TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 289.326 | Formula: C16H19NO4
H donors: 1 H acceptors: 3 LogP: 3.11 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCCCn1c(=O)c(C(=O)OCC)c(c2c1cccc2)O
InChi: 1S/C16H19NO4/c1-3-5-10-17-12-9-7-6-8-11(12)14(18)13(15(17)19)16(20)21-4-2/h6-9,18H,3-5,10H2,1-2H3
InChiKey: REXBLBADTJGIBP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	RAN, member RAS oncogene family		No references
Homo sapiens	karyopherin (importin) beta 1		No references
Homo sapiens	snurportin 1		No references
Homo sapiens	lysine (K)-specific demethylase 4E	Starlite/ChEMBL	No references
Homo sapiens	lamin A/C	Starlite/ChEMBL	No references
Influenza A virus	Nonstructural protein 1	Starlite/ChEMBL	No references
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Neospora caninum	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Trichomonas vaginalis	Importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus multilocularis	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Leishmania braziliensis	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania infantum	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma cruzi	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Brugia malayi	RNA, U transporter 1	Get druggable targets OG5_131808	All targets in OG5_131808
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Trichomonas vaginalis	ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Cryptosporidium hominis	importin-beta2	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus granulosus	snurportin 1	Get druggable targets OG5_131808	All targets in OG5_131808
Plasmodium falciparum	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma brucei gambiense	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus granulosus	importin subunit beta 1	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma brucei	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trichomonas vaginalis	Importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania mexicana	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Toxoplasma gondii	HEAT repeat-containing protein	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus granulosus	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Trypanosoma brucei gambiense	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Cryptosporidium parvum	importin/karyopherin	Get druggable targets OG5_127843	All targets in OG5_127843
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Candida albicans	karyopherin-beta	Get druggable targets OG5_127843	All targets in OG5_127843
Brugia malayi	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma japonicum	Lamin-C, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Leishmania infantum	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Trichomonas vaginalis	importin beta-1, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma japonicum	ko:K07936 GTP-binding nuclear protein Ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus granulosus	GTP binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus multilocularis	importin subunit beta 1	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Trypanosoma congolense	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Brugia malayi	Intermediate filament tail domain containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Plasmodium yoelii	importin beta-1 subunit	Get druggable targets OG5_127843	All targets in OG5_127843
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium yoelii	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania mexicana	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	Get druggable targets OG5_131808	All targets in OG5_131808
Babesia bovis	GTP-binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma japonicum	Snurportin-1, putative	Get druggable targets OG5_131808	All targets in OG5_131808
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus granulosus	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	Intermediate filament protein ifa-1, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Candida albicans	Ran, Ras family GTP-binding protein	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium knowlesi	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	Importin subunit beta-1, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Babesia bovis	importin beta subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Trypanosoma brucei	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania braziliensis	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma mansoni	ran	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania donovani	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Plasmodium berghei	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Neospora caninum	GTP-binding nuclear protein Ran, related	Get druggable targets OG5_127514	All targets in OG5_127514
Theileria parva	GTP-binding nuclear protein ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus multilocularis	GTP binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma japonicum	Importin subunit beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Candida albicans	karyopherin-beta	Get druggable targets OG5_127843	All targets in OG5_127843
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania major	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_131808	All targets in OG5_131808
Schistosoma mansoni	intermediate filament proteins	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Cryptosporidium parvum	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma mansoni	ran	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma congolense	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma mansoni	importin beta-1	Get druggable targets OG5_127843	All targets in OG5_127843
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Leishmania major	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Theileria parva	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus multilocularis	snurportin 1	Get druggable targets OG5_131808	All targets in OG5_131808
Echinococcus granulosus	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	musashi	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Plasmodium berghei	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Candida albicans	Ran, Ras family GTP-binding protein	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus granulosus	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Entamoeba histolytica	Ran family GTPase	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium vivax	importin-beta 2, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania donovani	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus multilocularis	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Plasmodium knowlesi	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma japonicum	ko:K07611 lamin, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	Importin beta-1 subunit	Get druggable targets OG5_127843	All targets in OG5_127843
Cryptosporidium hominis	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	lamin	Get druggable targets OG5_128723	All targets in OG5_128723

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Mycobacterium tuberculosis	Hypothetical protein	Nonstructural protein 1	230 aa	202 aa	23.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	dna polymerase kappa	0.0019	0.0108	0.0108
Brugia malayi	RNA binding protein	0.0076	0.0629	0.0629
Toxoplasma gondii	HEAT repeat-containing protein	0.0035	0.0254	1
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0028	0.0028
Brugia malayi	ecdysteroid receptor	0.001	0.0028	0.0028
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0015	0.0077	0.0077
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0028	0.0028
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0028	0.0028
Loa Loa (eye worm)	hypothetical protein	0.001	0.0028	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0108	0.0108
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0026	0.0171	0.7301
Echinococcus multilocularis	lamin	0.0033	0.0234	0.0234
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0028	0.0028
Echinococcus multilocularis	dna polymerase kappa	0.0019	0.0108	0.0108
Echinococcus granulosus	intermediate filament protein	0.0033	0.0234	0.0234
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0337	0.0337
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0028	0.0028
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0108	0.5
Schistosoma mansoni	jumonji domain containing protein	0.0019	0.0111	0.0111
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0019	0.0108	0.0108
Echinococcus granulosus	lysine specific demethylase 6a	0.0019	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.001	0.0028	0.0028
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.0372	0.0372
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0026	0.0171	0.6744
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0629	0.0629
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0108	0.4246
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0337	0.0337
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0028	0.0028
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0028	0.0028
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0016	0.0082	0.0082
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0019	0.0108	0.5538
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0017	0.0098	0.0098
Schistosoma mansoni	hypothetical protein	0.0015	0.0077	0.0077
Schistosoma mansoni	protein phosphatase 2C	0.0019	0.0111	0.0111
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0033	0.0234	0.0234
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0028	0.0195	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0236	0.0236
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.0629	0.0629
Echinococcus granulosus	snurportin 1	0.0372	0.3284	0.3284
Schistosoma mansoni	phd/f-box containing protein	0.0019	0.0111	0.0111
Leishmania major	GTP-binding protein, putative	0.0026	0.0171	0.8795
Schistosoma mansoni	hypothetical protein	0.0015	0.0077	0.0077
Schistosoma mansoni	hypothetical protein	0.0015	0.0077	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0111	0.0111
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0028	0.0028
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0028	0.0028
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0028	0.0028
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0108	0.4246
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0026	0.0171	0.0171
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0629	0.0629
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0108	0.4246
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0028	0.0028
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0028	0.0028
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0108	0.4246
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0028	0.0028
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.0337	0.0337
Schistosoma mansoni	hypothetical protein	0.0033	0.0236	0.0236
Plasmodium falciparum	JmjC domain-containing protein, putative	0.0019	0.0111	0.4375
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0082	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0077	0.0077
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0337	0.0337
Schistosoma mansoni	Protein orai-1	0.1119	1	1
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0028	0.0028
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0019	0.0111	0.0111
Echinococcus granulosus	lysine specific demethylase 5A	0.0071	0.0579	0.0579
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0019	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.001	0.0028	0.0028
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0028	0.0028
Echinococcus multilocularis	snurportin 1	0.0372	0.3284	0.3284
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0337	0.0337
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0228	0.0228
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0028	0.0028
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0026	0.0171	0.0171
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0015	0.0077	0.0077
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0028	0.0028
Echinococcus multilocularis	GPCR, family 2	0.0015	0.0077	0.0077
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0028	0.0028
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0028	0.0028
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0108	0.4246
Loa Loa (eye worm)	hypothetical protein	0.1119	1	1
Trypanosoma brucei	unspecified product	0.0013	0.0056	0.2204
Loa Loa (eye worm)	jmjC domain-containing protein	0.0071	0.0579	0.0579
Trypanosoma brucei	importin beta-1 subunit, putative	0.0035	0.0254	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0028	0.0028
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0028	0.0028
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.0372	0.0372
Schistosoma mansoni	hypothetical protein	0.0037	0.0276	0.0276
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.0028	0.0028
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0028	0.0028
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0056	0.2204
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0028	0.0028
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0028	0.0195	1
Schistosoma mansoni	ran	0.0026	0.0171	0.0171
Echinococcus granulosus	importin subunit beta 1	0.0035	0.0254	0.0254
Schistosoma mansoni	ran	0.0026	0.0171	0.0171
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0056	0.2204
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0254	0.0254
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0028	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0651	0.0651
Brugia malayi	jmjC domain containing protein	0.0071	0.0579	0.0579
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.0337	0.0337
Loa Loa (eye worm)	jmjC domain-containing protein	0.0019	0.0111	0.0111
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0028	0.0195	1
Entamoeba histolytica	hypothetical protein	0.0028	0.0195	0.7054
Brugia malayi	jmjC domain containing protein	0.0019	0.0111	0.0111
Leishmania major	hypothetical protein, conserved	0.0019	0.0111	0.5706
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0028	0.0028
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0108	0.0108
Brugia malayi	jmjC domain containing protein	0.0019	0.0111	0.0111
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0028	0.0028
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.0629	0.0629
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0372	0.3284	0.3284
Leishmania major	importin beta-1 subunit, putative	0.0028	0.0195	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0028	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0234	0.0234
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0015	0.0077	0.0077
Schistosoma mansoni	hypothetical protein	0.0015	0.0077	0.0077
Brugia malayi	hypothetical protein	0.0037	0.0276	0.0276
Schistosoma mansoni	Protein orai-1	0.1119	1	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0028	0.0028
Echinococcus multilocularis	musashi	0.0033	0.0234	0.0234
Toxoplasma gondii	histone lysine demethylase JMJD6a	0.0019	0.0111	0.4375
Schistosoma mansoni	importin beta-1	0.0035	0.0254	0.0254
Echinococcus multilocularis	phd:f box containing protein	0.0019	0.0111	0.0111
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0108	0.4246
Entamoeba histolytica	Ran family GTPase	0.0026	0.0171	0.6204
Brugia malayi	TAR-binding protein	0.0076	0.0629	0.0629
Echinococcus multilocularis	jumonji domain containing 1A	0.0019	0.0111	0.0111
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0028	0.0028
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0337	0.0337
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0026	0.0171	0.6744
Leishmania major	DNA polymerase kappa, putative	0.0019	0.0108	0.5538
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0629	0.0629
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0026	0.0171	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0028	0.0028
Entamoeba histolytica	hypothetical protein	0.0037	0.0276	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.0276	0.0276
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0077	0.0077
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0108	0.4246
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0108	0.4246
Trypanosoma brucei	importin beta-1 subunit, putative	0.0035	0.0254	1
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0071	0.0579	0.0579
Echinococcus multilocularis	lamin dm0	0.0033	0.0234	0.0234
Brugia malayi	jmjC domain containing protein	0.0071	0.0579	0.0579
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0028	0.0028
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0028	0.0028
Brugia malayi	jmjC domain containing protein	0.0019	0.0111	0.0111
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.0629	0.0629
Brugia malayi	nuclear receptor NHR-88	0.001	0.0028	0.0028
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0028	0.0028
Echinococcus granulosus	lamin	0.0033	0.0234	0.0234
Echinococcus granulosus	jumonji domain containing 1A	0.0019	0.0111	0.0111
Brugia malayi	steroid hormone receptor	0.001	0.0028	0.0028
Echinococcus multilocularis	lysine specific demethylase 6a	0.0019	0.0111	0.0111
Trichomonas vaginalis	importin beta-1, putative	0.0028	0.0195	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0108	0.4246
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0028	0.0028
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0028	0.0028
Schistosoma mansoni	lamin	0.0033	0.0234	0.0234
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0015	0.0077	0.0077
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0028	0.0028
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0028	0.0028
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.0276	0.0276
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0028	0.0028
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0108	0.4246
Entamoeba histolytica	hypothetical protein	0.0037	0.0276	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0337	0.0337
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0028	0.0028
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0019	0.0108	0.0108
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0071	0.0579	0.0579
Trypanosoma brucei	DNA polymerase eta, putative	0.0019	0.0108	0.4246
Plasmodium falciparum	importin beta, putative	0.0035	0.0254	1
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0019	0.0111	0.0378
Echinococcus multilocularis	lysine specific demethylase 5A	0.0071	0.0579	0.0579
Echinococcus multilocularis	calcium release activated calcium channel	0.1119	1	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0028	0.0028
Schistosoma mansoni	hypothetical protein	0.0372	0.3284	0.3284
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0028	0.0028
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0108	0.4246
Trypanosoma brucei	JmjC domain, hydroxylase, putative	0.0019	0.0111	0.4375
Brugia malayi	RNA, U transporter 1	0.0099	0.0831	0.0831
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0372	0.0372
Echinococcus granulosus	JmjC domain containing protein 4	0.0019	0.0111	0.0111
Echinococcus multilocularis	JmjC domain containing protein 4	0.0019	0.0111	0.0111
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0028	0.0028
Trypanosoma brucei	unspecified product	0.0013	0.0056	0.2204
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0629	0.0629
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0019	0.0108	0.5
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0019	0.0111	0.0111
Plasmodium vivax	importin-beta 2, putative	0.0035	0.0254	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0056	0.2204
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0629	0.0629
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0026	0.0171	0.0171
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0019	0.0108	0.0108
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0026	0.0171	0.6744
Loa Loa (eye worm)	RNA binding protein	0.0076	0.0629	0.0629
Brugia malayi	nuclear hormone receptor	0.001	0.0028	0.0028
Brugia malayi	Importin beta-1 subunit	0.0035	0.0254	0.0254
Echinococcus multilocularis	dna polymerase eta	0.0019	0.0108	0.0108
Echinococcus granulosus	tar DNA binding protein	0.0076	0.0629	0.0629
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0028	0.0028
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0028	0.0028
Echinococcus granulosus	calcium release activated calcium channel	0.1119	1	1
Echinococcus granulosus	lamin dm0	0.0033	0.0234	0.0234
Brugia malayi	jmjC domain containing protein	0.0019	0.0111	0.0111
Schistosoma mansoni	coup transcription factor	0.001	0.0028	0.0028
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0028	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0077	0.0077
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0028	0.0028
Schistosoma mansoni	DNA polymerase eta	0.0019	0.0108	0.0108
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0019	0.0108	0.0108
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0071	0.0579	0.0579
Schistosoma mansoni	jumonji domain containing protein	0.0071	0.0579	0.0579
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0108	0.0108
Plasmodium vivax	JmjC domain containing protein	0.0019	0.0111	0.4375
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0108	0.5
Leishmania major	DNA polymerase eta, putative	0.0019	0.0108	0.5538
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0019	0.0108	0.5
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0015	0.0077	0.0077
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0026	0.0171	0.7301
Trichomonas vaginalis	ran, putative	0.0026	0.0171	0.8795
Echinococcus multilocularis	importin subunit beta 1	0.0035	0.0254	0.0254
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0019	0.0108	0.5538
Entamoeba histolytica	hypothetical protein	0.0037	0.0276	1
Toxoplasma gondii	histone lysine demethylase JMJC1/KDM5D/JARID1D	0.0019	0.0111	0.4375
Loa Loa (eye worm)	hypothetical protein	0.001	0.0028	0.0028
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0019	0.0111	0.0378
Entamoeba histolytica	hypothetical protein	0.0037	0.0276	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0108	0.4246
Brugia malayi	Intermediate filament tail domain containing protein	0.0033	0.0234	0.0234
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0028	0.0028
Schistosoma mansoni	phosphatidylserine receptor	0.0019	0.0111	0.0111
Schistosoma mansoni	intermediate filament proteins	0.0033	0.0234	0.0234
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0337	0.0337
Brugia malayi	intermediate filament protein	0.0033	0.0234	0.0234
Loa Loa (eye worm)	hypothetical protein	0.001	0.0028	0.0028
Trichomonas vaginalis	DNA polymerase eta, putative	0.0019	0.0108	0.5538
Echinococcus granulosus	GPCR family 2	0.0015	0.0077	0.0077
Onchocerca volvulus		0.0033	0.0234	1
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0026	0.0171	0.6744
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.0372	0.0372
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0028	0.0028
Loa Loa (eye worm)	jmjC domain-containing protein	0.0019	0.0111	0.0111
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.0629	0.0629
Loa Loa (eye worm)	jmjC domain-containing protein	0.0019	0.0111	0.0111
Loa Loa (eye worm)	intermediate filament protein	0.0033	0.0234	0.0234
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0028	0.0028
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0028	0.0028
Trypanosoma brucei	unspecified product	0.0019	0.0108	0.4246
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0071	0.0579	0.0579
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.0276	0.0276
Brugia malayi	olfactory channel protein osm-9	0.0079	0.0651	0.0651
Onchocerca volvulus		0.0033	0.0234	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0236	0.0236
Echinococcus granulosus	phd:f box containing protein	0.0019	0.0111	0.0111
Schistosoma mansoni	lamin	0.0033	0.0234	0.0234
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0028	0.0028
Brugia malayi	Latrophilin receptor protein 2	0.0015	0.0077	0.0077
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0028	0.0028
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0028	0.0028
Echinococcus granulosus	dna polymerase eta	0.0019	0.0108	0.0108
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0026	0.0171	0.0171
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0015	0.0077	0.0077
Loa Loa (eye worm)	hypothetical protein	0.001	0.0028	0.0028
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0019	0.0108	0.3906
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0108	0.4246
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0028	0.0028
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0028	0.0028
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0019	0.0108	0.0108
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0016	0.0082	0.0082
Brugia malayi	cytoplasmic intermediate filament protein	0.0017	0.0098	0.0098

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 0.0035 um	PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	4.1475 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	5.2213 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 8.9125 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	10.3225 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262]	ChEMBL.	No reference
Potency (functional)	15.8489 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 19.9526 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	22.3872 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	79.4328 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	79.4328 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1588163

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1453004