Detailed information for compound 1460347

Basic information

Technical information
  • TDR Targets ID: 1460347
  • Name: 2-(3-phenylprop-2-enylsulfanyl)-1H-imidazo[4, 5-b]pyridine
  • MW: 267.349 | Formula: C15H13N3S
  • H donors: 1 H acceptors: 2 LogP: 3.45 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1ccc(cc1)/C=C/CSc1nc2c(n1)ccc[nH]2
  • InChi: 1S/C15H13N3S/c1-2-6-12(7-3-1)8-5-11-19-15-17-13-9-4-10-16-14(13)18-15/h1-10H,11H2,(H,16,17,18)/b8-5+
  • InChiKey: LYRMHQDYSNEQJO-VMPITWQZSA-N  


Substructure search Similarity search

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Synonyms

  • 2-[(E)-3-phenylprop-2-enyl]sulfanyl-1H-imidazo[4,5-b]pyridine
  • 2-(3-phenylprop-2-enylthio)-1H-imidazo[4,5-b]pyridine
  • 2-[[(E)-3-phenylprop-2-enyl]thio]-1H-imidazo[4,5-b]pyridine
  • 2-((E)-3-Phenyl-allylsulfanyl)-3H-imidazo[4,5-b]pyridine
  • MLS000333320
  • SMR000436630
  • ZINC05461463

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0128 0.1124 0.1345
Plasmodium falciparum serine repeat antigen 2 0.0128 0.1124 0.1843
Trypanosoma cruzi cysteine peptidase, putative 0.06 0.6043 0.6877
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0128 0.1124 0.1843
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.06 0.6043 1
Plasmodium falciparum serine repeat antigen 4 0.0128 0.1124 0.1843
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.06 0.6043 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.06 0.6043 1
Entamoeba histolytica cysteine protease, putative 0.0319 0.3118 0.5088
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0408 0.4048 0.5946
Entamoeba histolytica cysteine protease, putative 0.0319 0.3118 0.5088
Onchocerca volvulus 0.06 0.6043 1
Entamoeba histolytica cysteine protease, putative 0.0319 0.3118 0.5088
Brugia malayi cathepsin F-like cysteine proteinase 0.0191 0.1783 0.2071
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0191 0.1783 0.2143
Entamoeba histolytica cysteine protease, putative 0.0128 0.1124 0.174
Brugia malayi cathepsin Z-like cysteine proteinase 0.0128 0.1124 0.1265
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0319 0.3118 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.06 0.6043 1
Leishmania major cathepsin L-like protease 0.06 0.6043 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0408 0.4048 0.5946
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.06 0.6043 1
Trypanosoma cruzi cysteine proteinase, putative 0.0319 0.3118 0.2788
Entamoeba histolytica cysteine protease, putative 0.0319 0.3118 0.5088
Brugia malayi Cathepsin L-like precursor 0.0408 0.4048 0.4837
Loa Loa (eye worm) hypothetical protein 0.0029 0.0088 0.0091
Loa Loa (eye worm) hypothetical protein 0.0191 0.1783 0.2143
Onchocerca volvulus 0.0408 0.4048 0.6651
Trypanosoma cruzi cysteine peptidase, putative 0.0191 0.1783 0.0922
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0128 0.1124 0.1843
Brugia malayi Papain family cysteine protease containing protein 0.0128 0.1124 0.1265
Loa Loa (eye worm) papain family cysteine protease containing protein 0.06 0.6043 0.7297
Brugia malayi Papain family cysteine protease containing protein 0.0128 0.1124 0.1265
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0128 0.1124 0.1843
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0319 0.3118 0.2788
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.06 0.6043 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.034 0.3336 0.0745
Brugia malayi Cathepsin L-like precursor 0.06 0.6043 0.7272
Plasmodium vivax vivapain-3 0.0319 0.3118 0.515
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.06 0.6043 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0012 0.139
Plasmodium falciparum cysteine proteinase falcipain 1 0.0319 0.3118 0.515
Onchocerca volvulus 0.06 0.6043 1
Loa Loa (eye worm) hypothetical protein 0.0408 0.4048 0.4884
Echinococcus multilocularis cysteine protease 0.06 0.6043 0.5542
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.034 0.3336 0.5454
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0088 1
Brugia malayi Papain family cysteine protease containing protein 0.06 0.6043 0.7272
Loa Loa (eye worm) hypothetical protein 0.0408 0.4048 0.4884
Trypanosoma cruzi cruzipain precursor, putative 0.06 0.6043 0.6877
Echinococcus granulosus cathepsin b 0.0814 0.8277 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0128 0.1124 0.1265
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.06 0.6043 1
Leishmania major cathepsin L-like protease 0.06 0.6043 1
Plasmodium vivax serine-repeat antigen (SERA) 0.0128 0.1124 0.1843
Onchocerca volvulus 0.06 0.6043 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0093 0.0098
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.06 0.6043 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.06 0.6043 1
Trypanosoma cruzi cruzipain precursor, putative 0.0191 0.1783 0.0922
Trypanosoma cruzi cysteine peptidase, putative 0.06 0.6043 0.6877
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.06 0.6043 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0319 0.3118 0.2788
Entamoeba histolytica cysteine protease, putative 0.0319 0.3118 0.5088
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0814 0.8277 1
Entamoeba histolytica cysteine proteinase, putative 0.06 0.6043 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.06 0.6043 0.6877
Loa Loa (eye worm) hypothetical protein 0.0191 0.1783 0.2143
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0814 0.8277 1
Entamoeba histolytica cysteine protease, putative 0.0128 0.1124 0.174
Plasmodium vivax vivapain-1 0.0319 0.3118 0.515
Entamoeba histolytica cysteine protease, putative 0.0319 0.3118 0.5088
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.06 0.6043 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.06 0.6043 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.06 0.6043 0.6877
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0088 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.06 0.6043 1
Trypanosoma cruzi cysteine peptidase, putative 0.0319 0.3118 0.2788
Loa Loa (eye worm) hypothetical protein 0.0029 0.0088 0.0091
Schistosoma mansoni cathepsin F (C01 family) 0.0408 0.4048 0.4089
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0128 0.1124 0.174
Loa Loa (eye worm) hypothetical protein 0.0128 0.1124 0.1345
Loa Loa (eye worm) hypothetical protein 0.0191 0.1783 0.2143
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0088 1
Leishmania major cysteine peptidase A (CPA) 0.06 0.6043 1
Plasmodium falciparum serine repeat antigen 8 0.0128 0.1124 0.1843
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0191 0.1783 0.2071
Brugia malayi cathepsin B-like cysteine proteinase 0.0814 0.8277 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0088 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.06 0.6043 1
Entamoeba histolytica cysteine proteinase, putative 0.0319 0.3118 0.5088
Entamoeba histolytica cysteine proteinase, putative 0.0319 0.3118 0.5088
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.06 0.6043 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0814 0.8277 1
Entamoeba histolytica cysteine protease, putative 0.0319 0.3118 0.5088
Echinococcus multilocularis cathepsin b 0.0814 0.8277 0.8058
Onchocerca volvulus Cathepsin L homolog 0.06 0.6043 1
Entamoeba histolytica cysteine protease, putative 0.0319 0.3118 0.5088
Loa Loa (eye worm) hypothetical protein 0.0128 0.1124 0.1345
Brugia malayi Cathepsin L-like precursor 0.06 0.6043 0.7272
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0088 1
Onchocerca volvulus 0.06 0.6043 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.06 0.6043 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0012 0.5
Entamoeba histolytica cysteine proteinase 1, putative 0.0319 0.3118 0.5088
Echinococcus multilocularis cysteine protease 0.06 0.6043 0.5542
Loa Loa (eye worm) hypothetical protein 0.0128 0.1124 0.1345
Brugia malayi cathepsin Z-like cysteine proteinase 0.0128 0.1124 0.1265
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0128 0.1124 0.1843
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.06 0.6043 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0408 0.4048 0.4837
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.06 0.6043 1
Brugia malayi cathepsin L-like cysteine proteinase 0.0128 0.1124 0.1265
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0319 0.3118 0.2788
Entamoeba histolytica cysteine proteinase, putative 0.0408 0.4048 0.6651
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0088 0.5
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.06 0.6043 0.7297
Leishmania major cathepsin L-like protease 0.06 0.6043 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.06 0.6043 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0814 0.8277 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0088 1
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0128 0.1124 0.1843
Loa Loa (eye worm) fibroinase 0.06 0.6043 0.7297
Brugia malayi Cathepsin L-like precursor 0.06 0.6043 0.7272
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0128 0.1124 0.1843
Plasmodium falciparum serine repeat antigen 1 0.0128 0.1124 0.1843
Plasmodium vivax vivapain-2 0.06 0.6043 1
Echinococcus granulosus cysteine protease 0.0319 0.3118 0.2788
Brugia malayi Cytochrome P450 family protein 0.0029 0.0093 0.0006
Entamoeba histolytica cysteine protease, putative 0.0128 0.1124 0.174
Loa Loa (eye worm) cathepsin B 0.034 0.3336 0.4022
Giardia lamblia Cathepsin B precursor 0.034 0.3336 1
Leishmania major cathepsin L-like protease 0.06 0.6043 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0088 1
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0128 0.1124 0.1345
Schistosoma mansoni cathepsin F (C01 family) 0.06 0.6043 0.6877
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0088 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.06 0.6043 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0088 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.034 0.3336 0.4497
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.06 0.6043 1
Toxoplasma gondii cathepsin CPL 0.06 0.6043 1
Plasmodium vivax serine-repeat antigen (SERA) 0.0128 0.1124 0.1843
Plasmodium falciparum serine repeat antigen 7 0.0128 0.1124 0.1843
Loa Loa (eye worm) ctsf protein 0.06 0.6043 0.7297
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0128 0.1124 0.1843
Leishmania major cathepsin L-like protease 0.06 0.6043 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0128 0.1124 0.1843
Onchocerca volvulus 0.06 0.6043 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0128 0.1124 0.1345
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.06 0.6043 1
Echinococcus multilocularis cathepsin L cysteine protease 0.06 0.6043 0.5542
Plasmodium falciparum cysteine proteinase falcipain 2a 0.06 0.6043 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.06 0.6043 0.5542
Onchocerca volvulus 0.06 0.6043 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.06 0.6043 1
Brugia malayi Papain family cysteine protease containing protein 0.0319 0.3118 0.37
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0319 0.3118 0.2788
Leishmania major cathepsin L-like protease 0.06 0.6043 1
Leishmania major cathepsin L-like protease 0.06 0.6043 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.06 0.6043 1
Brugia malayi cathepsin L precursor 0.0128 0.1124 0.1265
Brugia malayi Papain family cysteine protease containing protein 0.0128 0.1124 0.1265
Plasmodium falciparum serine repeat antigen 9 0.0128 0.1124 0.1843
Plasmodium falciparum serine repeat antigen 5 0.0128 0.1124 0.1843
Entamoeba histolytica cysteine proteinase 2 0.0319 0.3118 0.5088
Plasmodium vivax unspecified product 0.0191 0.1783 0.2937
Plasmodium falciparum cysteine proteinase falcipain 2b 0.06 0.6043 1
Entamoeba histolytica cysteine protease, putative 0.0319 0.3118 0.5088
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0088 1
Onchocerca volvulus Cathepsin L homolog 0.06 0.6043 1
Loa Loa (eye worm) hypothetical protein 0.0128 0.1124 0.1345
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.06 0.6043 1
Entamoeba histolytica hypothetical protein 0.0128 0.1124 0.174
Giardia lamblia Cathepsin B precursor 0.034 0.3336 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0128 0.1124 0.1843
Entamoeba histolytica cysteine protease, putative 0.0128 0.1124 0.174
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.034 0.3336 0.3093
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0319 0.3118 0.4054
Plasmodium vivax unspecified product 0.0128 0.1124 0.1843
Plasmodium falciparum serine repeat antigen 6 0.0128 0.1124 0.1843
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.06 0.6043 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.06 0.6043 0.5542
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0408 0.4048 0.4089
Loa Loa (eye worm) hypothetical protein 0.0128 0.1124 0.1345
Schistosoma mansoni cathepsin s 0.0191 0.1783 0.0922
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0128 0.1124 0.1843
Loa Loa (eye worm) cysteine protease 0.06 0.6043 0.7297
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.06 0.6043 1
Schistosoma mansoni cathepsin F (C01 family) 0.06 0.6043 0.6877
Echinococcus granulosus cathepsin l1 0.0408 0.4048 0.4089
Echinococcus granulosus cathepsin l1 0.06 0.6043 0.6877
Brugia malayi Cathepsin L-like precursor 0.06 0.6043 0.7272
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.06 0.6043 1
Onchocerca volvulus Cathepsin F homolog 0.06 0.6043 1
Brugia malayi fibroinase precursor 0.0128 0.1124 0.1265
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0814 0.8277 1
Entamoeba histolytica cysteine protease, putative 0.06 0.6043 1
Leishmania major cathepsin L-like protease 0.06 0.6043 1
Brugia malayi Cathepsin L-like precursor 0.06 0.6043 0.7272
Loa Loa (eye worm) hypothetical protein 0.0814 0.8277 1
Onchocerca volvulus Cathepsin L homolog 0.0128 0.1124 0.174
Trypanosoma cruzi cysteine protease, putative 0.0319 0.3118 0.2788
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0128 0.1124 0.174
Entamoeba histolytica cysteine protease, putative 0.0128 0.1124 0.174
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0128 0.1124 0.1843
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0128 0.1124 0.1265
Brugia malayi Cathepsin L-like precursor 0.0191 0.1783 0.2071
Giardia lamblia Cathepsin B precursor 0.034 0.3336 1
Entamoeba histolytica cysteine proteinase, putative 0.06 0.6043 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0088 0.0091
Echinococcus granulosus cathepsin L 0.0319 0.3118 0.2788
Entamoeba histolytica cysteine protease, putative 0.0319 0.3118 0.5088
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.06 0.6043 1
Mycobacterium ulcerans hypothetical protein 0.0029 0.0088 1
Loa Loa (eye worm) hypothetical protein 0.0408 0.4048 0.4884
Onchocerca volvulus 0.0128 0.1124 0.174
Brugia malayi Cathepsin L-like precursor 0.0408 0.4048 0.4837
Brugia malayi Cathepsin L-like precursor 0.06 0.6043 0.7272
Plasmodium vivax unspecified product 0.0319 0.3118 0.515
Echinococcus multilocularis cathepsin L cysteine protease 0.06 0.6043 0.5542
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.06 0.6043 1
Entamoeba histolytica cysteine proteinase, putative 0.0319 0.3118 0.5088
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.06 0.6043 1
Echinococcus multilocularis cathepsin b 0.0814 0.8277 0.8058
Entamoeba histolytica cysteine protease, putative 0.0319 0.3118 0.5088
Trypanosoma cruzi cysteine proteinase, putative 0.0319 0.3118 0.2788
Echinococcus granulosus cathepsin b 0.0814 0.8277 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.06 0.6043 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.034 0.3336 0.3093
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0128 0.1124 0.1843
Echinococcus multilocularis cathepsin L 0.0319 0.3118 0.2247
Trypanosoma cruzi cysteine peptidase, putative 0.06 0.6043 0.6877
Entamoeba histolytica cysteine protease, putative 0.0319 0.3118 0.5088
Echinococcus granulosus cathepsin L cysteine protease 0.0319 0.3118 0.2788
Toxoplasma gondii cathepsin B 0.034 0.3336 0.4497
Plasmodium falciparum serine repeat antigen 3 0.0128 0.1124 0.1843
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.06 0.6043 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0128 0.1124 0.1345
Onchocerca volvulus 0.06 0.6043 1
Trypanosoma cruzi cysteine peptidase, putative 0.06 0.6043 0.6877
Entamoeba histolytica cysteine protease, putative 0.0319 0.3118 0.5088
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.06 0.6043 1
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0128 0.1124 0.1843
Entamoeba histolytica cysteine proteinase, putative 0.0319 0.3118 0.5088
Brugia malayi Papain family cysteine protease containing protein 0.0319 0.3118 0.37
Plasmodium vivax vivapain-2 0.06 0.6043 1
Entamoeba histolytica cysteine protease, putative 0.0128 0.1124 0.174
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.06 0.6043 1
Loa Loa (eye worm) hypothetical protein 0.06 0.6043 0.7297
Brugia malayi cathepsin L-like precursor 0.0408 0.4048 0.4837
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.06 0.6043 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.8184 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.5283 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 16.3535 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 23.1093 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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