Detailed information for compound 1478532

Basic information

Technical information
  • TDR Targets ID: 1478532
  • Name: 6-chloro-7-hydroxy-4-methyl-8-(pyrrolidin-1-y lmethyl)chromen-2-one
  • MW: 293.745 | Formula: C15H16ClNO3
  • H donors: 1 H acceptors: 2 LogP: 2.42 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1c(Cl)cc2c(c1CN1CCCC1)oc(=O)cc2C
  • InChi: 1S/C15H16ClNO3/c1-9-6-13(18)20-15-10(9)7-12(16)14(19)11(15)8-17-4-2-3-5-17/h6-7,19H,2-5,8H2,1H3
  • InChiKey: AQNCUUIANDEMCX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 6-chloro-7-hydroxy-4-methyl-8-(1-pyrrolidinylmethyl)-2-chromenone
  • 6-chloro-7-hydroxy-4-methyl-8-(pyrrolidin-1-ylmethyl)coumarin
  • Oprea1_041156
  • ST5184781

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens endoplasmic reticulum aminopeptidase 1 Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens snurportin 1 No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Homo sapiens sphingomyelin phosphodiesterase 1, acid lysosomal Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative Get druggable targets OG5_128629 All targets in OG5_128629
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128629 All targets in OG5_128629
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative Get druggable targets OG5_128629 All targets in OG5_128629
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Brugia malayi Peptidase family M1 containing protein endoplasmic reticulum aminopeptidase 1 941 aa 846 aa 29.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0017 0.2914
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0042 0.0046 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0011 0.158
Trypanosoma cruzi aminopeptidase, putative 0.0042 0.0046 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.012 0.1392
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0009 0.0103
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0042 0.0046 0.0531
Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.4058 1 1
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0017 0.2914
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0042 0.0046 0.0531
Echinococcus granulosus aminopeptidase N 0.0042 0.0046 0.0531
Treponema pallidum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.4058 1 0.5
Echinococcus multilocularis aminopeptidase N 0.0042 0.0046 0.0531
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0027 0.0009 0.0106
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0027 0.0009 0.0106
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0028 0.0023
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0042 0.0046 0.0531
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0005 0.0057
Loa Loa (eye worm) hypothetical protein 0.0182 0.0394 0.4543
Schistosoma mansoni hypothetical protein 0.0025 0.0003 0.0037
Echinococcus multilocularis snurportin 1 0.0372 0.0863 1
Brugia malayi hypothetical protein 0.0042 0.0046 0.1053
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.01 0.0189 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0049 0.0567
Wolbachia endosymbiont of Brugia malayi 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.4058 1 0.5
Mycobacterium tuberculosis Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras 0.2999 0.7374 0.5
Trypanosoma brucei Aminopeptidase M1, putative 0.0042 0.0046 1
Mycobacterium ulcerans 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.4058 1 1
Plasmodium falciparum importin beta, putative 0.0035 0.0028 0.0023
Loa Loa (eye worm) hypothetical protein 0.003 0.0017 0.0159
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0011 0.158
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0042 0.0046 0.0531
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0042 0.0046 0.0531
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0017 0.0012
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0042 0.0046 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0005 0.0057
Brugia malayi Peptidase family M1 containing protein 0.0042 0.0046 0.1053
Loa Loa (eye worm) hypothetical protein 0.01 0.0189 0.2157
Toxoplasma gondii 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.4058 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0069 0.0767
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0005 0.5
Loa Loa (eye worm) hypothetical protein 0.0027 0.0009 0.0069
Trypanosoma cruzi Aminopeptidase M1, putative 0.0042 0.0046 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0056 0.0618
Echinococcus granulosus snurportin 1 0.0372 0.0863 1
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0017 0.0012
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.01 0.0189 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0009 0.0069
Brugia malayi Bromodomain containing protein 0.0091 0.0166 0.414
Leishmania major hypothetical protein, conserved 0.003 0.0017 0.2914
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0009 0.0103
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0042 0.0046 1
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0042 0.0046 1
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0017 0.0012
Brugia malayi Peptidase family M1 containing protein 0.0042 0.0046 0.1053
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0042 0.0046 0.0531
Mycobacterium leprae PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS 0.4058 1 0.5
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0028 0.0321
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0042 0.0046 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0011 0.158
Loa Loa (eye worm) aminopeptidase N 0.0042 0.0046 0.0497
Schistosoma mansoni bromodomain containing protein 0.0076 0.0131 0.1516
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0017 0.0012
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0042 0.0046 0.0531
Loa Loa (eye worm) hypothetical protein 0.0085 0.0153 0.1744
Brugia malayi Bromodomain containing protein 0.0046 0.0056 0.1315
Plasmodium vivax importin-beta 2, putative 0.0035 0.0028 0.0023
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.012 0.1392
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.0863 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0042 0.0046 0.0531
Brugia malayi Importin beta-1 subunit 0.0035 0.0028 0.0586
Brugia malayi RNA, U transporter 1 0.0099 0.0187 0.4679
Entamoeba histolytica aminopeptidase, putative 0.0042 0.0046 0.2228
Brugia malayi hypothetical protein 0.0182 0.0394 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0028 0.5568
Loa Loa (eye worm) hypothetical protein 0.0035 0.0028 0.0286
Echinococcus granulosus importin subunit beta 1 0.0035 0.0028 0.0321
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0027 0.0009 0.1027
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0042 0.0046 1
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0042 0.0046 0.0531
Plasmodium vivax 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.4058 1 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0011 0.158
Leishmania major importin beta-1 subunit, putative 0.0028 0.0011 0.158
Schistosoma mansoni hypothetical protein 0.0372 0.0863 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0009 0.0069
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0009 0.0103
Schistosoma mansoni importin beta-1 0.0035 0.0028 0.0321
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0042 0.0046 0.0531
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0042 0.0046 0.0531
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0028 0.5568
Brugia malayi PHD-finger family protein 0.003 0.0016 0.0284
Loa Loa (eye worm) hypothetical protein 0.0049 0.0063 0.07
Schistosoma mansoni ran 0.0026 0.0005 0.0057
Onchocerca volvulus 0.0182 0.0394 1
Schistosoma mansoni ran 0.0026 0.0005 0.0057
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0042 0.0046 0.0531
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0017 0.2914
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0005 0.002
Trypanosoma brucei Aminopeptidase M1, putative 0.0042 0.0046 1
Brugia malayi hypothetical protein 0.003 0.0017 0.0307
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0049 0.0567
Entamoeba histolytica hypothetical protein 0.0028 0.0011 0.0352

Activities

Activity type Activity value Assay description Source Reference
AbsAC200_uM (binding) 1.4 uM PubChem BioAssay. MLPCN ERAP2 Measured in Biochemical System Using Plate Reader - 7016-02_Inhibitor_Dose_CherryPick_Activity. (absACnn = the concentration at which the curve crosses threshold nn uM) (Class of assay: confirmatory) ChEMBL. No reference
AC50 (binding) 5.76 uM PubChem BioAssay. MLPCN ERAP1 Measured in Biochemical System Using Plate Reader - 7016-01_Inhibitor_Dose_CherryPick_Activity_Set2. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.7079 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.581 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 70.7946 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 75.193 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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