Detailed information for compound 149962

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 441.562 | Formula: C22H39N3O6
  • H donors: 2 H acceptors: 5 LogP: 3.05 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC[C@@H](C(=O)N[C@@H](C(C)(C)C)C(=O)N1CCC(CC1)C(=O)OCC)CN(C=O)O
  • InChi: 1S/C22H39N3O6/c1-6-8-9-17(14-25(30)15-26)19(27)23-18(22(3,4)5)20(28)24-12-10-16(11-13-24)21(29)31-7-2/h15-18,30H,6-14H2,1-5H3,(H,23,27)/t17-,18-/m1/s1
  • InChiKey: BXZHBCLZYFTOAJ-QZTJIDSGSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli peptide deformylase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) Get druggable targets OG5_128237 All targets in OG5_128237
Wolbachia endosymbiont of Brugia malayi peptide deformylase Get druggable targets OG5_128237 All targets in OG5_128237
Plasmodium yoelii polypeptide deformylase, putative Get druggable targets OG5_128237 All targets in OG5_128237
Plasmodium knowlesi peptide deformylase, putative Get druggable targets OG5_128237 All targets in OG5_128237
Plasmodium falciparum peptide deformylase Get druggable targets OG5_128237 All targets in OG5_128237
Mycobacterium ulcerans peptide deformylase Get druggable targets OG5_128237 All targets in OG5_128237
Neospora caninum Peptide deformylase, related Get druggable targets OG5_128237 All targets in OG5_128237
Toxoplasma gondii hypothetical protein Get druggable targets OG5_128237 All targets in OG5_128237
Plasmodium berghei peptide deformylase, putative Get druggable targets OG5_128237 All targets in OG5_128237
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) Get druggable targets OG5_128237 All targets in OG5_128237
Chlamydia trachomatis peptide deformylase Get druggable targets OG5_128237 All targets in OG5_128237
Plasmodium vivax peptide deformylase, putative Get druggable targets OG5_128237 All targets in OG5_128237
Treponema pallidum polypeptide deformylase (def) Get druggable targets OG5_128237 All targets in OG5_128237
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.1341 0.1354
Entamoeba histolytica fatty acid elongase, putative 0.0083 0.1178 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0417 0.0421
Echinococcus multilocularis transportin 1 0.0011 0.0039 0.0037
Echinococcus multilocularis importin 5 0.0011 0.0039 0.0037
Loa Loa (eye worm) acetyltransferase 0.0145 0.2159 0.2182
Brugia malayi Ets-domain containing protein 0.0011 0.0037 0.0104
Plasmodium vivax peptide deformylase, putative 0.0279 0.4288 0.4266
Loa Loa (eye worm) hypothetical protein 0.0012 0.006 0.006
Schistosoma mansoni hypothetical protein 0.0016 0.0115 0.0079
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0106 0.155 0.2992
Plasmodium vivax M18 aspartyl aminopeptidase, putative 0.0073 0.1015 0.0979
Echinococcus granulosus cpg binding protein 0.003 0.0342 0.0344
Leishmania major GTP-binding protein, putative 0.0022 0.0216 0.0364
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0073 0.1015 1
Toxoplasma gondii HEAT repeat-containing protein 0.0059 0.0801 0.1794
Echinococcus multilocularis importin subunit beta 1 0.0059 0.0801 0.0808
Mycobacterium ulcerans lipase LipD 0.0035 0.0417 0.0308
Mycobacterium ulcerans beta-lactamase 0.0035 0.0417 0.0308
Brugia malayi Importin beta-1 subunit 0.0059 0.0801 0.2261
Onchocerca volvulus 0.0035 0.0417 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0417 0.3875
Echinococcus multilocularis ETS transcription factor Elf 1 0.0011 0.0037 0.0035
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0037 0.0035
Echinococcus granulosus importin subunit beta 1 0.0059 0.0801 0.0808
Echinococcus multilocularis ETS transcription factor Elf 5 0.0011 0.0037 0.0035
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0002 0.0002
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.048 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0417 0.042
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0055 0.0728 0.1281
Brugia malayi intermediate filament protein 0.0027 0.0289 0.0814
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0216 0.0611
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.1341 0.1354
Entamoeba histolytica fatty acid elongase, putative 0.0083 0.1178 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0067 0.0068
Brugia malayi acetyltransferase, GNAT family protein 0.0145 0.2159 0.6093
Loa Loa (eye worm) hypothetical protein 0.0073 0.1015 0.1025
Leishmania major hypothetical protein, conserved 0.0035 0.0417 0.0775
Entamoeba histolytica aminopeptidase, putative 0.0073 0.1015 0.8566
Trypanosoma cruzi Peptide deformylase 2, putative 0.0106 0.155 0.2992
Loa Loa (eye worm) hypothetical protein 0.0027 0.0289 0.0292
Echinococcus granulosus importin 5 0.0011 0.0039 0.0037
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0037 0.0035
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0417 0.3875
Schistosoma mansoni cpg binding protein 0.0029 0.0316 0.0283
Brugia malayi beta-lactamase family protein 0.0035 0.0417 0.1177
Loa Loa (eye worm) D-ets-2 protein 0.0011 0.0037 0.0037
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0417 0.3875
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0662 0.1868
Echinococcus multilocularis lamin 0.0027 0.0289 0.029
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0289 0.0292
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0115 0.0323
Echinococcus granulosus ETS transcription factor Elf 1 0.0011 0.0037 0.0035
Loa Loa (eye worm) hypothetical protein 0.0035 0.0417 0.0421
Brugia malayi Cytochrome P450 family protein 0.0016 0.0112 0.0316
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0076 0.1074 0.1085
Entamoeba histolytica fatty acid elongase, putative 0.0083 0.1178 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0572 0.0957
Loa Loa (eye worm) hypothetical protein 0.0026 0.0281 0.0284
Mycobacterium ulcerans peptide deformylase 0.0279 0.4288 0.4223
Loa Loa (eye worm) hypothetical protein 0.0035 0.0417 0.0421
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0537 0.0541
Echinococcus granulosus GA binding protein alpha chain 0.0076 0.1074 0.1083
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.3412 0.3126
Onchocerca volvulus 0.0035 0.0417 1
Brugia malayi beta-lactamase family protein 0.0035 0.0417 0.1177
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.1341 0.1356
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0417 0.0308
Schistosoma mansoni cpg binding protein 0.003 0.0342 0.031
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0216 0.0364
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0145 0.2159 0.2152
Echinococcus granulosus ewsr:fli fusion protein type 0.0011 0.0037 0.0035
Schistosoma mansoni intermediate filament proteins 0.0027 0.0289 0.0255
Plasmodium falciparum M18 aspartyl aminopeptidase 0.0073 0.1015 0.0979
Echinococcus multilocularis protein C ets 2 0.0011 0.0037 0.0035
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0073 0.1015 1
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0639 1 1
Echinococcus granulosus transportin 1 0.0011 0.0039 0.0037
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0417 0.1177
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.078 0.1744
Loa Loa (eye worm) hypothetical protein 0.0016 0.0115 0.0116
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.1341 0.1323
Trypanosoma cruzi aspartyl aminopeptidase, putative 0.0073 0.1015 0.1878
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0011 0.0037 0.0035
Echinococcus granulosus snurportin 1 0.0632 0.9894 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.0572 0.0957
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0289 0.0814
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0417 0.038
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.048 0.3877
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0417 0.3875
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0537 0.05
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0417 0.042
Brugia malayi DNA-binding protein D-ETS-3 0.0011 0.0037 0.0104
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0034 0.0402 0.3719
Schistosoma mansoni hypothetical protein 0.0016 0.0115 0.0079
Brugia malayi kap beta 3 protein 0.0011 0.0039 0.0109
Trichomonas vaginalis hypothetical protein 0.0034 0.0402 0.3719
Loa Loa (eye worm) importin-beta domain-containing protein 0.0011 0.0039 0.0039
Loa Loa (eye worm) ets-domain-containing protein 0.0011 0.0037 0.0037
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0145 0.2159 0.218
Leishmania major polypeptide deformylase-like protein, putative 0.0106 0.155 0.3098
Loa Loa (eye worm) kap beta 3 protein 0.0011 0.0039 0.0039
Toxoplasma gondii hypothetical protein 0.0051 0.0677 0.1501
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0402 0.3719
Loa Loa (eye worm) hypothetical protein 0.0035 0.0417 0.0421
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0216 0.0217
Echinococcus multilocularis cpg binding protein 0.003 0.0342 0.0344
Leishmania major cytochrome p450-like protein 0.0016 0.0112 0.015
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0106 0.155 0.2992
Trypanosoma cruzi Peptide deformylase 2, putative 0.0106 0.155 0.2992
Onchocerca volvulus 0.0035 0.0417 1
Schistosoma mansoni lamin 0.0027 0.0289 0.0255
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0073 0.1015 1
Schistosoma mansoni hypothetical protein 0.0016 0.0115 0.0079
Schistosoma mansoni lamin 0.0027 0.0289 0.0255
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0662 0.1868
Brugia malayi beta-lactamase 0.0035 0.0417 0.1177
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0034 0.0402 0.3719
Echinococcus granulosus intermediate filament protein 0.0027 0.0289 0.029
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0112 0.0113
Entamoeba histolytica aspartyl aminopeptidase, putative 0.0073 0.1015 0.8566
Toxoplasma gondii ABC1 family protein 0.0035 0.0417 0.089
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0402 0.3719
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0639 1 1
Leishmania major importin beta-1 subunit, putative 0.0048 0.0623 0.1198
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0115 0.0114
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.1341 0.1354
Loa Loa (eye worm) hypothetical protein 0.0011 0.0037 0.0037
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0639 1 1
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0011 0.0037 0.0037
Plasmodium falciparum peptide deformylase 0.0279 0.4288 0.4266
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0417 0.0421
Loa Loa (eye worm) hypothetical protein 0.0035 0.0417 0.0421
Echinococcus granulosus translational activator gcn1 0.0011 0.0039 0.0037
Loa Loa (eye worm) CYP4Cod1 0.0016 0.0112 0.0113
Brugia malayi Ets-domain containing protein 0.0076 0.1074 0.3031
Trypanosoma brucei cytochrome P450, putative 0.0016 0.0112 0.015
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0216 0.0178
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.0279 0.4288 0.4039
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0216 0.0217
Trichomonas vaginalis importin beta-1, putative 0.0048 0.0623 0.5989
Brugia malayi Fli-1 protein 0.0232 0.3542 1
Leishmania major aspartyl aminopeptidase, putative,metallo-peptidase, Clan MH, Family M20 0.0073 0.1015 0.2
Schistosoma mansoni importin beta-1 0.0059 0.0801 0.0775
Mycobacterium ulcerans hypothetical protein 0.0168 0.2525 0.244
Echinococcus multilocularis ets variant gene 4 0.0011 0.0037 0.0035
Echinococcus granulosus lamin dm0 0.0027 0.0289 0.029
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0115 0.0323
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0409 0.1153
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0216 0.0217
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0318 0.4918 1
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0045 0.0572 0.1093
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.0801 0.1562
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0537 0.1172
Trichomonas vaginalis esterase, putative 0.0035 0.0417 0.3875
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0623 0.5989
Trypanosoma cruzi importin beta-1 subunit, putative 0.0048 0.0623 0.1063
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0115 0.0116
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0623 0.5989
Echinococcus multilocularis musashi 0.0027 0.0289 0.029
Brugia malayi Cytochrome P450 family protein 0.0016 0.0112 0.0316
Loa Loa (eye worm) hypothetical protein 0.0059 0.0801 0.081
Loa Loa (eye worm) hypothetical protein 0.0073 0.1015 0.1025
Trypanosoma brucei Polypeptide deformylase 1 0.0106 0.155 0.3098
Brugia malayi CXXC zinc finger family protein 0.0029 0.0316 0.0893
Mycobacterium ulcerans hypothetical protein 0.0035 0.0417 0.0308
Toxoplasma gondii hypothetical protein 0.0279 0.4288 1
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.048 0.0443
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0537 0.1172
Entamoeba histolytica fatty acid elongase, putative 0.0083 0.1178 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0318 0.4918 1
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.0639 1 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0115 0.0114
Echinococcus granulosus ETS transcription factor Elf 5 0.0011 0.0037 0.0035
Echinococcus multilocularis snurportin 1 0.0632 0.9894 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0827 0.0801
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0417 0.3875
Brugia malayi Aspartyl aminopeptidase 0.0073 0.1015 0.2864
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0402 0.3719
Schistosoma mansoni aspartyl aminopeptidase (M18 family) 0.0073 0.1015 0.0992
Echinococcus granulosus GPCR family 2 0.0016 0.0115 0.0114
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0316 0.032
Schistosoma mansoni hypothetical protein 0.0016 0.0115 0.0079
Echinococcus granulosus histone acetyltransferase KAT2B 0.0141 0.2094 0.2115
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0112 0.0113
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0417 0.0634
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0289 0.0292
Onchocerca volvulus 0.0029 0.0316 0.2162
Schistosoma mansoni gabp alpha 0.0076 0.1074 0.1052
Loa Loa (eye worm) hypothetical protein 0.0012 0.006 0.006
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0115 0.0114
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.009 0.0091
Trypanosoma brucei aspartyl aminopeptidase, putative 0.0073 0.1015 0.2
Loa Loa (eye worm) fli-1 protein 0.0232 0.3542 0.358
Trichomonas vaginalis ran, putative 0.0022 0.0216 0.182
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0417 0.0385
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.1341 0.1323
Schistosoma mansoni ran 0.0022 0.0216 0.0182
Brugia malayi Ets-domain containing protein 0.0076 0.1074 0.3031
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0216 0.0219
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0537 0.5103
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.1341 0.1354
Schistosoma mansoni aspartyl aminopeptidase (M18 family) 0.0073 0.1015 0.0992
Entamoeba histolytica Ran family GTPase 0.0022 0.0216 0.1559
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.009 0.0254
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0011 0.0037 0.0037
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0216 0.0178
Loa Loa (eye worm) beta-lactamase 0.0035 0.0417 0.0421
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0639 1 1
Loa Loa (eye worm) aspartyl aminopeptidase 0.0073 0.1015 0.1025
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0037 0.0035
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.1341 0.3787
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0151 0.2254 0.4457
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0216 0.0418
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0537 0.5103
Echinococcus granulosus ETS domain containing protein Elk 1 0.0011 0.0037 0.0035
Brugia malayi transcription factor E74 isoform 0.0011 0.0037 0.0104
Brugia malayi RNA, U transporter 1 0.0168 0.2534 0.7153
Echinococcus multilocularis GA binding protein alpha chain 0.0076 0.1074 0.1083
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.1341 0.1323
Schistosoma mansoni ets-related 0.0232 0.3542 0.3556
Plasmodium vivax importin-beta 2, putative 0.0059 0.0801 0.0765
Schistosoma mansoni importin-beta 2 0.0011 0.0039 0.0002
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0417 0.0775
Echinococcus granulosus lamin 0.0027 0.0289 0.029
Trypanosoma cruzi metallo-peptidase, Clan MH, Family M20 0.0073 0.1015 0.1878
Echinococcus multilocularis GPCR, family 2 0.0016 0.0115 0.0114
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0067 0.0066
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0632 0.9894 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0168 0.2525 0.2199
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0662 0.0669
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0216 0.0217
Schistosoma mansoni cpg binding protein 0.003 0.0342 0.031
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.0279 0.4288 1
Echinococcus granulosus protein C ets 2 0.0011 0.0037 0.0035
Trypanosoma brucei Peptide deformylase 2 0.0106 0.155 0.3098
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0639 1 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0417 0.0385
Schistosoma mansoni ran 0.0022 0.0216 0.0182
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0151 0.2254 0.4541
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0115 0.0114
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0037 0.0035
Treponema pallidum polypeptide deformylase (def) 0.0279 0.4288 0.5
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0067 0.0066
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0318 0.4918 1
Entamoeba histolytica fatty acid elongase, putative 0.0083 0.1178 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0151 0.2254 0.4541
Trypanosoma brucei aspartyl aminopeptidase, putative 0.0073 0.1015 0.2
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0034 0.0402 0.3719
Mycobacterium tuberculosis Probable aminopeptidase PepC 0.0073 0.1015 0.0624
Echinococcus granulosus aspartyl aminopeptidase 0.0073 0.1015 0.1024
Echinococcus multilocularis aspartyl aminopeptidase 0.0073 0.1015 0.1024
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0639 1 1
Plasmodium falciparum importin beta, putative 0.0059 0.0801 0.0765
Loa Loa (eye worm) hypothetical protein 0.0065 0.0898 0.0907
Entamoeba histolytica hypothetical protein 0.0048 0.0623 0.513
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0417 0.0634
Loa Loa (eye worm) hypothetical protein 0.0034 0.0409 0.0413
Echinococcus multilocularis ewsr:fli fusion protein type 0.0011 0.0037 0.0035
Schistosoma mansoni hypothetical protein 0.0034 0.0409 0.0377
Loa Loa (eye worm) hypothetical protein 0.005 0.0662 0.0669
Loa Loa (eye worm) hypothetical protein 0.0011 0.0037 0.0037
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.0801 0.1562
Echinococcus multilocularis lamin dm0 0.0027 0.0289 0.029
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0417 0.0308
Leishmania major mitochondrial DNA polymerase beta 0.0318 0.4918 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0572 0.0957
Loa Loa (eye worm) hypothetical protein 0.0035 0.0417 0.0421
Echinococcus multilocularis translational activator gcn1 0.0011 0.0039 0.0037
Schistosoma mansoni hypothetical protein 0.0632 0.9894 1
Mycobacterium leprae PROBABLE AMINOPEPTIDASE PEPC 0.0073 0.1015 0.1544

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 10 nM Inhibition concentration against Escherichia coli peptide deformylase. ChEMBL. 12873500
IC50 (binding) = 10 nM Inhibition concentration against Escherichia coli peptide deformylase. ChEMBL. 12873500
MIC (functional) = 25 uM Antibacterial activity against Staphylococcus capitis. ChEMBL. 12873500
MIC (functional) > 200 uM Antibacterial activity against Escherichia coli. ChEMBL. 12873500
MIC (functional) > 200 uM Antibacterial activity against Escherichia coli. ChEMBL. 12873500

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.