Detailed information for compound 1486149

Basic information

Technical information
  • TDR Targets ID: 1486149
  • Name: (3E)-3-[[5-(4-nitrophenyl)furan-2-yl]methylid ene]-5-phenylfuran-2-one
  • MW: 359.332 | Formula: C21H13NO5
  • H donors: 0 H acceptors: 3 LogP: 4.57 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1OC(=C/C/1=C\c1ccc(o1)c1ccc(cc1)[N+](=O)[O-])c1ccccc1
  • InChi: 1S/C21H13NO5/c23-21-16(13-20(27-21)14-4-2-1-3-5-14)12-18-10-11-19(26-18)15-6-8-17(9-7-15)22(24)25/h1-13H/b16-12+
  • InChiKey: SMZUTULIDFQMRT-FOWTUZBSSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (3E)-3-[[5-(4-nitrophenyl)-2-furyl]methylene]-5-phenyl-furan-2-one
  • (3E)-3-[[5-(4-nitrophenyl)-2-furyl]methylene]-5-phenyl-2-furanone
  • (3E)-3-[[5-(4-nitrophenyl)furan-2-yl]methylidene]-5-phenyl-furan-2-one
  • ZINC04837524
  • STOCK2S-29696

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni amine GPCR 0.001 0.0031 0.0065
Schistosoma mansoni biogenic amine (5HT) receptor 0.001 0.0031 0.0065
Schistosoma mansoni hypothetical protein 0.0015 0.0098 0.0205
Echinococcus granulosus hypothetical protein 0.001 0.0031 0.0065
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0326 0.0685
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0031 0.0065
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.001 0.0031 0.0065
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0341 0.0718
Echinococcus multilocularis allatostatin A receptor 0.001 0.0031 0.0031
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0098 0.0205
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0031 0.0031
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0229 0.7279
Loa Loa (eye worm) hypothetical protein 0.0033 0.0309 0.4107
Echinococcus multilocularis g-protein coupled receptor 0.001 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0147
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0491 0.6055
Echinococcus granulosus g protein coupled receptor 0.001 0.0031 0.0065
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.001 0.0031 0.0031
Brugia malayi CXXC zinc finger family protein 0.0029 0.0255 0.2953
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0147
Echinococcus multilocularis expressed protein 0.0034 0.0311 0.0311
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0192 0.0192
Echinococcus granulosus neuropeptides capa receptor 0.001 0.0031 0.0065
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.001 0.0031 0.0065
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0311 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0147
Loa Loa (eye worm) hypothetical protein 0.0043 0.0421 0.5712
Echinococcus granulosus dro:myosuppressin receptor 0.001 0.0031 0.0065
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0031 0.0065
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.0302 0.3464 0.5
Schistosoma mansoni amine GPCR 0.001 0.0031 0.0065
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0147
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0147
Loa Loa (eye worm) hypothetical protein 0.0027 0.0229 0.297
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0229 0.3513
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0255 0.3343
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0031 0.0065
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.001 0.0031 0.0065
Echinococcus multilocularis alpha 1A adrenergic receptor 0.001 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0147
Schistosoma mansoni alpha-1 adrenergic receptor 0.001 0.0031 0.0065
Echinococcus granulosus neuropeptide Y receptor 0.001 0.0031 0.0065
Echinococcus granulosus neuropeptide Y receptor 0.001 0.0031 0.0065
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0147
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0147
Echinococcus multilocularis serotonin receptor 0.001 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0147
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.001 0.0031 0.0065
Echinococcus granulosus neuropeptide s receptor 0.001 0.0031 0.0065
Schistosoma mansoni growth hormone secretagogue receptor 0.001 0.0031 0.0065
Echinococcus multilocularis neuropeptides capa receptor 0.001 0.0031 0.0031
Trypanosoma cruzi ISWI complex protein 0.0015 0.009 0.2048
Schistosoma mansoni amine GPCR 0.001 0.0031 0.0065
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0118 0.0247
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0031 0.0065
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0341 0.0341
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.001 0.0031 0.0065
Echinococcus multilocularis sex peptide receptor 0.001 0.0031 0.0031
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0302 0.3464 1
Schistosoma mansoni rotamase 0.0034 0.0311 0.0654
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0301 1
Schistosoma mansoni hypothetical protein 0.0015 0.009 0.019
Schistosoma mansoni biogenic amine receptor 0.001 0.0031 0.0065
Echinococcus multilocularis neuropeptide receptor A26 0.001 0.0031 0.0031
Entamoeba histolytica hypothetical protein 0.0036 0.0341 1
Echinococcus granulosus dnaJ subfamily B 0.0412 0.4753 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0353 0.474
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0326 0.0326
Schistosoma mansoni hypothetical protein 0.0033 0.0309 0.065
Treponema pallidum hypothetical protein 0.0302 0.3464 0.5
Schistosoma mansoni neuropeptide f receptor 76f 0.001 0.0031 0.0065
Schistosoma mansoni hypothetical protein 0.0412 0.4753 1
Brugia malayi hypothetical protein 0.0027 0.0229 0.2608
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0302 0.3464 0.5
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0147
Schistosoma mansoni adenoreceptor 0.001 0.0031 0.0065
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0147
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0031 0.0065
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.001 0.0031 0.0065
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0147
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0031 0.0065
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0302 0.3464 0.5
Leishmania major hypothetical protein, conserved 0.0015 0.009 0.2048
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0031 0.0065
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0586 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.001 0.0031 0.0031
Schistosoma mansoni biogenic amine (5HT) receptor 0.001 0.0031 0.0065
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0147
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.001 0.0031 0.0065
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0118 0.0247
Schistosoma mansoni amine GPCR 0.001 0.0031 0.0065
Echinococcus multilocularis GPCR, family 2 0.0015 0.0098 0.0098
Trypanosoma cruzi ISWI complex protein 0.0015 0.009 0.2048
Loa Loa (eye worm) neuropeptide F receptor 0.001 0.0031 0.0147
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.001 0.0031 0.0065
Schistosoma mansoni opsin-like receptor 0.001 0.0031 0.0065
Schistosoma mansoni neuropeptide F-like receptor 0.001 0.0031 0.0065
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.001 0.0031 0.0147
Echinococcus granulosus neuropeptide receptor 0.001 0.0031 0.0065
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0151 0.1857
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0147
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.0031 0.0065
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0098 0.0877
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0147
Echinococcus multilocularis G-protein coupled receptor, putative 0.001 0.0031 0.0031
Loa Loa (eye worm) TYRA-2 protein 0.001 0.0031 0.0147
Echinococcus granulosus cpg binding protein 0.0032 0.0296 0.0624
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0117 0.1374
Echinococcus granulosus g protein coupled receptor 0.001 0.0031 0.0065
Entamoeba histolytica hypothetical protein 0.0036 0.0341 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0118 0.1381
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0118 0.0118
Schistosoma mansoni neuropeptide F-like receptor 0.001 0.0031 0.0065
Schistosoma mansoni hypothetical protein 0.0015 0.0098 0.0205
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0491 0.6055
Schistosoma mansoni hypothetical protein 0.001 0.0031 0.0065
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0031 0.0065
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0302 0.3464 1
Schistosoma mansoni neuropeptide receptor 0.001 0.0031 0.0065
Echinococcus multilocularis cpg binding protein 0.0032 0.0296 0.0296
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0147
Echinococcus granulosus g-protein coupled receptor 0.001 0.0031 0.0065
Schistosoma mansoni opsin-like receptor 0.001 0.0031 0.0065
Brugia malayi hypothetical protein 0.0036 0.0341 0.4083
Loa Loa (eye worm) G-protein coupled receptor 0.001 0.0031 0.0147
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0031 0.0065
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0056 0.0118
Schistosoma mansoni zinc finger protein 0.0021 0.0158 0.0333
Schistosoma mansoni cpg binding protein 0.0032 0.0296 0.0624
Schistosoma mansoni biogenic amine receptor 0.001 0.0031 0.0065
Echinococcus granulosus alpha 1A adrenergic receptor 0.001 0.0031 0.0065
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0034 0.0311 0.3682
Echinococcus granulosus orexin receptor type 2 0.001 0.0031 0.0065
Echinococcus granulosus neuropeptide FF receptor 2 0.001 0.0031 0.0065
Schistosoma mansoni hypothetical protein 0.0015 0.0098 0.0205
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.011 0.011
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0098 0.0098
Echinococcus multilocularis g protein coupled receptor 0.001 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0015 0.0098 0.1096
Echinococcus granulosus expressed protein 0.0034 0.0311 0.0654
Echinococcus granulosus zinc finger protein 0.0021 0.0158 0.0333
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0147
Schistosoma mansoni neuropeptide receptor 0.001 0.0031 0.0065
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.001 0.0031 0.0147
Echinococcus multilocularis g protein coupled receptor 0.001 0.0031 0.0031
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0147
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0147
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0616 0.0616
Echinococcus multilocularis somatostatin receptor 0.001 0.0031 0.0031
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0192 0.0404
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0118 0.0247
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.001 0.0031 0.0065
Schistosoma mansoni myosin xvIII 0.001 0.0031 0.0065
Loa Loa (eye worm) G-protein coupled receptor 0.001 0.0031 0.0147
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.001 0.0031 0.0031
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.0031 0.0065
Schistosoma mansoni neuropeptide receptor 0.001 0.0031 0.0065
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0147
Echinococcus granulosus thyrotropin releasing hormone receptor 0.001 0.0031 0.0065
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.001 0.0036 0.5
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0147
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.001 0.0031 0.0065
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0147
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.011 0.0232
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.0031 0.0065
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0309 0.3659
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.011 0.0232
Echinococcus granulosus allatostatin A receptor 0.001 0.0031 0.0065
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.0031 0.0031
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.001 0.0031 0.0065
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.001 0.0031 0.0147
Brugia malayi Bromodomain containing protein 0.0037 0.0353 0.4233
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0301 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0192 0.0404
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.001 0.0031 0.0147
Echinococcus multilocularis G protein coupled receptor 139 0.001 0.0031 0.0031
Echinococcus multilocularis dnaJ subfamily B 0.0412 0.4753 0.4753
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.001 0.0031 0.0065
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0147
Loa Loa (eye worm) hypothetical protein 0.004 0.038 0.5125
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0147
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0147
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0031 0.0031
Echinococcus granulosus biogenic amine 5HT receptor 0.001 0.0031 0.0065
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0031 0.0065
Loa Loa (eye worm) neuropeptide F receptor 0.001 0.0031 0.0147
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0021 0.0044
Brugia malayi PHD-finger family protein 0.0026 0.0219 0.2477
Echinococcus granulosus neuropeptides capa receptor 0.001 0.0031 0.0065
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0031 0.0065
Schistosoma mansoni cpg binding protein 0.0032 0.0296 0.0624
Echinococcus multilocularis neuropeptide Y receptor 0.001 0.0031 0.0031
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0031 0.0031
Entamoeba histolytica hypothetical protein 0.0036 0.0341 1
Echinococcus multilocularis dro:myosuppressin receptor 0.001 0.0031 0.0031
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0098 0.0098
Loa Loa (eye worm) melatonin receptor type 1A 0.001 0.0031 0.0147
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0031 0.0065
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.001 0.0031 0.0065
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.001 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0147
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0491 0.6701
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0301 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0147
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0147
Schistosoma mansoni histamine h1 receptor 0.001 0.0031 0.0065
Schistosoma mansoni biogenic amine receptor 0.001 0.0031 0.0065
Brugia malayi Bromodomain containing protein 0.0074 0.0791 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0491 0.6701
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.001 0.0031 0.0031
Schistosoma mansoni zinc finger protein 0.0015 0.009 0.019
Leishmania major hypothetical protein, conserved 0.0027 0.0229 0.7279
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0229 0.7279
Schistosoma mansoni neuropeptide receptor 0.001 0.0031 0.0065
Schistosoma mansoni hypothetical protein 0.0015 0.0098 0.0205
Echinococcus granulosus GPCR family 2 0.0015 0.0098 0.0205
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0147
Echinococcus granulosus peptide allatostatin:somatostatin 0.001 0.0031 0.0065
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.0031 0.0065
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0031 0.0031
Echinococcus granulosus somatostatin receptor 0.001 0.0031 0.0065
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0147
Echinococcus multilocularis g protein coupled receptor 0.001 0.0031 0.0031
Loa Loa (eye worm) follicle stimulating hormone receptor 0.001 0.0031 0.0147
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0147
Echinococcus granulosus 7tm_1 domain containing protein 0.001 0.0031 0.0065
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0147
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.0031 0.0065
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0147
Schistosoma mansoni hypothetical protein 0.0036 0.0341 0.0718
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0098 0.0205
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0616 0.1296
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.0031 0.0065
Entamoeba histolytica hypothetical protein 0.0036 0.0341 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0098 0.1096
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0021 0.0021
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.0031 0.0031
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.001 0.0031 0.0031
Schistosoma mansoni bromodomain containing protein 0.0063 0.0657 0.1382
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0229 0.7279
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0031 0.0065
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0147
Echinococcus multilocularis neuropeptides capa receptor 0.001 0.0031 0.0031
Echinococcus granulosus tachykinin peptides receptor 99D 0.001 0.0031 0.0065
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.001 0.0031 0.0065
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0147
Schistosoma mansoni opsin-like receptor 0.001 0.0031 0.0065
Echinococcus multilocularis fmrfamide receptor 0.001 0.0031 0.0031
Echinococcus granulosus g protein coupled receptor 0.001 0.0031 0.0065
Schistosoma mansoni cpg binding protein 0.0029 0.0255 0.0537
Echinococcus granulosus biogenic amine 5HT receptor 0.001 0.0031 0.0065
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0147
Echinococcus multilocularis fmrfamide receptor 0.001 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0069 0.0722 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0147
Echinococcus granulosus G protein coupled receptor 139 0.001 0.0031 0.0065
Schistosoma mansoni hypothetical protein 0.001 0.0031 0.0065
Echinococcus multilocularis neuropeptide s receptor 0.001 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0147
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0041 0.0134
Trichomonas vaginalis rotamase, putative 0.0034 0.0311 1
Echinococcus granulosus serotonin receptor 0.001 0.0031 0.0065
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.001 0.0031 0.0031
Echinococcus multilocularis serotonin receptor 0.001 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0147
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0147
Echinococcus multilocularis biogenic amine (5HT) receptor 0.001 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0147
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0636 0.1338
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0031 0.0031
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0031 0.0065
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0031 0.0031
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0034 0.0311 0.4132
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0098 0.0877
Schistosoma mansoni hypothetical protein 0.001 0.0031 0.0065
Trypanosoma brucei ISWI complex protein 0.0015 0.009 0.2048
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0147
Echinococcus multilocularis neuropeptide receptor 0.001 0.0031 0.0031
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.001 0.0031 0.0031
Echinococcus granulosus neuropeptide receptor 0.001 0.0031 0.0065
Brugia malayi hypothetical protein 0.0017 0.0118 0.1145
Echinococcus granulosus sex peptide receptor 0.001 0.0031 0.0065
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0301 0.4826
Echinococcus granulosus fmrfamide receptor 0.001 0.0031 0.0065
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0031 0.0065
Schistosoma mansoni hypothetical protein 0.002 0.0151 0.0318
Echinococcus multilocularis neuropeptide Y receptor 0.001 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0147
Echinococcus multilocularis orexin receptor type 2 0.001 0.0031 0.0031
Echinococcus granulosus neuropeptide receptor A26 0.001 0.0031 0.0065
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.001 0.0031 0.0031
Echinococcus multilocularis neuropeptide FF receptor 2 0.001 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0147
Echinococcus granulosus 7TM GPCR rhodopsin 0.001 0.0031 0.0065
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.011 0.0232
Schistosoma mansoni peptide (allatostatin)-like receptor 0.001 0.0031 0.0065
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0056 0.0056
Onchocerca volvulus 0.0029 0.0255 1
Echinococcus multilocularis neuropeptide receptor 0.001 0.0031 0.0031
Schistosoma mansoni hypothetical protein 0.001 0.0031 0.0065
Echinococcus multilocularis zinc finger protein 0.0021 0.0158 0.0158
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0301 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0147
Schistosoma mansoni hypothetical protein 0.0012 0.0056 0.0118
Schistosoma mansoni amine GPCR 0.001 0.0031 0.0065
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0341 0.0718
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0031 0.0031
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0031 0.0065

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) 50 uM PUBCHEM_BIOASSAY: Dose Response Confirmation for Small Molecule Inhibitors of Eukaryotic Translation Initiation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID782] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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