Detailed information for compound 1473588

Basic information

Technical information
  • TDR Targets ID: 1473588
  • Name: [2-[2-(3,4-diethoxyphenyl)ethylamino]-2-oxoet hyl] pyridine-4-carboxylate
  • MW: 372.415 | Formula: C20H24N2O5
  • H donors: 1 H acceptors: 3 LogP: 2.68 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1cc(CCNC(=O)COC(=O)c2ccncc2)ccc1OCC
  • InChi: 1S/C20H24N2O5/c1-3-25-17-6-5-15(13-18(17)26-4-2)7-12-22-19(23)14-27-20(24)16-8-10-21-11-9-16/h5-6,8-11,13H,3-4,7,12,14H2,1-2H3,(H,22,23)
  • InChiKey: VUPLIYXRCTXCQB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-[2-(3,4-diethoxyphenyl)ethylamino]-2-oxo-ethyl] pyridine-4-carboxylate
  • 4-pyridinecarboxylic acid [2-[2-(3,4-diethoxyphenyl)ethylamino]-2-oxoethyl] ester
  • isonicotinic acid [2-[2-(3,4-diethoxyphenyl)ethylamino]-2-keto-ethyl] ester
  • ZINC03359741
  • T0519-1251

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens snurportin 1 No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum methionine aminopeptidase 1a, putative 0.1073 0.6014 0.626
Echinococcus multilocularis snurportin 1 0.0372 0.1978 0.1947
Toxoplasma gondii creatinase domain-containing protein 0.0136 0.0618 0.0607
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0155 0.0118
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.1978 0.2032
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.1693 0.9585 1
Trypanosoma brucei methionine aminopeptidase 2, putative 0.0136 0.0618 0.0607
Echinococcus multilocularis Proliferation associated protein 2G4 0.0136 0.0618 0.0582
Leishmania major methionine aminopeptidase 2, putative 0.0136 0.0618 0.0644
Toxoplasma gondii methionine aminopeptidase, type i, putative 0.1073 0.6014 0.626
Plasmodium falciparum methionine aminopeptidase 2 0.0136 0.0618 0.0607
Toxoplasma gondii peptidase D, putative 0.0136 0.0618 0.0607
Mycobacterium ulcerans methionine aminopeptidase 0.1073 0.6014 1
Leishmania major hypothetical protein, conserved 0.0136 0.0618 0.0644
Echinococcus granulosus Xaa Pro aminopeptidase 3 0.0136 0.0618 0.0582
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.0136 0.0618 0.0582
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0136 0.0618 0.0644
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.1073 0.6014 0.5999
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0184 0.0153
Giardia lamblia Methionine aminopeptidase 0.0136 0.0618 0.5
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0136 0.0618 0.0607
Schistosoma mansoni aminopeptidase P1 (M24 family) 0.0136 0.0618 0.0582
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0155 0.0118
Trypanosoma brucei hypothetical protein, conserved 0.062 0.3408 0.353
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0136 0.0618 0.0607
Trypanosoma cruzi aminopeptidase P1, putative 0.0136 0.0618 0.0644
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.0136 0.0618 0.0582
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.1073 0.6014 1
Plasmodium falciparum aminopeptidase P 0.0136 0.0618 0.0607
Loa Loa (eye worm) methionine aminopeptidase type I 0.1693 0.9585 1
Trypanosoma brucei methionine aminopeptidase, putative 0.1693 0.9585 1
Echinococcus granulosus methionine aminopeptidase type I 0.0136 0.0618 0.0582
Schistosoma mansoni hypothetical protein 0.0041 0.0074 0.0037
Schistosoma mansoni microtubule-associated protein tau 0.1765 1 1
Schistosoma mansoni Xaa-Pro dipeptidase (M24 family) 0.0136 0.0618 0.0582
Loa Loa (eye worm) hypothetical protein 0.0136 0.0618 0.0607
Brugia malayi initiation factor 2-associated protein. 0.0136 0.0618 0.0607
Brugia malayi Methionine aminopeptidase protein type I 0.1693 0.9585 1
Schistosoma mansoni methionyl aminopeptidase 2 (M24 family) 0.0136 0.0618 0.0582
Schistosoma mansoni peptidase 0.0136 0.0618 0.0582
Loa Loa (eye worm) hypothetical protein 0.006 0.0184 0.0153
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0136 0.0618 0.0644
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) 0.1073 0.6014 1
Leishmania major hypothetical protein, conserved 0.062 0.3408 0.3555
Schistosoma mansoni chromatin-specific transcription elongation factor 140 kDa subunit (M24 family) 0.0136 0.0618 0.0582
Loa Loa (eye worm) DNA-binding protein 0.0136 0.0618 0.0607
Loa Loa (eye worm) hypothetical protein 0.0041 0.0074 0.0038
Brugia malayi metallopeptidase family M24 containing protein 0.0136 0.0618 0.0607
Echinococcus multilocularis xaa Pro dipeptidase 0.0136 0.0618 0.0582
Echinococcus granulosus snurportin 1 0.0372 0.1978 0.1947
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0184 0.0153
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0136 0.0618 1
Echinococcus granulosus FACT complex subunit SPT16 0.0136 0.0618 0.0582
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0136 0.0618 0.0644
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) 0.1073 0.6014 1
Brugia malayi metallopeptidase family M24 containing protein 0.0136 0.0618 0.0607
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0155 0.0118
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0136 0.0618 0.0644
Entamoeba histolytica aminopeptidase, putative 0.0136 0.0618 1
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.1693 0.9585 0.9583
Treponema pallidum methionine aminopeptidase (map) 0.1073 0.6014 1
Echinococcus granulosus methionyl aminopeptidase 2 0.0136 0.0618 0.0582
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0136 0.0618 1
Onchocerca volvulus FACT complex subunit SPT16 homolog 0.0136 0.0618 0.5
Trypanosoma cruzi Metallopeptidase family M24, putative 0.0136 0.0618 0.0644
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0155 0.0118
Echinococcus multilocularis xaa pro aminopeptidase 0.0136 0.0618 0.0582
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0155 0.0118
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) 0.1073 0.6014 1
Toxoplasma gondii methionine aminopeptidase 2, putative 0.0136 0.0618 0.0607
Echinococcus multilocularis methionine aminopeptidase, type I 0.0136 0.0618 0.0582
Schistosoma mansoni hypothetical protein 0.0372 0.1978 0.1947
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) 0.1073 0.6014 1
Toxoplasma gondii transcriptional elongation factor FACT140 0.0136 0.0618 0.0607
Echinococcus multilocularis Xaa Pro aminopeptidase 3 0.0136 0.0618 0.0582
Mycobacterium ulcerans methionine aminopeptidase MapB 0.1073 0.6014 1
Onchocerca volvulus Methionine aminopeptidase 2 homolog 0.0136 0.0618 0.5
Trypanosoma brucei Facilitates chromatin transcription complex subunit spt16 0.0136 0.0618 0.0607
Plasmodium vivax methionine aminopeptidase 1a, putative 0.1073 0.6014 0.626
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0155 0.0123
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0136 0.0618 1
Brugia malayi DNA-binding protein, 42 kDa containing protein 0.0136 0.0618 0.0607
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0136 0.0618 1
Loa Loa (eye worm) hypothetical protein 0.0136 0.0618 0.0607
Trypanosoma brucei Metallopeptidase family M24, putative 0.0136 0.0618 0.0607
Plasmodium vivax methionine aminopeptidase 2, putative 0.0136 0.0618 0.0607
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24, putative 0.0136 0.0618 0.0644
Schistosoma mansoni aminopeptidase P homologue (M24 family) 0.0136 0.0618 0.0582
Leishmania major transcription factor-like protein 0.0136 0.0618 0.0644
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24, putative 0.0136 0.0618 0.0644
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0136 0.0618 1
Toxoplasma gondii methionine aminopeptidase 0.1693 0.9585 1
Brugia malayi metallopeptidase family M24 containing protein 0.0136 0.0618 0.0607
Echinococcus granulosus xaa Pro dipeptidase 0.0136 0.0618 0.0582
Echinococcus granulosus xaa Pro dipeptidase 0.0136 0.0618 0.0582
Trypanosoma brucei Xaa-Pro aminopeptidase, putative 0.0136 0.0618 0.0607
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0074 0.0038
Plasmodium falciparum proliferation-associated protein 2g4, putative 0.0136 0.0618 0.0607
Toxoplasma gondii methionine aminopeptidase 0.1073 0.6014 0.626
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0184 0.0153
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0136 0.0618 1
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.1693 0.9585 0.9583
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0136 0.0618 0.0644
Entamoeba histolytica Xaa-Pro dipeptidase, putative 0.0136 0.0618 1
Leishmania major aminopeptidase P, putative,metallo-peptidase, Clan MG, Family M24 0.0136 0.0618 0.0644
Plasmodium falciparum methionine aminopeptidase 1c, putative 0.0136 0.0618 0.0607
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.1693 0.9585 1
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0136 0.0618 1
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0136 0.0618 1
Echinococcus granulosus xaa pro aminopeptidase 0.0136 0.0618 0.0582
Giardia lamblia Xaa-Pro dipeptidase 0.0136 0.0618 0.5
Echinococcus multilocularis microtubule associated protein 2 0.1765 1 1
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0136 0.0618 1
Chlamydia trachomatis methionine aminopeptidase 0.1073 0.6014 1
Plasmodium vivax peptidase, putative 0.0136 0.0618 0.0607
Onchocerca volvulus Dipeptidase C homolog 0.0136 0.0618 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.062 0.3408 0.3555
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0136 0.0618 0.0644
Loa Loa (eye worm) initiation factor 2-associated protein 0.0136 0.0618 0.0607
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0136 0.0618 0.0607
Echinococcus multilocularis methionyl aminopeptidase 2 0.0136 0.0618 0.0582
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0136 0.0618 1
Loa Loa (eye worm) metallopeptidase family M24 containing protein 0.0136 0.0618 0.0607
Entamoeba histolytica methionine aminopeptidase, putative 0.0136 0.0618 1
Plasmodium falciparum methionine aminopeptidase 1b, putative 0.1693 0.9585 1
Plasmodium falciparum HP12 protein homolog, putative 0.062 0.3408 0.353
Plasmodium vivax proliferation-associated protein 2g4, putative 0.0136 0.0618 0.0607
Echinococcus multilocularis xaa Pro dipeptidase 0.0136 0.0618 0.0582
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0155 0.0118
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.1073 0.6014 0.5999
Trypanosoma cruzi Metallopeptidase family M24/FACT complex subunit (SPT16/CDC68)/Histone chaperone Rttp106-like, putative 0.0136 0.0618 0.0644
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0136 0.0618 0.0644
Plasmodium vivax methionine aminopeptidase 1c, putative 0.0136 0.0618 0.0607
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0155 0.0123
Plasmodium vivax hypothetical protein, conserved 0.062 0.3408 0.353
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.1693 0.9585 1
Entamoeba histolytica hypothetical protein, conserved 0.0136 0.0618 1
Brugia malayi RNA, U transporter 1 0.0099 0.0408 0.0387
Entamoeba histolytica peptidase, putative 0.0136 0.0618 1
Echinococcus multilocularis FACT complex subunit SPT16 0.0136 0.0618 0.0582
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0136 0.0618 1
Trypanosoma cruzi Metallopeptidase family M24, putative 0.0136 0.0618 0.0644
Plasmodium vivax FACT complex subunit SPT16, putative 0.0136 0.0618 0.0607
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0155 0.0118
Loa Loa (eye worm) hypothetical protein 0.0136 0.0618 0.0607
Plasmodium falciparum FACT complex subunit SPT16, putative 0.0136 0.0618 0.0607
Echinococcus granulosus Proliferation associated protein 2G4 0.0136 0.0618 0.0582
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0136 0.0618 1
Toxoplasma gondii proliferation-associated protein 2G4, putative 0.0136 0.0618 0.0607
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.1693 0.9585 1
Toxoplasma gondii hypothetical protein 0.062 0.3408 0.353
Plasmodium vivax methionine aminopeptidase 1b, putative 0.1693 0.9585 1
Giardia lamblia Xaa-Pro dipeptidase 0.0136 0.0618 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.062 0.3408 0.3555
Onchocerca volvulus 0.0136 0.0618 0.5
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0136 0.0618 1
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.1693 0.9585 1
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0136 0.0618 0.0644
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.1073 0.6014 0.5999
Trypanosoma cruzi aminopeptidase P, putative 0.0136 0.0618 0.0644

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0073 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) = 100 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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