Detailed information for compound 1474917

Basic information

Technical information
  • TDR Targets ID: 1474917
  • Name: [1-[(4-methoxy-3-nitrophenyl)methyl]imidazol- 2-yl]methanol
  • MW: 263.249 | Formula: C12H13N3O4
  • H donors: 1 H acceptors: 4 LogP: 0.56 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1[N+](=O)[O-])Cn1ccnc1CO
  • InChi: 1S/C12H13N3O4/c1-19-11-3-2-9(6-10(11)15(17)18)7-14-5-4-13-12(14)8-16/h2-6,16H,7-8H2,1H3
  • InChiKey: NGRNARRTVQPMPJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [1-[(4-methoxy-3-nitro-phenyl)methyl]imidazol-2-yl]methanol
  • [1-[(4-methoxy-3-nitrophenyl)methyl]-2-imidazolyl]methanol
  • [1-(4-methoxy-3-nitro-benzyl)imidazol-2-yl]methanol
  • Oprea1_035372
  • Oprea1_140785
  • BAS 00208302
  • [1-(4-Methoxy-3-nitro-benzyl)-1H-imidazol-2-yl]-methanol
  • ZINC00374920
  • AG-690/34034049

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0021 0.0389 0.0386
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0497 0.3115
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.0177 0.4542 0.454
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0087 0.2162 0.2159
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0007 0.0027 0.0177
Echinococcus granulosus ectonucleotide 0.0149 0.3801 0.8368
Mycobacterium ulcerans hypothetical protein 0.0028 0.0573 0.3622
Loa Loa (eye worm) hypothetical protein 0.0177 0.4542 0.4527
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0177 0.4542 0.454
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0669 0.2435
Brugia malayi Pre-SET motif family protein 0.0031 0.0669 0.0665
Echinococcus granulosus roundabout 2 0.0008 0.0053 0.0109
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0497 0.3115
Trypanosoma cruzi protein tyrosine phosphatase, putative 0.0021 0.0394 0.1393
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0023 0.0452 0.0989
Echinococcus granulosus expressed conserved protein 0.0097 0.2424 0.5333
Echinococcus granulosus gpi ethanolamine phosphate transferase 3 0.0028 0.0573 0.1254
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0021 0.0394 0.1431
Entamoeba histolytica phosphatidylinositol-glycan biosynthesis class O protein, putative 0.0028 0.0573 0.2128
Trypanosoma cruzi endonuclease G, putative 0.0106 0.2662 1
Echinococcus multilocularis gpi ethanolamine phosphate transferase 1 0.0028 0.0573 0.1254
Mycobacterium ulcerans hypothetical protein 0.0025 0.0497 0.3115
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0497 0.0493
Leishmania major ethanolamine phosphotransferase, putative 0.0028 0.0573 0.2071
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0022 0.0414 0.0387
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0027 0.0177
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0177 0.4542 1
Schistosoma mansoni hypothetical protein 0.0028 0.0573 0.0569
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0025 0.0487 0.1747
Echinococcus granulosus contactin 0.0008 0.0053 0.0109
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0021 0.0389 0.0363
Entamoeba histolytica hypothetical protein 0.0025 0.0487 0.1795
Loa Loa (eye worm) hypothetical protein 0.0028 0.0573 0.0547
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0177 0.4542 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0497 0.3115
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.0106 0.2662 1
Echinococcus multilocularis transferase 0.0028 0.0573 0.1254
Loa Loa (eye worm) hypothetical protein 0.0019 0.0329 0.0302
Schistosoma mansoni patched 1 0.0044 0.1016 0.1013
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0018 0.0312 0.1083
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0025 0.0487 1
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.0106 0.2662 1
Schistosoma mansoni protein tyrosine phosphatase prl 0.0021 0.0394 0.0391
Trypanosoma cruzi protein tyrosine phosphatase-like protein, putative 0.0021 0.0394 0.1393
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0669 0.0665
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0018 0.0312 0.068
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0007 0.0027 0.0177
Loa Loa (eye worm) hypothetical protein 0.0031 0.0669 0.0643
Loa Loa (eye worm) hypothetical protein 0.0025 0.0497 0.0471
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0025 0.0487 0.3055
Plasmodium falciparum protein tyrosine phosphatase 0.0021 0.0394 0.6724
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.1534 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0026 0.0533 0.1167
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0028 0.0573 0.1254
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0018 0.0312 0.1083
Giardia lamblia Phosphatidylinositol-glycan biosynthesis, class O protein 0.0028 0.0573 0.5
Brugia malayi CHE-14 protein 0.0044 0.1016 0.1013
Echinococcus granulosus roundabout 2 0.0008 0.0053 0.0109
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0007 0.0027 0.0052
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0497 0.183
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0497 0.3115
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0105 0.2634 0.2631
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0028 0.0573 0.1254
Onchocerca volvulus Ectonucleotide pyrophosphatase\/phosphodiesterase family member 6 homolog 0.0028 0.0573 0.0547
Trypanosoma cruzi protein tyrosine phosphatase-like protein, putative 0.0021 0.0394 0.1393
Echinococcus multilocularis ectonucleotide 0.0149 0.3801 0.8368
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0497 0.1782
Brugia malayi Niemann-Pick C1 protein precursor 0.0104 0.2591 0.2589
Echinococcus granulosus neuroglian 0.0008 0.0053 0.0109
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0497 0.1782
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.1534 0.3372
Onchocerca volvulus GPI ethanolamine phosphate transferase 3 homolog 0.0028 0.0573 0.0547
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0008 0.0053 0.0026
Onchocerca volvulus 0.0011 0.0135 0.0109
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.1016 0.1535
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.1534 0.5719
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0025 0.0487 0.1747
Loa Loa (eye worm) type I phosphodiesterase/nucleotide pyrophosphatase 0.0028 0.0573 0.0547
Brugia malayi hypothetical protein 0.0028 0.0573 0.0569
Trypanosoma brucei phosphatase of regenerating liver-type phosphatase, putative 0.0021 0.0394 0.1393
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0018 0.0312 0.068
Trypanosoma brucei endonuclease G, putative 0.0106 0.2662 1
Schistosoma mansoni protein tyrosine phosphatase prl 0.0021 0.0394 0.0391
Echinococcus multilocularis protein dispatched 1 0.0051 0.1183 0.26
Mycobacterium leprae hypothetical protein 0.0028 0.0573 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0301 0.1965
Echinococcus granulosus transferase 0.0028 0.0573 0.1254
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.1016 0.2231
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0027 0.0024
Loa Loa (eye worm) thrombospondin type 1 domain-containing protein 0.0382 1 1
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0487 0.8434
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0007 0.0027 0.0052
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0018 0.0312 0.068
Loa Loa (eye worm) hypothetical protein 0.0177 0.4542 0.4527
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0301 0.1965
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.1534 1
Leishmania major endonuclease G, putative 0.0106 0.2662 1
Onchocerca volvulus 0.0177 0.4542 0.4527
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.1534 0.5719
Loa Loa (eye worm) hypothetical protein 0.0019 0.0329 0.0302
Onchocerca volvulus GPI ethanolamine phosphate transferase 1 homolog 0.0028 0.0573 0.0547
Brugia malayi AEL166Cp 0.0028 0.0573 0.0569
Loa Loa (eye worm) hypothetical protein 0.0025 0.0497 0.0471
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0025 0.0487 0.5
Loa Loa (eye worm) hypothetical protein 0.0019 0.0329 0.0302
Trypanosoma cruzi protein tyrosine phosphatase, putative 0.0021 0.0394 0.1393
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0022 0.0414 0.041
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0497 0.1782
Mycobacterium leprae conserved hypothetical protein 0.0025 0.0487 0.8434
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0104 0.2591 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0329 0.0302
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0177 0.4542 1
Trypanosoma cruzi protein tyrosine phosphatase, putative 0.0021 0.0394 0.1393
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0007 0.0027 0.0177
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0669 0.0665
Leishmania major protein tyrosine phosphatase-likie protein 0.0021 0.0394 0.1393
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.0028 0.0573 0.0569
Echinococcus multilocularis roundabout 2 0.0008 0.0053 0.0109
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0177 0.4542 1
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0177 0.4542 0.454
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0177 0.4542 1
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0007 0.0027 0.0024
Schistosoma mansoni hypothetical protein 0.0028 0.0573 0.0569
Leishmania major DNA/RNA non-specific endonuclease-like protein 0.0106 0.2662 1
Echinococcus granulosus L aminoadipate semialdehyde 0.0087 0.2162 0.4756
Schistosoma mansoni hypothetical protein 0.0043 0.0973 0.097
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0497 0.3115
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0669 0.1465
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0008 0.0053 0.0109
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0021 0.0389 0.0849
Echinococcus multilocularis L aminoadipate semialdehyde 0.0087 0.2162 0.4756
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0638 0.1398
Echinococcus multilocularis Alkaline phosphatase, core domain 0.0028 0.0573 0.1254
Onchocerca volvulus 0.0018 0.0312 0.0286
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0329 0.5523
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0487 0.1747
Loa Loa (eye worm) hypothetical protein 0.0025 0.0497 0.0471
Schistosoma mansoni hypothetical protein 0.0028 0.0573 0.0569
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.1016 0.0992
Onchocerca volvulus 0.0031 0.0669 0.0643
Echinococcus multilocularis roundabout 2 0.0008 0.0053 0.0109
Schistosoma mansoni hypothetical protein 0.0043 0.0973 0.097
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0329 0.4698
Echinococcus multilocularis gpi ethanolamine phosphate transferase 3 0.0028 0.0573 0.1254
Loa Loa (eye worm) hypothetical protein 0.0054 0.1283 0.1259
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0497 0.0493
Onchocerca volvulus 0.0025 0.0497 0.0471
Trypanosoma cruzi protein tyrosine phosphatase-like protein, putative 0.0021 0.0394 0.1393
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0497 0.3115
Schistosoma mansoni cell adhesion molecule 0.0008 0.0053 0.005
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0027 0.0177
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0497 0.3237
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0497 0.3237
Echinococcus multilocularis Niemann Pick C1 protein 0.0104 0.2591 0.5702
Loa Loa (eye worm) hypothetical protein 0.0019 0.0329 0.0302
Schistosoma mansoni hypothetical protein 0.0043 0.0973 0.097
Echinococcus granulosus Protein patched homolog 1 0.0044 0.1016 0.2231
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0177 0.4542 1
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0021 0.0389 0.0386
Brugia malayi hypothetical protein 0.0028 0.0573 0.0569
Loa Loa (eye worm) hypothetical protein 0.0028 0.0573 0.0547
Loa Loa (eye worm) hypothetical protein 0.0017 0.0294 0.0268
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0669 0.1465
Echinococcus multilocularis protein patched 0.0044 0.1016 0.2231
Loa Loa (eye worm) hypothetical protein 0.0149 0.3801 0.3785
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0008 0.0053 0.0026
Entamoeba histolytica phosphatidylinositol-glycan biosynthesis class O protein, putative 0.0028 0.0573 0.2128
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0026 0.0533 0.1167
Schistosoma mansoni acetyl-CoA synthetase 0.0007 0.0027 0.0024
Echinococcus granulosus Niemann Pick C1 protein 0.0104 0.2591 0.5702
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.1534 0.3372
Echinococcus multilocularis roundabout 2 0.0008 0.0053 0.0109
Leishmania major protein tyrosine phosphatase-like protein 0.0021 0.0394 0.1393
Onchocerca volvulus 0.0177 0.4542 0.4527
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0219 0.5665 0.5653
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0329 0.2142
Toxoplasma gondii hypothetical protein 0.0018 0.0319 0.1107
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0319 0.0452
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0497 0.183
Loa Loa (eye worm) hypothetical protein 0.0104 0.2591 0.2571
Loa Loa (eye worm) hypothetical protein 0.0044 0.1016 0.0992
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0028 0.0573 0.0569
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0025 0.0487 0.3055
Plasmodium vivax SET domain protein, putative 0.0031 0.0669 1
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0007 0.0027 0.0177
Toxoplasma gondii DNA/RNA non-specific endonuclease 0.0106 0.2662 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.1534 1
Trypanosoma brucei GPI ethanolamine phosphate transferase 3, putative 0.0028 0.0573 0.2071
Echinococcus multilocularis neuroglian 0.0008 0.0053 0.0109
Echinococcus multilocularis protein tyrosine phosphatase PRL 0.0021 0.0394 0.086
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0026 0.0533 0.053
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0669 0.1465
Echinococcus multilocularis Endonuclease G 0.0106 0.2662 0.5857
Onchocerca volvulus Ectonucleotide pyrophosphatase\/phosphodiesterase family member 7 homolog 0.0028 0.0573 0.0547
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0177 0.4542 1
Trypanosoma cruzi protein tyrosine phosphatase-like protein, putative 0.0021 0.0394 0.1393
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0497 0.8601
Schistosoma mansoni hypothetical protein 0.0028 0.0573 0.0569
Echinococcus multilocularis Niemann Pick C1 protein 0.0148 0.3776 0.8311
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0007 0.0027 0.0177
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0301 0.1965
Echinococcus granulosus roundabout 2 0.0008 0.0053 0.0109
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0669 0.0665
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0021 0.0389 0.0849
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0301 0.1965
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0149 0.3801 0.8368
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0497 0.183
Loa Loa (eye worm) hypothetical protein 0.0087 0.2162 0.2141
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.1534 1
Schistosoma mansoni endonuclease related 0.0106 0.2662 0.2659
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0329 0.2
Brugia malayi endonuclease G, mitochondrial precursor 0.0106 0.2662 0.2659
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0026 0.0533 0.1167
Loa Loa (eye worm) hypothetical protein 0.0177 0.4542 0.4527
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.1534 0.1531
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0018 0.0312 0.0309
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0177 0.4542 1
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0025 0.0487 0.3178
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0027 0.0024
Leishmania major phosphopantetheinyl transferase-like protein 0.0025 0.0487 0.1747
Echinococcus granulosus Endonuclease G 0.0106 0.2662 0.5857
Plasmodium falciparum GPI ethanolamine phosphate transferase 3, putative 0.0028 0.0573 1
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0087 0.2162 0.2159
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.1534 0.1531
Echinococcus multilocularis expressed conserved protein 0.0097 0.2424 0.5333
Brugia malayi Pre-SET motif family protein 0.0219 0.5665 0.5664
Loa Loa (eye worm) hypothetical protein 0.0008 0.0053 0.0026
Schistosoma mansoni cell adhesion molecule 0.0008 0.0053 0.005
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0026 0.0533 0.1167
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0027 0.0024
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0027 0.0024
Loa Loa (eye worm) hypothetical protein 0.0028 0.0573 0.0547
Loa Loa (eye worm) hypothetical protein 0.0028 0.0573 0.0547
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0497 0.0493
Leishmania major tyrosine specific protein phosphatase, putative 0.0018 0.0312 0.1083
Schistosoma mansoni neuroglian 0.0008 0.0053 0.005
Echinococcus multilocularis sortilin receptor 0.0014 0.0217 0.0471
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0027 0.0177
Plasmodium vivax protein tyrosine phosphatase, putative 0.0021 0.0394 0.572
Echinococcus granulosus protein tyrosine phosphatase PRL 0.0021 0.0394 0.086
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0027 0.0177
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0177 0.4542 0.454
Brugia malayi Immunoglobulin I-set domain containing protein 0.0008 0.0053 0.005
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0497 0.3115
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0669 0.0665
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0487 0.7174
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0007 0.0027 0.0177
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.1016 0.2231
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0497 0.8601
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0149 0.3801 0.8368
Echinococcus granulosus Niemann Pick C1 protein 0.0148 0.3776 0.8311
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0177 0.4542 1
Onchocerca volvulus 0.0382 1 1
Trypanosoma brucei endonuclease G, putative 0.0106 0.2662 1
Trypanosoma cruzi endonuclease G, putative 0.0106 0.2662 1
Trypanosoma brucei endonuclease G, putative 0.0106 0.2662 1
Onchocerca volvulus 0.0249 0.6471 0.6461
Schistosoma mansoni hypothetical protein 0.0043 0.0973 0.097
Loa Loa (eye worm) hypothetical protein 0.0017 0.0281 0.0254
Onchocerca volvulus GPI ethanolamine phosphate transferase 2 homolog 0.0028 0.0573 0.0547
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0028 0.0573 0.1254
Brugia malayi Immunoglobulin I-set domain containing protein 0.0008 0.0053 0.005
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0177 0.4542 1
Schistosoma mansoni nephrin 0.0008 0.0053 0.005
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0177 0.4542 0.454
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0025 0.0487 0.5
Schistosoma mansoni hypothetical protein 0.0382 1 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0008 0.0053 0.005
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0177 0.4542 1
Onchocerca volvulus 0.0087 0.2162 0.2141
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0027 0.0024
Trichomonas vaginalis set domain proteins, putative 0.0249 0.6471 1
Trypanosoma cruzi protein tyrosine phosphatase PRL 0.0021 0.0394 0.1393
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0007 0.0027 0.0177

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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