Detailed information for compound 1470156

Basic information

Technical information
  • TDR Targets ID: 1470156
  • Name: N-[2-(3-hydroxyphenyl)-4-oxo-1,2-dihydroquina zolin-3-yl]-4-methylbenzenesulfonamide
  • MW: 409.458 | Formula: C21H19N3O4S
  • H donors: 3 H acceptors: 4 LogP: 3.63 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)S(=O)(=O)NN1C(Nc2c(C1=O)cccc2)c1cccc(c1)O
  • InChi: 1S/C21H19N3O4S/c1-14-9-11-17(12-10-14)29(27,28)23-24-20(15-5-4-6-16(25)13-15)22-19-8-3-2-7-18(19)21(24)26/h2-13,20,22-23,25H,1H3
  • InChiKey: KFFGDCFVDLPPRX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[2-(3-hydroxyphenyl)-4-oxo-1,2-dihydroquinazolin-3-yl]-4-methyl-benzenesulfonamide
  • N-[2-(3-hydroxyphenyl)-4-keto-1,2-dihydroquinazolin-3-yl]-4-methyl-benzenesulfonamide
  • MLS000686458
  • N-[2-(3-hydroxyphenyl)-4-oxo-1,4-dihydroquinazolin-3(2H)-yl]-4-methylbenzenesulfonamide
  • SMR000313301

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica hypothetical protein 0.0071 0.0424 0.0407
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.003 0.0145 0.0145
Brugia malayi exodeoxyribonuclease III family protein 0.0056 0.0322 0.0322
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1457 0.98 0.98
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0344 0.0473
Echinococcus granulosus intermediate filament protein 0.0027 0.0121 0.0452
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0255 0.0237
Loa Loa (eye worm) hypothetical protein 0.005 0.0281 0.028
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0102 0.019
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.005 0.0281 0.0991
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0024
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0283 0.0283
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0028 0.0103
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0056 0.0322 0.0321
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0173 0.0173
Schistosoma mansoni RAR-like nuclear receptor 0.005 0.0281 0.0991
Trypanosoma cruzi pyruvate kinase 2, putative 0.0099 0.0614 0.1971
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0018 0.0018
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0056 0.0322 0.1202
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.028 0.028
Brugia malayi Nuclear hormone receptor family member nhr-49 0.005 0.0281 0.0281
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0018 0.0018
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0056 0.0322 0.5
Echinococcus multilocularis pyruvate kinase 0.0099 0.0614 0.1156
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0011 0.0018 0.0017
Echinococcus granulosus pyruvate kinase 0.0051 0.0287 0.1072
Loa Loa (eye worm) steroid hormone receptor 0.005 0.0281 0.028
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.1486 1 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0281 0.028
Onchocerca volvulus Huntingtin homolog 0.012 0.0752 0.0736
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0049 0.009
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0011 0.0018 0.0033
Echinococcus granulosus lamin dm0 0.0027 0.0121 0.0452
Brugia malayi intermediate filament protein 0.0027 0.0121 0.0121
Onchocerca volvulus 0.1486 1 1
Echinococcus granulosus geminin 0.0341 0.2249 0.8423
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.005 0.0281 0.028
Echinococcus granulosus nuclear receptor nhr 48 0.0024 0.0102 0.0378
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.0571 0.1827
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0712 0.4758 0.6887
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0056 0.0322 0.0304
Onchocerca volvulus 0.0024 0.0102 0.0084
Loa Loa (eye worm) DR-78 0.0024 0.0102 0.0101
Loa Loa (eye worm) hypothetical protein 0.0024 0.0102 0.0101
Loa Loa (eye worm) hypothetical protein 0.005 0.0281 0.028
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0056 0.0322 0.0304
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.005 0.0281 0.028
Schistosoma mansoni hypothetical protein 0.0071 0.0424 0.1532
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0026 0.0121 0.012
Schistosoma mansoni lamin 0.0027 0.0121 0.0389
Brugia malayi ecdysteroid receptor 0.005 0.0281 0.0281
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.005 0.0281 0.0281
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0024 0.0102 0.0084
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.005 0.0281 0.105
Loa Loa (eye worm) pyruvate kinase 0.0099 0.0614 0.0614
Giardia lamblia Pyruvate kinase 0.0099 0.0614 0.0597
Echinococcus multilocularis geminin 0.0341 0.2249 0.4235
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0283 0.0266
Loa Loa (eye worm) hypothetical protein 0.0016 0.0049 0.0048
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1457 0.98 0.98
Onchocerca volvulus Pyruvate kinase homolog 0.0099 0.0614 0.0597
Plasmodium vivax pyruvate kinase 2, putative 0.0051 0.0287 0.4506
Brugia malayi Nuclear hormone receptor family member nhr-40 0.005 0.0281 0.0281
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.005 0.0281 0.0528
Loa Loa (eye worm) hypothetical protein 0.005 0.028 0.0279
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.005 0.0281 0.028
Schistosoma mansoni thyroid hormone receptor 0.005 0.0281 0.0991
Schistosoma mansoni steroid hormone receptor ad4bp 0.005 0.0281 0.0991
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0102 0.0378
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0093 0.0571 0.1827
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0024 0.0102 0.0084
Echinococcus multilocularis pyruvate kinase 0.0051 0.0287 0.0539
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0049 0.009
Brugia malayi Nuclear hormone receptor family member nhr-1 0.005 0.0281 0.0281
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0283 0.0877
Schistosoma mansoni retinoid-x-receptor (RXR) 0.005 0.0281 0.0991
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0011 0.0018 0.0033
Onchocerca volvulus Protein ultraspiracle homolog 0.005 0.0281 0.0263
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0344 0.1229
Echinococcus granulosus nuclear receptor 2DBD gamma 0.005 0.0281 0.105
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.005 0.0281 0.0263
Loa Loa (eye worm) hypothetical protein 0.005 0.0281 0.028
Brugia malayi nuclear receptor RXR 0.0026 0.0121 0.0121
Schistosoma mansoni hypothetical protein 0.0341 0.2249 0.8413
Loa Loa (eye worm) hypothetical protein 0.0026 0.0121 0.012
Brugia malayi Steroid receptor seven-up type 2 0.005 0.0281 0.0281
Brugia malayi nuclear hormone receptor family member nhr-6 0.0024 0.0102 0.0102
Schistosoma mansoni nuclear hormone receptor 0.005 0.0281 0.0991
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.0322 0.5089
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.005 0.0281 0.028
Echinococcus multilocularis synaptojanin 1 0.0011 0.0018 0.0033
Brugia malayi tailless protein 0.0024 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0069 0.0411 0.041
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1457 0.98 0.98
Echinococcus granulosus dnaJ subfamily B 0.0403 0.267 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.0322 0.5089
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0038 0.0037
Schistosoma mansoni hypothetical protein 0.0016 0.0049 0.0115
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0011 0.0018 0.0065
Brugia malayi serine/threonine-protein kinase plk-2 0.0093 0.0571 0.0571
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.1486 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1457 0.98 0.98
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0093 0.0571 0.1074
Loa Loa (eye worm) hypothetical protein 0.005 0.0281 0.028
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.005 0.0281 0.0528
Entamoeba histolytica hypothetical protein 0.0071 0.0424 0.0407
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0017
Toxoplasma gondii pyruvate kinase PyKII 0.0051 0.0287 0.4506
Giardia lamblia Kinase, PLK 0.0093 0.0571 0.0554
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0024 0.0102 0.0101
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.1486 1 1
Brugia malayi nuclear hormone receptor 0.0024 0.0102 0.0102
Onchocerca volvulus Bile acid receptor homolog 0.005 0.0281 0.0263
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0571 0.0554
Brugia malayi hypothetical protein 0.0026 0.0121 0.0121
Trypanosoma brucei protein kinase, putative 0.0051 0.0283 0.0877
Loa Loa (eye worm) hypothetical protein 0.0026 0.0121 0.012
Loa Loa (eye worm) hypothetical protein 0.0024 0.0102 0.0101
Brugia malayi steroid hormone receptor 0.005 0.0281 0.0281
Loa Loa (eye worm) hypothetical protein 0.005 0.0281 0.028
Giardia lamblia Fructose-bisphosphate aldolase 0.1457 0.98 0.98
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.005 0.0281 0.0991
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.0121 0.0121
Schistosoma mansoni hypothetical protein 0.0034 0.0173 0.0584
Trypanosoma brucei pyruvate kinase 1 0.0099 0.0614 0.1971
Echinococcus multilocularis lamin dm0 0.0027 0.0121 0.0227
Schistosoma mansoni pyruvate kinase 0.0099 0.0614 0.2248
Brugia malayi Nuclear hormone receptor family member nhr-31 0.005 0.0281 0.0281
Brugia malayi Nuclear hormone receptor-like 1 0.005 0.0281 0.0281
Loa Loa (eye worm) pyruvate kinase 0.0099 0.0614 0.0614
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0049 0.018
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.1486 1 1
Toxoplasma gondii exonuclease III APE 0.0056 0.0322 0.5089
Treponema pallidum exodeoxyribonuclease (exoA) 0.0056 0.0322 0.031
Entamoeba histolytica hypothetical protein 0.0071 0.0424 0.0407
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0024 0.0102 0.0314
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0283 0.0877
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0026 0.0121 0.0387
Plasmodium falciparum pyruvate kinase 0.0099 0.0614 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0102 0.0378
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0049 0.0048
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0344 0.1286
Loa Loa (eye worm) pyruvate kinase-PB 0.0069 0.0411 0.041
Treponema pallidum fructose-bisphosphate aldolase 0.1457 0.98 1
Brugia malayi CXXC zinc finger family protein 0.0028 0.0133 0.0133
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0049 0.018
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.005 0.0281 0.0528
Leishmania major pyruvate kinase 0.0099 0.0614 0.1971
Trichomonas vaginalis pyruvate kinase, putative 0.0099 0.0614 0.0597
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1457 0.98 0.98
Echinococcus multilocularis nuclear receptor nhr 48 0.0024 0.0102 0.019
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0056 0.0322 0.0604
Brugia malayi hypothetical protein 0.0071 0.0424 0.0424
Loa Loa (eye worm) hypothetical protein 0.0034 0.0173 0.0172
Onchocerca volvulus Huntingtin homolog 0.012 0.0752 0.0736
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0121 0.0121
Onchocerca volvulus Pyruvate kinase homolog 0.0099 0.0614 0.0597
Echinococcus multilocularis dnaJ subfamily B 0.0403 0.267 0.5027
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0024
Onchocerca volvulus 0.0027 0.0121 0.0103
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.005 0.0281 0.0528
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0011 0.0018 0.0017
Loa Loa (eye worm) hypothetical protein 0.0024 0.0102 0.0101
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0024 0.0102 0.0102
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0121 0.0121
Echinococcus granulosus thyroid hormone receptor alpha 0.0024 0.0102 0.0378
Leishmania major hypothetical protein, conserved 0.0458 0.3042 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.005 0.0281 0.0281
Entamoeba histolytica protein tyrosine phosphatase, putative 0.1486 1 1
Onchocerca volvulus 0.0027 0.0121 0.0103
Echinococcus granulosus lamin 0.0027 0.0121 0.0452
Brugia malayi Pyruvate kinase, muscle isozyme 0.0099 0.0614 0.0614
Echinococcus multilocularis traf and tnf receptor associated protein 0.0011 0.0018 0.0033
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0571 0.0554
Loa Loa (eye worm) hypothetical protein 0.0024 0.0102 0.0101
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.005 0.0281 0.0528
Loa Loa (eye worm) hypothetical protein 0.005 0.0281 0.028
Schistosoma mansoni zinc finger protein 0.0024 0.0102 0.0314
Brugia malayi CCR4 0.0011 0.0018 0.0018
Onchocerca volvulus 0.005 0.0281 0.0263
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0093 0.0571 0.057
Brugia malayi hypothetical protein 0.0026 0.0121 0.0121
Echinococcus granulosus synaptojanin 1 0.0011 0.0018 0.0065
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-19 0.005 0.0281 0.0281
Echinococcus granulosus GPCR family 2 0.0016 0.0049 0.018
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0571 0.0554
Trypanosoma cruzi pyruvate kinase 2, putative 0.0099 0.0614 0.1971
Brugia malayi hypothetical protein 0.0024 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0017
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0011 0.0018 0.0033
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.0571 0.1827
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0283 0.0532
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0344 0.5466
Onchocerca volvulus Serine\/threonine kinase homolog 0.0093 0.0571 0.0554
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0056 0.0322 0.1003
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.005 0.0281 0.0281
Toxoplasma gondii pyruvate kinase PyK1 0.0099 0.0614 1
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0458 0.3042 0.3029
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.1486 1 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0102 0.0101
Brugia malayi hypothetical protein 0.012 0.0752 0.0752
Loa Loa (eye worm) hypothetical protein 0.0024 0.0102 0.0101
Trypanosoma cruzi hypothetical protein, conserved 0.0458 0.3042 1
Plasmodium falciparum pyruvate kinase 2 0.0051 0.0287 0.4506
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0121 0.0121
Echinococcus granulosus pyruvate kinase 0.0099 0.0614 0.2299
Loa Loa (eye worm) nuclear receptor NHR-67 0.0024 0.0102 0.0101
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0344 0.1229
Echinococcus multilocularis GPCR, family 2 0.0016 0.0049 0.009
Schistosoma mansoni ap endonuclease 0.0056 0.0322 0.1144
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.1486 1 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0102 0.0101
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.0322 0.0304
Schistosoma mansoni nuclear receptor 0.0024 0.0102 0.0314
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0018 0.0018
Entamoeba histolytica protein tyrosine phosphatase, putative 0.1486 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.005 0.0281 0.105
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.1486 1 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0028
Brugia malayi ecdysone receptor 0.0024 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0024 0.0102 0.0101
Echinococcus granulosus FTZ F1 alpha 0.005 0.0281 0.105
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0102 0.0314
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0024 0.0102 0.019
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0011 0.0018 0.0065
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0283 0.0266
Brugia malayi Nuclear hormone receptor family member nhr-25 0.005 0.0281 0.0281
Brugia malayi pyruvate kinase 0.0021 0.0083 0.0083
Schistosoma mansoni cpg binding protein 0.003 0.0144 0.0474
Schistosoma mansoni nuclear receptor nhr-48 0.0024 0.0102 0.0314
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0102 0.019
Brugia malayi conserved hypotetical protein 0.0024 0.0102 0.0102
Schistosoma mansoni hypothetical protein 0.0341 0.2249 0.8413
Brugia malayi nuclear receptor NHR-88 0.0024 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0026 0.0121 0.012
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0424 0.0798
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1457 0.98 0.98
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0011 0.0018 0.0017
Schistosoma mansoni retinoic acid receptor RXR 0.005 0.0281 0.0991
Echinococcus granulosus pyruvate kinase 0.0099 0.0614 0.2299
Brugia malayi pyruvate kinase, muscle isozyme 0.0021 0.0083 0.0083
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.005 0.0281 0.028
Schistosoma mansoni ap endonuclease 0.0056 0.0322 0.1144
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0283 0.0877
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.1028 0.6899 1
Schistosoma mansoni pyruvate kinase 0.0099 0.0614 0.2248
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0348 0.1243
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1457 0.98 0.98
Entamoeba histolytica pyruvate kinase, putative 0.0069 0.0411 0.0393
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.0121 0.0121
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.005 0.0281 0.028
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0793 0.5309 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0121 0.012
Loa Loa (eye worm) hypothetical protein 0.0026 0.0118 0.0117
Mycobacterium ulcerans pyruvate kinase 0.0099 0.0614 0.0302
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.005 0.0281 0.0991
Loa Loa (eye worm) hypothetical protein 0.0027 0.0121 0.0121
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0712 0.4758 0.4583
Giardia lamblia Pyruvate kinase 0.0051 0.0287 0.0269
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.0322 0.0304
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0011 0.0018 0.0017
Plasmodium vivax pyruvate kinase, putative 0.0099 0.0614 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0093 0.0571 0.2136
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1457 0.98 0.98
Echinococcus granulosus pyruvate kinase 0.0051 0.0287 0.1072
Schistosoma mansoni kinase 0.0047 0.0263 0.0923
Brugia malayi Nuclear hormone receptor family member nhr-41 0.005 0.0281 0.0281
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0283 0.0266
Schistosoma mansoni Tr4/Tr2 (homologue) 0.005 0.0281 0.0991
Onchocerca volvulus 0.0028 0.0133 0.0115
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.005 0.0281 0.028
Echinococcus multilocularis ecdysone induced protein 78C 0.005 0.0281 0.0528
Loa Loa (eye worm) hypothetical protein 0.0024 0.0102 0.0101
Schistosoma mansoni hypothetical protein 0.0016 0.0049 0.0115
Echinococcus multilocularis pyruvate kinase 0.0099 0.0614 0.1156
Echinococcus multilocularis musashi 0.0027 0.0121 0.0227
Loa Loa (eye worm) hypothetical protein 0.005 0.0281 0.028
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0283 0.0877
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0028 0.0052
Echinococcus granulosus pyruvate kinase 0.0051 0.0287 0.1072
Trypanosoma brucei polo-like protein kinase 0.0093 0.0571 0.1827
Schistosoma mansoni intermediate filament proteins 0.0027 0.0121 0.0389
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0283 0.0532
Leishmania major pyruvate kinase 0.0099 0.0614 0.1971
Schistosoma mansoni hypothetical protein 0.0016 0.0049 0.0115
Onchocerca volvulus Pyruvate kinase homolog 0.0099 0.0614 0.0597
Loa Loa (eye worm) hypothetical protein 0.012 0.0752 0.0752
Brugia malayi nuclear hormone receptor family member odr-7 0.0024 0.0102 0.0102
Echinococcus multilocularis cpg binding protein 0.003 0.0144 0.027
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0283 0.0266
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0458 0.3042 1
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0018 0.0018
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0024 0.0102 0.0101
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0571 0.0554
Loa Loa (eye worm) hypothetical protein 0.012 0.0752 0.0752
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0571 0.2084
Echinococcus granulosus ecdysone induced protein 78C 0.005 0.0281 0.105
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0026 0.0121 0.0226
Loa Loa (eye worm) hypothetical protein 0.0026 0.0121 0.012
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0344 0.0023
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0049 0.0049
Brugia malayi nuclear hormone receptor 0.005 0.0281 0.0281
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0018 0.0018
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0011 0.0018 0.0065
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0102 0.0102
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0344 0.1077
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0102 0.0378
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0255 0.0237
Loa Loa (eye worm) hypothetical protein 0.0024 0.0102 0.0101
Chlamydia trachomatis pyruvate kinase 0.0099 0.0614 0.5
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.005 0.0281 0.105
Echinococcus multilocularis pyruvate kinase 0.0051 0.0287 0.0539
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0571 0.0554
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.028 0.028
Schistosoma mansoni lamin 0.0027 0.0121 0.0389
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.1486 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0458 0.3042 1
Trypanosoma brucei pyruvate kinase 1, putative 0.0099 0.0614 0.1971
Schistosoma mansoni nuclear receptor 0.0024 0.0102 0.0314
Echinococcus multilocularis neutral sphingomyelinase 0.0011 0.0018 0.0033
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0056 0.0322 0.1003
Echinococcus multilocularis lamin 0.0027 0.0121 0.0227
Loa Loa (eye worm) nuclear hormone receptor 0.0024 0.0102 0.0101
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0099 0.0614 0.0866
Brugia malayi Pyruvate kinase, M2 isozyme 0.0099 0.0614 0.0614
Schistosoma mansoni hypothetical protein 0.0403 0.267 1
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0424 0.1532
Loa Loa (eye worm) pyruvate kinase 0.0099 0.0614 0.0614
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0102 0.019
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.005 0.0281 0.105
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0344 0.0023
Entamoeba histolytica serine/threonine protein kinase, putative 0.0093 0.0571 0.0554
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1457 0.98 0.98
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0056 0.0322 0.0441
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0344 0.0023
Schistosoma mansoni cpg binding protein 0.003 0.0144 0.0474
Brugia malayi orphan nuclear receptor NR2E1 0.0024 0.0102 0.0102
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0056 0.0322 0.1003
Onchocerca volvulus 0.0024 0.0102 0.0084
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.005 0.0281 0.0991
Brugia malayi hypothetical protein 0.0024 0.0102 0.0102
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0571 0.0554
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0283 0.1
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0011 0.0018 0.0017
Entamoeba histolytica hypothetical protein 0.0071 0.0424 0.0407
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0283 0.0877
Brugia malayi nuclear receptor NHR-88 0.005 0.0281 0.0281
Echinococcus multilocularis FTZ F1 alpha 0.005 0.0281 0.0528
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0133 0.0132
Brugia malayi nuclear receptor RXR 0.0024 0.0102 0.0102
Brugia malayi Nuclear hormone receptor family member nhr-19 0.005 0.0281 0.0281
Echinococcus multilocularis thyroid hormone receptor alpha 0.005 0.0281 0.0528
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0283 0.0266
Brugia malayi nuclear receptor NHR-67 0.0024 0.0102 0.0102
Brugia malayi photoreceptor-specific nuclear receptor 0.005 0.0281 0.0281
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0026 0.0121 0.045
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.005 0.0281 0.105
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0049 0.0049
Echinococcus granulosus retinoic acid receptor rxr beta a 0.005 0.0281 0.105
Schistosoma mansoni thyroid hormone receptor 0.005 0.0281 0.0991
Loa Loa (eye worm) hypothetical protein 0.0024 0.0102 0.0101
Brugia malayi Nuclear hormone receptor family member nhr-3 0.005 0.0281 0.0281
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0304 0.4801
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0102 0.0102
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1457 0.98 0.98
Schistosoma mansoni coup transcription factor 0.005 0.0281 0.0991
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0018 0.0018
Schistosoma mansoni pyruvate kinase 0.0051 0.0287 0.1013
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0283 0.0877
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0038 0.0038
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0458 0.3042 0.3029
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0571 0.0554
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0024 0.0102 0.0314
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.1486 1 1
Schistosoma mansoni cpg binding protein 0.0028 0.0133 0.0433
Echinococcus granulosus cpg binding protein 0.003 0.0144 0.0537
Echinococcus multilocularis deoxyribonuclease 1 2 0.0011 0.0018 0.0033
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0344 0.0647
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.005 0.0281 0.0528
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0024 0.0102 0.0378
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.028 0.0279
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0056 0.0322 0.1003
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0018 0.0018
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0102 0.0314
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0283 0.1059
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0024 0.0102 0.019
Brugia malayi Nuclear hormone receptor family member nhr-14 0.005 0.0281 0.0281
Echinococcus multilocularis pyruvate kinase 0.0078 0.0473 0.0889
Schistosoma mansoni hypothetical protein 0.0016 0.0049 0.0115
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0712 0.4758 1
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0018 0.0018
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0026 0.0121 0.0387
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0011 0.0018 0.0017
Echinococcus multilocularis pyruvate kinase 0.0051 0.0287 0.0539
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0283 0.4449
Brugia malayi MAP kinase sur-1 0.0051 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0024 0.0102 0.0101
Echinococcus granulosus neutral sphingomyelinase 0.0011 0.0018 0.0065
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0017
Loa Loa (eye worm) pyruvate kinase 0.0021 0.0083 0.0082
Echinococcus granulosus traf and tnf receptor associated protein 0.0011 0.0018 0.0065
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0283 0.0877
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0424 0.1588
Loa Loa (eye worm) hypothetical protein 0.0099 0.0614 0.0614
Trichomonas vaginalis pyruvate kinase, putative 0.0099 0.0614 0.0597
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0283 0.1059

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.2213 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.