TDR Targets

Basic information

Technical information

TDR Targets ID: 147618
Name: 2-[3-[4-(4-hydroxy-2-methoxyphenyl)piperazin- 1-yl]propylamino]-N,N-dimethylpyridine-3-carb oxamide
MW: 413.513 | Formula: C22H31N5O3
H donors: 2 H acceptors: 3 LogP: 2.78 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(O)ccc1N1CCN(CC1)CCCNc1ncccc1C(=O)N(C)C
InChi: 1S/C22H31N5O3/c1-25(2)22(29)18-6-4-9-23-21(18)24-10-5-11-26-12-14-27(15-13-26)19-8-7-17(28)16-20(19)30-3/h4,6-9,16,28H,5,10-15H2,1-3H3,(H,23,24)
InChiKey: CYLRLGCCLYSRGB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[3-[4-(4-hydroxy-2-methoxy-phenyl)piperazin-1-yl]propylamino]-N,N-dimethyl-pyridine-3-carboxamide
2-[3-[4-(4-hydroxy-2-methoxyphenyl)-1-piperazinyl]propylamino]-N,N-dimethyl-3-pyridinecarboxamide
2-[3-[4-(4-hydroxy-2-methoxy-phenyl)piperazino]propylamino]-N,N-dimethyl-nicotinamide
2-[3-[4-(4-hydroxy-2-methoxy-phenyl)piperazin-1-yl]propylamino]-N,N-dimethyl-nicotinamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Oryctolagus cuniculus	Alpha-1a adrenergic receptor	Starlite/ChEMBL	References
Rattus norvegicus	Alpha-1d adrenergic receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	Alpha-1D adrenergic receptor, putative	Get druggable targets OG5_128924	All targets in OG5_128924
Schistosoma mansoni	amine GPCR	Get druggable targets OG5_128924	All targets in OG5_128924
Schistosoma japonicum	ko:K04135 adrenergic receptor, alpha 1a, putative	Get druggable targets OG5_128924	All targets in OG5_128924

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma japonicum	ko:K04136 adrenergic receptor, alpha 1b, putative	Alpha-1a adrenergic receptor	466 aa	395 aa	31.1 %
Echinococcus granulosus	biogenic amine 5HT receptor	Alpha-1a adrenergic receptor	466 aa	416 aa	32.0 %
Echinococcus granulosus	g protein coupled receptor	Alpha-1a adrenergic receptor	466 aa	397 aa	20.9 %
Echinococcus multilocularis	g protein coupled receptor	Alpha-1a adrenergic receptor	466 aa	396 aa	21.7 %
Schistosoma japonicum	ko:K04135 adrenergic receptor, alpha 1a, putative	Alpha-1a adrenergic receptor	466 aa	446 aa	30.7 %
Echinococcus granulosus	g protein coupled receptor	Alpha-1a adrenergic receptor	466 aa	415 aa	21.4 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0013	0.0074	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0036	0.0017
Brugia malayi	RNA binding protein	0.0125	0.1427	0.1537
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0036	0.0018
Loa Loa (eye worm)	hypothetical protein	0.001	0.0036	0.0018
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0036	0.0018
Schistosoma mansoni	coup transcription factor	0.001	0.0036	0.002
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0036	0.002
Schistosoma mansoni	hypothetical protein	0.0062	0.0664	0.0649
Schistosoma mansoni	amine GPCR	0.0206	0.2413	0.2401
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0036	0.0017
Schistosoma mansoni	hypothetical protein	0.0048	0.0491	0.0476
Schistosoma mansoni	hypothetical protein	0.0676	0.8129	0.8126
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0036	0.0017
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0036	0.0018
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0014	0.009	0.0071
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0036	0.0017
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0062	0.0664	0.0704
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0062	0.0664	0.0646
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0036	0.0018
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0013	0.0074	1
Schistosoma mansoni	hypothetical protein	0.0062	0.0664	0.0649
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0036	0.002
Brugia malayi	hypothetical protein	0.0466	0.5568	0.606
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0036	0.0018
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0014	0.009	0.0071
Brugia malayi	ecdysteroid receptor	0.001	0.0036	0.0018
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0074	1
Brugia malayi	RNA recognition motif domain containing protein	0.0125	0.1427	0.1537
Echinococcus multilocularis	tar DNA binding protein	0.0125	0.1427	0.141
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0074	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0195	0.2283	0.2473
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0074	1
Echinococcus granulosus	geminin	0.0676	0.8129	0.8125
Brugia malayi	CXXC zinc finger family protein	0.0058	0.0622	0.0659
Onchocerca volvulus	Protein ultraspiracle homolog	0.001	0.0036	0.0031
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0074	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0063	0.0678	0.0664
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.001	0.0036	0.0031
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0195	0.2283	0.2473
Onchocerca volvulus		0.0466	0.5568	1
Onchocerca volvulus	Bile acid receptor homolog	0.001	0.0036	0.0031
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0036	0.0018
Echinococcus multilocularis	geminin	0.0676	0.8129	0.8125
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1478	0.1593
Onchocerca volvulus	Huntingtin homolog	0.0129	0.1478	0.2629
Schistosoma mansoni	dishevelled	0.0009	0.0019	0.0003
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0062	0.0664	0.0646
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0018	0.0133	0.0114
Loa Loa (eye worm)	RNA binding protein	0.0125	0.1427	0.1537
Toxoplasma gondii	aldehyde dehydrogenase	0.0063	0.0678	0.5333
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0344	0.0326
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0036	0.0018
Loa Loa (eye worm)	runx1	0.0058	0.0623	0.066
Echinococcus multilocularis	Protein lozenge	0.0058	0.0623	0.0605
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0195	0.2283	0.2473
Schistosoma mansoni	hypothetical protein	0.0133	0.1534	0.1521
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0063	0.0678	0.5
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0036	0.002
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0074	1
Brugia malayi	hypothetical protein	0.0763	0.9177	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0036	0.0018
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0036	0.0018
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0036	0.002
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0063	0.0678	0.0661
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0036	0.0017
Entamoeba histolytica	hypothetical protein	0.0035	0.0344	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0036	0.0018
Echinococcus multilocularis	serine:threonine protein kinase TAO1	0.0763	0.9177	0.9175
Echinococcus granulosus	serine:threonine protein kinase TAO1	0.0763	0.9177	0.9175
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0036	0.0018
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0036	0.0018
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0344	0.0326
Loa Loa (eye worm)	hypothetical protein	0.001	0.0036	0.0018
Schistosoma mansoni	hypothetical protein	0.0676	0.8129	0.8126
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0063	0.0678	0.5
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0036	0.002
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0036	0.0017
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0036	0.0017
Loa Loa (eye worm)	TAR-binding protein	0.0125	0.1427	0.1537
Echinococcus granulosus	survival motor neuron protein 1	0.0233	0.2743	0.273
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0014	0.009	0.0074
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0062	0.0664	0.0704
Loa Loa (eye worm)	hypothetical protein	0.001	0.0036	0.0018
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0014	0.009	0.0071
Echinococcus granulosus	GPCR family 2	0.0062	0.0664	0.0646
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0036	0.002
Brugia malayi	TAR-binding protein	0.0125	0.1427	0.1537
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0036	0.0017
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0036	0.0017
Echinococcus granulosus	cpg binding protein	0.0062	0.0662	0.0645
Schistosoma mansoni	tar DNA-binding protein	0.0125	0.1427	0.1413
Schistosoma mansoni	cpg binding protein	0.0062	0.0662	0.0648
Entamoeba histolytica	hypothetical protein	0.0035	0.0344	0.5
Brugia malayi	nuclear receptor NHR-88	0.001	0.0036	0.0018
Loa Loa (eye worm)	hypothetical protein	0.015	0.1734	0.1873
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0036	0.0017
Loa Loa (eye worm)	histone methyltransferase	0.0018	0.0133	0.0125
Echinococcus multilocularis	cpg binding protein	0.0062	0.0662	0.0645
Schistosoma mansoni	serine/threonine protein kinase	0.0763	0.9177	0.9176
Schistosoma mansoni	regulator of G protein signaling	0.0009	0.0019	0.0003
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0063	0.0678	0.5
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0013	0.0074	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0062	0.0664	0.0646
Brugia malayi	N-terminal motif family protein	0.0176	0.2047	0.2215
Schistosoma mansoni	z-protein (S1r protein)	0.0009	0.0019	0.0003
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0036	0.0018
Brugia malayi	hypothetical protein	0.015	0.1734	0.1873
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0013	0.0074	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0013	0.0074	1
Schistosoma mansoni	hypothetical protein	0.0062	0.0664	0.0649
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1534	0.1654
Schistosoma mansoni	hypothetical protein	0.0035	0.0344	0.0329
Brugia malayi	Latrophilin receptor protein 2	0.0062	0.0664	0.0704
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0125	0.1427	0.1537
Brugia malayi	hypothetical protein	0.0035	0.0344	0.0355
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0344	0.0329
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0036	0.002
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0074	1
Entamoeba histolytica	hypothetical protein	0.0035	0.0344	0.5
Schistosoma mansoni	hypothetical protein	0.0062	0.0664	0.0649
Schistosoma mansoni	aldehyde dehydrogenase	0.0063	0.0678	0.0664
Schistosoma mansoni	dishevelled	0.0009	0.0019	0.0003
Onchocerca volvulus		0.0048	0.0491	0.0851
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0036	0.0018
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0124	0.1416	0.1403
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0036	0.0018
Brugia malayi	hypothetical protein	0.0129	0.1478	0.1593
Echinococcus granulosus	tar DNA binding protein	0.0125	0.1427	0.141
Schistosoma mansoni	tar DNA-binding protein	0.0125	0.1427	0.1413
Brugia malayi	hypothetical protein	0.0233	0.2743	0.2975
Loa Loa (eye worm)	hypothetical protein	0.001	0.0036	0.0018
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0074	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0036	0.0018
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0036	0.0017
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0036	0.002
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0036	0.0018
Schistosoma mansoni	survival motor neuron protein	0.0048	0.0491	0.0476
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0036	0.002
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0664	0.0704
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0062	0.0664	0.0646
Onchocerca volvulus		0.015	0.1734	0.309
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0018	0.0133	0.0114
Brugia malayi	latrophilin 2 splice variant baaae	0.0133	0.1534	0.1654
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0058	0.0622	0.0659
Loa Loa (eye worm)	hypothetical protein	0.0466	0.5568	0.606
Toxoplasma gondii	histone lysine methyltransferase SET1	0.011	0.1256	1
Trichomonas vaginalis	helicase, putative	0.0013	0.0074	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0036	0.0017
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0036	0.0017
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0063	0.0678	0.5
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0013	0.0074	1
Schistosoma mansoni	tar DNA-binding protein	0.0125	0.1427	0.1413
Loa Loa (eye worm)	hypothetical protein	0.001	0.0036	0.0018
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0036	0.0017
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0036	0.0018
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0036	0.0018
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0074	1
Loa Loa (eye worm)	hypothetical protein	0.0466	0.5568	0.606
Schistosoma mansoni	dep domain containing protein	0.0009	0.0019	0.0003
Echinococcus multilocularis	dnaJ subfamily B	0.083	1	1
Loa Loa (eye worm)	hypothetical protein	0.0195	0.2283	0.2473
Echinococcus multilocularis	GPCR, family 2	0.0062	0.0664	0.0646
Schistosoma mansoni	lozenge	0.0058	0.0623	0.0609
Schistosoma mansoni	hypothetical protein	0.083	1	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0036	0.0018
Brugia malayi	steroid hormone receptor	0.001	0.0036	0.0018
Brugia malayi	Serine/threonine-protein kinase SULU	0.0763	0.9177	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0036	0.0017
Loa Loa (eye worm)	hypothetical protein	0.001	0.0036	0.0018
Loa Loa (eye worm)	STE/STE20/TAO protein kinase	0.0763	0.9177	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.0036	0.0017
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0036	0.002
Loa Loa (eye worm)	hypothetical protein	0.0233	0.2743	0.2975
Brugia malayi	F/Y-rich N-terminus family protein	0.0018	0.013	0.0122
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0074	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0036	0.0017
Loa Loa (eye worm)	hypothetical protein	0.001	0.0036	0.0018
Schistosoma mansoni	tar DNA-binding protein	0.0125	0.1427	0.1413
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0176	0.2047	0.3654
Entamoeba histolytica	hypothetical protein	0.0035	0.0344	0.5
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0036	0.002
Onchocerca volvulus	Huntingtin homolog	0.0129	0.1478	0.2629
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0013	0.0074	1
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0036	0.0017
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0063	0.0678	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0036	0.0018
Schistosoma mansoni	tar DNA-binding protein	0.0125	0.1427	0.1413
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.0491	0.0516
Echinococcus multilocularis	survival motor neuron protein 1	0.0233	0.2743	0.273
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0013	0.0074	1
Brugia malayi	nuclear hormone receptor	0.001	0.0036	0.0018
Onchocerca volvulus		0.001	0.0036	0.0031
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0036	0.0018
Onchocerca volvulus		0.0058	0.0622	0.1087
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0036	0.002
Schistosoma mansoni	cpg binding protein	0.0058	0.0622	0.0608
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0014	0.009	0.0071
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0063	0.0678	0.0661
Schistosoma mansoni	cpg binding protein	0.0062	0.0662	0.0648
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0036	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1478	0.1593
Schistosoma mansoni	fyve finger-containing phosphoinositide kinase fyv1	0.0009	0.0019	0.0003
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0036	0.0018
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0036	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0176	0.2047	0.2215

Activities

Activity type	Activity value	Assay description	Source	Reference
Kd (functional)	= 7.1	Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor	ChEMBL.	9276013
Kd (functional)	= 7.9	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL.	9276013
pA2 (functional)	= 7.1	Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor	ChEMBL.	9276013
pA2 (functional)	= 7.9	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL.	9276013

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL327351
PubChem: 10787895

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 147618