Detailed information for compound 1467596

Basic information

Technical information
  • TDR Targets ID: 1467596
  • Name: N-cyclohexyl-4-methyl-5-(5-methyl-3-pyridin-3 -yl-4H-1,2-oxazol-5-yl)-1,3-thiazole-2-carbox amide
  • MW: 384.495 | Formula: C20H24N4O2S
  • H donors: 1 H acceptors: 3 LogP: 3.32 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1nc(sc1C1(C)ON=C(C1)c1cccnc1)C(=O)NC1CCCCC1
  • InChi: 1S/C20H24N4O2S/c1-13-17(20(2)11-16(24-26-20)14-7-6-10-21-12-14)27-19(22-13)18(25)23-15-8-4-3-5-9-15/h6-7,10,12,15H,3-5,8-9,11H2,1-2H3,(H,23,25)
  • InChiKey: YYUPMAYEFDNJFB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-cyclohexyl-4-methyl-5-[5-methyl-3-(3-pyridyl)-4H-isoxazol-5-yl]thiazole-2-carboxamide
  • N-cyclohexyl-4-methyl-5-[5-methyl-3-(3-pyridyl)-4H-isoxazol-5-yl]-2-thiazolecarboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0697 0.4162 0.883
Echinococcus multilocularis histone deacetylase 3 0.0041 0.0159 0.0151
Entamoeba histolytica histone deacetylase, putative 0.0041 0.0159 0.0803
Loa Loa (eye worm) hypothetical protein 0.0025 0.0059 0.0124
Brugia malayi Phospholipase A2 family protein 0.0697 0.4162 0.883
Echinococcus multilocularis integrin alpha ps 0.0074 0.0361 0.0352
Schistosoma mansoni hypothetical protein 0.0509 0.3015 1
Schistosoma mansoni hypothetical protein 0.0073 0.0351 0.1141
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0068 0.0322 0.1043
Echinococcus granulosus intermediate filament protein 0.0028 0.0079 0.011
Loa Loa (eye worm) hypothetical protein 0.0205 0.1162 0.2465
Schistosoma mansoni ap endonuclease 0.0018 0.002 0.0037
Loa Loa (eye worm) hypothetical protein 0.013 0.07 0.1485
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0278 0.1605 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0159 0.0337
Schistosoma mansoni hypothetical protein 0.0073 0.0351 0.1141
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0064 0.0302 0.3864
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0303 0.1755 1
Brugia malayi acetyltransferase, GNAT family protein 0.015 0.0824 0.1749
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0137 0.0742 0.114
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.0742 0.2441
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0059 0.0532
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.1755 1
Loa Loa (eye worm) histone deacetylase 1 0.0041 0.0159 0.0337
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0059 0.0277
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.1755 1
Trypanosoma cruzi aminopeptidase, putative 0.0138 0.075 1
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0129 0.04
Loa Loa (eye worm) peptidase family M13 containing protein 0.0205 0.1162 0.2465
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0057 0.1337
Mycobacterium leprae probable zinc metalloprotease 0.0278 0.1605 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0057 0.1337
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0057 0.0238
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0326 0.4191
Loa Loa (eye worm) hypothetical protein 0.0064 0.0302 0.064
Schistosoma mansoni hypothetical protein 0.0035 0.0124 0.0385
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0068 0.0322 0.1043
Loa Loa (eye worm) peptidase family M1 containing protein 0.0336 0.1959 0.4155
Brugia malayi histone deacetylase 3 (HD3) 0.0041 0.0159 0.0337
Entamoeba histolytica hypothetical protein 0.0036 0.0129 0.0629
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0138 0.075 1
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.0326 0.4191
Schistosoma mansoni hypothetical protein 0.0073 0.0351 0.1141
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.015 0.0824 0.0817
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0303 0.1755 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0059 0.0245
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0059 0.0245
Echinococcus granulosus histone acetyltransferase KAT2B 0.0146 0.0799 0.1227
Loa Loa (eye worm) hypothetical protein 0.0039 0.0144 0.0305
Echinococcus multilocularis musashi 0.0028 0.0079 0.0071
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.1755 1
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0079 0.0168
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0068 0.0322 0.1043
Loa Loa (eye worm) hypothetical protein 0.021 0.1192 0.2528
Loa Loa (eye worm) hypothetical protein 0.021 0.1192 0.2528
Loa Loa (eye worm) hypothetical protein 0.0035 0.0125 0.0266
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0021 0.0038
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0277 0.1601 0.3397
Loa Loa (eye worm) zinc metallopeptidase 4 0.0068 0.0322 0.0683
Loa Loa (eye worm) hypothetical protein 0.0279 0.1612 0.342
Brugia malayi Histone deacetylase 1 0.0041 0.0159 0.0337
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.0068 0.0322 0.1043
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.0326 0.0493
Trypanosoma brucei Aminopeptidase M1, putative 0.0138 0.075 1
Echinococcus granulosus histone deacetylase 3 0.0041 0.0159 0.0234
Loa Loa (eye worm) hypothetical protein 0.0032 0.0106 0.0226
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.0326 0.0318
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0224 0.0474
Loa Loa (eye worm) histone deacetylase 3 0.0041 0.0159 0.0337
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.002 0.5
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0148 0.0811 0.499
Schistosoma mansoni intermediate filament proteins 0.0028 0.0079 0.0235
Loa Loa (eye worm) hypothetical protein 0.0278 0.1605 0.3405
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.014 0.0765 0.2515
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0138 0.075 0.1152
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0057 0.1337
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0041 0.0159 0.0803
Echinococcus granulosus integrin alpha 3 0.0127 0.0681 0.1045
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0138 0.075 0.0742
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.1755 1
Echinococcus granulosus integrin alpha ps 0.0074 0.0361 0.0547
Schistosoma mansoni lamin 0.0028 0.0079 0.0235
Loa Loa (eye worm) hypothetical protein 0.021 0.1192 0.2528
Echinococcus granulosus aminopeptidase N 0.0409 0.2407 0.3725
Loa Loa (eye worm) hypothetical protein 0.0278 0.1605 0.3405
Loa Loa (eye worm) hypothetical protein 0.0091 0.0465 0.0986
Schistosoma mansoni lamin 0.0028 0.0079 0.0235
Onchocerca volvulus 0.0138 0.075 0.1685
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.014 0.0765 0.2515
Loa Loa (eye worm) hypothetical protein 0.0125 0.0671 0.1423
Entamoeba histolytica hypothetical protein 0.0036 0.0129 0.0629
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0044
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0059 0.0124
Loa Loa (eye worm) hypothetical protein 0.021 0.1192 0.2528
Schistosoma mansoni hypothetical protein 0.0036 0.0129 0.04
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0326 0.4191
Onchocerca volvulus 0.0138 0.0749 0.1683
Toxoplasma gondii aminopeptidase N protein 0.0064 0.0302 0.1781
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0138 0.075 0.0742
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0059 0.0245
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0138 0.075 0.1152
Echinococcus granulosus leukotriene A 4 hydrolase 0.0277 0.1601 0.2473
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0059 0.0245
Trichomonas vaginalis histone deacetylase, putative 0.0041 0.0159 0.0803
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0059 0.0224
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0125 0.0671 0.1423
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0224 0.0474
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.002 0.0042
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0059 0.0124
Trichomonas vaginalis histone deacetylase, putative 0.0041 0.0159 0.0803
Trichomonas vaginalis histone deacetylase, putative 0.0041 0.0159 0.0803
Brugia malayi hypothetical protein 0.0064 0.0302 0.064
Brugia malayi peptidase family M13 containing protein 0.0068 0.0322 0.0683
Loa Loa (eye worm) hypothetical protein 0.0025 0.0059 0.0124
Onchocerca volvulus 0.0064 0.0297 0.0581
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0129 0.0187
Brugia malayi Peptidase family M1 containing protein 0.0138 0.075 0.1591
Loa Loa (eye worm) TATA binding protein associated factor 0.0064 0.0302 0.064
Loa Loa (eye worm) hypothetical protein 0.0138 0.0749 0.1589
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0021 0.5
Echinococcus granulosus transcription factor Dp 1 0.004 0.015 0.022
Loa Loa (eye worm) hypothetical protein 0.0052 0.0224 0.0474
Trypanosoma brucei aminopeptidase, putative 0.0064 0.0302 0.3864
Brugia malayi ephrin receptor 1 precursor 0.0031 0.0096 0.0204
Echinococcus granulosus ephrin type A receptor 4 A 0.0064 0.0301 0.0455
Loa Loa (eye worm) hypothetical protein 0.0035 0.0124 0.0263
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0137 0.0742 0.114
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0044
Schistosoma mansoni integrin alpha-ps 0.0074 0.0361 0.1171
Leishmania major hypothetical protein, conserved 0.0024 0.0057 0.0517
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0138 0.075 0.2467
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0008 0.0018
Onchocerca volvulus Phospholipase A2 homolog 0.0697 0.4162 1
Echinococcus multilocularis integrin alpha ps 0.0035 0.0125 0.0117
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0079 0.0168
Echinococcus multilocularis integrin alpha 3 0.0127 0.0681 0.0673
Echinococcus multilocularis ephrin type A receptor 4 A 0.0064 0.0301 0.0293
Onchocerca volvulus 0.0064 0.0302 0.0593
Trichomonas vaginalis histone deacetylase, putative 0.0041 0.0159 0.0803
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0064 0.0302 0.3864
Mycobacterium ulcerans aminopeptidase N PepN 0.0064 0.0302 0.1781
Echinococcus multilocularis endothelin converting enzyme 1 0.0278 0.1605 0.1598
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0073 0.0351 0.1141
Brugia malayi hypothetical protein 0.0024 0.0057 0.0122
Brugia malayi Peptidase family M1 containing protein 0.0409 0.2407 0.5106
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0156 0.0783
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0044
Leishmania major histone deacetylase, putative 0.0041 0.0159 0.1908
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0138 0.075 0.0742
Schistosoma mansoni integrin alpha 0.0165 0.0917 0.3021
Loa Loa (eye worm) hypothetical protein 0.0205 0.1162 0.2465
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.0326 0.0691
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.002 0.0011
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0064 0.0302 0.3864
Onchocerca volvulus Phospholipase A2 homolog 0.0279 0.1612 0.3786
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.0326 0.1056
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0059 0.0532
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0064 0.0302 0.1626
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0064 0.0302 1
Echinococcus multilocularis integrin alpha ps 0.0074 0.0361 0.0352
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0008 0.0018
Schistosoma mansoni endothelin-converting enzyme-related 0.0068 0.0322 0.1043
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.002 0.0032
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0224 0.0474
Loa Loa (eye worm) aminopeptidase N 0.0138 0.075 0.1591
Toxoplasma gondii histone deacetylase HDAC2 0.0041 0.0159 0.0879
Loa Loa (eye worm) hypothetical protein 0.0271 0.1566 0.3321
Schistosoma mansoni Nep2 peptidase (M13 family) 0.014 0.0765 0.2515
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.0664 0.141
Loa Loa (eye worm) hypothetical protein 0.0064 0.0302 0.064
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0064 0.0302 0.3864
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0073 0.0357 0.1159
Loa Loa (eye worm) integrin alpha pat-2 0.0255 0.1462 0.3102
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0068 0.0322 0.1043
Leishmania major histone deacetylase, putative 0.0041 0.0159 0.1908
Echinococcus granulosus Solute carrier family 22 5 0.1071 0.6448 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0178 0.0999
Loa Loa (eye worm) hypothetical protein 0.0024 0.0057 0.0122
Echinococcus multilocularis transcription factor Dp 1 0.004 0.015 0.0142
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.0326 0.1764
Schistosoma mansoni hypothetical protein 0.0073 0.0351 0.1141
Schistosoma mansoni histone deacetylase 0.0041 0.0159 0.0501
Entamoeba histolytica hypothetical protein 0.0036 0.0129 0.0629
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0138 0.075 0.1152
Treponema pallidum fructose-bisphosphate aldolase 0.0303 0.1755 1
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0124 0.0263
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0073 0.0357 0.4618
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0137 0.0742 0.0735
Onchocerca volvulus 0.0028 0.0079 0.005
Entamoeba histolytica hypothetical protein 0.0036 0.0129 0.0629
Brugia malayi Peptidase family M1 containing protein 0.0064 0.0302 0.064
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0138 0.075 0.1152
Mycobacterium ulcerans hypothetical protein 0.0025 0.0059 0.0245
Echinococcus granulosus lamin dm0 0.0028 0.0079 0.011
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0156 0.0783
Schistosoma mansoni ephrin receptor 0.0064 0.0301 0.0975
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.002 0.0017
Trypanosoma cruzi histone deacetylase 1, putative 0.0041 0.0159 0.1908
Loa Loa (eye worm) hypothetical protein 0.0073 0.0357 0.0757
Schistosoma mansoni neprilysin 0.0073 0.0351 0.1141
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0059 0.0124
Giardia lamblia Fructose-bisphosphate aldolase 0.0303 0.1755 1
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0021 0.0036
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0079 0.0168
Loa Loa (eye worm) hypothetical protein 0.0028 0.0079 0.0168
Schistosoma mansoni hypothetical protein 0.0509 0.3015 1
Mycobacterium ulcerans zinc metalloprotease 0.0278 0.1605 1
Giardia lamblia Histone deacetylase 0.0041 0.0159 0.0803
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0138 0.075 0.2467
Trichomonas vaginalis histone deacetylase, putative 0.0041 0.0159 0.0803
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.0742 0.2441
Toxoplasma gondii aminopeptidase N, putative 0.0064 0.0302 0.1781
Loa Loa (eye worm) hypothetical protein 0.0064 0.0302 0.064
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0064 0.0302 0.3864
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0156 0.4816
Brugia malayi Integrin alpha pat-2 precursor 0.0165 0.0917 0.1944
Toxoplasma gondii aminopeptidase n, putative 0.0064 0.0302 0.1781
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.1755 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0129 0.012
Brugia malayi TATA binding protein associated factor 0.0064 0.0302 0.064
Brugia malayi histone deacetylase 1 (HD1) 0.0041 0.0159 0.0337
Brugia malayi hypothetical protein 0.0036 0.0129 0.0273
Trypanosoma cruzi histone deacetylase 1, putative 0.0041 0.0159 0.1908
Plasmodium vivax histone deacetylase 1, putative 0.0041 0.0159 0.4937
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0008 0.0018
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0138 0.075 0.0742
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0057 0.0517
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0326 0.4191
Schistosoma mansoni integrin alpha-ps 0.0039 0.0144 0.0451
Schistosoma mansoni neprilysin-2 (M13 family) 0.014 0.0765 0.2515
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0073 0.0357 0.0349
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0148 0.0811 0.5006
Loa Loa (eye worm) hypothetical protein 0.0278 0.1605 0.3405
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0064 0.0302 1
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0138 0.075 1
Mycobacterium ulcerans aminopeptidase N PepN 0.0138 0.075 0.4608
Echinococcus granulosus geminin 0.0509 0.3015 0.4668
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.1755 1
Entamoeba histolytica aminopeptidase, putative 0.0138 0.075 0.4209
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0178 0.0913
Trypanosoma cruzi aminopeptidase, putative 0.0064 0.0302 0.3864
Brugia malayi hypothetical protein 0.0138 0.075 0.1591
Loa Loa (eye worm) hypothetical protein 0.0016 0.0008 0.0018
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.0742 0.2441
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.1755 1
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0278 0.1605 0.3405
Schistosoma mansoni hypothetical protein 0.0073 0.0351 0.1141
Toxoplasma gondii histone deacetylase HDAC3 0.0041 0.0159 0.0879
Toxoplasma gondii peptidase family M13 protein 0.0278 0.1605 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0059 0.0245
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0041 0.0159 0.0803
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0064 0.0302 0.0456
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0059 0.0224
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0021 0.0006
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0064 0.0302 0.0456
Brugia malayi MH2 domain containing protein 0.0124 0.0664 0.141
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0064 0.0302 1
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.014 0.0765 0.2515
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0178 0.0263
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0064 0.0302 0.3864
Loa Loa (eye worm) hypothetical protein 0.021 0.1192 0.2528
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0787 0.4714 1
Schistosoma mansoni hypothetical protein 0.0035 0.0125 0.0389
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0059 0.0277
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0148 0.0811 0.4864
Echinococcus granulosus lamin 0.0028 0.0079 0.011
Loa Loa (eye worm) hypothetical protein 0.0025 0.0059 0.0124
Loa Loa (eye worm) hypothetical protein 0.0064 0.0297 0.063
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0059 0.0245
Schistosoma mansoni aminopeptidase A (M01 family) 0.0064 0.0302 0.0976
Echinococcus granulosus histone deacetylase 1 0.0041 0.0159 0.0234
Onchocerca volvulus 0.0409 0.2407 0.5723
Echinococcus multilocularis histone deacetylase 1 0.0041 0.0159 0.0151
Echinococcus multilocularis geminin 0.0509 0.3015 0.3009
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0044
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0138 0.075 0.0742
Trichomonas vaginalis histone deacetylase, putative 0.0041 0.0159 0.0803
Loa Loa (eye worm) hypothetical protein 0.0345 0.2014 0.4272
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0057 0.0517
Schistosoma mansoni hypothetical protein 0.0073 0.0351 0.1141
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0138 0.075 0.4209
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0277 0.1601 0.1594
Echinococcus granulosus integrin alpha ps 0.0035 0.0125 0.0182
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0137 0.0742 0.0735
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0137 0.0742 0.1575
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.1755 1
Echinococcus multilocularis lamin 0.0028 0.0079 0.0071
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0064 0.0302 0.0976
Loa Loa (eye worm) hypothetical protein 0.0205 0.1162 0.2465
Loa Loa (eye worm) hypothetical protein 0.021 0.1192 0.2528
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0064 0.0302 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.002 0.0042
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0059 0.0224
Loa Loa (eye worm) hypothetical protein 0.0205 0.1162 0.2465
Loa Loa (eye worm) hypothetical protein 0.0073 0.0357 0.0757
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.0664 0.141
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0138 0.075 1
Trypanosoma brucei histone deacetylase 1 0.0041 0.0159 0.1908
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0178 0.5611
Schistosoma mansoni ap endonuclease 0.0018 0.002 0.0037
Schistosoma mansoni histone deacetylase 0.0041 0.0159 0.0501
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0059 0.0532
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0138 0.075 1
Trypanosoma cruzi Aminopeptidase M1, putative 0.0138 0.075 1
Brugia malayi intermediate filament protein 0.0028 0.0079 0.0168
Echinococcus granulosus endothelin converting enzyme 1 0.0278 0.1605 0.2479
Brugia malayi Angiotensin-converting enzyme family protein 0.0787 0.4714 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0178 0.0913
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0059 0.0245
Onchocerca volvulus 0.0028 0.0079 0.005
Loa Loa (eye worm) peptidase family M13 containing protein 0.0205 0.1162 0.2465
Echinococcus multilocularis lamin dm0 0.0028 0.0079 0.0071
Brugia malayi hypothetical protein 0.0213 0.1208 0.2563
Loa Loa (eye worm) hypothetical protein 0.0027 0.0076 0.0161
Brugia malayi Peptidase family M13 containing protein 0.0278 0.1605 0.3405
Plasmodium falciparum histone deacetylase 1 0.0041 0.0159 0.4937
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0057 0.0517
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0041 0.0159 0.0803
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.015 0.0824 0.2715
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0278 0.1605 0.5311
Echinococcus multilocularis aminopeptidase N 0.0409 0.2407 0.2401
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0021 0.0036
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0044
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0277 0.1601 0.5299
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.0326 0.0691
Trypanosoma brucei Aminopeptidase M1, putative 0.0138 0.075 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0138 0.075 0.0742
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0137 0.0742 0.1575
Loa Loa (eye worm) TK/EPH protein kinase 0.0082 0.0408 0.0865
Loa Loa (eye worm) acetyltransferase 0.015 0.0824 0.1749
Brugia malayi hypothetical protein 0.0016 0.0005 0.001
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0178 0.0999
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0138 0.075 0.4209

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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