TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 391.294 | Formula: C19H20Cl2N4O
H donors: 1 H acceptors: 2 LogP: 5.11 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCCCNC(=O)c1nn(c(c1C)n1cccc1)c1ccc(cc1Cl)Cl
InChi: 1S/C19H20Cl2N4O/c1-3-4-9-22-18(26)17-13(2)19(24-10-5-6-11-24)25(23-17)16-8-7-14(20)12-15(16)21/h5-8,10-12H,3-4,9H2,1-2H3,(H,22,26)
InChiKey: ZOTYAJXIEVKGPQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cannabinoid receptor 1 (brain)	Starlite/ChEMBL	References
Homo sapiens	cannabinoid receptor 2 (macrophage)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0026	0.0379	0.0363
Mycobacterium ulcerans	short chain dehydrogenase	0.0026	0.0379	0.0363
Mycobacterium ulcerans	DNA polymerase IV	0.0041	0.0763	0.0748
Brugia malayi	polk-prov protein	0.0013	0.0016	0.0034
Trichomonas vaginalis	CAMK family protein kinase	0.01	0.2331	0.2331
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0026	0.0379	0.0363
Schistosoma mansoni	rotamase	0.0032	0.0543	0.0616
Entamoeba histolytica	serine/threonine protein kinase, putative	0.01	0.2331	1
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0031	0.0498	0.0565
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0763	0.3227
Schistosoma mansoni	DNA polymerase eta	0.0068	0.1478	0.1677
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0093	0.2146	0.2434
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, putative	0.0032	0.0523	0.2243
Schistosoma mansoni	hypothetical protein	0.0037	0.067	0.076
Brugia malayi	acetyltransferase, GNAT family protein	0.0153	0.3748	0.7896
Echinococcus multilocularis	3 oxoacyl acyl carrier protein reductase	0.0026	0.0379	0.043
Echinococcus granulosus	chromobox protein 1	0.0074	0.1636	0.1855
Trypanosoma brucei	polo-like protein kinase	0.01	0.2331	1
Brugia malayi	jmjC domain containing protein	0.0101	0.236	0.4972
Toxoplasma gondii	2,4-dienoyl CoA reductase 2, peroxisomal family protein	0.0026	0.0379	0.0379
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0038	0.069	0.0782
Trichomonas vaginalis	CAMK family protein kinase	0.01	0.2331	0.2331
Echinococcus granulosus	dna polymerase eta	0.0068	0.1478	0.1677
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0379	0.0798
Wolbachia endosymbiont of Brugia malayi	enoyl-ACP reductase	0.0388	1	1
Entamoeba histolytica	hypothetical protein	0.0038	0.069	0.2959
Mycobacterium ulcerans	20-beta-hydroxysteroid dehydrogenase FabG3	0.0026	0.0379	0.0363
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0041	0.0776	0.1635
Trichomonas vaginalis	chromobox protein, putative	0.0074	0.1636	0.1636
Trypanosoma brucei	DNA polymerase eta, putative	0.0068	0.1478	0.6316
Echinococcus granulosus	chromobox protein 1	0.0074	0.1636	0.1855
Trypanosoma cruzi	beta-ketoacyl-ACP reductase	0.0026	0.0379	0.1566
Plasmodium vivax	DNA repair protein REV1, putative	0.0013	0.0016	0.0016
Trypanosoma brucei	DNA polymerase kappa, putative	0.0028	0.0427	0.1775
Leishmania major	dehydrogenase/oxidoreductase-like protein	0.0026	0.0379	0.1566
Mycobacterium ulcerans	short chain dehydrogenase	0.0026	0.0379	0.0363
Toxoplasma gondii	3-ketoacyl-(acyl-carrier-protein) reductase	0.0026	0.0379	0.0379
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0543	0.0543
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0041	0.0763	0.04
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0041	0.0763	0.0866
Giardia lamblia	Histone acetyltransferase GCN5	0.0041	0.0777	0.3285
Echinococcus multilocularis	lysine specific demethylase 5A	0.0037	0.067	0.076
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0045	0.0876	0.0876
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0016	0.0034
Trypanosoma cruzi	polo-like protein kinase, putative	0.01	0.2331	1
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0013	0.0016	0.0016
Loa Loa (eye worm)	Pin1-type peptidyl-prolyl cis-trans isomerase	0.0032	0.0543	0.1144
Mycobacterium ulcerans	short chain dehydrogenase	0.0026	0.0379	0.0363
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0763	0.3227
Trichomonas vaginalis	CAMK family protein kinase	0.01	0.2331	0.2331
Mycobacterium ulcerans	enoyl-(acyl carrier protein) reductase	0.0388	1	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0093	0.2146	0.2434
Leishmania major	oxidoreductase-like protein	0.0026	0.0379	0.1566
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.01	0.2331	0.2644
Echinococcus multilocularis	peregrin	0.0035	0.0598	0.0678
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0093	0.2146	0.4521
Toxoplasma gondii	enoyl-acyl carrier reductase ENR	0.0388	1	1
Brugia malayi	serine/threonine-protein kinase plk-2	0.01	0.2331	0.4911
Onchocerca volvulus	Serine\/threonine kinase homolog	0.01	0.2331	0.4911
Trichomonas vaginalis	chromobox protein, putative	0.0074	0.1636	0.1636
Mycobacterium tuberculosis	NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase)	0.0388	1	1
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0026	0.0379	0.0363
Plasmodium vivax	enoyl-acyl carrier protein reductase	0.0388	1	1
Trichomonas vaginalis	hypothetical protein	0.0388	1	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0026	0.0379	0.0363
Mycobacterium ulcerans	3-oxoacyl-ACP reductase	0.0026	0.0379	0.0363
Leishmania major	DNA polymerase kappa, putative	0.0041	0.0763	0.3227
Schistosoma mansoni	hypothetical protein	0.0344	0.8816	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0026	0.0379	0.0363
Leishmania major	DNA polymerase eta, putative	0.004	0.0731	0.3088
Echinococcus multilocularis	expressed protein	0.0032	0.0543	0.0616
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0153	0.3748	0.4252
Trypanosoma brucei	beta-ketoacyl-ACP reductase	0.0026	0.0379	0.1566
Trichomonas vaginalis	DNA polymerase eta, putative	0.0041	0.0763	0.0763
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0041	0.0763	0.0763
Mycobacterium ulcerans	short chain dehydrogenase	0.0026	0.0379	0.0363
Echinococcus granulosus	dna polymerase kappa	0.0041	0.0763	0.0866
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0045	0.0876	0.0876
Mycobacterium ulcerans	short chain dehydrogenase	0.0026	0.0379	0.0363
Trypanosoma cruzi	kinetoplast DNA-associated protein, putative	0.0037	0.067	0.2824
Plasmodium falciparum	DNA repair protein REV1, putative	0.0013	0.0016	0.0016
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0026	0.0379	0.0363
Giardia lamblia	PHD finger protein 15	0.0031	0.0498	0.2082
Trichomonas vaginalis	CAMK family protein kinase	0.0049	0.0992	0.0992
Brugia malayi	Growth-Arrest-Specific Protein 2 Domain containing protein	0.0037	0.067	0.1411
Trypanosoma brucei	unspecified product	0.0028	0.0427	0.1775
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0041	0.0763	0.0866
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0041	0.0763	0.3274
Loa Loa (eye worm)	jmjC domain-containing protein	0.0037	0.067	0.1412
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0037	0.067	0.076
Trichomonas vaginalis	CAMK family protein kinase	0.01	0.2331	0.2331
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0045	0.0876	0.0876
Schistosoma mansoni	chromobox protein	0.0074	0.1636	0.1855
Echinococcus granulosus	jumonji domain containing protein	0.0043	0.0819	0.0929
Onchocerca volvulus		0.0026	0.0379	0.0798
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0044	0.0859	0.181
Trypanosoma brucei	oxidoreductase-like protein	0.0026	0.0379	0.1566
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0041	0.0763	0.3227
Echinococcus granulosus	3 oxoacyl acyl carrier protein reductase	0.0026	0.0379	0.043
Plasmodium falciparum	enoyl-acyl carrier reductase	0.0388	1	1
Loa Loa (eye worm)	acetyltransferase	0.0153	0.3748	0.7896
Mycobacterium ulcerans	short chain dehydrogenase	0.0026	0.0379	0.0363
Schistosoma mansoni	jumonji domain containing protein	0.008	0.1809	0.2052
Plasmodium falciparum	phd finger protein, putative	0.0031	0.0498	0.0498
Onchocerca volvulus		0.0026	0.0379	0.0798
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0026	0.0379	0.0363
Schistosoma mansoni	hypothetical protein	0.0038	0.069	0.0782
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0041	0.0763	0.3227
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0026	0.0379	0.0363
Trypanosoma cruzi	polo-like protein kinase, putative	0.01	0.2331	1
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0026	0.0379	0.0798
Schistosoma mansoni	chromobox protein	0.0074	0.1636	0.1855
Loa Loa (eye worm)	jmjC domain-containing protein	0.0064	0.137	0.2885
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.01	0.2331	0.4911
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0776	0.1635
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0037	0.067	0.076
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0045	0.0876	0.0876
Entamoeba histolytica	acetyltransferase, GNAT family	0.0041	0.0777	0.3331
Brugia malayi	ImpB/MucB/SamB family protein	0.0041	0.0763	0.1608
Trichomonas vaginalis	CAMK family protein kinase	0.01	0.2331	0.2331
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0763	0.3227
Leishmania major	DNA polymerase eta, putative	0.0068	0.1478	0.6316
Brugia malayi	hypothetical protein	0.0038	0.069	0.1453
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0031	0.0498	0.0565
Mycobacterium ulcerans	short chain dehydrogenase	0.0026	0.0379	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0037	0.067	0.1411
Brugia malayi	N-terminal motif family protein	0.0191	0.4747	1
Entamoeba histolytica	hypothetical protein	0.0038	0.069	0.2959
Trypanosoma brucei	DNA polymerase kappa, putative	0.0028	0.0427	0.1775
Trypanosoma brucei	unspecified product	0.0041	0.0763	0.3227
Brugia malayi	Bromodomain containing protein	0.0035	0.0598	0.126
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0045	0.0876	0.0994
Leishmania major	dehydrogenase/oxidoreductase-like protein	0.0026	0.0379	0.1566
Trypanosoma cruzi	DNA polymerase eta, putative	0.0068	0.1478	0.6316
Loa Loa (eye worm)	retinol dehydrogenase 12	0.0026	0.0379	0.0798
Entamoeba histolytica	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0026	0.0379	0.1625
Mycobacterium ulcerans	3-alpha-hydroxysteroid dehydrogenase	0.0026	0.0379	0.0363
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0041	0.0763	0.3227
Trypanosoma brucei	DNA polymerase IV, putative	0.0041	0.0763	0.3227
Leishmania major	3-oxoacyl-ACP reductase, putative	0.0026	0.0379	0.1566
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0041	0.0763	0.1608
Trichomonas vaginalis	chromobox protein, putative	0.0044	0.0859	0.0859
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0041	0.0763	0.3227
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0093	0.2146	0.2434
Trichomonas vaginalis	CAMK family protein kinase	0.0049	0.0992	0.0992
Trypanosoma brucei	unspecified product	0.0028	0.0427	0.1775
Trypanosoma cruzi	beta-ketoacyl-ACP reductase	0.0026	0.0379	0.1566
Brugia malayi	ImpB/MucB/SamB family protein	0.0068	0.1478	0.3114
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0101	0.236	0.2677
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0093	0.2146	0.2434
Schistosoma mansoni	hypothetical protein	0.0037	0.067	0.076
Mycobacterium leprae	NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE)	0.0388	1	1
Mycobacterium ulcerans	3-oxoacyl-ACP reductase	0.0026	0.0379	0.0363
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0101	0.236	0.2677
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0026	0.0379	0.0798
Schistosoma mansoni	transcription factor LCR-F1	0.0038	0.069	0.0782
Trypanosoma brucei	DNA polymerase IV, putative	0.0041	0.0763	0.3227
Loa Loa (eye worm)	PHD-finger family protein	0.0031	0.0498	0.105
Echinococcus multilocularis	Spectrin alpha actinin	0.0037	0.067	0.076
Loa Loa (eye worm)	hypothetical protein	0.0068	0.1478	0.3114
Plasmodium vivax	3-oxoacyl-[acyl-carrier-protein] reductase, putative	0.0026	0.0379	0.0379
Schistosoma mansoni	serine/threonine protein kinase	0.01	0.2331	0.2644
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0456	0.0456
Plasmodium falciparum	3-oxoacyl-[acyl-carrier-protein] reductase	0.0026	0.0379	0.0379
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0093	0.2146	0.4521
Toxoplasma gondii	peptidylprolyl isomerase	0.0032	0.0523	0.0523
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase/rotamase, putative	0.0032	0.0523	0.2189
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0041	0.0763	0.3227
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0026	0.0379	0.0363
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0026	0.0379	0.0363
Schistosoma mansoni	hypothetical protein	0.0031	0.0498	0.0565
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0149	0.3634	0.4122
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0093	0.2146	0.2434
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.004	0.0731	0.0731
Loa Loa (eye worm)	oxidoreductase	0.0026	0.0379	0.0798
Echinococcus multilocularis	geminin	0.0344	0.8816	1
Entamoeba histolytica	hypothetical protein	0.0038	0.069	0.2959
Mycobacterium ulcerans	short chain dehydrogenase	0.0026	0.0379	0.0363
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0153	0.3748	0.4252
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0763	0.3227
Echinococcus multilocularis	dna polymerase eta	0.0068	0.1478	0.1677
Plasmodium vivax	hypothetical protein, conserved	0.0031	0.0498	0.0498
Trichomonas vaginalis	rotamase, putative	0.0032	0.0543	0.0543
Echinococcus multilocularis	jumonji domain containing protein	0.0043	0.0819	0.0929
Loa Loa (eye worm)	heterochromatin protein 1	0.0074	0.1636	0.3445
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0026	0.0379	0.0363
Brugia malayi	chromobox protein homolog 3	0.0041	0.0776	0.1635
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0032	0.0523	0.2189
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0026	0.0379	0.0798
Brugia malayi	VAB-10A protein	0.0037	0.067	0.1411
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0763	0.3227
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0041	0.0763	0.04
Trypanosoma brucei	pteridine reductase 1	0.0026	0.0379	0.1566
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.01	0.2331	1
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0776	0.0776
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0763	0.3227
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0191	0.4747	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0763	0.3227
Trichomonas vaginalis	CAMK family protein kinase	0.01	0.2331	0.2331
Schistosoma mansoni	hypothetical protein	0.0344	0.8816	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0539	0.1136
Trypanosoma brucei	DNA polymerase kappa, putative	0.0028	0.0427	0.1775
Schistosoma mansoni	DNA polymerase IV / kappa	0.0013	0.0016	0.0018
Brugia malayi	Heterochromatin protein 1	0.0074	0.1636	0.3445
Echinococcus granulosus	PHD finger protein rhinoceros	0.0031	0.0498	0.0565
Echinococcus multilocularis	dna polymerase kappa	0.0041	0.0763	0.0866
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0026	0.0379	0.0363
Echinococcus multilocularis	chromobox protein 1	0.0074	0.1636	0.1855
Toxoplasma gondii	PHD-finger domain-containing protein	0.0031	0.0498	0.0498
Onchocerca volvulus	Alhambra homolog	0.0031	0.0498	0.105
Mycobacterium ulcerans	oxidoreductase	0.0026	0.0379	0.0363
Toxoplasma gondii	PHD-finger domain-containing protein	0.0031	0.0498	0.0498
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0763	0.3227
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0026	0.0379	0.0363
Echinococcus granulosus	lysine specific demethylase 5A	0.0037	0.067	0.076
Echinococcus granulosus	geminin	0.0344	0.8816	1
Trypanosoma cruzi	DNA polymerase eta, putative	0.004	0.0731	0.3088
Toxoplasma gondii	BRCA1 C Terminus (BRCT) domain-containing protein	0.0013	0.0016	0.0016
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0763	0.3227
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0041	0.0763	0.0866
Trichomonas vaginalis	CAMK family protein kinase	0.01	0.2331	0.2331
Brugia malayi	jmjC domain containing protein	0.0037	0.067	0.1412
Leishmania major	peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative	0.0032	0.0523	0.2189
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0763	0.3227
Loa Loa (eye worm)	hypothetical protein	0.0191	0.4747	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0041	0.0763	0.3227
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0498	0.105
Brugia malayi	PHD-finger family protein	0.0031	0.0498	0.105
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.01	0.2331	0.2644
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0032	0.0523	0.2189
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0776	0.0776
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0026	0.0379	0.1566
Giardia lamblia	DINP protein human, muc B family	0.0041	0.0763	0.3227
Loa Loa (eye worm)	spectraplakin	0.0037	0.067	0.1411
Echinococcus granulosus	Spectrin alpha actinin	0.0037	0.067	0.076
Schistosoma mansoni	3-oxoacyl-[ACP] reductase	0.0026	0.0379	0.043
Schistosoma mansoni	dihydropteridine reductase	0.0026	0.0379	0.043
Trichomonas vaginalis	chromobox protein, putative	0.0044	0.0859	0.0859
Mycobacterium ulcerans	short chain dehydrogenase	0.0026	0.0379	0.0363
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0026	0.0379	0.0363
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0093	0.2146	0.2434
Schistosoma mansoni	kinase	0.0051	0.1027	0.1165
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0456	0.0456
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0038	0.069	0.0782
Onchocerca volvulus		0.0032	0.0539	0.1136
Echinococcus granulosus	expressed protein	0.0032	0.0543	0.0616
Echinococcus granulosus	peregrin	0.0035	0.0598	0.0678
Entamoeba histolytica	hypothetical protein	0.0038	0.069	0.2959
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0045	0.0876	0.0876
Leishmania major	pteridine reductase 1	0.0026	0.0379	0.1566
Mycobacterium ulcerans	DNA polymerase IV	0.0041	0.0763	0.0748
Toxoplasma gondii	short chain dehydrogenase family protein, putative	0.0026	0.0379	0.0379
Echinococcus multilocularis	chromobox protein 1	0.0074	0.1636	0.1855
Loa Loa (eye worm)	hypothetical protein	0.0053	0.1083	0.2281
Mycobacterium ulcerans	short chain dehydrogenase	0.0026	0.0379	0.0363
Brugia malayi	Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1	0.0032	0.0543	0.1144
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0093	0.2146	0.2434
Plasmodium falciparum	histone acetyltransferase GCN5	0.0041	0.0777	0.0777
Giardia lamblia	Kinase, PLK	0.01	0.2331	1
Trichomonas vaginalis	rotamase, putative	0.0032	0.0523	0.0523
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0026	0.0379	0.0363
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0041	0.0763	0.0866

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 272.6 nM	Displacement of [3H]CP-55,940 from recombinant human CB1 receptor transfected in HEK cells	ChEMBL.	20943290
Ki (binding)	= 795.7 nM	Displacement of [3H]CP-55,940 from recombinant human CB2 receptor transfected in HEK cells	ChEMBL.	20943290

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1631161

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1465989