.0264 0.0776
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0012 0.0083 0.003
Brugia malayi hypothetical protein 0.0019 0.0256 0.0841
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0025 0.0395 0.0344
Echinococcus granulosus metabotropic glutamate receptor 5 0.0083 0.1891 0.1848
Loa Loa (eye worm) hypothetical protein 0.0025 0.0395 0.1162
Schistosoma mansoni nuclear receptor nhr-48 0.0012 0.0061 0.0009
Leishmania major heat shock protein 83-1 0.0071 0.1585 0.5087
Schistosoma mansoni tyrosine kinase 0.0016 0.0173 0.0122
Mycobacterium ulcerans putative regulatory protein 0.0049 0.1014 0.693
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.002 0.0265 0.1384
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1307 0.3845
Echinococcus multilocularis serine threonine protein kinase 0.0048 0.0995 0.0948
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0051 0.1083 1
Schistosoma mansoni coup transcription factor 0.0025 0.0395 0.0344
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.004 0.0794 0.2431
Echinococcus granulosus heat shock protein 90 0.0071 0.1585 0.1541
Onchocerca volvulus Putative endochitinase 0.0086 0.1966 0.5785
Leishmania major heat shock protein 83-1 0.0071 0.1585 0.5087
Trypanosoma brucei heat shock protein 90, putative 0.0071 0.1585 0.5087
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0025 0.0395 0.1162
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0061 0.0009
Schistosoma mansoni tyrosine kinase 0.0016 0.0173 0.0122
Brugia malayi hypothetical protein 0.0039 0.0763 0.2502
Treponema pallidum heat shock protein 90 0.0051 0.1083 1
Echinococcus granulosus transmembrane protease serine 3 0.0012 0.0083 0.003
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0028 0.0472 0.1547
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0015 0.016 0.0469
Schistosoma mansoni thyroid hormone receptor 0.0025 0.0395 0.0344
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.004 0.0794 0.2431
Echinococcus multilocularis heat shock protein 90 0.0051 0.1083 0.1036
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.002 0.0265 0.1529
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0128 0.3049 0.3012
Brugia malayi Receptor family ligand binding region containing protein 0.0016 0.0173 0.0569
Echinococcus granulosus thyroid hormone receptor alpha 0.0012 0.0061 0.0009
Brugia malayi Glycosyl hydrolases family 18 protein 0.0011 0.0052 0.0172
Onchocerca volvulus 0.002 0.0264 0.0776
Brugia malayi steroid hormone receptor 0.0025 0.0395 0.1295
Loa Loa (eye worm) MaxiK calcium-activated potassium channel 0.003 0.0528 0.1554
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0083 0.003
Loa Loa (eye worm) hypothetical protein 0.002 0.0264 0.0776
Echinococcus granulosus nuclear factor of activated T cells 5 0.008 0.181 0.1766
Loa Loa (eye worm) hypothetical protein 0.0016 0.0162 0.0478
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1307 0.4286
Loa Loa (eye worm) hypothetical protein 0.006 0.1307 0.3845
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.002 0.0265 0.0213
Echinococcus multilocularis RUN 0.0019 0.0256 0.0205
Brugia malayi hypothetical protein 0.0012 0.0061 0.02
Echinococcus multilocularis Mastin 0.0012 0.0083 0.003
Loa Loa (eye worm) heat shock protein 90 0.0071 0.1585 0.4664
Loa Loa (eye worm) hypothetical protein 0.0016 0.0173 0.051
Loa Loa (eye worm) hypothetical protein 0.0125 0.2974 0.8751
Loa Loa (eye worm) hypothetical protein 0.0012 0.0083 0.0243
Loa Loa (eye worm) hypothetical protein 0.0013 0.0097 0.0285
Echinococcus multilocularis Ankyrin 0.0016 0.0166 0.0114
Loa Loa (eye worm) hypothetical protein 0.0013 0.0097 0.0285
Echinococcus granulosus atrial natriuretic peptide receptor 0.0016 0.0173 0.0122
Brugia malayi PAS domain containing protein 0.0066 0.1453 0.4766
Echinococcus multilocularis nuclear factor of activated T cells 5 0.008 0.181 0.1766
Mycobacterium ulcerans heat shock protein 90 0.0051 0.1083 0.7432
Schistosoma mansoni metabotropic glutamate receptor 0.0083 0.1891 0.1848
Onchocerca volvulus 0.0012 0.0083 0.0243
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0016 0.0173 0.0122
Echinococcus granulosus protein kinase C gamma type 0.0048 0.0995 0.0948
Toxoplasma gondii DNA topoisomerase 2, putative 0.002 0.0265 0.0261
Brugia malayi ecdysteroid receptor 0.0025 0.0395 0.1295
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0025 0.0395 0.1295
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0054 0.1146 0.11
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0128 0.3049 0.3012
Echinococcus multilocularis potassium large conductance calcium activated 0.0045 0.0915 0.0867
Echinococcus granulosus glutamate receptor 2 0.0016 0.0173 0.0122
Schistosoma mansoni atypical protein kinase C 0.0014 0.0128 0.0076
Leishmania major heat shock protein 83-1 0.0071 0.1585 0.5087
Leishmania major protein kinase, putative 0.0017 0.0207 0.0462
Brugia malayi Metabotropic glutamate receptor precursor. 0.0044 0.0882 0.2894
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.002 0.0265 0.1529
Loa Loa (eye worm) hypothetical protein 0.0019 0.0256 0.0754
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0083 0.003
Echinococcus multilocularis enteropeptidase 0.0012 0.0083 0.003
Brugia malayi protein kinase C II. 0.0015 0.016 0.0523
Brugia malayi CXXC zinc finger family protein 0.0028 0.0482 0.158
Trypanosoma brucei developmentally regulated phosphoprotein 0.0128 0.3049 1
Echinococcus multilocularis aryl hydrocarbon receptor 0.0142 0.3413 0.3378
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0012 0.0061 0.0179
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0013 0.0097 0.0045
Loa Loa (eye worm) hypothetical protein 0.002 0.0264 0.0776
Echinococcus multilocularis nmda type glutamate receptor 0.0016 0.0173 0.0122
Loa Loa (eye worm) hypothetical protein 0.0044 0.0882 0.2596
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0067 0.1481 0.1436
Mycobacterium ulcerans DNA gyrase subunit B 0.002 0.0265 0.1529
Giardia lamblia Grp94/Hsp90 0.0051 0.1083 0.6201
Mycobacterium tuberculosis Possible chitinase 0.0065 0.144 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0025 0.0395 0.1295
Leishmania major hypothetical protein, conserved 0.002 0.0265 0.0656
Toxoplasma gondii subtilisin SUB12 0.002 0.0264 0.026
Entamoeba histolytica hypothetical protein 0.0039 0.0763 0.4237
Leishmania major developmentally regulated phosphoprotein-like protein 0.0128 0.3049 1
Echinococcus multilocularis GPCR, family 3, C terminal 0.0028 0.0472 0.0421
Loa Loa (eye worm) hypothetical protein 0.0012 0.0061 0.0179
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0251 0.0824
Leishmania major heat shock protein 83-1 0.0071 0.1585 0.5087
Brugia malayi Nuclear hormone receptor-like 1 0.0013 0.0097 0.0317
Brugia malayi PAN domain containing protein 0.002 0.0264 0.0865
Mycobacterium ulcerans putative regultory protein 0.002 0.0265 0.1529
Onchocerca volvulus 0.002 0.0264 0.0776
Echinococcus granulosus glycoprotein Antigen 5 0.0012 0.0083 0.003
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0256 0.072
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0018 0.0217 0.0638
Schistosoma mansoni cpg binding protein 0.003 0.0523 0.0473
Trypanosoma cruzi heat shock protein 85, putative 0.0071 0.1585 0.5087
Loa Loa (eye worm) hypothetical protein 0.0025 0.0395 0.1162
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0051 0.1083 0.1036
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0061 0.0009
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0018 0.0217 0.0165
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.002 0.0265 0.1384
Echinococcus granulosus death domain containing protein 0.0016 0.0162 0.0111
Echinococcus multilocularis glycoprotein Antigen 5 0.0012 0.0083 0.003
Leishmania major heat shock protein 83-1 0.0071 0.1585 0.5087
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.0042 0.0834 0.2455
Schistosoma mansoni rab6-interacting 0.0019 0.0256 0.0205
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.004 0.0794 0.2431
Plasmodium falciparum heat shock protein 90 0.0071 0.1585 0.5411
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.004 0.0786 0.2312
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0083 0.003
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0013 0.0097 0.0045
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0025 0.0395 0.1162
Trypanosoma brucei Heat shock protein 83, putative 0.0071 0.1585 0.5087
Brugia malayi Trypsin-like protease protein 5 0.0012 0.0083 0.0271
Trypanosoma cruzi heat shock protein 90, putative 0.0045 0.0906 0.2807
Trichomonas vaginalis heat shock protein, putative 0.0051 0.1083 0.6726
Loa Loa (eye worm) hypothetical protein 0.0016 0.0173 0.051
Leishmania major chitinase 0.0077 0.1729 0.5571
Loa Loa (eye worm) hypothetical protein 0.0013 0.0097 0.0285
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.002 0.0265 0.0656
Schistosoma mansoni steroid hormone receptor ad4bp 0.0025 0.0395 0.0344
Echinococcus multilocularis dnaJ subfamily B 0.0399 1 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0012 0.0061 0.02
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0025 0.0395 0.1295
Giardia lamblia Heat shock protein HSP 90-alpha 0.0051 0.1083 0.6201
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.002 0.0265 0.0868
Loa Loa (eye worm) hypothetical protein 0.0011 0.0052 0.0154
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.002 0.0265 0.1529
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0025 0.0395 0.1295
Plasmodium vivax heat shock protein 90, putative 0.0026 0.0442 0.1376
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.0395 0.0344
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0018 0.0217 0.0165
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0025 0.0395 0.0344
Brugia malayi Hsp90 protein 0.0026 0.0442 0.1451
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0251 0.0824
Echinococcus multilocularis calcium activated potassium channel 0.0045 0.092 0.0872
Trichomonas vaginalis receptor histidine kinase, putative 0.002 0.0265 0.1384
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0016 0.0173 0.0122
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.002 0.0265 0.0656
Echinococcus multilocularis thyroid hormone receptor alpha 0.0025 0.0395 0.0344
Entamoeba histolytica heat shock protein 90, putative 0.0071 0.1585 0.914
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0012 0.0061 0.0009
Onchocerca volvulus 0.002 0.0264 0.0776
Loa Loa (eye worm) hypothetical protein 0.0013 0.0097 0.0285
Schistosoma mansoni lipoxygenase 0.0115 0.2715 0.2676
Loa Loa (eye worm) hypothetical protein 0.002 0.0264 0.0776
Brugia malayi Endoplasmin precursor 0.0071 0.1585 0.5199
Brugia malayi nuclear receptor NHR-88 0.0012 0.0061 0.02
Loa Loa (eye worm) hypothetical protein 0.0025 0.0395 0.1162
Echinococcus granulosus cpg binding protein 0.003 0.0523 0.0473
Onchocerca volvulus 0.002 0.0264 0.0776
Loa Loa (eye worm) hypothetical protein 0.0012 0.0061 0.0179
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0256 0.0205
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0016 0.0173 0.0122
Toxoplasma gondii microneme protein MIC4 0.002 0.0264 0.026
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.1146 0.11
Brugia malayi Nuclear hormone receptor E75 0.0012 0.0061 0.02
Loa Loa (eye worm) PAN domain-containing protein 0.002 0.0264 0.0776
Trypanosoma cruzi DNA topoisomerase II, putative 0.002 0.0265 0.0656
Loa Loa (eye worm) hypothetical protein 0.0012 0.0061 0.0179
Toxoplasma gondii PAN domain-containing protein 0.0303 0.7546 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.1137 0.3347
Onchocerca volvulus Putative endochitinase 0.0077 0.1729 0.5088
Plasmodium falciparum DNA gyrase subunit B 0.002 0.0265 0.0749
Loa Loa (eye worm) hypothetical protein 0.0012 0.0061 0.0179
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0012 0.0061 0.0179
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0051 0.1083 0.6968
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0818 0.2684
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0083 0.003
Onchocerca volvulus DNA topoisomerase 2 homolog 0.002 0.0265 0.0778
Schistosoma mansoni hypothetical protein 0.0016 0.0162 0.0111
Brugia malayi orphan nuclear receptor NR2E1 0.0012 0.0061 0.02
Trypanosoma brucei DNA topoisomerase II beta, putative 0.002 0.0265 0.0656
Brugia malayi Steroid receptor seven-up type 2 0.0025 0.0395 0.1295
Loa Loa (eye worm) hypothetical protein 0.0012 0.0061 0.0179
Onchocerca volvulus 0.0012 0.0083 0.0243
Echinococcus multilocularis GPCR, family 2 0.0019 0.0251 0.02
Loa Loa (eye worm) hypothetical protein 0.0012 0.0083 0.0243
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0012 0.0061 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.0264 0.0776
Schistosoma mansoni netrin receptor unc5 0.0016 0.0162 0.0111
Loa Loa (eye worm) PAN domain-containing protein 0.002 0.0264 0.0776
Toxoplasma gondii heat shock protein 90, putative 0.0071 0.1585 0.2027
Echinococcus granulosus nuclear receptor nhr 48 0.0012 0.0061 0.0009
Trichomonas vaginalis guanylate cyclase, putative 0.0017 0.0202 0.0976
Leishmania major heat shock protein 83-1 0.0071 0.1585 0.5087
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1307 0.4286
Schistosoma mansoni hypothetical protein 0.0039 0.0763 0.0714
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0026 0.0442 0.2325
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0025 0.0395 0.0344
Schistosoma mansoni rab6-interacting 0.0019 0.0256 0.0205
Loa Loa (eye worm) glycosyl hydrolase family 18 protein 0.0011 0.0052 0.0154
Schistosoma mansoni pyruvate dehydrogenase 0.0109 0.2547 0.2508
Schistosoma mansoni hypothetical protein 0.0122 0.2884 0.2847
Echinococcus granulosus netrin receptor unc 5 0.0016 0.0162 0.0111
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0037 0.0704 1
Onchocerca volvulus Putative endochitinase 0.0086 0.1966 0.5785
Trypanosoma cruzi Heat shock protein 83, putative 0.0071 0.1585 0.5087
Leishmania major heat shock protein 83-1 0.0071 0.1585 0.5087
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.002 0.0265 0.0261
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0051 0.1083 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0025 0.0395 0.1295
Trypanosoma brucei heat shock protein, putative 0.0071 0.1585 0.5087
Loa Loa (eye worm) hypothetical protein 0.0012 0.0083 0.0243
Loa Loa (eye worm) hypothetical protein 0.0013 0.0097 0.0285
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0025 0.0395 0.1162
Toxoplasma gondii microneme protein MIC17B 0.002 0.0264 0.026
Brugia malayi nuclear hormone receptor 0.0012 0.0061 0.02
Brugia malayi metabotropic glutamate receptor type 2 0.0083 0.1891 0.6203
Brugia malayi hypothetical protein 0.0011 0.0052 0.0172
Echinococcus granulosus protein kinase c iota type 0.0014 0.0128 0.0076
Leishmania major heat shock protein 83-1 0.0071 0.1585 0.5087
Onchocerca volvulus 0.0025 0.0395 0.1162
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0017 0.0202 0.0976
Loa Loa (eye worm) hypothetical protein 0.0012 0.0083 0.0243
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0442 0.2544
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0012 0.0083 0.003
Schistosoma mansoni calcium-activated potassium channel 0.0042 0.0834 0.0786
Loa Loa (eye worm) hypothetical protein 0.0016 0.0173 0.051
Onchocerca volvulus Putative endochitinase 0.0011 0.0052 0.0154
Brugia malayi Trypsin family protein 0.0012 0.0083 0.0271
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.002 0.0265 0.1384
Schistosoma mansoni nuclear receptor 0.0012 0.0061 0.0009
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0016 0.0162 0.0111
Brugia malayi heat shock protein 90 0.0071 0.1585 0.5199
Loa Loa (eye worm) hypothetical protein 0.0012 0.0061 0.0179
Toxoplasma gondii PAN domain-containing protein 0.002 0.0264 0.026
Loa Loa (eye worm) trypsin family protein 0.0012 0.0083 0.0243

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.7943 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 63.0957 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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