Detailed information for compound 145055

Basic information

Technical information
  • TDR Targets ID: 145055
  • Name: N-[3-(3,4-dimethylphenyl)propyl]-2-(4-hydroxy -3-methoxyphenyl)acetamide
  • MW: 327.417 | Formula: C20H25NO3
  • H donors: 2 H acceptors: 2 LogP: 3.79 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1O)CC(=O)NCCCc1ccc(c(c1)C)C
  • InChi: 1S/C20H25NO3/c1-14-6-7-16(11-15(14)2)5-4-10-21-20(23)13-17-8-9-18(22)19(12-17)24-3/h6-9,11-12,22H,4-5,10,13H2,1-3H3,(H,21,23)
  • InChiKey: QKPILXKEMJWKBI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[3-(3,4-dimethylphenyl)propyl]-2-(4-hydroxy-3-methoxy-phenyl)acetamide
  • N-[3-(3,4-dimethylphenyl)propyl]-2-(4-hydroxy-3-methoxy-phenyl)ethanamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Vanilloid receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis sphingosine kinase, putative 0.0051 0.0357 0.2121
Onchocerca volvulus 0.0009 0.0038 0.0239
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0051 0.0357 0.0357
Trichomonas vaginalis diacylglycerol kinase, putative 0.0051 0.0357 0.2121
Schistosoma mansoni coup transcription factor 0.0009 0.0038 0.0038
Schistosoma mansoni diacylglycerol kinase theta 0.0051 0.0357 0.0357
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0049 0.0339 0.1645
Loa Loa (eye worm) hypothetical protein 0.0009 0.0038 0.0038
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0009 0.0038 0.0185
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0051 0.0357 0.0357
Entamoeba histolytica hypothetical protein, conserved 0.1317 1 1
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.0051 0.0357 0.8767
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0005 0.0004 0.0004
Schistosoma mansoni microtubule-associated protein tau 0.127 0.9638 0.9638
Loa Loa (eye worm) hypothetical protein 0.0009 0.0038 0.0038
Onchocerca volvulus 0.0214 0.1595 1
Loa Loa (eye worm) steroid hormone receptor 0.0009 0.0038 0.0038
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0051 0.0357 0.0357
Trypanosoma brucei diacylglycerol kinase, putative 0.0051 0.0357 0.5
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0027 0.0171 0.0171
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0043 0.0293 0.0293
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.0051 0.0357 0.8767
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0004 0.002
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0008 0.0024 0.5
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0009 0.0038 0.0038
Brugia malayi nuclear receptor NHR-88 0.0009 0.0038 0.0185
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0009 0.0038 0.0185
Loa Loa (eye worm) hypothetical protein 0.0009 0.0038 0.0038
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0043 0.0293 0.0293
Schistosoma mansoni thyroid hormone receptor 0.0009 0.0038 0.0038
Schistosoma mansoni aldehyde dehydrogenase 0.0055 0.0383 0.0383
Loa Loa (eye worm) hypothetical protein 0.0049 0.0339 0.0339
Schistosoma mansoni myelin transcription factor 1 myt1 0.0049 0.0339 0.0339
Brugia malayi mbt repeat family protein 0.0043 0.0293 0.1425
Schistosoma mansoni diacylglycerol kinase theta 0.0051 0.0357 0.0357
Echinococcus granulosus muscleblind protein 0.0275 0.206 0.206
Echinococcus multilocularis sphingosine kinase 1 0.1317 1 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0027 0.0171 0.0171
Echinococcus multilocularis ecdysone induced protein 78C 0.0009 0.0038 0.0038
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.0051 0.0357 0.5
Plasmodium vivax diacylglycerol kinase, putative 0.0051 0.0357 1
Loa Loa (eye worm) diacylglycerol kinase 2 0.0051 0.0357 0.0357
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0009 0.0038 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0009 0.0038 0.0185
Echinococcus granulosus polycomb protein SCMH1 0.0043 0.0293 0.0293
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0009 0.0038 0.0185
Toxoplasma gondii aldehyde dehydrogenase 0.0055 0.0383 1
Brugia malayi hypothetical protein 0.0005 0.0004 0.002
Brugia malayi Muscleblind-like protein 0.0275 0.206 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0005 0.0004 0.0004
Echinococcus granulosus expressed protein 0.0008 0.0024 0.0024
Echinococcus multilocularis SAM and MBT domain containing protein 0.0043 0.0293 0.0293
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0009 0.0038 0.0185
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0005 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.1317 1 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0009 0.0038 0.0185
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0051 0.0357 0.0357
Schistosoma mansoni ferritin light chain 0.0008 0.0024 0.0024
Mycobacterium ulcerans diacylglycerol kinase 0.0051 0.0357 0.0333
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0009 0.0038 0.0038
Onchocerca volvulus Bile acid receptor homolog 0.0009 0.0038 0.0239
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0055 0.0383 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0009 0.0038 0.0038
Mycobacterium ulcerans aldehyde dehydrogenase 0.0055 0.0383 0.036
Brugia malayi steroid hormone receptor 0.0009 0.0038 0.0185
Echinococcus multilocularis thyroid hormone receptor alpha 0.0009 0.0038 0.0038
Schistosoma mansoni sex comb on midleg homolog 0.0043 0.0293 0.0293
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0038 0.0038
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0009 0.0038 0.0038
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0043 0.0293 0.0293
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0009 0.0038 0.0038
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0051 0.0357 0.2121
Loa Loa (eye worm) hypothetical protein 0.0051 0.0357 0.0357
Loa Loa (eye worm) hypothetical protein 0.0005 0.0004 0.0004
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0038 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0009 0.0038 0.0185
Brugia malayi Ceramide kinase 0.0051 0.0357 0.1732
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0043 0.0293 0.0293
Echinococcus multilocularis ferritin 0.0008 0.0024 0.0024
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0009 0.0038 0.0038
Schistosoma mansoni apoferritin-2 0.0008 0.0024 0.0024
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0169 0.1257 0.1257
Loa Loa (eye worm) hypothetical protein 0.0005 0.0004 0.0004
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0051 0.0357 0.0357
Brugia malayi diacylglycerol kinase 0.0051 0.0357 0.1732
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0009 0.0038 0.0185
Echinococcus multilocularis Diacylglycerol kinase theta 0.0051 0.0357 0.0357
Loa Loa (eye worm) hypothetical protein 0.0005 0.0004 0.0004
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0055 0.0383 0.0383
Brugia malayi ecdysteroid receptor 0.0009 0.0038 0.0185
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0051 0.0357 0.2121
Echinococcus multilocularis polycomb protein SCMH1 0.0043 0.0293 0.0293
Mycobacterium ulcerans aldehyde dehydrogenase 0.0055 0.0383 0.036
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0169 0.1257 0.1257
Trypanosoma cruzi hypothetical protein, conserved 0.0051 0.0357 0.5
Brugia malayi Diacylglycerol kinase protein 2 0.0051 0.0357 0.1732
Brugia malayi hypothetical protein 0.0051 0.0357 0.1732
Brugia malayi Nuclear hormone receptor-like 1 0.0009 0.0038 0.0185
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0004 0.002
Onchocerca volvulus Protein ultraspiracle homolog 0.0009 0.0038 0.0239
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0009 0.0038 0.0185
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0188 0.1395 0.1395
Schistosoma mansoni ferritin light chain 0.0008 0.0024 0.0024
Schistosoma mansoni hypothetical protein 0.0261 0.1957 0.1957
Loa Loa (eye worm) hypothetical protein 0.0275 0.206 0.206
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0027 0.0171 0.0171
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0043 0.0293 0.0293
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0038 0.0038
Schistosoma mansoni ferritin 0.0008 0.0024 0.0024
Mycobacterium ulcerans hypothetical protein 0.1317 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0009 0.0038 0.0038
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0009 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0043 0.0293 0.0293
Schistosoma mansoni ferritin 0.0008 0.0024 0.0024
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0043 0.0293 0.0293
Trichomonas vaginalis diacylglycerol kinase, putative 0.0051 0.0357 0.2121
Echinococcus granulosus ecdysone induced protein 78C 0.0009 0.0038 0.0038
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0026 0.0163 0.0163
Mycobacterium ulcerans aldehyde dehydrogenase 0.0055 0.0383 0.036
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0038 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0009 0.0038 0.0185
Echinococcus granulosus ceramide kinase 0.0051 0.0357 0.0357
Treponema pallidum bacterioferrin (TpF1) 0.0008 0.0024 0.5
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0009 0.0038 0.0185
Echinococcus multilocularis expressed protein 0.0008 0.0024 0.0024
Plasmodium vivax diacylglycerol kinase, putative 0.0051 0.0357 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0009 0.0038 0.0038
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0043 0.0293 0.1422
Schistosoma mansoni apoferritin-2 0.0008 0.0024 0.0024
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0043 0.0293 0.0293
Schistosoma mansoni ferritin 0.0008 0.0024 0.0024
Echinococcus multilocularis muscleblind protein 0.0275 0.206 0.206
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0051 0.0357 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0038 0.0038
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0027 0.0171 0.0171
Schistosoma mansoni steroid hormone receptor ad4bp 0.0009 0.0038 0.0038
Echinococcus granulosus histone lysine methyltransferase setb 0.0027 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0009 0.0038 0.0038
Brugia malayi photoreceptor-specific nuclear receptor 0.0009 0.0038 0.0185
Onchocerca volvulus 0.0043 0.0293 0.184
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0043 0.0293 0.184
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0051 0.0357 0.2121
Toxoplasma gondii diacylglycerol kinase, putative 0.0051 0.0357 0.8767
Mycobacterium tuberculosis Diacylglycerol kinase 0.0051 0.0357 0.0333
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0049 0.0339 0.0339
Schistosoma mansoni sphingoid long chain base kinase 0.1317 1 1
Trichomonas vaginalis set domain proteins, putative 0.0214 0.1593 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0009 0.0038 0.0038
Brugia malayi Eye-specific diacylglycerol kinase 0.0051 0.0357 0.1732
Schistosoma mansoni sphingosine kinase A B 0.1317 1 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0009 0.0038 0.0185
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0009 0.0038 0.0038
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0005 0.0004 0.0004
Echinococcus granulosus Diacylglycerol kinase zeta 0.0051 0.0357 0.0357
Brugia malayi nuclear hormone receptor 0.0009 0.0038 0.0185
Schistosoma mansoni thyroid hormone receptor 0.0009 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0009 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0005 0.0004 0.0004
Echinococcus granulosus Diacylglycerol kinase theta 0.0051 0.0357 0.0357
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0005 0.0004 0.0004
Brugia malayi hypothetical protein 0.0005 0.0004 0.002
Schistosoma mansoni sex comb on midleg homolog 0.0043 0.0293 0.0293
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0009 0.0038 0.0038
Trypanosoma cruzi diacylglycerol kinase, putative 0.0051 0.0357 0.5
Trypanosoma cruzi Sphingosine kinase 0.0051 0.0357 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0009 0.0038 0.0038
Echinococcus multilocularis ceramide kinase 0.0051 0.0357 0.0357
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0027 0.0171 0.0171
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0357 0.2121
Loa Loa (eye worm) hypothetical protein 0.0009 0.0038 0.0038
Trypanosoma brucei Diacylglycerol kinase catalytic domain containing protein, putative 0.0051 0.0357 0.5
Echinococcus multilocularis histone acetyltransferase MYST2 0.0049 0.0339 0.0339
Onchocerca volvulus 0.0051 0.0357 0.2237
Loa Loa (eye worm) mbt repeat family protein 0.0043 0.0293 0.0293
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0051 0.0357 0.5
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0027 0.0171 0.0171
Brugia malayi Steroid receptor seven-up type 2 0.0009 0.0038 0.0185
Brugia malayi Pre-SET motif family protein 0.0188 0.1395 0.6773
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0009 0.0038 0.0038
Loa Loa (eye worm) MBCTL1 0.0049 0.0339 0.0339
Echinococcus multilocularis FTZ F1 alpha 0.0009 0.0038 0.0038
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0009 0.0038 0.0038
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0055 0.0383 0.0383
Trichomonas vaginalis sphingosine kinase, putative 0.0051 0.0357 0.2121
Echinococcus granulosus microtubule associated protein 2 0.127 0.9638 0.9638
Echinococcus granulosus FTZ F1 alpha 0.0009 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0009 0.0038 0.0038
Echinococcus granulosus histone acetyltransferase MYST2 0.0049 0.0339 0.0339
Trichomonas vaginalis bmru protein, putative 0.0051 0.0357 0.2121
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0055 0.0383 0.036
Schistosoma mansoni hypothetical protein 0.0051 0.0357 0.0357
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0008 0.0024 0.5
Schistosoma mansoni RAR-like nuclear receptor 0.0009 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0275 0.206 0.206
Mycobacterium tuberculosis Conserved protein 0.1317 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0043 0.0293 0.0293
Trypanosoma brucei Sphingosine kinase 0.0051 0.0357 0.5
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0009 0.0038 0.0239
Schistosoma mansoni ferritin 0.0008 0.0024 0.0024
Trichomonas vaginalis bmru protein, putative 0.0051 0.0357 0.2121
Loa Loa (eye worm) hypothetical protein 0.0051 0.0357 0.0357
Plasmodium falciparum diacylglycerol kinase, putative 0.0051 0.0357 0.5
Loa Loa (eye worm) hypothetical protein 0.0027 0.0171 0.0171
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0009 0.0038 0.0038
Trypanosoma brucei hypothetical protein, conserved 0.0051 0.0357 0.5
Trypanosoma cruzi Sphingosine kinase 0.0051 0.0357 0.5
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0009 0.0038 0.0038
Schistosoma mansoni retinoic acid receptor RXR 0.0009 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0051 0.0357 0.0357
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0009 0.0038 0.0185
Plasmodium falciparum diacylglycerol kinase, putative 0.0051 0.0357 0.5
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0009 0.0038 0.0038
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0009 0.0038 0.0038
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0009 0.0038 0.0038
Onchocerca volvulus 0.0027 0.0171 0.1072
Echinococcus multilocularis microtubule associated protein 2 0.127 0.9638 0.9638
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0043 0.0293 0.0293
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0009 0.0038 0.0038
Onchocerca volvulus Ceramide kinase 1 homolog 0.0051 0.0357 0.2237
Schistosoma mansoni diacylglycerol kinase zeta iota 0.0051 0.0357 0.0357
Loa Loa (eye worm) ceramide kinase 0.0051 0.0357 0.0357
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0005 0.0004 0.0004
Brugia malayi Pre-SET motif family protein 0.0027 0.0171 0.083
Brugia malayi nuclear receptor RXR 0.0005 0.0004 0.002
Echinococcus granulosus SAM and MBT domain containing protein 0.0043 0.0293 0.0293
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0049 0.0339 0.0339
Brugia malayi diacylglycerol kinase 0.0051 0.0357 0.1732
Echinococcus granulosus ferritin 0.0008 0.0024 0.0024
Schistosoma mansoni aldehyde dehydrogenase 0.0055 0.0383 0.0383
Brugia malayi mbt repeat family protein 0.0043 0.0293 0.1425
Echinococcus multilocularis muscleblind protein 1 0.0275 0.206 0.206
Trypanosoma cruzi diacylglycerol kinase, putative 0.0051 0.0357 0.5

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 41 nM Agonist activity at rat TRPV1 expressed in CHO cells assessed as calcium uptake ChEMBL. 22796184
IC50 (functional) = 25.09 uM Inhibition of lipid peroxidation in Sprague-Dawley rat brain after 30 mins by TBARS assay ChEMBL. 18249541
IC50 (functional) = 25.9 uM Compound was tested for its inhibitory concentration against formation of lipid peroxides in rat brain homogenates by thiobarbituric acid reactive substances (TBARS) assay according to the method of Stocks. ChEMBL. 12182869
IC50 (functional) = 178.6 uM Compound was tested for its DPPH radical scavenging activity in rat brain homogenates ChEMBL. 12182869
Ki (functional) Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of calcium uptake ChEMBL. 22796184
Ki (binding) = 354 nM Displacement of [3H]RTX from rat TRPV1 expressed in CHO cells ChEMBL. 22796184

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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