TDR Targets

Basic information

Technical information

TDR Targets ID: 1501357
Name: 3-[4-[[3-(2,6-dimethylphenoxy)phenyl]methoxy] phenyl]propanoic acid
MW: 376.445 | Formula: C24H24O4
H donors: 1 H acceptors: 2 LogP: 5.4 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)CCc1ccc(cc1)OCc1cccc(c1)Oc1c(C)cccc1C
InChi: 1S/C24H24O4/c1-17-5-3-6-18(2)24(17)28-22-8-4-7-20(15-22)16-27-21-12-9-19(10-13-21)11-14-23(25)26/h3-10,12-13,15H,11,14,16H2,1-2H3,(H,25,26)
InChiKey: LVEBWTURJCJOLX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-[4-[3-(2,6-dimethylphenoxy)benzyl]oxyphenyl]propionic acid

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	free fatty acid receptor 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0201	0.0894
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0014	0.0201	0.4944
Leishmania major	lysyl-tRNA synthetase, putative	0.0023	0.0398	0.3791
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Plasmodium vivax	hexose transporter	0.0102	0.2251	0.2251
Leishmania major	glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270	0.0051	0.105	1
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0007	0.0025	0.011
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0607	0.2697
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0007	0.0025	0.0235
Schistosoma mansoni	glucose transporter	0.0014	0.0201	0.0894
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0407	0.3874
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0036	0.07	0.1058
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0606	0.269
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0102	0.2251	1
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Echinococcus granulosus	solute carrier family 22	0.0014	0.0201	0.0894
Schistosoma mansoni	hypothetical protein	0.0102	0.2251	1
Schistosoma mansoni	sugar transporter	0.0014	0.0201	0.0894
Plasmodium vivax	sugar transporter, putative	0.0014	0.0201	0.0201
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.0025	0.011
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0007	0.0025	0.011
Mycobacterium leprae	POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0007	0.0025	0.0425
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0019	0.0318	0.5469
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0894
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0032	0.0608	0.0608
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0031	0.0581	0.2583
Mycobacterium ulcerans	acyl-CoA synthetase	0.0007	0.0025	0.0607
Entamoeba histolytica	hypothetical protein	0.0023	0.0398	0.3791
Onchocerca volvulus		0.0014	0.0201	0.1721
Trypanosoma cruzi	hexose transporter, putative	0.0017	0.027	0.2572
Toxoplasma gondii	sugar transporter ST3	0.0014	0.0201	0.0304
Plasmodium vivax	acetyl-CoA synthetase, putative	0.0007	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0894
Giardia lamblia	Kinase, CMGC GSK	0.0051	0.105	1
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0032	0.0608	0.0608
Trypanosoma brucei	long-chain-fatty-acid-CoA ligase, putative	0.0007	0.0025	0.0235
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0606	0.5765
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0007	0.0025	0.0607
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0607	0.2697
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0007	0.0025	0.0235
Trichomonas vaginalis	conserved hypothetical protein	0.0102	0.2251	1
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0607	0.2697
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0032	0.0607	0.2697
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0606	0.5765
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0007	0.0025	0.011
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0201	0.0894
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0606	0.269
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0607	0.2697
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0607	0.2697
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0032	0.0607	0.2697
Brugia malayi	intracellular kinase	0.0051	0.105	0.4666
Plasmodium falciparum	glycogen synthase kinase 3	0.0051	0.105	0.105
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0201	0.0894
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0032	0.0608	0.0608
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0102	0.2251	1
Brugia malayi	Sugar transporter family protein	0.0102	0.2251	1
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Brugia malayi	Major Facilitator Superfamily protein	0.0014	0.0201	0.0894
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0248	0.6096
Entamoeba histolytica	protein kinase domain containing protein	0.0051	0.105	1
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0007	0.0025	0.011
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0007	0.0025	0.0607
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0102	0.2251	1
Toxoplasma gondii	protein kinase, putative	0.0289	0.6616	1
Entamoeba histolytica	protein kinase, putative	0.0051	0.105	1
Plasmodium vivax	proline--tRNA ligase, putative	0.0036	0.07	0.07
Mycobacterium leprae	Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase)	0.0007	0.0025	0.0425
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	0.0051	0.105	0.4666
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Trypanosoma cruzi	hexose transporter, putative	0.0014	0.0201	0.1916
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0025	0.0607
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0606	0.5765
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0007	0.0025	0.011
Schistosoma mansoni	glucose transport protein	0.0102	0.2251	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0607	0.2697
Mycobacterium ulcerans	sugar transporter	0.0014	0.0201	0.4944
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0407	0.1808
Plasmodium vivax	glycogen synthase kinase 3, putative	0.0051	0.105	0.105
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0007	0.0025	0.0235
Onchocerca volvulus		0.0014	0.0201	0.1721
Giardia lamblia	Sugar-proton symporter	0.0014	0.0201	0.1916
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Schistosoma mansoni	sugar transporter	0.0014	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0017	0.027	0.12
Echinococcus granulosus	calcium dependent protein kinase	0.0029	0.0551	0.2448
Loa Loa (eye worm)	hypothetical protein	0.0017	0.027	0.12
Onchocerca volvulus		0.0014	0.0201	0.1721
Schistosoma mansoni	protein kinase	0.0032	0.0607	0.2697
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0102	0.2251	1
Chlamydia trachomatis	lysine--tRNA ligase	0.0023	0.0398	1
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0014	0.0201	0.0894
Mycobacterium ulcerans	bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase	0.0007	0.0025	0.0607
Echinococcus multilocularis	lysyl tRNA synthetase	0.0023	0.0398	0.1769
Trypanosoma brucei	glucose transporter 1E	0.0032	0.0606	0.5765
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0007	0.0025	0.0607
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0032	0.0608	0.0608
Treponema pallidum	prolyl-tRNA synthetase	0.0011	0.0119	1
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.5765
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0032	0.0608	0.0608
Schistosoma mansoni	glucose transport protein	0.0102	0.2251	1
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0407	1
Onchocerca volvulus		0.0014	0.0201	0.1721
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0014	0.0201	0.0201
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0031	0.0581	0.2583
Schistosoma mansoni	protein kinase	0.0032	0.0607	0.2697
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0894
Echinococcus granulosus	lysyl tRNA synthetase	0.0023	0.0398	0.1769
Trichomonas vaginalis	antibiotic synthetase, putative	0.0007	0.0025	0.011
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0398	0.9786
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.0581	0.2583
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0013	0.016	0.0709
Onchocerca volvulus		0.0014	0.0201	0.1721
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0606	0.5765
Onchocerca volvulus		0.0014	0.0201	0.1721
Entamoeba histolytica	acyl-coA synthetase, putative	0.0023	0.0407	0.3874
Trichomonas vaginalis	glucose transporter, putative	0.0014	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Onchocerca volvulus		0.0023	0.0407	0.3727
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0606	0.269
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.5765
Mycobacterium ulcerans	acyl-CoA synthetase	0.0007	0.0025	0.0607
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0019	0.0318	0.7814
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0032	0.0606	0.5765
Loa Loa (eye worm)	hypothetical protein	0.0017	0.027	0.12
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0407	0.1808
Onchocerca volvulus	Putative transporter	0.0014	0.0201	0.1721
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.0407	1
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0032	0.0607	0.578
Toxoplasma gondii	sugar transporter ST2	0.0014	0.0201	0.0304
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Onchocerca volvulus		0.0014	0.0201	0.1721
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0023	0.0398	0.6849
Loa Loa (eye worm)	sugar transporter	0.0102	0.2251	1
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0032	0.0608	0.0608
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0032	0.0608	0.0918
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0201	0.0894
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0407	0.1808
Echinococcus multilocularis	glycogen synthase kinase 3 beta	0.0051	0.105	0.4666
Toxoplasma gondii	sugar transporter ST1	0.0014	0.0201	0.0304
Brugia malayi	Cam kinase protein 1	0.0032	0.0607	0.2697
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0011	0.0119	0.2914
Schistosoma mansoni	sugar transporter	0.0014	0.0201	0.0894
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0407	0.3874
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0607	0.2697
Echinococcus granulosus	synaptic vesicle 2 protein	0.0014	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0894
Mycobacterium ulcerans	acyl-CoA synthetase	0.0007	0.0025	0.0607
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0031	0.0581	0.2583
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Toxoplasma gondii	propionate-CoA ligase	0.0007	0.0025	0.0037
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Mycobacterium ulcerans	O-succinylbenzoic acid--CoA ligase	0.0007	0.0025	0.0607
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0031	0.0581	1
Brugia malayi	hypothetical protein	0.0014	0.0201	0.0894
Onchocerca volvulus		0.0014	0.0201	0.1721
Echinococcus granulosus	glycogen synthase kinase 3 beta	0.0051	0.105	0.4666
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0014	0.0201	0.0894
Brugia malayi	hypothetical protein	0.0014	0.0201	0.0894
Mycobacterium tuberculosis	PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0006	0.0003	0.0064
Chlamydia trachomatis	proline--tRNA ligase	0.0011	0.0119	0.2978
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0014	0.0201	0.4944
Giardia lamblia	Prolyl-tRNA synthetase	0.0031	0.0581	0.5536
Echinococcus multilocularis	protein kinase shaggy	0.0051	0.105	0.4666
Plasmodium falciparum	acyl-CoA synthetase	0.0017	0.027	0.027
Leishmania major	hypothetical protein, conserved	0.0014	0.0201	0.1916
Entamoeba histolytica	protein kinase, putative	0.0032	0.0607	0.578
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0894
Schistosoma mansoni	serine/threonine protein kinase	0.0032	0.0607	0.2697
Trichomonas vaginalis	CAMK family protein kinase	0.0032	0.0607	0.2697
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0007	0.0025	0.0607
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0407	0.1808
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0407	0.6999
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0201	0.0894
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0407	1
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0023	0.0398	0.1769
Onchocerca volvulus		0.0014	0.0201	0.1721
Schistosoma mansoni	protein kinase	0.0032	0.0607	0.2697
Trypanosoma cruzi	glucose transporter, putative	0.0014	0.0201	0.1916
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0017	0.027	0.6638
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.07	0.6664
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0606	0.269
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.07	0.6664
Onchocerca volvulus		0.0051	0.105	1
Loa Loa (eye worm)	oxidoreductase	0.0007	0.0025	0.011
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0102	0.2251	1
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0201	0.0894
Trichomonas vaginalis	sugar transport protein, putative	0.0014	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0894
Echinococcus granulosus	solute carrier family 22	0.0014	0.0201	0.0894
Onchocerca volvulus		0.0014	0.0201	0.1721
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0398	0.1769
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.07	0.6664
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.07	0.6664
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0201	0.0894
Brugia malayi	Major Facilitator Superfamily protein	0.0014	0.0201	0.0894
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0014	0.0201	0.4944
Echinococcus multilocularis	calcium dependent protein kinase	0.0029	0.0551	0.2448
Plasmodium falciparum	lysine--tRNA ligase	0.0023	0.0398	0.0398
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0894
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.5765
Brugia malayi	Sugar transporter family protein	0.0014	0.0201	0.0894
Schistosoma mansoni	acetyl-CoA synthetase	0.0007	0.0025	0.011
Giardia lamblia	Hexose transporter	0.0014	0.0201	0.1916
Mycobacterium leprae	POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE)	0.0007	0.0025	0.0425
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0398	0.1769
Brugia malayi	Major Facilitator Superfamily protein	0.0014	0.0201	0.0894
Mycobacterium ulcerans	peptide synthetase Nrp (peptide synthase)	0.0007	0.0025	0.0607
Toxoplasma gondii	facilitative glucose transporter GT1	0.0102	0.2251	0.3403
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.07	0.6664
Trypanosoma cruzi	glycogen synthase kinase 3, putative	0.0051	0.105	1
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0032	0.0608	0.0608
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.0025	0.011
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0165	0.3731	0.564
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0007	0.0025	0.0607
Trypanosoma brucei	glucose transporter 2A	0.0032	0.0606	0.5765
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0407	0.3874
Giardia lamblia	Lysyl-tRNA synthetase	0.0023	0.0398	0.3791
Onchocerca volvulus		0.0014	0.0201	0.1721
Echinococcus granulosus	solute carrier family 22	0.0014	0.0201	0.0894
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.105	0.4666
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Mycobacterium ulcerans	phenyloxazoline synthase MbtB	0.0007	0.0025	0.0607
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0032	0.0607	0.2697
Mycobacterium ulcerans	acetyl-CoA synthetase	0.0007	0.0025	0.0607
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0407	0.1808
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0025	0.0607
Trypanosoma brucei	sugar transporter, putative	0.0014	0.0201	0.1916
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0407	1
Schistosoma mansoni	sugar transporter	0.0014	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0447	0.1987
Echinococcus granulosus	protein kinase shaggy	0.0051	0.105	0.4666
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0051	0.105	0.4666
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0032	0.0608	0.0918
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0025	0.0607
Trichomonas vaginalis	antibiotic synthetase, putative	0.0007	0.0025	0.011
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0581	0.2583
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0031	0.0581	0.2583
Plasmodium vivax	acyl-CoA synthetase, putative	0.0017	0.027	0.027
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0102	0.2251	1
Brugia malayi	hypothetical protein	0.0014	0.0201	0.0894
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0407	0.6999
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.0407	1
Echinococcus granulosus	General substrate transporter	0.0088	0.1916	0.851
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0017	0.027	0.12
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0032	0.0608	0.0608
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0165	0.3731	0.3731
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.105	0.4666
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0014	0.0201	1
Leishmania major	glucose transporter, lmgt2	0.0032	0.0606	0.5765
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0007	0.0025	0.0607
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0014	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0407	0.1808
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.0025	0.011
Mycobacterium ulcerans	acyl-CoA synthetase	0.0007	0.0025	0.0607
Plasmodium falciparum	hexose transporter	0.0102	0.2251	0.2251
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0894
Leishmania major	long-chain-fatty-acid-CoA ligase, putative	0.0007	0.0025	0.0235
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0894
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.0581	0.2583
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0031	0.0581	0.5536
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0407	1
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0032	0.0608	0.0918
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0025	0.0607
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtE	0.0007	0.0025	0.0607
Plasmodium vivax	lysine--tRNA ligase, putative	0.0023	0.0398	0.0398
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Entamoeba histolytica	long-chain-fatty-acid--CoA ligase, putative	0.0007	0.0025	0.0235
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Toxoplasma gondii	Acetyl-coenzyme A synthetase 2, putative	0.0007	0.0025	0.0037
Plasmodium falciparum	protein kinase 7	0.0289	0.6616	0.6616
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0032	0.0608	0.0608
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0007	0.0025	0.011
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0201	0.0894
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0407	1
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0017	0.027	0.6783
Toxoplasma gondii	cell-cycle-associated protein kinase GSK, putative	0.0051	0.105	0.1588
Entamoeba histolytica	protein kinase domain containing protein	0.0051	0.105	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0398	0.1769
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0017	0.027	0.6638
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.5765
Brugia malayi	lysyl-tRNA synthetase	0.0023	0.0398	0.1769
Toxoplasma gondii	transporter, major facilitator family protein	0.0014	0.0201	0.0304
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0894
Loa Loa (eye worm)	sugar transporter	0.0014	0.0201	0.0894
Giardia lamblia	Kinase, CMGC GSK	0.0051	0.105	1
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0025	0.011
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0248	0.6096
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0606	0.5765
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0606	0.269
Leishmania major	glucose transporter, lmgt3	0.0032	0.0606	0.5765
Leishmania major	protein kinase, putative	0.0032	0.0607	0.578
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.002	0.0333	0.1477
Brugia malayi	major facilitator superfamily protein	0.0014	0.0201	0.0894
Trypanosoma cruzi	hexose transporter	0.0032	0.0606	0.5765
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0894
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0031	0.0581	0.2583
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0607	0.2697
Onchocerca volvulus		0.0014	0.0201	0.1721
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0248	0.6096
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0407	0.3874
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.0025	0.011
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Leishmania major	glucose transporter, lmgt1	0.0032	0.0606	0.5765
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0606	0.269
Trichomonas vaginalis	myo-inositol transporter, putative	0.0014	0.0201	0.0894
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0606	0.269
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0007	0.0025	0.0037
Onchocerca volvulus		0.0014	0.0201	0.1721
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0407	0.3874
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0007	0.0025	0.0235
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0025	0.011
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0023	0.0398	0.3791
Trypanosoma brucei	protein kinase, putative	0.0051	0.105	1
Brugia malayi	major facilitator superfamily protein	0.0014	0.0201	0.0894
Plasmodium falciparum	proline--tRNA ligase	0.0036	0.07	0.07
Mycobacterium ulcerans	acyl-CoA synthetase	0.0007	0.0025	0.0607
Loa Loa (eye worm)	hypothetical protein	0.0017	0.027	0.12
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.0407	1
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.5765
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0248	0.6096
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Mycobacterium ulcerans	acyl-CoA synthetase	0.0007	0.0025	0.0607
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.5765
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0581	0.2583
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0007	0.0025	0.0607
Mycobacterium ulcerans	acyl-CoA synthetase	0.0007	0.0025	0.0607
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0102	0.2251	1
Leishmania major	acetyl-CoA synthetase, putative	0.0007	0.0025	0.0235
Mycobacterium ulcerans	integral membrane transport protein	0.0014	0.0201	0.4944
Echinococcus granulosus	solute carrier family 22	0.0014	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0894
Brugia malayi	Sugar transporter family protein	0.0014	0.0201	0.0894
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0014	0.0201	0.4944
Mycobacterium ulcerans	acyl-CoA synthetase	0.0007	0.0025	0.0607
Trypanosoma cruzi	sugar transporter, putative	0.0014	0.0201	0.1916
Echinococcus multilocularis	General substrate transporter	0.0088	0.1916	0.851
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.5765
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0014	0.0201	0.0894
Onchocerca volvulus		0.0014	0.0201	0.1721
Schistosoma mansoni	glucose transport protein	0.0102	0.2251	1
Leishmania major	myo-inositol/proton symporter (MIT)	0.0014	0.0201	0.1916
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0894
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0051	0.105	0.4666
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0014	0.0201	0.0894
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0023	0.0398	0.3791
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0434	1	1
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0019	0.0318	0.7814
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0102	0.2251	1
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0201	0.0894
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.0407	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0032	0.0607	0.2697
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0606	0.5765
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.5765
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtF	0.0007	0.0025	0.0607
Entamoeba histolytica	protein kinase, putative	0.0032	0.0607	0.578
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0007	0.0025	0.0607
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0014	0.0201	0.1916
Trypanosoma brucei	acetyl-CoA synthetase, putative	0.0007	0.0025	0.0235
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0165	0.3731	0.3731
Onchocerca volvulus		0.0014	0.0201	0.1721
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0398	0.9786
Onchocerca volvulus		0.0014	0.0201	0.1721
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Mycobacterium ulcerans	long-chain-acyl-CoA synthetase	0.0007	0.0025	0.0607
Plasmodium falciparum	acetyl-CoA synthetase, putative	0.0007	0.0025	0.0025
Leishmania major	acetyl-CoA synthetase, putative	0.0007	0.0025	0.0235
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0014	0.0201	0.0894
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.0407	1
Toxoplasma gondii	lysine-tRNA ligase	0.0023	0.0398	0.0602
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0894

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 47 nM	Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BSA	ChEMBL.	21319751

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1688462

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1501357