Detailed information for compound 1484103

Basic information

Technical information
  • TDR Targets ID: 1484103
  • Name: N-cyclooctyl-2-[(4-oxo-6-propyl-1H-pyrimidin- 2-yl)sulfanyl]acetamide
  • MW: 337.48 | Formula: C17H27N3O2S
  • H donors: 2 H acceptors: 4 LogP: 4.45 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCc1nc(SCC(=O)NC2CCCCCCC2)nc(c1)O
  • InChi: 1S/C17H27N3O2S/c1-2-8-14-11-15(21)20-17(19-14)23-12-16(22)18-13-9-6-4-3-5-7-10-13/h11,13H,2-10,12H2,1H3,(H,18,22)(H,19,20,21)
  • InChiKey: KJRZIBXWOVUDJA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-cyclooctyl-2-[(4-oxo-6-propyl-1H-pyrimidin-2-yl)thio]acetamide
  • N-cyclooctyl-2-[(4-keto-6-propyl-1H-pyrimidin-2-yl)thio]acetamide
  • N-cyclooctyl-2-[(4-oxo-6-propyl-1H-pyrimidin-2-yl)sulfanyl]ethanamide
  • T0512-3273
  • ZINC04865227
  • Oprea1_500797

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.0058 0.0298 0.0805
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0005
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0058 0.0298 0.0367
Onchocerca volvulus 0.0027 0.0063 0.0089
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0028 0.0103
Echinococcus multilocularis tar DNA binding protein 0.0041 0.0167 0.1066
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0028 0.5
Schistosoma mansoni tar DNA-binding protein 0.0041 0.0167 0.0446
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.0058 0.0298 0.2784
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0027 0.0063 0.0436
Onchocerca volvulus 0.002 0.0007 0.0004
Loa Loa (eye worm) hypothetical protein 0.0154 0.1022 0.1986
Echinococcus granulosus protein prenyltransferase alpha subunit 0.004 0.0159 0.1014
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0023 0.0033 0.0188
Entamoeba histolytica hypothetical protein 0.0027 0.0063 0.0231
Mycobacterium tuberculosis Acetolactate synthase (large subunit) IlvB1 (acetohydroxy-acid synthase) 0.0045 0.0201 0.0188
Trypanosoma cruzi phosphonopyruvate decarboxylase, putative 0.0034 0.0117 0.1122
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0198 0.0298
Loa Loa (eye worm) hypothetical protein 0.0035 0.0123 0.0231
Loa Loa (eye worm) hypothetical protein 0.0027 0.0063 0.0113
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.004 0.0159 0.1612
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0198 0.0211
Schistosoma mansoni hypothetical protein 0.0109 0.0686 0.187
Toxoplasma gondii N-acetylglucosaminylphosphatidylinositol deacetylase 0.0044 0.0192 0.1382
Loa Loa (eye worm) hypothetical protein 0.0195 0.1336 0.2599
Loa Loa (eye worm) hexokinase 0.0051 0.0247 0.0473
Loa Loa (eye worm) hypothetical protein 0.0187 0.1272 0.2474
Onchocerca volvulus 0.0051 0.0247 0.0374
Schistosoma mansoni SET domain protein 0.0028 0.007 0.0178
Brugia malayi Hexokinase family protein 0.0051 0.0247 0.0473
Brugia malayi M-phase phosphoprotein, mpp8 0.0027 0.0063 0.0113
Entamoeba histolytica N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase, putative 0.0044 0.0192 0.1094
Schistosoma mansoni hypothetical protein 0.0109 0.0686 0.187
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0221 0.1529 0.2975
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.0058 0.0298 0.1925
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0023 0.0033 0.0188
Plasmodium vivax heterochromatin protein 1, putative 0.0027 0.0063 0.0349
Leishmania major hexokinase, putative 0.0051 0.0247 0.2618
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0198 0.0211
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.004 0.0159 0.0151
Mycobacterium leprae Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) 0.0106 0.066 0.066
Trichomonas vaginalis chromobox protein, putative 0.0065 0.0348 0.0444
Loa Loa (eye worm) hypothetical protein 0.0072 0.0405 0.0781
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0041 0.0167 0.0317
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0154 0.1022 0.1494
Brugia malayi latrophilin 2 splice variant baaae 0.0022 0.0024 0.0038
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0159 0.1612
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0027 0.0063 0.0159
Schistosoma mansoni CD36-like class B scavenger receptor 0.0072 0.0405 0.1098
Echinococcus granulosus Chromobox protein 3 0.0027 0.0063 0.0379
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.004 0.0159 0.1121
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0154 0.1022 1
Onchocerca volvulus 0.0195 0.1336 0.2054
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.004 0.0159 0.0424
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.004 0.0159 0.1612
Mycobacterium ulcerans hypothetical protein 0.0106 0.066 0.066
Echinococcus multilocularis CD36 class B scavenger receptor 0.0072 0.0405 0.2625
Brugia malayi CHD4 protein 0.0027 0.0063 0.0113
Giardia lamblia Glucosamine-6-phosphate isomerase, putative 0.0044 0.0192 0.038
Entamoeba histolytica glucosamine-6-phosphate isomerase, putative 0.0044 0.0192 0.1094
Echinococcus multilocularis Chromo domain 0.0027 0.0063 0.0379
Echinococcus granulosus lysosome membrane protein 2 0.0072 0.0405 0.2625
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0078 0.0449 0.3436
Schistosoma mansoni single-minded 0.0022 0.0024 0.0051
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0027 0.0063 0.0379
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.0058 0.0298 0.3205
Loa Loa (eye worm) ILVBL protein 0.0064 0.0343 0.066
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0136 0.089 0.1289
Echinococcus granulosus N acetylglucosaminyl phosphatidylinositol 0.0044 0.0192 0.1229
Echinococcus granulosus L aminoadipate semialdehyde 0.008 0.0464 0.3012
Schistosoma mansoni chromobox protein 0.0065 0.0348 0.0941
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0027 0.0063 0.0349
Mycobacterium ulcerans acetolactate synthase 1 catalytic subunit 0.0106 0.066 0.066
Schistosoma mansoni chromobox protein 0.0027 0.0063 0.0159
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0028 0.0028
Trypanosoma cruzi hypothetical protein, conserved 0.0058 0.0298 0.3205
Echinococcus multilocularis CD36 class B scavenger receptor 0.0072 0.0405 0.2625
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0187 0.1272 0.3477
Plasmodium falciparum N-acetylglucosaminylphosphatidylinositol deacetylase, putative 0.0044 0.0192 0.1726
Trichomonas vaginalis set domain proteins, putative 0.0875 0.6484 1
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0063 0.0231
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0154 0.1022 0.6675
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0179 0.1215 0.794
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0058 0.0298 0.2229
Entamoeba histolytica hypothetical protein 0.0023 0.0033 0.0036
Loa Loa (eye worm) hexokinase type II 0.0051 0.0247 0.0473
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0136 0.089 0.1289
Brugia malayi hexokinase 0.0051 0.0247 0.0473
Loa Loa (eye worm) hypothetical protein 0.0058 0.0298 0.0573
Trypanosoma brucei N-acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase 0.0044 0.0192 0.1988
Onchocerca volvulus 0.008 0.0464 0.0708
Brugia malayi Calcitonin receptor-like protein seb-1 0.0032 0.0101 0.0188
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0136 0.089 0.1289
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0136 0.089 0.1289
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0063 0.0349
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0028 0.0072
Brugia malayi glutathione reductase 0.0021 0.0019 0.0028
Plasmodium falciparum geranylgeranyltransferase, putative 0.0058 0.0298 0.2784
Schistosoma mansoni hypothetical protein 0.0027 0.0063 0.0159
Onchocerca volvulus 0.0051 0.0247 0.0374
Trypanosoma brucei phosphonopyruvate decarboxylase-like protein, putative 0.0034 0.0117 0.1122
Leishmania major geranylgeranyltransferase, putative 0.0058 0.0298 0.3205
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.0058 0.0298 0.2229
Schistosoma mansoni N-acetylglucosaminyl-phosphatidylinositol de-n-acetylase 0.0044 0.0192 0.0514
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0154 0.1022 0.6624
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0136 0.089 0.1729
Mycobacterium tuberculosis Conserved hypothetical protein 0.0044 0.0192 0.018
Giardia lamblia Prenyltransferase 0.0136 0.089 0.8472
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0136 0.089 0.8686
Schistosoma mansoni tar DNA-binding protein 0.0041 0.0167 0.0446
Mycobacterium ulcerans putative oxalyl-CoA decarboxylase 0.0106 0.066 0.066
Trypanosoma cruzi protein farnesyltransferase, putative 0.0136 0.089 1
Brugia malayi Pre-SET motif family protein 0.0696 0.5127 1
Echinococcus granulosus tar DNA binding protein 0.0041 0.0167 0.1066
Loa Loa (eye worm) thioredoxin reductase 0.0021 0.0019 0.0028
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.0221 0.1529 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0696 0.5127 1
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0063 0.0349
Trypanosoma cruzi lanosterol synthase, putative 0.0058 0.0298 0.3205
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0187 0.1272 0.8315
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.004 0.0159 0.1612
Loa Loa (eye worm) hypothetical protein 0.0045 0.0198 0.0377
Trypanosoma cruzi N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative 0.0044 0.0192 0.1988
Brugia malayi MH2 domain containing protein 0.0077 0.0441 0.0852
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0114 0.072 0.1024
Mycobacterium ulcerans pyruvate or indole-3-pyruvate decarboxylase Pdc 0.0061 0.0316 0.0316
Echinococcus granulosus histone lysine methyltransferase setb 0.0187 0.1272 0.8315
Loa Loa (eye worm) TAR-binding protein 0.0041 0.0167 0.0317
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0058 0.0298 0.0367
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0027 0.0063 0.0159
Loa Loa (eye worm) heterochromatin protein 1 0.0065 0.0348 0.0669
Echinococcus granulosus chromobox protein 1 0.0065 0.0348 0.225
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0063 0.0231
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0136 0.089 0.5811
Mycobacterium ulcerans acetolactate synthase large subunit IlvB 0.0061 0.0316 0.0316
Echinococcus multilocularis Chromobox protein 3 0.0027 0.0063 0.0379
Trichomonas vaginalis chromobox protein, putative 0.0065 0.0348 0.0444
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.004 0.0159 0.1612
Brugia malayi PAS domain containing protein 0.0022 0.0024 0.0037
Schistosoma mansoni acetolactate synthase 0.0091 0.0543 0.1477
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0187 0.1272 0.3477
Loa Loa (eye worm) hypothetical protein 0.0027 0.0063 0.0113
Mycobacterium tuberculosis N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB (GlcNAc-Ins deacetylase) 0.0044 0.0192 0.018
Schistosoma mansoni aryl hydrocarbon receptor 0.0022 0.0024 0.0051
Entamoeba histolytica hypothetical protein 0.0023 0.0033 0.0036
Schistosoma mansoni chromobox protein 0.0065 0.0348 0.0941
Mycobacterium ulcerans acetolactate synthase 0.0061 0.0316 0.0316
Echinococcus multilocularis CD36 class B scavenger receptor 0.0072 0.0405 0.2625
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.004 0.0159 0.1014
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0154 0.1022 0.1986
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0136 0.089 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0212 0.032
Mycobacterium ulcerans N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB 0.0044 0.0192 0.0192
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0028 0.007 0.0425
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0221 0.1529 0.2283
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0221 0.1529 1
Brugia malayi Uncharacterized LmbE-like protein, COG2120 containing protein 0.0044 0.0192 0.0366
Echinococcus multilocularis lysosome membrane protein 2 0.0072 0.0405 0.2625
Mycobacterium leprae PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) 0.0106 0.066 0.066
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0028 0.0072
Onchocerca volvulus Lysosome membrane protein 2 homolog 0.0072 0.0405 0.0617
Schistosoma mansoni tar DNA-binding protein 0.0041 0.0167 0.0446
Loa Loa (eye worm) hypothetical protein 0.0027 0.0064 0.0116
Loa Loa (eye worm) hypothetical protein 0.0032 0.0101 0.0188
Echinococcus multilocularis L aminoadipate semialdehyde 0.008 0.0464 0.3012
Leishmania major protein farnesyltransferase alpha subunit, putative 0.004 0.0159 0.1612
Plasmodium falciparum heterochromatin protein 1 0.0027 0.0063 0.0436
Brugia malayi hypothetical protein 0.0027 0.0063 0.0113
Leishmania major N-acetyl-D-acetylglucosaminylphosphatidylinositol deacetylase 0.0044 0.0192 0.1988
Trypanosoma cruzi protein farnesyltransferase, putative 0.0136 0.089 1
Mycobacterium tuberculosis Mycothiol conjugate amidase Mca (mycothiol S-conjugate amidase) 0.1295 0.9665 1
Schistosoma mansoni acetolactate synthase 0.0091 0.0543 0.1477
Brugia malayi hypothetical protein 0.0074 0.0415 0.0801
Echinococcus granulosus hexokinase 0.0051 0.0247 0.159
Brugia malayi SET domain containing protein 0.0321 0.2291 0.4464
Loa Loa (eye worm) hypothetical protein 0.0294 0.2086 0.4063
Plasmodium vivax acyl-CoA synthetase, putative 0.0061 0.0316 0.2374
Loa Loa (eye worm) hypothetical protein 0.0027 0.0063 0.0113
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.004 0.0159 0.0302
Giardia lamblia Rab geranylgeranyltransferase 0.0058 0.0298 0.1609
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0501 0.3648 1
Mycobacterium ulcerans hypothetical protein 0.0034 0.0117 0.0117
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0212 0.0233
Echinococcus granulosus CD36 class B scavenger receptor 0.0072 0.0405 0.2625
Onchocerca volvulus 0.0027 0.0063 0.0089
Trypanosoma cruzi hypothetical protein, conserved 0.0058 0.0298 0.3205
Mycobacterium tuberculosis Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) 0.0106 0.066 0.0664
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.008 0.0464 0.1259
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.008 0.0464 0.0896
Entamoeba histolytica hexokinase 1 0.0051 0.0247 0.146
Leishmania major hexokinase, putative 0.0051 0.0247 0.2618
Plasmodium vivax geranylgeranyltransferase, putative 0.0058 0.0298 0.2229
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.004 0.0159 0.0302
Loa Loa (eye worm) hypothetical protein 0.0022 0.0024 0.0038
Echinococcus multilocularis CD36 class B scavenger receptor 0.0072 0.0405 0.2625
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.0058 0.0298 0.1801
Echinococcus granulosus chromobox protein 1 0.0065 0.0348 0.225
Brugia malayi Protein cec-1. 0.0027 0.0063 0.0113
Loa Loa (eye worm) hexokinase 0.0051 0.0247 0.0473
Onchocerca volvulus 0.0051 0.0247 0.0374
Trypanosoma brucei hexokinase 0.0051 0.0247 0.2618
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.004 0.0159 0.0876
Brugia malayi Pre-SET motif family protein 0.0187 0.1272 0.2474
Brugia malayi RNA recognition motif domain containing protein 0.0041 0.0167 0.0317
Loa Loa (eye worm) phosphatidylinositol glycan anchor biosynthesis protein 0.0044 0.0192 0.0366
Leishmania major farnesyltransferase beta subunit 0.0136 0.089 1
Echinococcus multilocularis chromobox protein 2 0.0027 0.0063 0.0379
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0027 0.0063 0.0379
Onchocerca volvulus 0.004 0.0159 0.0239
Entamoeba histolytica hexokinase 2 0.0051 0.0247 0.146
Plasmodium vivax N-acetylglucosaminylphosphatidylinositol deacetylase, putative 0.0044 0.0192 0.1382
Trypanosoma cruzi lanosterol synthase, putative 0.0058 0.0298 0.3205
Loa Loa (eye worm) thiamine pyrophosphate enzyme 0.0061 0.0317 0.061
Loa Loa (eye worm) hypothetical protein 0.0072 0.0405 0.0781
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0187 0.1272 1
Brugia malayi hypothetical protein 0.0023 0.0033 0.0056
Loa Loa (eye worm) hypothetical protein 0.0072 0.0405 0.0781
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0212 0.0233
Brugia malayi chromobox protein homolog 3 0.0045 0.0198 0.0377
Echinococcus multilocularis chromobox protein 1 0.0065 0.0348 0.225
Trypanosoma cruzi N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative 0.0044 0.0192 0.1988
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0028 0.009
Plasmodium falciparum hexokinase 0.0051 0.0247 0.2274
Brugia malayi Valyl-tRNA synthetase 0.0027 0.0063 0.0113
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.004 0.0159 0.1612
Loa Loa (eye worm) helicase 0.0027 0.0063 0.0113
Echinococcus granulosus CD36 class B scavenger receptor 0.0072 0.0405 0.2625
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0136 0.089 0.6954
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0136 0.089 0.1289
Brugia malayi hypoxia-induced factor 1 0.0068 0.0372 0.0716
Echinococcus granulosus Chromo domain 0.0027 0.0063 0.0379
Schistosoma mansoni tar DNA-binding protein 0.0041 0.0167 0.0446
Brugia malayi Thioredoxin reductase 0.0021 0.0019 0.0028
Echinococcus granulosus chromobox protein 2 0.0027 0.0063 0.0379
Plasmodium falciparum acyl-CoA synthetase 0.0061 0.0316 0.2966
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0028 0.0028
Echinococcus multilocularis geminin 0.0109 0.0686 0.4472
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0063 0.0231
Brugia malayi Thiamine pyrophosphate enzyme, central domain containing protein 0.0106 0.066 0.1278
Echinococcus granulosus hexokinase type 2 0.0051 0.0247 0.159
Onchocerca volvulus 0.0875 0.6484 1
Schistosoma mansoni hexokinase 0.0051 0.0247 0.0665
Brugia malayi hypothetical protein 0.0027 0.0064 0.0116
Brugia malayi hypothetical protein 0.0195 0.1336 0.2599
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.0058 0.0298 0.3205
Brugia malayi Associated with TFs and helicases family protein 0.0027 0.0063 0.0113
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0221 0.1529 0.4182
Echinococcus multilocularis hexokinase type 2 0.0051 0.0247 0.159
Mycobacterium tuberculosis Probable oxalyl-CoA decarboxylase OxcA 0.0106 0.066 0.0664
Treponema pallidum hexokinase (hxk) 0.0051 0.0247 1
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0154 0.1022 0.1986
Plasmodium vivax SET domain protein, putative 0.0187 0.1272 1
Echinococcus multilocularis hexokinase 0.0051 0.0247 0.159
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.004 0.0159 0.1014
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.0058 0.0298 0.2229
Loa Loa (eye worm) hypothetical protein 0.0074 0.0415 0.0801
Brugia malayi hypothetical protein 0.0027 0.0064 0.0116
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0044 0.0192 0.0202
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0028 0.0028
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0221 0.1529 0.2975
Trypanosoma brucei hexokinase 0.0051 0.0247 0.2618
Loa Loa (eye worm) hypothetical protein 0.0314 0.2234 0.4352
Echinococcus multilocularis N acetylglucosaminyl phosphatidylinositol 0.0044 0.0192 0.1229
Echinococcus granulosus CD36 class B scavenger receptor 0.0072 0.0405 0.2625
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0027 0.0063 0.0349
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0154 0.1022 0.6675
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0028 0.0103
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0027 0.0063 0.0113
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0136 0.089 0.6954
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0159 0.1612
Onchocerca volvulus 0.0501 0.3648 0.5624
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0154 0.1022 0.1494
Toxoplasma gondii hexokinase 0.0051 0.0247 0.1821
Mycobacterium ulcerans mycothiol conjugate amidase Mca 0.134 1 1
Entamoeba histolytica hypothetical protein 0.0023 0.0033 0.0036
Loa Loa (eye worm) hexokinase 0.0032 0.0102 0.0189
Toxoplasma gondii hypothetical protein 0.0114 0.072 0.5596
Brugia malayi TAR-binding protein 0.0041 0.0167 0.0317
Echinococcus granulosus CD36 class B scavenger receptor 0.0072 0.0405 0.2625
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.004 0.0159 0.1612
Trypanosoma brucei hexokinase, putative 0.0051 0.0247 0.2618
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0221 0.1529 0.4182
Loa Loa (eye worm) MH2 domain-containing protein 0.0077 0.0441 0.0852
Giardia lamblia Rab geranylgeranyltransferase 0.0154 0.1022 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0187 0.1272 0.3477
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0154 0.1022 0.2792
Loa Loa (eye worm) hypothetical protein 0.0058 0.0298 0.0573
Loa Loa (eye worm) CHromoDomain protein family member 0.0027 0.0063 0.0113
Loa Loa (eye worm) hypothetical protein 0.0027 0.0063 0.0113
Leishmania major phosphonopyruvate decarboxylase-like protein 0.0034 0.0117 0.1122
Echinococcus granulosus geminin 0.0109 0.0686 0.4472
Loa Loa (eye worm) RNA binding protein 0.0041 0.0167 0.0317
Brugia malayi Heterochromatin protein 1 0.0065 0.0348 0.0669
Schistosoma mansoni hypothetical protein 0.0022 0.0024 0.0053
Trypanosoma cruzi hexokinase, putative 0.0051 0.0247 0.2618
Toxoplasma gondii hypothetical protein 0.004 0.0159 0.1121
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0154 0.1022 0.8006
Entamoeba histolytica hypothetical protein 0.0023 0.0033 0.0036
Loa Loa (eye worm) hypoxia-induced factor 1 0.0068 0.0372 0.0716
Echinococcus multilocularis CD36 class B scavenger receptor 0.0072 0.0405 0.2625
Echinococcus multilocularis chromobox protein 1 0.0065 0.0348 0.225
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0154 0.1022 0.1494
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0027 0.0063 0.0436
Echinococcus granulosus thioredoxin glutathione reductase 0.0022 0.0021 0.0107
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0028 0.5
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0136 0.089 0.5811
Mycobacterium leprae N-Acetyl-1-D-myo-Inosityl-2-Amino-2-Deoxy-alpha-D-Glucopyranoside Deacetylase MshB (GlcNAc-Ins deacetylase) 0.0044 0.0192 0.0192
Plasmodium vivax hexokinase, putative 0.0051 0.0247 0.1821
Schistosoma mansoni transcription factor LCR-F1 0.0023 0.0033 0.0078
Loa Loa (eye worm) glutathione reductase 0.0021 0.0019 0.0028
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0027 0.0063 0.0379
Leishmania major putative pyruvate/indole-pyruvate carboxylase, putative 0.0061 0.0316 0.3414
Brugia malayi Hexokinase family protein 0.0032 0.0102 0.0189
Entamoeba histolytica hypothetical protein 0.0027 0.0063 0.0231
Echinococcus granulosus hexokinase 0.0051 0.0247 0.159
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0136 0.089 0.1729
Brugia malayi RNA binding protein 0.0041 0.0167 0.0317
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.004 0.0159 0.14
Onchocerca volvulus Hexokinase homolog 0.0032 0.0102 0.015
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0028 0.007 0.0425
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0027 0.0063 0.0349
Loa Loa (eye worm) hypothetical protein 0.0027 0.0063 0.0113
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0058 0.0298 0.0573
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0187 0.1272 0.8315
Echinococcus multilocularis hexokinase 0.0051 0.0247 0.159
Echinococcus multilocularis hexokinase 0.0051 0.0247 0.159
Echinococcus granulosus CD36 class B scavenger receptor 0.0072 0.0405 0.2625
Trypanosoma brucei lanosterol synthase 0.0058 0.0298 0.3205
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0136 0.089 0.5746
Schistosoma mansoni cd36 antigen 0.0027 0.0064 0.0163
Loa Loa (eye worm) hypothetical protein 0.008 0.0464 0.0896
Brugia malayi CD36 family protein 0.0072 0.0405 0.0781
Entamoeba histolytica hypothetical protein 0.0027 0.0063 0.0231
Loa Loa (eye worm) hypothetical protein 0.0027 0.0064 0.0116
Schistosoma mansoni scavenger receptor class B type-2 (sr-B2) 0.0072 0.0405 0.1098
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0028 0.0072
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0032 0.0101 0.0188
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.004 0.0159 0.1014
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0136 0.089 0.1289
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0032 0.0101 0.0188
Onchocerca volvulus 0.0032 0.0102 0.015
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0058 0.0298 0.029
Trypanosoma brucei phosphonopyruvate decarboxylase-like protein, putative 0.0034 0.0117 0.1122
Trypanosoma cruzi hexokinase, putative 0.0051 0.0247 0.2618
Schistosoma mansoni chromobox protein 0.0027 0.0063 0.0159
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0136 0.089 0.243
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0027 0.0063 0.0159
Schistosoma mansoni tar DNA-binding protein 0.0041 0.0167 0.0446
Loa Loa (eye worm) transcription factor SMAD2 0.0077 0.0441 0.0852
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0028 0.0009
Loa Loa (eye worm) hypothetical protein 0.0027 0.0063 0.0113
Trypanosoma cruzi phosphonopyruvate decarboxylase, putative 0.0034 0.0117 0.1122
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0027 0.0063 0.0159
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0221 0.1529 1
Schistosoma mansoni CD36-like class B scavenger receptor 0.0072 0.0405 0.1098
Echinococcus granulosus hexokinase 0.0051 0.0247 0.159
Loa Loa (eye worm) hypothetical protein 0.0027 0.0064 0.0116
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0027 0.0063 0.0379
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0159 0.1612
Echinococcus multilocularis thioredoxin glutathione reductase 0.0022 0.0021 0.0107
Schistosoma mansoni hypothetical protein 0.0023 0.0033 0.0078

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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