Detailed information for compound 1453912

Basic information

Technical information
  • TDR Targets ID: 1453912
  • Name: 2-methoxy-N-(2-piperidin-1-ylphenyl)benzamide
  • MW: 310.39 | Formula: C19H22N2O2
  • H donors: 1 H acceptors: 1 LogP: 3.7 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1C(=O)Nc1ccccc1N1CCCCC1
  • InChi: 1S/C19H22N2O2/c1-23-18-12-6-3-9-15(18)19(22)20-16-10-4-5-11-17(16)21-13-7-2-8-14-21/h3-6,9-12H,2,7-8,13-14H2,1H3,(H,20,22)
  • InChiKey: JIJHXIZEVCVPCP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-methoxy-N-[2-(1-piperidyl)phenyl]benzamide
  • 2-methoxy-N-(2-piperidinophenyl)benzamide
  • STK248178
  • Oprea1_737232

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus histone lysine methyltransferase setb 0.0092 0.1156 0.2215
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.037 0.071
Loa Loa (eye worm) MBCTL1 0.0111 0.1423 0.1622
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0923 0.6735
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0923 0.6735
Brugia malayi hypothetical protein 0.0027 0.025 0.0285
Echinococcus multilocularis dna polymerase eta 0.0019 0.0147 0.0282
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0092 0.1156 0.8639
Echinococcus granulosus dual specificity 0.009 0.1131 0.2168
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.1299 0.1169
Mycobacterium tuberculosis Probable lipase LipD 0.0075 0.0923 0.1214
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0147 0.0669
Schistosoma mansoni lozenge 0.0058 0.0677 0.0834
Leishmania major hypothetical protein, conserved 0.0075 0.0923 0.6735
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0092 0.1156 0.1425
Schistosoma mansoni sex comb on midleg homolog 0.0098 0.1236 0.1523
Loa Loa (eye worm) hypothetical protein 0.0111 0.1423 0.1622
Loa Loa (eye worm) hypothetical protein 0.0075 0.0923 0.1052
Entamoeba histolytica protein kinase, putative 0.009 0.1131 0.8543
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.0923 1
Echinococcus multilocularis GPCR, family 2 0.0035 0.037 0.071
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0923 0.0787
Loa Loa (eye worm) hypothetical protein 0.0458 0.6224 0.7095
Mycobacterium tuberculosis Conserved protein 0.0075 0.0923 0.1214
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.0923 0.6953
Giardia lamblia Kinase, CMGC GSK 0.0103 0.1299 1
Echinococcus granulosus dna polymerase kappa 0.0019 0.0147 0.0282
Echinococcus multilocularis polycomb protein SCMH1 0.0098 0.1236 0.2368
Echinococcus multilocularis SAM and MBT domain containing protein 0.0098 0.1236 0.2368
Loa Loa (eye worm) mbt repeat family protein 0.0098 0.1236 0.1409
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0923 0.0787
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0046 0.0089
Brugia malayi beta-lactamase 0.0075 0.0923 0.1052
Echinococcus multilocularis leucine rich repeat serine:threonine protein 0.0188 0.2487 0.4765
Echinococcus multilocularis protein kinase shaggy 0.0103 0.1299 0.2489
Loa Loa (eye worm) hypothetical protein 0.0035 0.037 0.0422
Brugia malayi MH2 domain containing protein 0.0126 0.1626 0.1854
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0103 0.1299 0.1481
Loa Loa (eye worm) hypothetical protein 0.0098 0.1236 0.1409
Schistosoma mansoni sex comb on midleg homolog 0.0098 0.1236 0.1523
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0103 0.1299 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0147 0.0168
Loa Loa (eye worm) TKL/LRRK protein kinase 0.0188 0.2487 0.2835
Loa Loa (eye worm) transcription factor SMAD2 0.0126 0.1626 0.1854
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0923 0.0787
Echinococcus granulosus polycomb protein SCMH1 0.0098 0.1236 0.2368
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0103 0.1299 0.2489
Trichomonas vaginalis set domain proteins, putative 0.0731 1 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0923 0.0787
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.1299 0.1169
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0075 0.0923 0.1214
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0103 0.1299 0.1481
Plasmodium vivax SET domain protein, putative 0.0092 0.1156 0.8639
Brugia malayi Protein kinase domain containing protein 0.0188 0.2487 0.2835
Loa Loa (eye worm) runx1 0.0058 0.0677 0.0771
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.1142 0.1407
Echinococcus granulosus leucine rich repeat serine:threonine protein 0.0189 0.2503 0.4795
Entamoeba histolytica hypothetical protein 0.0037 0.0396 0.2163
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0386 0.5219 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0112 0.1428 0.1628
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0147 0.0669
Mycobacterium ulcerans beta-lactamase 0.0075 0.0923 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0147 0.0168
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0147 0.0669
Echinococcus multilocularis dual specificity 0.009 0.1131 0.2168
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0112 0.1428 0.1628
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0147 0.0669
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0396 0.0488
Schistosoma mansoni hypothetical protein 0.0037 0.0396 0.0488
Plasmodium falciparum glycogen synthase kinase 3 0.0103 0.1299 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0147 0.0168
Leishmania major hypothetical protein, conserved 0.0027 0.025 0.0889
Schistosoma mansoni hypothetical protein 0.0012 0.0046 0.0057
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0075 0.0923 0.1214
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.037 0.071
Loa Loa (eye worm) hypothetical protein 0.0075 0.0923 0.1052
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0147 0.0669
Echinococcus granulosus dna polymerase eta 0.0019 0.0147 0.0282
Loa Loa (eye worm) beta-lactamase 0.0075 0.0923 0.1052
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0923 0.0787
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0147 0.0669
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0098 0.1236 0.0345
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0396 0.0759
Schistosoma mansoni hypothetical protein 0.0595 0.8116 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0147 0.0282
Brugia malayi Pre-SET motif family protein 0.0643 0.8772 1
Onchocerca volvulus 0.0458 0.6224 0.584
Schistosoma mansoni hypothetical protein 0.0205 0.2712 0.3342
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0046 0.0089
Brugia malayi hypothetical protein 0.0037 0.0396 0.0452
Brugia malayi hypothetical protein 0.0458 0.6224 0.7095
Schistosoma mansoni serine/threonine protein kinase 0.009 0.1131 0.1394
Loa Loa (eye worm) hypothetical protein 0.0075 0.0923 0.1052
Mycobacterium tuberculosis Conserved protein 0.0075 0.0923 0.1214
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0098 0.1236 0.1523
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.009 0.1131 0.8543
Loa Loa (eye worm) hypothetical protein 0.0027 0.025 0.0285
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.1142 0.1302
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0103 0.1299 0.2489
Echinococcus multilocularis histone acetyltransferase MYST2 0.0111 0.1423 0.2727
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0481 0.6538 1
Entamoeba histolytica protein kinase domain containing protein 0.0103 0.1299 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0126 0.1626 0.1854
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.1142 0.1302
Echinococcus granulosus histone acetyltransferase MYST2 0.0111 0.1423 0.2727
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0643 0.8772 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.1142 0.2188
Schistosoma mansoni hypothetical protein 0.0035 0.037 0.0456
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0111 0.1423 0.1622
Onchocerca volvulus 0.0098 0.1236 0.0345
Echinococcus multilocularis Protein lozenge 0.0058 0.0677 0.1297
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.037 0.0422
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0147 0.0669
Schistosoma mansoni DNA polymerase eta 0.0019 0.0147 0.0181
Brugia malayi beta-lactamase family protein 0.0075 0.0923 0.1052
Loa Loa (eye worm) hypothetical protein 0.0076 0.0938 0.107
Giardia lamblia Kinase, CMGC GSK 0.0103 0.1299 1
Mycobacterium leprae Probable lipase LipE 0.0075 0.0923 0.5
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0147 0.0168
Schistosoma mansoni hypothetical protein 0.0035 0.037 0.0456
Brugia malayi Latrophilin receptor protein 2 0.0035 0.037 0.0422
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0092 0.1156 0.1425
Mycobacterium tuberculosis Probable esterase LipL 0.0075 0.0923 0.1214
Entamoeba histolytica hypothetical protein 0.009 0.1131 0.8543
Loa Loa (eye worm) hypothetical protein 0.0112 0.1428 0.1628
Echinococcus granulosus geminin 0.0205 0.2712 0.5196
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.009 0.1131 0.8543
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0147 0.0282
Schistosoma mansoni hypothetical protein 0.0076 0.0938 0.1156
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0111 0.1423 0.2727
Echinococcus granulosus SAM and MBT domain containing protein 0.0098 0.1236 0.2368
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0232 0.3091 0.3524
Entamoeba histolytica protein kinase, putative 0.009 0.1131 0.8543
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.1142 0.2188
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0147 0.0669
Loa Loa (eye worm) hypothetical protein 0.0092 0.1156 0.1318
Echinococcus granulosus GPCR family 2 0.0035 0.037 0.071
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.1142 0.2188
Trichomonas vaginalis esterase, putative 0.0075 0.0923 0.0787
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.009 0.1131 0.129
Brugia malayi intracellular kinase 0.0103 0.1299 0.1481
Entamoeba histolytica hypothetical protein 0.0037 0.0396 0.2163
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.037 0.071
Mycobacterium tuberculosis Probable hydrolase 0.0075 0.0923 0.1214
Brugia malayi follicle stimulating hormone receptor 0.0232 0.3091 0.3524
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.025 0.0889
Loa Loa (eye worm) hypothetical protein 0.0075 0.0923 0.1052
Plasmodium vivax hypothetical protein, conserved 0.0075 0.0923 0.6416
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.009 0.1131 0.864
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0386 0.5219 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.0923 0.1768
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0147 0.0669
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.025 0.1498
Loa Loa (eye worm) hypothetical protein 0.0075 0.0923 0.1052
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0396 0.0759
Toxoplasma gondii ABC1 family protein 0.0075 0.0923 0.6416
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0092 0.1156 0.2215
Brugia malayi Calcitonin receptor-like protein seb-1 0.0112 0.1428 0.1628
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0147 0.0181
Trypanosoma brucei protein kinase, putative 0.0103 0.1299 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.1142 0.1407
Brugia malayi latrophilin 2 splice variant baaae 0.0076 0.0938 0.107
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.0923 0.1052
Plasmodium vivax glycogen synthase kinase 3, putative 0.0103 0.1299 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0075 0.0923 0.1214
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.0923 0.1768
Mycobacterium tuberculosis Probable lipase LipE 0.0075 0.0923 0.1214
Echinococcus granulosus protein kinase shaggy 0.0103 0.1299 0.2489
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0147 0.0181
Brugia malayi Pre-SET motif family protein 0.0092 0.1156 0.1318
Mycobacterium leprae conserved hypothetical protein 0.0075 0.0923 0.5
Entamoeba histolytica hypothetical protein 0.0037 0.0396 0.2163
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.1142 0.1407
Brugia malayi Protein kinase domain containing protein 0.009 0.1131 0.129
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0092 0.1156 0.1425
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0923 0.1137
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0103 0.1299 1
Schistosoma mansoni hypothetical protein 0.0035 0.037 0.0456
Loa Loa (eye worm) hypothetical protein 0.0458 0.6224 0.7095
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0147 0.0669
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.009 0.1131 0.8543
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0147 0.0669
Entamoeba histolytica protein kinase domain containing protein 0.009 0.1131 0.8543
Schistosoma mansoni hypothetical protein 0.0205 0.2712 0.3342
Trypanosoma brucei unspecified product 0.0019 0.0147 0.0669
Onchocerca volvulus 0.0103 0.1299 0.0414
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0147 0.0669
Entamoeba histolytica protein kinase domain containing protein 0.0103 0.1299 1
Brugia malayi mbt repeat family protein 0.0098 0.1236 0.1409
Loa Loa (eye worm) hypothetical protein 0.0088 0.1105 0.1259
Mycobacterium ulcerans lipase LipD 0.0075 0.0923 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0092 0.1156 0.2215
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0147 0.0282
Brugia malayi beta-lactamase family protein 0.0075 0.0923 0.1052
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0111 0.1423 0.2727
Onchocerca volvulus 0.0092 0.1156 0.0257
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.037 0.0422
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0923 0.1137
Entamoeba histolytica protein kinase, putative 0.0103 0.1299 1
Schistosoma mansoni myelin transcription factor 1 myt1 0.0111 0.1423 0.1754
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0147 0.0669
Schistosoma mansoni hypothetical protein 0.0035 0.037 0.0456
Loa Loa (eye worm) hypothetical protein 0.0088 0.1105 0.1259
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0147 0.0669
Mycobacterium ulcerans hypothetical protein 0.0075 0.0923 1
Echinococcus multilocularis geminin 0.0205 0.2712 0.5196
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0103 0.1299 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.0923 0.1052
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0103 0.1299 0.1601
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.037 0.071
Entamoeba histolytica hypothetical protein 0.0037 0.0396 0.2163
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.1142 0.2188
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.0923 0.1052
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0089 0.1109 0.2126
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.025 0.0889
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0092 0.1156 0.1425
Brugia malayi hypothetical protein 0.0017 0.0119 0.0136
Mycobacterium tuberculosis Conserved protein 0.0075 0.0923 0.1214
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.0923 1
Brugia malayi mbt repeat family protein 0.0098 0.1236 0.1409

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.1689 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.9185 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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