Detailed information for compound 1464775

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1892.62 | Formula: C35H53N3O60S13
  • H donors: 13 H acceptors: 41 LogP: -12.61 Rotable bonds: 42
    Rule of 5 violations (Lipinski): 4
  • SMILES: OS(=O)(=O)O[C@@H]1[C@@H](O[C@@H]2[C@H](OS(=O)(=O)O)[C@H](O[C@@H]([C@H]2OS(=O)(=O)O)COS(=O)(=O)O)O[C@@H]2[C@@H](OCCCn3nnc(c3)c3ccccc3)O[C@@H]([C@H]([C@@H]2OS(=O)(=O)O)OS(=O)(=O)O)COS(=O)(=O)O)O[C@@H]([C@H]([C@@H]1O[C@H]1O[C@H](COS(=O)(=O)O)[C@H]([C@@H]([C@@H]1OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)COS(=O)(=O)O
  • InChi: 1S/C35H53N3O60S13/c39-99(40,41)79-10-16-20(90-103(51,52)53)24(88-35-31(98-111(75,76)77)27(95-108(66,67)68)23(93-106(60,61)62)19(86-35)13-82-102(48,49)50)29(96-109(69,70)71)33(84-16)87-25-21(91-104(54,55)56)17(11-80-100(42,43)44)85-34(30(25)97-110(72,73)74)89-28-26(94-107(63,64)65)22(92-105(57,58)59)18(12-81-101(45,46)47)83-32(28)78-8-4-7-38-9-15(36-37-38)14-5-2-1-3-6-14/h1-3,5-6,9,16-35H,4,7-8,10-13H2,(H,39,40,41)(H,42,43,44)(H,45,46,47)(H,48,49,50)(H,51,52,53)(H,54,55,56)(H,57,58,59)(H,60,61,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)(H,75,76,77)/t16-,17-,18-,19-,20-,21-,22-,23-,24+,25+,26+,27+,28+,29+,30+,31+,32+,33-,34-,35-/m1/s1
  • InChiKey: RBWDOUOLUKRISD-IAYASBFJSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0445 0.0258 0.3486
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0042 0.0001 0.001
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0008 0.0103
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0042 0.0001 0.0001
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0238 0.0126 0.0126
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 1.5703 1 1
Trichomonas vaginalis cyclins, putative 0.0062 0.0014 0.0185
Brugia malayi Cyclin, N-terminal domain containing protein 0.0164 0.0079 0.1045
Trichomonas vaginalis PIKK family atypical protein kinase 0.1178 0.0726 0.9798
Trichomonas vaginalis PIKK family atypical protein kinase 0.1188 0.0733 0.9888
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0369 0.021 0.2829
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0369 0.021 0.0587
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.1201 0.0741 0.2118
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0879 0.0535 0.0535
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.1201 0.0741 0.9804
Trichomonas vaginalis PIKK family atypical protein kinase 0.0249 0.0133 0.1793
Leishmania major cyclin 0.0062 0.0014 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0427 0.0247 0.3332
Trichomonas vaginalis PIKK family atypical protein kinase 0.1178 0.0726 0.9798
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0296 0.0163 0.2204
Trypanosoma cruzi cytochrome P450, putative 0.006 0.0012 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.1178 0.0726 0.9798
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.005 0.0006 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0682 0.041 0.553
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0238 0.0126 0.167
Echinococcus multilocularis serine protein kinase ATM 0.0682 0.041 0.041
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0238 0.0126 0.0346
Trichomonas vaginalis PIKK family atypical protein kinase 0.1201 0.0741 1
Echinococcus multilocularis cyclin dependent kinase 9 0.0053 0.0008 0.0008
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0238 0.0126 0.7728
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0296 0.0163 0.2204
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.048 0.0281 0.0281
Echinococcus multilocularis cyclin 0.0091 0.0032 0.0032
Echinococcus granulosus cyclin dependent kinase 5 0.005 0.0006 0.0006
Plasmodium vivax hypothetical protein, conserved 0.0238 0.0126 0.7639
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0131 0.0057 0.0148
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0296 0.0163 1
Brugia malayi Cytochrome P450 family protein 0.006 0.0012 0.0162
Giardia lamblia GTOR 0.1201 0.0741 1
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0006 0.0084
Loa Loa (eye worm) phosphatidylinositol 3 0.1179 0.0727 0.9813
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0296 0.0163 0.2204
Loa Loa (eye worm) phosphatidylinositol 3 0.1201 0.0741 1
Trichomonas vaginalis cyclin A, putative 0.0062 0.0014 0.0185
Loa Loa (eye worm) hypothetical protein 0.0444 0.0257 0.3475
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.006 0.0012 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0238 0.0126 0.1704
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0684 0.041 0.1166
Loa Loa (eye worm) phosphatidylinositol kinase 0.0238 0.0126 0.1704
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1224 0.0756 0.0756
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0369 0.021 0.2829
Loa Loa (eye worm) phosphatidylinositol 3 0.0238 0.0126 0.1704
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0296 0.0163 0.2139
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1167 0.0719 0.9706
Entamoeba histolytica protein kinase domain containing protein 0.0053 0.0008 0.0105
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0006 0.0082
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0238 0.0126 0.7639
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0684 0.041 0.5541
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0369 0.021 0.2829
Trichomonas vaginalis PIKK family atypical protein kinase 0.118 0.0728 0.9821
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0296 0.0163 0.2161
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0238 0.0126 0.1704
Toxoplasma gondii target of rapamycin (TOR), putative 0.1188 0.0733 1
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0042 0.0001 0.001
Echinococcus granulosus cyclin dependent kinase 9 0.0062 0.0014 0.0014
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0196 0.0099 0.1308
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0296 0.0163 0.2204
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0238 0.0126 0.0126
Trichomonas vaginalis PIKK family atypical protein kinase 0.1167 0.0719 0.9708
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0006 0.0084
Leishmania major phosphatidylinositol 3-kinase, putative 0.1167 0.0719 0.197
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0369 0.021 0.2769
Echinococcus multilocularis cyclin B 0.0062 0.0014 0.0014
Brugia malayi cyclin-dependent kinase 9 0.0053 0.0008 0.0103
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1224 0.0756 1
Trypanosoma cruzi hypothetical protein, conserved 0.5482 0.3474 1
Trypanosoma brucei cytochrome P450, putative 0.006 0.0012 0.0082
Brugia malayi Cyclin, N-terminal domain containing protein 0.0062 0.0014 0.0181
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.048 0.0281 0.3714
Loa Loa (eye worm) hypothetical protein 0.0666 0.0399 0.5387
Trichomonas vaginalis PIKK family atypical protein kinase 0.07 0.0421 0.5678
Onchocerca volvulus 0.0238 0.0126 1
Trichomonas vaginalis cyclin B, putative 0.0062 0.0014 0.0185
Trypanosoma brucei mitotic cyclin 6 0.0062 0.0014 0.0102
Mycobacterium leprae conserved hypothetical protein 0.0238 0.0126 0.5
Giardia lamblia Kinase, CMGC CDK 0.005 0.0006 0.0084
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.005 0.0006 0.0084
Trypanosoma cruzi cyclin, putative 0.0062 0.0014 0.0022
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0684 0.041 0.5432
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0091 0.0032 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0427 0.0247 0.3332
Trichomonas vaginalis cyclins, putative 0.0062 0.0014 0.0185
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0408 0.0234 0.3163
Entamoeba histolytica hypothetical protein 0.0682 0.041 0.553
Trypanosoma brucei target of rapamycin kinase 3, putative 0.1191 0.0734 0.991
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0572 0.0339 0.4582
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0296 0.0163 0.2161
Trichomonas vaginalis PIKK family atypical protein kinase 0.1167 0.0719 0.9708
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0682 0.041 0.5492
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1179 0.0727 0.9811
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0238 0.0126 0.167
Schistosoma mansoni hypothetical protein 0.0238 0.0126 0.167
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0238 0.0126 0.167
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.1201 0.0741 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.118 0.0728 0.9821
Loa Loa (eye worm) cytochrome P450 family protein 0.0126 0.0055 0.0738
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0006 0.0084
Toxoplasma gondii non-specific serine/threonine protein kinase 0.074 0.0446 0.606
Echinococcus granulosus serine protein kinase ATM 0.0682 0.041 0.041
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0238 0.0126 0.1652
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0238 0.0126 0.7639
Schistosoma mansoni hypothetical protein 0.0501 0.0294 0.3893
Loa Loa (eye worm) phosphatidylinositol 3 0.0238 0.0126 0.1704
Trichomonas vaginalis PIKK family atypical protein kinase 0.0689 0.0414 0.5589
Trichomonas vaginalis cyclin H, putative 0.0073 0.0021 0.0278
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.1201 0.0741 0.2029
Plasmodium vivax hypothetical protein 0.0238 0.0126 0.7639
Trichomonas vaginalis PIKK family atypical protein kinase 0.0678 0.0407 0.5491
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0238 0.0126 0.1634
Trichomonas vaginalis PIKK family atypical protein kinase 0.1191 0.0734 0.991
Trichomonas vaginalis PIKK family atypical protein kinase 0.1191 0.0734 0.991
Loa Loa (eye worm) phosphatidylinositol 3 0.0131 0.0057 0.0775
Trichomonas vaginalis PIKK family atypical protein kinase 0.1191 0.0734 0.991
Loa Loa (eye worm) cytochrome P450 family protein 0.006 0.0012 0.0165
Giardia lamblia Hypothetical protein 0.0238 0.0126 0.1704
Leishmania major hypothetical protein, unknown function 0.0238 0.0126 0.0332
Trichomonas vaginalis PIKK family atypical protein kinase 0.1191 0.0734 0.991
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0238 0.0126 0.0346
Echinococcus multilocularis cyclin dependent kinase 0.005 0.0006 0.0006
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0296 0.0163 0.2161
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0296 0.0163 0.2163
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1201 0.0741 0.9804
Mycobacterium tuberculosis Conserved hypothetical protein 0.0238 0.0126 0.5
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0238 0.0126 0.0126
Trichomonas vaginalis conserved hypothetical protein 0.0501 0.0294 0.3971
Loa Loa (eye worm) cytochrome P450 family protein 0.006 0.0012 0.0165
Trichomonas vaginalis cyclin B, putative 0.0062 0.0014 0.0185
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0501 0.0294 0.0294
Trichomonas vaginalis cyclins, putative 0.0062 0.0014 0.0185
Entamoeba histolytica hypothetical protein 0.0238 0.0126 0.1704
Loa Loa (eye worm) hypothetical protein 0.0062 0.0014 0.0185
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.1201 0.0741 0.0741
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.075 0.0453 0.6082
Schistosoma mansoni kinase 0.0053 0.0008 0.0103
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0062 0.0014 0.0021
Echinococcus granulosus cyclin B 0.0062 0.0014 0.0014
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0238 0.0126 0.1704
Loa Loa (eye worm) cyclin domain-containing protein 0.0164 0.0079 0.1066
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0369 0.021 0.2774
Echinococcus granulosus cyclin dependent kinase 9 0.0053 0.0008 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.074 0.0446 0.6025
Trichomonas vaginalis PIKK family atypical protein kinase 0.1178 0.0726 0.9798
Brugia malayi Cyclin, N-terminal domain containing protein 0.0062 0.0014 0.0181
Trichomonas vaginalis PIKK family atypical protein kinase 0.1167 0.0719 0.9708
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0684 0.041 0.5541
Echinococcus multilocularis cyclin dependent kinase 9 0.0062 0.0014 0.0014
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1224 0.0756 0.0756
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0684 0.041 0.5541
Loa Loa (eye worm) hypothetical protein 0.0062 0.0014 0.0185
Trichomonas vaginalis PIKK family atypical protein kinase 0.1178 0.0726 0.9798
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0238 0.0126 0.0126
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0684 0.041 0.1166
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0238 0.0126 0.0346
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.005 0.0006 0.0084
Schistosoma mansoni fkbp-rapamycin associated protein 0.0666 0.0399 0.5281
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0003 0.0042
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0238 0.0126 0.1652
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0501 0.0294 0.0294
Giardia lamblia G2/mitotic-specific cyclin B 0.0062 0.0014 0.0185
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0369 0.021 0.2829
Trichomonas vaginalis cyclin B, putative 0.0062 0.0014 0.0185
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0238 0.0126 0.0346
Entamoeba histolytica cell division protein kinase 2, putative 0.0059 0.0012 0.0162
Toxoplasma gondii FATC domain-containing protein 0.0682 0.041 0.5555
Trichomonas vaginalis PIKK family atypical protein kinase 0.1188 0.0733 0.9888
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0572 0.0339 0.4582
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.1201 0.0741 0.2118
Giardia lamblia Phosphatidylinositol 4-kinase 0.0238 0.0126 0.1704
Trypanosoma cruzi cyclin, putative 0.0062 0.0014 0.0022
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.1191 0.0734 0.2011
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0369 0.021 0.2774
Entamoeba histolytica hypothetical protein 0.0073 0.0021 0.0278
Trichomonas vaginalis PIKK family atypical protein kinase 0.1188 0.0733 0.9888
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0238 0.0126 0.0126
Entamoeba histolytica hypothetical protein 0.0238 0.0126 0.1704
Trichomonas vaginalis PIKK family atypical protein kinase 0.1179 0.0727 0.9813
Schistosoma mansoni cyclin B 0.0062 0.0014 0.0181
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.048 0.0281 0.0281
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0611 0.0364 0.4915
Trichomonas vaginalis PIKK family atypical protein kinase 0.1188 0.0733 0.9888
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0678 0.0407 0.5491
Trichomonas vaginalis PIKK family atypical protein kinase 0.0666 0.0399 0.5387
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0259 0.0139 0.1814
Loa Loa (eye worm) hypothetical protein 0.0049 0.0005 0.0073
Brugia malayi FAT domain containing protein 0.0501 0.0294 0.3893
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0296 0.0163 0.0453
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1224 0.0756 1
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0296 0.0163 0.2204
Trichomonas vaginalis PIKK family atypical protein kinase 0.1167 0.0719 0.9708
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.1201 0.0741 0.0741
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0296 0.0163 0.2163
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0296 0.0163 0.0163
Trypanosoma cruzi CYC2-like cyclin, putative 0.0062 0.0014 0.0022
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0238 0.0126 0.167
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0255 0.0137 0.0377
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.05 0.0293 0.3957
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0238 0.0126 0.1704
Trichomonas vaginalis PIKK family atypical protein kinase 0.0687 0.0412 0.5566
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0666 0.0399 0.1133
Trypanosoma cruzi target of rapamycin kinase 3 0.1191 0.0734 0.2099
Trichomonas vaginalis PIKK family atypical protein kinase 0.1188 0.0733 0.9888
Entamoeba histolytica hypothetical protein 0.0238 0.0126 0.1704
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0296 0.0163 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.1201 0.0741 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0682 0.041 0.1163
Echinococcus multilocularis cyclin dependent kinase 1 0.005 0.0006 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0763 0.0461 0.6227
Trichomonas vaginalis PIKK family atypical protein kinase 0.1188 0.0733 0.9888
Schistosoma mansoni g1/s-specific cyclin C 0.0091 0.0032 0.0429
Giardia lamblia Kinase, CMGC CDK 0.005 0.0006 0.0084
Entamoeba histolytica hypothetical protein 0.0611 0.0364 0.4915
Loa Loa (eye worm) hypothetical protein 0.074 0.0446 0.6025
Trichomonas vaginalis cyclins, putative 0.0062 0.0014 0.0185
Entamoeba histolytica protein kinase rad3, putative 0.0666 0.0399 0.5387
Plasmodium falciparum protein kinase 5 0.005 0.0006 0.0379
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0238 0.0126 0.7728
Loa Loa (eye worm) hypothetical protein 0.048 0.0281 0.3788
Trichomonas vaginalis PIKK family atypical protein kinase 0.0687 0.0412 0.5566
Echinococcus granulosus cyclin dependent kinase 1 0.005 0.0006 0.0006
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.005 0.0006 0.0084
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0296 0.0163 0.0453
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0003 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.1178 0.0726 0.9798
Loa Loa (eye worm) hypothetical protein 0.0238 0.0126 0.1704
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0296 0.0163 0.0434
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0879 0.0535 0.0535
Loa Loa (eye worm) CYP4Cod1 0.006 0.0012 0.0165
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0311 0.0173 0.2329
Leishmania major hypothetical protein, conserved 0.5721 0.3627 1
Echinococcus granulosus cyclin dependent kinase 0.005 0.0006 0.0006
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase 0.0053 0.0008 0.0105
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0296 0.0163 0.0163
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0666 0.0399 0.0399
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.1201 0.0741 0.2029
Trichomonas vaginalis cyclin B, putative 0.0062 0.0014 0.0185
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0879 0.0535 0.7084
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0006 0.0082
Echinococcus multilocularis Zinc finger, PHD finger 0.0296 0.0163 0.0163
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0042 0.0001 0.0001
Trypanosoma cruzi cyclin 6, putative 0.0062 0.0014 0.0022
Onchocerca volvulus 0.0238 0.0126 1
Echinococcus multilocularis cyclin dependent kinase 5 0.005 0.0006 0.0006
Loa Loa (eye worm) cyclin C 0.0091 0.0032 0.0437
Loa Loa (eye worm) hypothetical protein 0.0203 0.0104 0.1402
Loa Loa (eye worm) hypothetical protein 0.0501 0.0294 0.3971
Leishmania major phosphatidylinositol 4-kinase, putative 0.0238 0.0126 0.0332
Brugia malayi Cytochrome P450 family protein 0.0126 0.0055 0.0723
Entamoeba histolytica cell division protein kinase 2, putative 0.005 0.0006 0.0084
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0296 0.0163 0.2204
Loa Loa (eye worm) phosphatidylinositol 3 0.0807 0.0489 0.6601
Leishmania major phosphatidylinositol kinase, putative 0.0238 0.0126 0.0332
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0238 0.0126 0.1652
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0238 0.0126 0.7639
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0684 0.041 0.5541
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1224 0.0756 0.2161
Echinococcus multilocularis 0.0238 0.0126 0.0126
Brugia malayi cell division control protein 2 homolog 0.005 0.0006 0.0082
Echinococcus multilocularis cyclin dependent kinase 1 0.005 0.0006 0.0006
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0666 0.0399 0.0399
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1224 0.0756 0.2161
Echinococcus granulosus cyclin 0.0091 0.0032 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0238 0.0126 0.1704
Trypanosoma cruzi cytochrome P450, putative 0.006 0.0012 0.0017
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0444 0.0257 0.0725
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0369 0.021 0.2829
Leishmania major phosphatidylinositol kinase related protein, putative 0.0255 0.0137 0.0361
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.1201 0.0741 1
Brugia malayi Protein kinase domain containing protein 0.005 0.0006 0.0082
Trichomonas vaginalis PIKK family atypical protein kinase 0.1191 0.0734 0.991
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0238 0.0126 0.1634
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.1201 0.0741 1
Brugia malayi Cyclin C 0.0091 0.0032 0.0429
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0238 0.0126 0.167
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0682 0.041 0.5421
Brugia malayi Cytochrome P450 family protein 0.006 0.0012 0.0162
Leishmania major cytochrome p450-like protein 0.006 0.0012 0.0017
Loa Loa (eye worm) phosphatidylinositol 3 0.0238 0.0126 0.1704
Trichomonas vaginalis PIKK family atypical protein kinase 0.1188 0.0733 0.9888
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1179 0.0727 0.1991
Loa Loa (eye worm) phosphatidylinositol 3 0.0238 0.0126 0.1704
Trichomonas vaginalis PIKK family atypical protein kinase 0.1201 0.0741 1
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0296 0.0163 0.0163
Trichomonas vaginalis PIKK family atypical protein kinase 0.1178 0.0726 0.9798
Leishmania major phosphatidylinositol 3-kinase, putative 0.0296 0.0163 0.0434
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0682 0.041 0.5421
Trichomonas vaginalis PIKK family atypical protein kinase 0.0687 0.0412 0.5566
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0238 0.0126 0.167
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0666 0.0399 0.5281
Entamoeba histolytica cyclin, putative 0.0062 0.0014 0.0185
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0091 0.0032 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.1201 0.0741 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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