Detailed information for compound 1494347

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 242.233 | Formula: C12H10N4O2
  • H donors: 2 H acceptors: 3 LogP: 1.27 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNC(=O)c1noc(c1)c1ccc2c(c1)cn[nH]2
  • InChi: 1S/C12H10N4O2/c1-13-12(17)10-5-11(18-16-10)7-2-3-9-8(4-7)6-14-15-9/h2-6H,1H3,(H,13,17)(H,14,15)
  • InChiKey: PYWUGDQVHDHKLX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens Rho-associated, coiled-coil containing protein kinase 2 Starlite/ChEMBL References
Homo sapiens kinase insert domain receptor Starlite/ChEMBL References
Homo sapiens aurora kinase B Starlite/ChEMBL References
Homo sapiens Pim-1 proto-oncogene, serine/threonine kinase Starlite/ChEMBL References
Homo sapiens p21 protein (Cdc42/Rac)-activated kinase 4 Starlite/ChEMBL References
Homo sapiens glycogen synthase kinase 3 beta Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) CAMK/PIM protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania mexicana protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CAMK/PIM protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium vivax glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium yoelii putative protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Onchocerca volvulus Serine\/threonine protein kinase homolog Get druggable targets OG5_134863 All targets in OG5_134863
Echinococcus multilocularis serine:threonine protein kinase PAK 4 Get druggable targets OG5_131977 All targets in OG5_131977
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase Get druggable targets OG5_131020 All targets in OG5_131020
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_134863 All targets in OG5_134863
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum IPR002219,Protein kinase C, phorbol ester/diacylglycerol binding,domain-containing Get druggable targets OG5_131020 All targets in OG5_131020
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania major protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) TK/KIN16 protein kinase Get druggable targets OG5_130320 All targets in OG5_130320
Echinococcus granulosus proto oncogene serine:threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Candida albicans hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania donovani glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus rho-associated protein kinase 1 Get druggable targets OG5_131020 All targets in OG5_131020
Trypanosoma cruzi aurora B kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum ko:K08850 aurora kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Onchocerca volvulus Tyrosine kinase homolog Get druggable targets OG5_130320 All targets in OG5_130320
Plasmodium falciparum serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum ko:K04702 proto-oncogene serine/threonine-protein kinase Pim-1, putative Get druggable targets OG5_134863 All targets in OG5_134863
Leishmania infantum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica serine/threonine- protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Onchocerca volvulus Get druggable targets OG5_131020 All targets in OG5_131020
Theileria parva glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_131020 All targets in OG5_131020
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Onchocerca volvulus Get druggable targets OG5_130320 All targets in OG5_130320
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Neospora caninum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium vivax serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium falciparum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum Serine/threonine-protein kinase 12, putative Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative Get druggable targets OG5_126888 All targets in OG5_126888
Neospora caninum hypothetical protein Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania braziliensis protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis proto oncogene serine:threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Plasmodium berghei glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica serine/threonine- protein kinase 6 , putative Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi intracellular kinase Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei gambiense protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis rho associated protein kinase Get druggable targets OG5_131020 All targets in OG5_131020
Plasmodium knowlesi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania donovani Aurora I-related kinase Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Onchocerca volvulus Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K08822 glycogen synthase kinase 3 alpha, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium knowlesi serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase , putative Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) STE/STE20/PAKB protein kinase Get druggable targets OG5_131977 All targets in OG5_131977
Cryptosporidium hominis protein kinase (EC 2.7.1.-) p46XlEg22 Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Onchocerca volvulus Get druggable targets OG5_131020 All targets in OG5_131020
Schistosoma japonicum Rho-associated protein kinase 1, putative Get druggable targets OG5_131020 All targets in OG5_131020
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium parvum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi serine/threonine kinase 12 Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus serine:threonine protein kinase PAK 4 Get druggable targets OG5_131977 All targets in OG5_131977
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi serine/threonine-protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi Serine/threonine-protein kinase Pim-3 Get druggable targets OG5_134863 All targets in OG5_134863
Toxoplasma gondii aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi serine/threonine-protein kinase PAK 7 Get druggable targets OG5_131977 All targets in OG5_131977
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_131020 All targets in OG5_131020
Brugia malayi Immunoglobulin I-set domain containing protein Get druggable targets OG5_130320 All targets in OG5_130320
Brugia malayi serine/threonine protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium berghei serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126888 All targets in OG5_126888
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans Serine/threonine protein kinase required for induction of IME2 by Ime1p Get druggable targets OG5_126888 All targets in OG5_126888
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 aurora kinase B 303 aa 299 aa 22.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus aurora kinase A 0.007 0.1094 0.3049
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.006 0.0906 0.2525
Echinococcus granulosus somatostatin receptor 0.0015 0.0076 0.0211
Brugia malayi hypothetical protein 0.0015 0.0076 0.0076
Trichomonas vaginalis STE family protein kinase 0.0021 0.0186 0.0472
Echinococcus granulosus g protein coupled receptor 0.0015 0.0076 0.0211
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0076
Echinococcus granulosus dro:myosuppressin receptor 0.0015 0.0076 0.0211
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0015 0.0076 0.0222
Trichomonas vaginalis AGC family protein kinase 0.007 0.1094 1
Schistosoma mansoni hypothetical protein 0.0018 0.012 0.0352
Echinococcus multilocularis g protein coupled receptor 0.0015 0.0076 0.0211
Echinococcus granulosus alpha 1A adrenergic receptor 0.0015 0.0076 0.0211
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0076
Onchocerca volvulus 0.0178 0.3103 0.908
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.007 0.1094 0.3049
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0015 0.0076 0.0211
Echinococcus multilocularis neuropeptide Y receptor 0.0015 0.0076 0.0211
Brugia malayi hypothetical protein 0.0015 0.0076 0.0076
Schistosoma mansoni amine GPCR 0.0015 0.0076 0.0222
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0015 0.0076 0.0211
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0015 0.0076 0.0211
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0161 0.0471
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0076
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0076 0.0211
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.0076 0.0222
Echinococcus granulosus tachykinin peptides receptor 99D 0.0015 0.0076 0.0211
Plasmodium vivax sortilin, putative 0.0072 0.1134 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0076
Echinococcus granulosus allatostatin A receptor 0.0015 0.0076 0.0211
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0076
Echinococcus granulosus neuropeptide s receptor 0.0015 0.0076 0.0211
Brugia malayi Tachykinin-like peptides receptor 99D 0.0015 0.0076 0.0076
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.0076 0.0222
Schistosoma mansoni biogenic amine (5HT) receptor 0.0015 0.0076 0.0222
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.007 0.1094 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0015 0.0076 0.0222
Echinococcus granulosus biogenic amine 5HT receptor 0.0015 0.0076 0.0211
Entamoeba histolytica protein kinase, putative 0.0021 0.0186 0.0472
Schistosoma mansoni biogenic amine receptor 0.0015 0.0076 0.0222
Schistosoma mansoni hypothetical protein 0.0019 0.0142 0.0415
Brugia malayi hypothetical protein 0.0015 0.0076 0.0076
Schistosoma mansoni serine/threonine protein kinase 0.007 0.1094 0.3208
Echinococcus granulosus sex peptide receptor 0.0015 0.0076 0.0211
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.0076 0.0211
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0076 0.0211
Echinococcus multilocularis G-protein coupled receptor, putative 0.0015 0.0076 0.0211
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0015 0.0076 0.0076
Echinococcus multilocularis fmrfamide receptor 0.0015 0.0076 0.0211
Loa Loa (eye worm) CMGC/GSK protein kinase 0.006 0.0906 0.0906
Echinococcus multilocularis serotonin receptor 0.0015 0.0076 0.0211
Brugia malayi ORL1-like opioid receptor 0.0015 0.0076 0.0076
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0021 0.0186 0.052
Echinococcus granulosus g protein coupled receptor 0.0015 0.0076 0.0211
Trichomonas vaginalis AGC family protein kinase 0.007 0.1094 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.0076 0.0211
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0076
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.0076 0.0211
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0021 0.0186 0.052
Echinococcus multilocularis neuropeptide s receptor 0.0015 0.0076 0.0211
Echinococcus granulosus neuropeptide receptor A26 0.0015 0.0076 0.0211
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0204 0.3588 1
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0223 0.3938 0.3938
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.0076 0.0222
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0076
Echinococcus granulosus neural Wiskott Aldrich syndrome protein 0.0019 0.0142 0.0394
Onchocerca volvulus 0.0175 0.3058 0.8945
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0015 0.0076 0.0211
Plasmodium vivax serine/threonine protein kinase 6, putative 0.007 0.1094 0.8242
Echinococcus multilocularis PAK box P21 Rho binding 0.0021 0.0186 0.052
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0015 0.0076 0.0076
Giardia lamblia Aurora kinase 0.007 0.1094 1
Echinococcus multilocularis sortilin 0.0072 0.1134 0.3161
Echinococcus granulosus peptide allatostatin:somatostatin 0.0015 0.0076 0.0211
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0015 0.0076 0.0211
Schistosoma mansoni hypothetical protein 0.0018 0.012 0.0352
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0076
Echinococcus granulosus 7tm_1 domain containing protein 0.0015 0.0076 0.0211
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0076
Brugia malayi Immunoglobulin I-set domain containing protein 0.0183 0.3191 0.3191
Toxoplasma gondii sortilin, putative 0.0072 0.1134 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0076
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0015 0.0076 0.0222
Brugia malayi G protein-coupled receptor 0.0015 0.0076 0.0076
Echinococcus multilocularis sex peptide receptor 0.0015 0.0076 0.0211
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0015 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0076
Echinococcus multilocularis neuropeptide receptor 0.0015 0.0076 0.0211
Entamoeba histolytica protein kinase domain containing protein 0.006 0.0906 0.8026
Echinococcus multilocularis g protein coupled receptor 0.0015 0.0076 0.0211
Trichomonas vaginalis STE family protein kinase 0.0021 0.0186 0.0472
Schistosoma mansoni hypothetical protein 0.0015 0.0076 0.0222
Echinococcus granulosus neuroglian 0.0014 0.0053 0.0149
Schistosoma mansoni opsin-like receptor 0.0015 0.0076 0.0222
Entamoeba histolytica protein kinase, putative 0.007 0.1094 1
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.007 0.1094 1
Brugia malayi P21-Rho-binding domain containing protein 0.0019 0.0142 0.0142
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0194 0.341 0.341
Trichomonas vaginalis STE family protein kinase 0.0021 0.0186 0.0472
Echinococcus granulosus sortilin 0.0072 0.1134 0.3161
Schistosoma mansoni neuropeptide receptor 0.0015 0.0076 0.0222
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0015 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0076
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0015 0.0076 0.0211
Brugia malayi G protein-coupled receptor F59B2.13 0.0015 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0076
Schistosoma mansoni nephrin 0.0014 0.0053 0.0157
Schistosoma mansoni opsin-like receptor 0.0015 0.0076 0.0222
Plasmodium falciparum sortilin 0.0072 0.1134 1
Echinococcus granulosus tm gpcr rhodopsin 0.0015 0.0076 0.0211
Echinococcus granulosus tm gpcr rhodopsin 0.0015 0.0076 0.0211
Loa Loa (eye worm) TYRA-2 protein 0.0015 0.0076 0.0076
Echinococcus granulosus neuropeptide Y receptor 0.0015 0.0076 0.0211
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0021 0.0186 0.052
Echinococcus granulosus roundabout 2 0.0018 0.0122 0.0339
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0015 0.0076 0.0222
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0076
Echinococcus granulosus neuropeptide receptor 0.0015 0.0076 0.0211
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0194 0.341 0.341
Echinococcus multilocularis serotonin receptor 0.0015 0.0076 0.0211
Loa Loa (eye worm) hypothetical protein 0.0018 0.0122 0.0122
Brugia malayi Dopamine receptor 0.0015 0.0076 0.0076
Echinococcus multilocularis g-protein coupled receptor 0.0015 0.0076 0.0211
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0076
Echinococcus granulosus g protein coupled receptor 0.0015 0.0076 0.0211
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0076
Loa Loa (eye worm) neuropeptide F receptor 0.0015 0.0076 0.0076
Brugia malayi neuropeptide F receptor 0.0015 0.0076 0.0076
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0076 0.0211
Brugia malayi hypothetical protein 0.0015 0.0076 0.0076
Echinococcus granulosus fmrfamide receptor 0.0015 0.0076 0.0211
Brugia malayi putative neuropeptide receptor NPR1 0.0015 0.0076 0.0076
Echinococcus multilocularis dro:myosuppressin receptor 0.0015 0.0076 0.0211
Schistosoma mansoni hypothetical protein 0.0015 0.0076 0.0222
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0076
Echinococcus granulosus neuropeptide receptor 0.0015 0.0076 0.0211
Trichomonas vaginalis AGC family protein kinase 0.007 0.1094 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0015 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0019 0.0142 0.0142
Giardia lamblia Kinase, CMGC GSK 0.006 0.0906 0.7928
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0015 0.0076 0.0076
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.0076 0.0211
Schistosoma mansoni hypothetical protein 0.0019 0.0142 0.0415
Brugia malayi hypothetical protein 0.0015 0.0076 0.0076
Loa Loa (eye worm) G-protein coupled receptor 0.0015 0.0076 0.0076
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0015 0.0076 0.0222
Brugia malayi sulfakinin receptor protein 0.0015 0.0076 0.0076
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0015 0.0076 0.0211
Plasmodium falciparum serine/threonine protein kinase, putative 0.007 0.1094 0.8242
Brugia malayi hypothetical protein 0.0015 0.0076 0.0076
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.0076 0.0211
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0015 0.0076 0.0222
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0204 0.3588 1
Schistosoma mansoni histamine h1 receptor 0.0015 0.0076 0.0222
Schistosoma mansoni cell adhesion molecule 0.0015 0.0068 0.02
Echinococcus multilocularis neural Wiskott Aldrich syndrome protein 0.0019 0.0142 0.0394
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0015 0.0076 0.0211
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0015 0.0076 0.0222
Schistosoma mansoni biogenic amine receptor 0.0015 0.0076 0.0222
Loa Loa (eye worm) AUR protein kinase 0.007 0.1094 0.1094
Echinococcus granulosus hypothetical protein 0.0015 0.0076 0.0211
Echinococcus granulosus 3'partial|serine:threonine protein kinase PAK 2 0.0019 0.0142 0.0394
Brugia malayi intracellular kinase 0.006 0.0906 0.0906
Trypanosoma cruzi aurora B kinase, putative 0.007 0.1094 1
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0183 0.3191 0.3191
Entamoeba histolytica protein kinase domain containing protein 0.007 0.1094 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0076
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0015 0.0076 0.0211
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0076
Brugia malayi Dopamine receptor protein 2 0.0015 0.0076 0.0076
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0015 0.0076 0.0211
Brugia malayi putative neuropeptide receptor 0.0015 0.0076 0.0076
Echinococcus granulosus PAK box P21 Rho binding 0.0019 0.0142 0.0394
Entamoeba histolytica protein kinase, putative 0.007 0.1094 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0015 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0076
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0015 0.0076 0.0211
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0015 0.0076 0.0222
Schistosoma mansoni protein kinase 0.0021 0.0186 0.0547
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0015 0.0076 0.0211
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0015 0.0076 0.0211
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0015 0.0076 0.0222
Trichomonas vaginalis AGC family protein kinase 0.007 0.1094 1
Echinococcus granulosus protein kinase shaggy 0.006 0.0906 0.2525
Schistosoma mansoni tyrosine kinase 0.002 0.0161 0.0471
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0076
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0015 0.0076 0.0076
Echinococcus granulosus glycogen synthase kinase 3 beta 0.006 0.0906 0.2525
Entamoeba histolytica protein kinase, putative 0.0021 0.0186 0.0472
Schistosoma mansoni protein kinase 0.0019 0.0142 0.0415
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0076
Schistosoma mansoni protein kinase 0.0021 0.0186 0.0547
Schistosoma mansoni protein kinase 0.007 0.1094 0.3208
Loa Loa (eye worm) AUR protein kinase 0.007 0.1094 0.1094
Echinococcus multilocularis fmrfamide receptor 0.0015 0.0076 0.0211
Brugia malayi follicle stimulating hormone receptor 0.0015 0.0076 0.0076
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.007 0.1094 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0015 0.0076 0.0211
Echinococcus granulosus biogenic amine 5HT receptor 0.0015 0.0076 0.0211
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0015 0.0076 0.0222
Echinococcus multilocularis protein kinase shaggy 0.006 0.0906 0.2525
Brugia malayi hypothetical protein 0.0015 0.0076 0.0076
Loa Loa (eye worm) neuropeptide F receptor 0.0015 0.0076 0.0076
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0015 0.0076 0.0222
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0076
Loa Loa (eye worm) AUR protein kinase 0.007 0.1094 0.1094
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0015 0.0068 0.019
Brugia malayi G-protein coupled receptor 0.0015 0.0076 0.0076
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0015 0.0076 0.0076
Brugia malayi hypothetical protein 0.0015 0.0076 0.0076
Echinococcus granulosus twitchin 0.0017 0.0098 0.0274
Loa Loa (eye worm) hypothetical protein 0.0015 0.0068 0.0068
Echinococcus multilocularis neuroglian 0.0014 0.0053 0.0149
Schistosoma mansoni hypothetical protein 0.0015 0.0076 0.0222
Brugia malayi P21-Rho-binding domain containing protein 0.0019 0.0142 0.0142
Echinococcus granulosus g-protein coupled receptor 0.0015 0.0076 0.0211
Schistosoma mansoni protein kinase 0.0021 0.0186 0.0547
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.0076 0.0222
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0076 0.0211
Entamoeba histolytica protein kinase, putative 0.0021 0.0186 0.0472
Trypanosoma brucei aurora B kinase 0.007 0.1094 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0076 0.0211
Schistosoma mansoni hypothetical protein 0.0015 0.0076 0.0222
Toxoplasma gondii aurora kinase 0.007 0.1094 0.8242
Echinococcus granulosus G protein coupled receptor 139 0.0015 0.0076 0.0211
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0076
Schistosoma mansoni serine/threonine protein kinase 0.0178 0.3103 0.91
Echinococcus multilocularis orexin receptor type 2 0.0015 0.0076 0.0211
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0015 0.0076 0.0211
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0076
Brugia malayi Serotonin receptor 0.0015 0.0076 0.0076
Schistosoma mansoni neuropeptide receptor 0.0015 0.0076 0.0222
Schistosoma mansoni neuropeptide receptor 0.0015 0.0076 0.0222
Brugia malayi Melatonin receptor type 1A 0.0015 0.0076 0.0076
Echinococcus multilocularis neuropeptides capa receptor 0.0015 0.0076 0.0211
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0076 0.0211
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0076
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0015 0.0076 0.0211
Brugia malayi GnHR receptor homolog 0.0015 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0076
Brugia malayi Serotonin receptor 0.0015 0.0076 0.0076
Schistosoma mansoni amine GPCR 0.0015 0.0076 0.0222
Brugia malayi serine/threonine-protein kinase PAK 7 0.0223 0.3938 0.3938
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0015 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0076
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0548 1 1
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0021 0.0186 0.052
Trichomonas vaginalis STE family protein kinase 0.0021 0.0186 0.0472
Brugia malayi Protein kinase domain containing protein 0.0194 0.341 0.341
Brugia malayi G-protein coupled receptor 0.0015 0.0076 0.0076
Brugia malayi serine/threonine-protein kinase 6 0.007 0.1094 0.1094
Brugia malayi neuropeptide F receptor 0.0015 0.0076 0.0076
Echinococcus granulosus serine:threonine protein kinase 12 B 0.007 0.1094 0.3049
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0076
Schistosoma mansoni wiskott-aldrich syndrome protein 0.0019 0.0142 0.0415
Trichomonas vaginalis STE family protein kinase 0.0021 0.0186 0.0472
Brugia malayi RE15519p 0.0015 0.0076 0.0076
Schistosoma mansoni neuropeptide F-like receptor 0.0015 0.0076 0.0222
Loa Loa (eye worm) G-protein coupled receptor 0.0015 0.0076 0.0076
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0021 0.0186 0.052
Schistosoma mansoni amine GPCR 0.0015 0.0076 0.0222
Loa Loa (eye worm) CMGC/GSK protein kinase 0.006 0.0906 0.0906
Echinococcus multilocularis aurora kinase A 0.007 0.1094 0.3049
Brugia malayi larval opioid receptor 0.0015 0.0076 0.0076
Schistosoma mansoni neuropeptide F-like receptor 0.0015 0.0076 0.0222
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0015 0.0076 0.0076
Echinococcus multilocularis roundabout 2 0.0018 0.0122 0.0339
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0076
Echinococcus granulosus rho-associated protein kinase 1 0.0178 0.3103 0.8649
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0015 0.0076 0.0211
Onchocerca volvulus 0.006 0.0906 0.2491
Echinococcus multilocularis G protein coupled receptor 139 0.0015 0.0076 0.0211
Echinococcus granulosus orexin receptor type 2 0.0015 0.0076 0.0211
Schistosoma mansoni amine GPCR 0.0015 0.0076 0.0222
Schistosoma mansoni growth hormone secretagogue receptor 0.0015 0.0076 0.0222
Entamoeba histolytica protein kinase, putative 0.006 0.0906 0.8026
Schistosoma mansoni biogenic amine (5HT) receptor 0.0015 0.0076 0.0222
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0076
Echinococcus granulosus neuropeptides capa receptor 0.0015 0.0076 0.0211
Loa Loa (eye worm) P21-Rho-binding domain-containing protein 0.0019 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0076
Schistosoma mansoni sortilin 0.0051 0.0742 0.2177
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.0076 0.0211
Echinococcus multilocularis PAK box P21 Rho binding 0.0019 0.0142 0.0394
Brugia malayi AKH receptor 0.0015 0.0076 0.0076
Echinococcus multilocularis neuropeptide Y receptor 0.0015 0.0076 0.0211
Echinococcus multilocularis somatostatin receptor 0.0015 0.0076 0.0211
Brugia malayi serine/threonine kinase 12 0.007 0.1094 0.1094
Schistosoma mansoni neuropeptide f receptor 76f 0.0015 0.0076 0.0222
Onchocerca volvulus Tyrosine kinase homolog 0.0171 0.2967 0.8672
Entamoeba histolytica protein kinase, putative 0.0021 0.0186 0.0472
Echinococcus multilocularis neuropeptide receptor 0.0015 0.0076 0.0211
Brugia malayi hypothetical protein 0.0015 0.0076 0.0076
Echinococcus multilocularis allatostatin A receptor 0.0015 0.0076 0.0211
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0194 0.341 0.9504
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0021 0.0186 0.052
Echinococcus multilocularis neuropeptides capa receptor 0.0015 0.0076 0.0211
Brugia malayi Protein kinase domain 0.0021 0.0186 0.0186
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.0076 0.0211
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.0076 0.0222
Echinococcus multilocularis neuropeptide FF receptor 2 0.0015 0.0076 0.0211
Entamoeba histolytica protein kinase , putative 0.007 0.1094 1
Echinococcus granulosus neuropeptides capa receptor 0.0015 0.0076 0.0211
Brugia malayi hypothetical protein 0.0015 0.0076 0.0076
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0194 0.341 0.341
Schistosoma mansoni hypothetical protein 0.0019 0.0142 0.0415
Schistosoma mansoni hypothetical protein 0.0021 0.0183 0.0536
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0015 0.0076 0.0211
Echinococcus granulosus neuropeptide FF receptor 2 0.0015 0.0076 0.0211
Leishmania major protein kinase, putative 0.007 0.1094 1
Echinococcus multilocularis rho associated protein kinase 0.0178 0.3103 0.8649
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0076
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0015 0.0076 0.0222
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0015 0.0076 0.0211
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0076 0.0211
Schistosoma mansoni myosin xvIII 0.0015 0.0076 0.0222
Schistosoma mansoni opsin-like receptor 0.0015 0.0076 0.0222
Echinococcus granulosus serotonin receptor 0.0015 0.0076 0.0211
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0906 0.8026
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0076
Brugia malayi serine/threonine protein kinase 6 0.007 0.1094 0.1094
Entamoeba histolytica p21-activated kinase 0.0021 0.0186 0.0472
Schistosoma mansoni biogenic amine receptor 0.0015 0.0076 0.0222
Giardia lamblia Kinase, CMGC GSK 0.006 0.0906 0.7928
Brugia malayi Dopamine receptor protein 1 0.0015 0.0076 0.0076
Echinococcus multilocularis g protein coupled receptor 0.0015 0.0076 0.0211
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0015 0.0076 0.0211
Echinococcus granulosus tm gpcr rhodopsin 0.0015 0.0076 0.0211
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0015 0.0076 0.0211
Schistosoma mansoni serine/threonine protein kinase 0.0194 0.341 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0076
Brugia malayi WH1 domain containing protein 0.0019 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0076
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0194 0.341 1
Schistosoma mansoni amine GPCR 0.0015 0.0076 0.0222
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.0076 0.0222
Schistosoma mansoni alpha-1 adrenergic receptor 0.0015 0.0076 0.0222
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0076
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.0076 0.0222
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.0076 0.0222
Entamoeba histolytica protein kinase domain containing protein 0.006 0.0906 0.8026
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0015 0.0076 0.0222
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0076 0.0211
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.006 0.0906 0.2657
Onchocerca volvulus 0.0167 0.2895 0.8455
Schistosoma mansoni neuropeptide receptor 0.0015 0.0076 0.0222
Echinococcus granulosus neuropeptide Y receptor 0.0015 0.0076 0.0211
Loa Loa (eye worm) hypothetical protein 0.0018 0.0122 0.0122
Schistosoma mansoni adenoreceptor 0.0015 0.0076 0.0222
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.0076 0.0222
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0194 0.341 0.9504
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0076
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0906 0.8026
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0076
Echinococcus multilocularis neuropeptide receptor A26 0.0015 0.0076 0.0211

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) Inhibition of JAK2 after 1 hr using biotinylated PDKtide as substrate ChEMBL. 21282054
Ki (binding) Inhibition of EGFR after 1 hr ChEMBL. 21282054
Ki (binding) = 0.402 uM Inhibition of Rock2 after 1 hr using biotinylated longS peptide as substrate ChEMBL. 21282054
Ki (binding) = 3.685 uM Inhibition of Pim1 after 1 hr using biotinylated AL1peptide as substrate ChEMBL. 21282054
Ki (binding) > 3.75 uM Inhibition of Pak4 after 1 hr using biotinylated L15 peptide as substrate ChEMBL. 21282054
Ki (binding) = 4.272 uM Inhibition of GSK3-beta after 1 hr ChEMBL. 21282054
Ki (binding) > 4.9 uM Inhibition of Aurora kinase 2 after 1 hr using biotinylated kemptide as substrate ChEMBL. 21282054
Ki (binding) > 8.88 uM Inhibition of KDR after 1 hr ChEMBL. 21282054

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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