Detailed information for compound 1468412

Basic information

Technical information
  • TDR Targets ID: 1468412
  • Name: N-(2,6-difluorophenyl)-2-[methyl-[(4-methylsu lfanylphenyl)methyl]amino]acetamide
  • MW: 336.399 | Formula: C17H18F2N2OS
  • H donors: 1 H acceptors: 1 LogP: 3.37 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSc1ccc(cc1)CN(CC(=O)Nc1c(F)cccc1F)C
  • InChi: 1S/C17H18F2N2OS/c1-21(10-12-6-8-13(23-2)9-7-12)11-16(22)20-17-14(18)4-3-5-15(17)19/h3-9H,10-11H2,1-2H3,(H,20,22)
  • InChiKey: ZUWQYCNUFZVFOZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2,6-difluorophenyl)-2-[methyl-[[4-(methylthio)phenyl]methyl]amino]acetamide
  • N-(2,6-difluorophenyl)-2-[methyl-[4-(methylthio)benzyl]amino]acetamide
  • N-(2,6-difluorophenyl)-2-[methyl-[(4-methylsulfanylphenyl)methyl]amino]ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni lamin 0.0028 0.0065 0.0123
Schistosoma mansoni hypothetical protein 0.0072 0.0333 0.0626
Echinococcus multilocularis Transglutaminase 0.0489 0.2869 0.2869
Schistosoma mansoni hypothetical protein 0.0042 0.0149 0.0279
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0209 0.1168 0.1168
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.1658 1 1
Schistosoma mansoni hypothetical protein 0.0177 0.097 0.1822
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0083 0.0083
Onchocerca volvulus 0.0074 0.0345 0.0362
Schistosoma mansoni aldehyde dehydrogenase 0.0133 0.0701 0.1317
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0158 0.0158
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0059 0.025 0.2875
Mycobacterium tuberculosis Hypothetical protein 0.0489 0.2869 0.7725
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0028 0.0061 0.0115
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.1052 0.1975
Onchocerca volvulus 0.0031 0.0083 0.0022
Loa Loa (eye worm) hypothetical protein 0.0091 0.0446 0.0664
Echinococcus granulosus intermediate filament protein 0.0028 0.0065 0.0065
Echinococcus granulosus adam 0.0028 0.0061 0.0061
Echinococcus granulosus geminin 0.0891 0.5325 0.5325
Brugia malayi hypothetical protein 0.0072 0.0333 0.0533
Brugia malayi Latrophilin receptor protein 2 0.0082 0.0391 0.0625
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0345 0.0688
Trichomonas vaginalis esterase, putative 0.0074 0.0345 0.0688
Schistosoma mansoni hypothetical protein 0.0082 0.0391 0.0734
Brugia malayi beta-lactamase family protein 0.0074 0.0345 0.0552
Schistosoma mansoni patched 1 0.0044 0.0158 0.0297
Brugia malayi intermediate filament protein 0.0028 0.0065 0.0104
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0057 0.0239 0.0383
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0345 1
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.0197 0.0171
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0345 0.0513
Echinococcus multilocularis cpg binding protein 0.0032 0.0089 0.0089
Mycobacterium ulcerans hypothetical protein 0.0489 0.2869 0.7725
Brugia malayi Pre-SET motif family protein 0.0031 0.0083 0.0132
Loa Loa (eye worm) hypothetical protein 0.0102 0.0513 0.0763
Schistosoma mansoni cpg binding protein 0.0032 0.0089 0.0168
Mycobacterium ulcerans transglutaminase family protein 0.0489 0.2869 0.7725
Loa Loa (eye worm) hypothetical protein 0.0074 0.0345 0.0513
Loa Loa (eye worm) hypothetical protein 0.0074 0.0345 0.0513
Echinococcus multilocularis musashi 0.0028 0.0065 0.0065
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.025 0.034
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0059 0.025 0.2875
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0345 0.0279
Giardia lamblia Transglutaminase/protease, putative 0.0489 0.2869 1
Schistosoma mansoni hypothetical protein 0.0489 0.2869 0.5388
Loa Loa (eye worm) beta-lactamase 0.0074 0.0345 0.0513
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0333 0.0626
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0057 0.0239 0.0239
Brugia malayi Pre-SET motif family protein 0.0215 0.1199 0.1918
Brugia malayi Niemann-Pick C1 protein precursor 0.0102 0.0513 0.0821
Entamoeba histolytica hypothetical protein 0.0072 0.0333 0.3152
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0286 0.0536
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0345 0.0345
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0345 0.0688
Loa Loa (eye worm) MBCTL1 0.0057 0.0239 0.0356
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0345 0.0688
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0215 0.1199 0.1785
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0101 0.0505 0.0505
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.0212 0.494
Loa Loa (eye worm) hypothetical protein 0.0306 0.1758 0.2616
Mycobacterium ulcerans hypothetical protein 0.0074 0.0345 0.0279
Onchocerca volvulus Matrilysin homolog 0.112 0.6719 0.861
Onchocerca volvulus Matrix metalloproteinase homolog 0.112 0.6719 0.861
Echinococcus granulosus cpg binding protein 0.0032 0.0089 0.0089
Brugia malayi Thioredoxin family protein 0.0489 0.2869 0.459
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0004 0.0004
Echinococcus granulosus muscleblind protein 0.0306 0.1758 0.1758
Schistosoma mansoni cpg binding protein 0.0031 0.0079 0.0148
Loa Loa (eye worm) hypothetical protein 0.0028 0.0062 0.0092
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.0076 0.0353 0.0353
Onchocerca volvulus 0.0031 0.0079 0.0017
Mycobacterium leprae Conserved hypothetical protein 0.0489 0.2869 0.766
Echinococcus multilocularis protein patched 0.0044 0.0158 0.0158
Mycobacterium ulcerans hydrolase 0.0615 0.3641 1
Trichomonas vaginalis peptide N-glycanase, putative 0.0489 0.2869 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.019 0.1052 0.1052
Onchocerca volvulus 0.005 0.0197 0.0171
Echinococcus granulosus histone acetyltransferase MYST2 0.0057 0.0239 0.0239
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0253 0.2756
Mycobacterium tuberculosis Conserved protein 0.0074 0.0345 0.0279
Brugia malayi latrophilin 2 splice variant baaae 0.0177 0.097 0.1552
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0035 0.0035
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0133 0.0701 1
Schistosoma mansoni hypothetical protein 0.0082 0.0391 0.0734
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0133 0.0701 0.0701
Mycobacterium ulcerans aldehyde dehydrogenase 0.0133 0.0701 0.133
Mycobacterium tuberculosis Conserved protein 0.0074 0.0345 0.0279
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0345 0.0279
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0345 1
Toxoplasma gondii aldehyde dehydrogenase 0.0133 0.0701 1
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.0197 0.0197
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0158 0.0158
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0083 0.0155
Schistosoma mansoni hypothetical protein 0.0024 0.0035 0.0066
Loa Loa (eye worm) hypothetical protein 0.0044 0.0158 0.0235
Schistosoma mansoni hypothetical protein 0.0082 0.0391 0.0734
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0475 0.2788 0.7484
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0286 0.0536
Loa Loa (eye worm) hypothetical protein 0.0074 0.0345 0.0513
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0104 0.0523 0.0981
Brugia malayi jmjC domain containing protein 0.0063 0.0275 0.044
Loa Loa (eye worm) hypothetical protein 0.0028 0.0065 0.0097
Echinococcus multilocularis muscleblind protein 0.0306 0.1758 0.1758
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.0197 0.0197
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0345 0.0552
Echinococcus granulosus adam 17 protease 0.0176 0.0966 0.0966
Mycobacterium ulcerans hypothetical protein 0.0489 0.2869 0.7725
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.019 0.1052 0.1565
Echinococcus granulosus lysine specific demethylase 5A 0.0065 0.0286 0.0286
Loa Loa (eye worm) hypothetical protein 0.005 0.0197 0.0293
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0083 0.0083
Mycobacterium tuberculosis Long conserved protein 0.0489 0.2869 0.7725
Loa Loa (eye worm) hypothetical protein 0.0031 0.0083 0.0123
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0345 0.0279
Mycobacterium tuberculosis Conserved protein 0.0074 0.0345 0.0279
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0345 0.0688
Leishmania major hypothetical protein, conserved 0.0074 0.0345 0.2714
Schistosoma mansoni hypothetical protein 0.0042 0.0149 0.0279
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0083 0.0155
Entamoeba histolytica hypothetical protein 0.0072 0.0333 0.3152
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0102 0.0513 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0333 0.0333
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.025 0.6395
Brugia malayi MH2 domain containing protein 0.0261 0.1483 0.2372
Echinococcus multilocularis histone acetyltransferase MYST2 0.0057 0.0239 0.0239
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0158 0.0158
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0345 0.0279
Brugia malayi Muscleblind-like protein 0.0306 0.1758 0.2812
Loa Loa (eye worm) latrophilin receptor protein 2 0.0082 0.0391 0.0582
Loa Loa (eye worm) hypothetical protein 0.0259 0.147 0.2187
Schistosoma mansoni hypothetical protein 0.0538 0.3173 0.5958
Echinococcus granulosus a disintegrin and metalloproteinase with 0.0076 0.0353 0.0353
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0082 0.0391 0.0391
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0063 0.0275 0.0275
Brugia malayi Matrixin family protein 0.0505 0.297 0.4751
Schistosoma mansoni intermediate filament proteins 0.0028 0.0065 0.0123
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.0076 0.0353 0.0663
Echinococcus multilocularis adam 0.0028 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0074 0.0345 0.0513
Giardia lamblia Hypothetical protein 0.0489 0.2869 1
Toxoplasma gondii ABC1 family protein 0.0074 0.0345 0.424
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0082 0.0391 0.0391
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0059 0.025 0.5
Schistosoma mansoni ap endonuclease 0.0059 0.025 0.047
Mycobacterium tuberculosis Conserved hypothetical protein 0.0489 0.2869 0.7725
Brugia malayi beta-lactamase 0.0074 0.0345 0.0552
Brugia malayi Calcitonin receptor-like protein seb-1 0.0259 0.147 0.2351
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.019 0.1052 0.1052
Echinococcus multilocularis lysine specific demethylase 5A 0.0063 0.0275 0.0275
Loa Loa (eye worm) hypothetical protein 0.0337 0.1945 0.2894
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0082 0.0391 0.0391
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0063 0.0275 0.0275
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0345 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0059 0.025 0.025
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0197 0.037
Brugia malayi CXXC zinc finger family protein 0.0031 0.0079 0.0126
Brugia malayi Matrixin family protein 0.1043 0.6251 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0158 0.0235
Schistosoma mansoni ADAM17 peptidase (M12 family) 0.016 0.0869 0.1631
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0065 0.0104
Schistosoma mansoni jumonji domain containing protein 0.0063 0.0275 0.0516
Brugia malayi Matrixin family protein 0.0505 0.297 0.4751
Mycobacterium tuberculosis Conserved hypothetical protein 0.0489 0.2869 0.7725
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0082 0.0391 0.0391
Onchocerca volvulus Matrilysin homolog 0.0505 0.297 0.3759
Brugia malayi hypothetical protein 0.0034 0.0099 0.0158
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0083 0.0155
Schistosoma mansoni hypothetical protein 0.0317 0.1822 0.3421
Loa Loa (eye worm) MH2 domain-containing protein 0.0261 0.1483 0.2207
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0083 0.0083
Onchocerca volvulus 0.0505 0.297 0.3759
Schistosoma mansoni aldehyde dehydrogenase 0.0133 0.0701 0.1317
Echinococcus multilocularis lamin 0.0028 0.0065 0.0065
Entamoeba histolytica hypothetical protein 0.0072 0.0333 0.3152
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.019 0.1052 0.1052
Loa Loa (eye worm) hypothetical protein 0.0053 0.0212 0.0316
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0345 0.0648
Schistosoma mansoni hypothetical protein 0.0891 0.5325 1
Loa Loa (eye worm) hypothetical protein 0.0505 0.297 0.442
Loa Loa (eye worm) mbt repeat family protein 0.005 0.0197 0.0293
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0345 0.0279
Echinococcus multilocularis Niemann Pick C1 protein 0.0102 0.0513 0.0513
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0059 0.025 0.025
Onchocerca volvulus 0.0538 0.3173 0.4021
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.0197 0.037
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0035 0.0035
Mycobacterium ulcerans putative transglutaminase-like protein 0.0489 0.2869 0.7725
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0345 0.0688
Treponema pallidum exodeoxyribonuclease (exoA) 0.0059 0.025 0.5
Mycobacterium tuberculosis Conserved protein 0.0489 0.2869 0.7725
Loa Loa (eye worm) matrixin family protein 0.112 0.6719 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0057 0.0239 0.0239
Brugia malayi CHE-14 protein 0.0044 0.0158 0.0253
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0065 0.0097
Loa Loa (eye worm) hypothetical protein 0.0505 0.297 0.442
Echinococcus granulosus polycomb protein SCMH1 0.005 0.0197 0.0197
Echinococcus multilocularis muscleblind protein 1 0.0306 0.1758 0.1758
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0505 0.297 0.5577
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.1052 0.1975
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0615 0.3641 1
Echinococcus multilocularis adam 17 protease 0.016 0.0869 0.0869
Mycobacterium ulcerans beta-lactamase 0.0074 0.0345 0.0279
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.019 0.1052 0.1682
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.1052 0.1975
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0133 0.0701 0.0701
Echinococcus multilocularis Niemann Pick C1 protein 0.0146 0.078 0.078
Onchocerca volvulus 0.1296 0.7793 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0345 0.0345
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0345 0.0279
Brugia malayi hypothetical protein 0.0028 0.0061 0.0098
Echinococcus granulosus expressed conserved protein 0.0096 0.0475 0.0475
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0079 0.0117
Schistosoma mansoni hypothetical protein 0.0042 0.0149 0.0279
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0345 0.0648
Echinococcus granulosus Niemann Pick C1 protein 0.0102 0.0513 0.0513
Brugia malayi metalloprotease disintegrin 16 with thrombospondin type I motif 0.0076 0.0353 0.0565
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0615 0.3641 0.5824
Brugia malayi jmjC domain containing protein 0.0065 0.0286 0.0457
Loa Loa (eye worm) hypothetical protein 0.0091 0.0446 0.0664
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0142 0.0756 0.142
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0345 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0259 0.147 0.2351
Schistosoma mansoni hypothetical protein 0.0891 0.5325 1
Schistosoma mansoni hypothetical protein 0.0042 0.0149 0.0279
Onchocerca volvulus 0.0074 0.0345 0.0362
Schistosoma mansoni cpg binding protein 0.0032 0.0089 0.0168
Brugia malayi Hemopexin family protein 0.0538 0.3173 0.5076
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0059 0.025 0.0373
Brugia malayi mbt repeat family protein 0.005 0.0197 0.0315
Onchocerca volvulus 0.0074 0.0345 0.0362
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0259 0.147 0.2187
Toxoplasma gondii exonuclease III APE 0.0059 0.025 0.2712
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0059 0.025 0.2875
Mycobacterium leprae PROBABLE HYDROLASE 0.0615 0.3641 1
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.025 0.034
Echinococcus multilocularis expressed conserved protein 0.0096 0.0475 0.0475
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0209 0.1168 0.1168
Mycobacterium ulcerans aldehyde dehydrogenase 0.0133 0.0701 0.133
Loa Loa (eye worm) hypothetical protein 0.0505 0.297 0.442
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0083 0.0155
Brugia malayi Matrixin family protein 0.0505 0.297 0.4751
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0004 0.0004
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.025 1
Brugia malayi beta-lactamase family protein 0.0074 0.0345 0.0552
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0295 0.0555
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0867 0.5177 0.5177
Echinococcus granulosus GPCR family 2 0.0082 0.0391 0.0391
Brugia malayi exodeoxyribonuclease III family protein 0.0059 0.025 0.04
Schistosoma mansoni hypothetical protein 0.0082 0.0391 0.0734
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0133 0.0701 0.133
Echinococcus multilocularis lamin dm0 0.0028 0.0065 0.0065
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0101 0.0505 0.0505
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0345 0.0279
Schistosoma mansoni eyes absent homolog 0.0091 0.0446 0.0838
Brugia malayi hypothetical protein 0.0091 0.0446 0.0714
Loa Loa (eye worm) hypothetical protein 0.0057 0.0239 0.0356
Mycobacterium ulcerans aldehyde dehydrogenase 0.0133 0.0701 0.133
Entamoeba histolytica hypothetical protein 0.0072 0.0333 0.3152
Schistosoma mansoni lamin 0.0028 0.0065 0.0123
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0059 0.025 0.078
Echinococcus granulosus Transglutaminase 0.0489 0.2869 0.2869
Onchocerca volvulus 0.0244 0.1379 0.17
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0072 0.0072
Brugia malayi Matrixin family protein 0.0505 0.297 0.4751
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0345 0.0279
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0082 0.0391 0.0625
Loa Loa (eye worm) hypothetical protein 0.0082 0.0391 0.0582
Echinococcus multilocularis GPCR, family 2 0.0082 0.0391 0.0391
Loa Loa (eye worm) hypothetical protein 0.0306 0.1758 0.2616
Loa Loa (eye worm) hypothetical protein 0.0615 0.3641 0.5419
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0065 0.0097
Loa Loa (eye worm) matrixin family protein 0.1043 0.6251 0.9304
Schistosoma mansoni myelin transcription factor 1 myt1 0.0057 0.0239 0.045
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0197 0.037
Echinococcus granulosus Niemann Pick C1 protein 0.0146 0.078 0.078
Echinococcus granulosus lamin dm0 0.0028 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0074 0.0345 0.0513
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.019 0.1052 0.1052
Echinococcus multilocularis geminin 0.0891 0.5325 0.5325
Loa Loa (eye worm) hypothetical protein 0.0074 0.0345 0.0513
Mycobacterium ulcerans lipase LipD 0.0074 0.0345 0.0279
Brugia malayi hypothetical protein 0.0053 0.0212 0.0339
Trichomonas vaginalis set domain proteins, putative 0.0244 0.1379 0.4504
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.0212 0.2095
Echinococcus multilocularis protein dispatched 1 0.005 0.0196 0.0196
Mycobacterium leprae Conserved hypothetical protein 0.0489 0.2869 0.766
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0333 0.0333
Loa Loa (eye worm) transcription factor SMAD2 0.0261 0.1483 0.2207
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0286 0.0425
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0345 0.0279
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.0197 0.0197
Loa Loa (eye worm) hypothetical protein 0.0054 0.0218 0.0325
Brugia malayi mbt repeat family protein 0.005 0.0197 0.0315
Echinococcus granulosus lamin 0.0028 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0177 0.097 0.1444
Loa Loa (eye worm) matrix metalloproteinase 0.0505 0.297 0.442
Schistosoma mansoni ap endonuclease 0.0059 0.025 0.047

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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