Detailed information for compound 15108

Basic information

Technical information
  • TDR Targets ID: 15108
  • Name: 2,2,5,5-tetramethyl-N-[3-[(3,4,5-trimethoxybe nzoyl)amino]propyl]-1H-pyrrole-3-carboxamide
  • MW: 419.515 | Formula: C22H33N3O5
  • H donors: 3 H acceptors: 2 LogP: 1.45 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(cc(c1OC)OC)C(=O)NCCCNC(=O)C1=CC(NC1(C)C)(C)C
  • InChi: 1S/C22H33N3O5/c1-21(2)13-15(22(3,4)25-21)20(27)24-10-8-9-23-19(26)14-11-16(28-5)18(30-7)17(12-14)29-6/h11-13,25H,8-10H2,1-7H3,(H,23,26)(H,24,27)
  • InChiKey: DSUAGLJMMIPSBT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2,2,5,5-tetramethyl-N-[3-[[oxo-(3,4,5-trimethoxyphenyl)methyl]amino]propyl]-1H-pyrrole-3-carboxamide
  • 2,2,5,5-tetramethyl-N-[3-[(3,4,5-trimethoxyphenyl)carbonylamino]propyl]-1H-pyrrole-3-carboxamide
  • 2,2,5,5-tetramethyl-N-[3-[(3,4,5-trimethoxybenzoyl)amino]propyl]-3-pyrroline-3-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica cysteine protease, putative 0.0078 0.0875 0.2137
Echinococcus multilocularis calcium uptake protein 1 0.0009 0.0015 0.0015
Brugia malayi Matrixin family protein 0.0053 0.0567 0.062
Brugia malayi Cathepsin L-like precursor 0.0331 0.406 0.4441
Schistosoma mansoni neuronal calcium sensor 0.0009 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0229 0.2769 0.3029
Brugia malayi Papain family cysteine protease containing protein 0.0331 0.406 0.4441
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0181 0.2166 0.2369
Echinococcus granulosus cathepsin L 0.0181 0.2166 0.2369
Entamoeba histolytica cysteine protease, putative 0.0078 0.0875 0.2137
Loa Loa (eye worm) hypothetical protein 0.0053 0.056 0.0612
Plasmodium falciparum serine repeat antigen 8 0.0078 0.0875 0.2137
Entamoeba histolytica cysteine protease, putative 0.0181 0.2166 0.5325
Schistosoma mansoni hypothetical protein 0.0009 0.001 0.001
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0022 0.0175 0.0192
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0148 0.0152
Entamoeba histolytica cysteine protease, putative 0.0181 0.2166 0.5325
Giardia lamblia Cathepsin L precursor 0.0078 0.0875 0.2517
Echinococcus multilocularis calmodulin 0.0009 0.001 0.001
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0078 0.0875 0.2137
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0061 0.0671 0.0734
Echinococcus multilocularis cathepsin b 0.0736 0.9142 0.9142
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0078 0.0875 0.0957
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0736 0.9142 1
Echinococcus multilocularis EF HAND 1, calcium binding site 0.0009 0.001 0.001
Schistosoma mansoni calpain-7 (C02 family) 0.002 0.0148 0.0162
Onchocerca volvulus 0.0331 0.406 1
Onchocerca volvulus 0.0009 0.0015 0.0014
Echinococcus granulosus cathepsin l1 0.0331 0.406 0.4441
Echinococcus granulosus dnaJ subfamily B 0.0401 0.4938 0.5402
Entamoeba histolytica cysteine protease, putative 0.0078 0.0875 0.2137
Echinococcus multilocularis calpain 0.002 0.0148 0.0148
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0229 0.2769 0.6812
Brugia malayi Cathepsin L-like cysteine proteinase 0.0229 0.2769 0.3029
Giardia lamblia Cathepsin B precursor 0.0078 0.0875 0.2517
Schistosoma mansoni hypothetical protein 0.0031 0.0287 0.0314
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0078 0.0875 0.2137
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0078 0.0875 0.0957
Loa Loa (eye worm) hypothetical protein 0.0078 0.0875 0.0957
Echinococcus multilocularis cathepsin L cysteine protease 0.0331 0.406 0.406
Entamoeba histolytica cysteine protease, putative 0.0181 0.2166 0.5325
Onchocerca volvulus Cathepsin L homolog 0.0331 0.406 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0331 0.406 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0331 0.406 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0331 0.406 1
Loa Loa (eye worm) fibroinase 0.0331 0.406 0.4441
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0875 0.2137
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0331 0.406 1
Loa Loa (eye worm) hypothetical protein 0.0103 0.119 0.1301
Loa Loa (eye worm) hypothetical protein 0.0039 0.0385 0.0422
Echinococcus multilocularis calmodulin 0.0009 0.001 0.001
Echinococcus multilocularis cathepsin L cysteine protease 0.0331 0.406 0.406
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0078 0.0875 0.0957
Giardia lamblia Cathepsin B precursor 0.0078 0.0875 0.2517
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0285 0.0285
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0078 0.0875 0.2137
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0078 0.0875 0.0957
Onchocerca volvulus 0.0229 0.2769 0.6812
Loa Loa (eye worm) hypothetical protein 0.0027 0.0235 0.0257
Echinococcus granulosus neuronal calcium sensor 0.0009 0.001 0.001
Schistosoma mansoni calpain C (C02 family) 0.002 0.0148 0.0162
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0738 0.0808
Brugia malayi Cathepsin L-like precursor 0.0331 0.406 0.4441
Entamoeba histolytica cysteine protease, putative 0.0181 0.2166 0.5325
Trypanosoma brucei calpain-like protein, putative 0.002 0.0148 0.0342
Onchocerca volvulus 0.0031 0.0285 0.068
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0736 0.9142 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0078 0.0875 0.0957
Plasmodium vivax serine-repeat antigen (SERA) 0.0078 0.0875 0.2137
Leishmania major cathepsin L-like protease 0.0331 0.406 1
Schistosoma mansoni cpg binding protein 0.0028 0.0253 0.0276
Brugia malayi programmed cell death protein 6 0.0009 0.001 0.001
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0078 0.0875 0.2517
Brugia malayi Pre-SET motif family protein 0.0031 0.0285 0.0312
Giardia lamblia Cathepsin B precursor 0.0078 0.0875 0.2517
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0331 0.406 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0331 0.406 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0285 0.0312
Entamoeba histolytica calpain large subunit domain III containing protein 0.0014 0.0073 0.0157
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0027 0.0235 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0875 0.2137
Entamoeba histolytica cysteine protease, putative 0.0181 0.2166 0.5325
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0078 0.0875 0.2137
Schistosoma mansoni hypothetical protein 0.0067 0.0738 0.0808
Brugia malayi Matrixin family protein 0.0022 0.0175 0.0192
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0736 0.9142 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0078 0.0875 0.0957
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0181 0.2166 0.5325
Trypanosoma cruzi cysteine protease, putative 0.0181 0.2166 0.2362
Echinococcus multilocularis calpain A 0.0062 0.0676 0.0676
Brugia malayi cathepsin F-like cysteine proteinase 0.0103 0.119 0.1301
Loa Loa (eye worm) matrixin family protein 0.0053 0.0567 0.062
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0078 0.0875 0.2517
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0287 0.0314
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0331 0.406 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0181 0.2166 0.2369
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0061 0.0671 0.0734
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0281 0.3432 0.845
Brugia malayi Papain family cysteine protease containing protein 0.0078 0.0875 0.0957
Entamoeba histolytica cysteine protease, putative 0.0078 0.0875 0.2137
Echinococcus granulosus cathepsin b 0.0736 0.9142 1
Loa Loa (eye worm) hypothetical protein 0.0229 0.2769 0.3029
Schistosoma mansoni calmodulin 0.0009 0.001 0.001
Giardia lamblia Cathepsin L precursor 0.0078 0.0875 0.2517
Trypanosoma cruzi cysteine peptidase, putative 0.0331 0.406 0.4435
Echinococcus granulosus calcium uptake protein 1 0.0009 0.0015 0.0017
Giardia lamblia Cysteine protease 0.0078 0.0875 0.2517
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0053 0.056 0.0612
Brugia malayi cathepsin Z-like cysteine proteinase 0.0078 0.0875 0.0957
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0078 0.0875 0.2137
Entamoeba histolytica hypothetical protein, conserved 0.0009 0.0015 0.0014
Giardia lamblia Cathepsin B precursor 0.0281 0.3432 1
Schistosoma mansoni calmodulin 0.0009 0.001 0.001
Entamoeba histolytica cysteine protease, putative 0.0181 0.2166 0.5325
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0078 0.0875 0.2517
Echinococcus granulosus cathepsin l cysteine peptidase 0.0331 0.406 0.4441
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0287 0.0287
Entamoeba histolytica cysteine proteinase 1, putative 0.0181 0.2166 0.5325
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0285 0.0312
Leishmania major hypothetical protein, conserved 0.0009 0.0015 0.0014
Schistosoma mansoni cathepsin C 0.0078 0.0875 0.0957
Loa Loa (eye worm) hypothetical protein 0.0078 0.0875 0.0957
Schistosoma mansoni Mername-AA248 (C02 family) 0.002 0.0148 0.0162
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0331 0.406 1
Schistosoma mansoni cathepsin S (C01 family) 0.0078 0.0875 0.0957
Plasmodium vivax unspecified product 0.0181 0.2166 0.5325
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0078 0.0875 0.2137
Brugia malayi Cathepsin L-like precursor 0.0331 0.406 0.4441
Toxoplasma gondii preprocathepsin c precursor, putative 0.0078 0.0875 0.2137
Schistosoma mansoni rab 0.0009 0.001 0.001
Entamoeba histolytica cysteine protease, putative 0.0181 0.2166 0.5325
Trypanosoma cruzi major cysteine proteinase, putative 0.0078 0.0875 0.0948
Toxoplasma gondii calmodulin CAM1 0.0009 0.0015 0.0014
Trypanosoma brucei kinesin, putative 0.0014 0.0073 0.0157
Echinococcus granulosus centrin 2 0.0009 0.001 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0281 0.3432 0.845
Loa Loa (eye worm) hypothetical protein 0.0033 0.031 0.034
Entamoeba histolytica cysteine proteinase, putative 0.0181 0.2166 0.5325
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0103 0.119 0.1301
Echinococcus granulosus calbindin 32 0.0009 0.0015 0.0017
Loa Loa (eye worm) hypothetical protein 0.0067 0.0738 0.0808
Giardia lamblia Hypothetical protein 0.0078 0.0875 0.2517
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0331 0.406 0.406
Brugia malayi Calmodulin-like protein 0.0009 0.001 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0331 0.406 1
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0009 0.0015 0.0006
Onchocerca volvulus 0.024 0.2911 0.7163
Trypanosoma cruzi cysteine proteinase, putative 0.0181 0.2166 0.2362
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0148 0.0152
Echinococcus granulosus calpain 7 C02 family 0.002 0.0148 0.0162
Echinococcus multilocularis cathepsin b 0.0736 0.9142 0.9142
Onchocerca volvulus 0.0028 0.0253 0.06
Echinococcus multilocularis cysteine protease 0.0331 0.406 0.406
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0331 0.406 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0331 0.406 1
Trypanosoma cruzi cysteine peptidase, putative 0.0331 0.406 0.4435
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0078 0.0875 0.2137
Brugia malayi calpain 5 0.0014 0.0073 0.008
Onchocerca volvulus 0.0033 0.031 0.0743
Echinococcus multilocularis cathepsin L 0.0078 0.0875 0.0875
Trypanosoma cruzi cysteine peptidase, putative 0.0103 0.119 0.1292
Schistosoma mansoni cathepsin B (C01 family) 0.0078 0.0875 0.0957
Plasmodium vivax vivapain-3 0.0181 0.2166 0.5325
Echinococcus granulosus calumenin 0.0009 0.0015 0.0017
Brugia malayi Papain family cysteine protease containing protein 0.0078 0.0875 0.0957
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0875 0.2137
Echinococcus multilocularis calpain family protein 1, d 0.0039 0.0385 0.0385
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0078 0.0875 0.2137
Brugia malayi Papain family cysteine protease containing protein 0.0181 0.2166 0.2369
Plasmodium falciparum serine repeat antigen 3 0.0078 0.0875 0.2137
Brugia malayi Cathepsin L-like precursor 0.0331 0.406 0.4441
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.1127 0.1233
Loa Loa (eye worm) hypothetical protein 0.0103 0.119 0.1301
Entamoeba histolytica cysteine proteinase, putative 0.0181 0.2166 0.5325
Plasmodium vivax SET domain protein, putative 0.0031 0.0285 0.068
Entamoeba histolytica cysteine proteinase, putative 0.0331 0.406 1
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0021 0.0023
Loa Loa (eye worm) calpain family protein 1 0.0053 0.056 0.0612
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0148 0.0342
Echinococcus granulosus calmodulin 0.0009 0.001 0.001
Schistosoma mansoni centrin 0.0009 0.001 0.001
Plasmodium falciparum serine repeat antigen 9 0.0078 0.0875 0.2137
Brugia malayi calpain 7 0.002 0.0148 0.0162
Echinococcus granulosus EF hand domain containing family member A2 0.0009 0.0015 0.0017
Trichomonas vaginalis calcineurin B subunit, putative 0.0009 0.0015 0.0014
Plasmodium falciparum serine repeat antigen 1 0.0078 0.0875 0.2137
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0285 0.068
Plasmodium vivax unspecified product 0.0078 0.0875 0.2137
Loa Loa (eye worm) calpain family protein 1 0.0039 0.0385 0.0422
Brugia malayi Matrixin family protein 0.0022 0.0175 0.0192
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0061 0.0671 0.0734
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0875 0.2137
Giardia lamblia Cathepsin B precursor 0.0078 0.0875 0.2517
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0078 0.0875 0.2137
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0875 0.2137
Loa Loa (eye worm) hypothetical protein 0.0031 0.0287 0.0314
Loa Loa (eye worm) histone methyltransferase 0.001 0.0022 0.0024
Giardia lamblia Cathepsin L-like protease 0.0078 0.0875 0.2517
Echinococcus multilocularis calpain 7 (C02 family) 0.002 0.0148 0.0148
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.1026 0.1026
Trypanosoma brucei cysteine peptidase C (CPC) 0.0281 0.3432 0.845
Echinococcus granulosus EF hand domain containing family member A2 0.0009 0.001 0.001
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0078 0.0875 0.2517
Brugia malayi cathepsin L precursor 0.0078 0.0875 0.0957
Brugia malayi Matrixin family protein 0.0022 0.0175 0.0192
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0078 0.0875 0.0957
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0331 0.406 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0148 0.0152
Loa Loa (eye worm) matrixin family protein 0.0049 0.0512 0.056
Brugia malayi calpain family protein 1 0.0053 0.056 0.0612
Entamoeba histolytica cysteine proteinase, putative 0.0181 0.2166 0.5325
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0148 0.0342
Echinococcus granulosus calpain A 0.0062 0.0676 0.074
Schistosoma mansoni calpain (C02 family) 0.002 0.0148 0.0162
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0331 0.406 1
Schistosoma mansoni mitochondrial solute carrier 0.0009 0.001 0.001
Echinococcus multilocularis EF hand domain containing family member A2 0.0009 0.0015 0.0015
Plasmodium vivax vivapain-1 0.0181 0.2166 0.5325
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0285 0.0312
Echinococcus granulosus cpg binding protein 0.003 0.0273 0.0298
Onchocerca volvulus 0.0331 0.406 1
Onchocerca volvulus 0.0031 0.0291 0.0694
Trypanosoma brucei calpain-like protein, putative 0.002 0.0148 0.0342
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0583 0.1416
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0287 0.0314
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0331 0.406 1
Toxoplasma gondii cathepsin B 0.0281 0.3432 0.845
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0736 0.9142 1
Trypanosoma cruzi cysteine peptidase, putative 0.0331 0.406 0.4435
Echinococcus granulosus calpain A 0.002 0.0148 0.0162
Brugia malayi cathepsin L-like precursor 0.0229 0.2769 0.3029
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0875 0.2137
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0078 0.0875 0.2137
Onchocerca volvulus Cathepsin L homolog 0.0078 0.0875 0.2137
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0078 0.0875 0.2137
Brugia malayi Cathepsin L-like precursor 0.0331 0.406 0.4441
Onchocerca volvulus Matrix metalloproteinase homolog 0.0049 0.0512 0.124
Echinococcus multilocularis calbindin 32 0.0009 0.0015 0.0015
Giardia lamblia Cysteine protease 0.0078 0.0875 0.2517
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0009 0.001 0.001
Brugia malayi Cathepsin L-like precursor 0.0229 0.2769 0.3029
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0078 0.0875 0.2137
Plasmodium falciparum cysteine proteinase falcipain 1 0.0181 0.2166 0.5325
Entamoeba histolytica cysteine protease, putative 0.0181 0.2166 0.5325
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0181 0.2166 0.5325
Echinococcus multilocularis cathepsin L 0.0181 0.2166 0.2166
Toxoplasma gondii cathepsin CPC2 0.0078 0.0875 0.2137
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.002 0.0148 0.0342
Giardia lamblia Cathepsin B precursor 0.0078 0.0875 0.2517
Loa Loa (eye worm) hypothetical protein 0.0098 0.1127 0.1233
Onchocerca volvulus 0.0022 0.0175 0.0409
Schistosoma mansoni hypothetical protein 0.0031 0.0287 0.0314
Loa Loa (eye worm) programmed cell death protein 6 0.0009 0.0015 0.0017
Plasmodium vivax unspecified product 0.0103 0.119 0.2914
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0001 0.0001
Echinococcus multilocularis cpg binding protein 0.003 0.0273 0.0273
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0331 0.406 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0001 0.0001
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0148 0.0342
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0331 0.406 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.1026 0.1122
Plasmodium falciparum serine repeat antigen 2 0.0078 0.0875 0.2137
Schistosoma mansoni ef hand domain family member A2 0.0009 0.001 0.001
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0148 0.0152
Echinococcus granulosus cysteine protease 0.0181 0.2166 0.2369
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.1127 0.1233
Leishmania major kinesin, putative 0.0014 0.0073 0.0157
Loa Loa (eye worm) hypothetical protein 0.0009 0.001 0.001
Plasmodium vivax serine-repeat antigen (SERA) 0.0078 0.0875 0.2137
Entamoeba histolytica cysteine protease, putative 0.0181 0.2166 0.5325
Echinococcus granulosus EF HAND 1 calcium binding site 0.0009 0.001 0.001
Schistosoma mansoni cpg binding protein 0.003 0.0273 0.0298
Entamoeba histolytica cysteine proteinase 2 0.0181 0.2166 0.5325
Loa Loa (eye worm) hypothetical protein 0.0229 0.2769 0.3029
Echinococcus multilocularis calpain 5 0.002 0.0148 0.0148
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0078 0.0875 0.0957
Echinococcus multilocularis programmed cell death protein 0.0009 0.001 0.001
Brugia malayi MH2 domain containing protein 0.0118 0.1386 0.1516
Brugia malayi CXXC zinc finger family protein 0.0028 0.0253 0.0276
Onchocerca volvulus 0.0331 0.406 1
Leishmania major cathepsin L-like protease 0.0331 0.406 1
Leishmania major cathepsin L-like protease 0.0331 0.406 1
Schistosoma mansoni calcium binding atopy-related autoantigen 0.0009 0.0015 0.0017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0331 0.406 1
Loa Loa (eye worm) calmodulin-like protein 0.0009 0.001 0.001
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.1386 0.1516
Brugia malayi calcium-binding protein 0.0009 0.001 0.001
Brugia malayi Papain family cysteine protease containing protein 0.0078 0.0875 0.0957
Echinococcus multilocularis neurocalcin 0.0009 0.001 0.001
Mycobacterium leprae PROBABLE HYDROLASE 0.0027 0.0235 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.1026 0.1122
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0331 0.406 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0281 0.3432 0.3747
Schistosoma mansoni calmodulin related calcium binding protein 0.0009 0.001 0.001
Echinococcus multilocularis EF hand domain containing family member A2 0.0009 0.001 0.001
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0061 0.0671 0.0671
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0181 0.2166 0.5325
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0285 0.0312
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0078 0.0875 0.0957
Entamoeba histolytica cysteine protease, putative 0.0078 0.0875 0.2137
Leishmania major cathepsin L-like protease 0.0331 0.406 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0331 0.406 0.406
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.1026 0.1122
Plasmodium vivax vivapain-2 0.0331 0.406 1
Schistosoma mansoni cathepsin F (C01 family) 0.0331 0.406 0.4441
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0001 0.0001
Giardia lamblia Cathepsin L precursor 0.0078 0.0875 0.2517
Echinococcus multilocularis neuronal calcium sensor 0.0009 0.001 0.001
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0078 0.0875 0.2137
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.1386 0.1516
Loa Loa (eye worm) hypothetical protein 0.0331 0.406 0.4441
Brugia malayi cathepsin Z-like cysteine proteinase 0.0078 0.0875 0.0957
Trichomonas vaginalis set domain proteins, putative 0.024 0.2911 0.7163
Echinococcus multilocularis hypothetical protein 0.002 0.0148 0.0148
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0078 0.0875 0.2137
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0287 0.0314
Loa Loa (eye worm) ctsf protein 0.0331 0.406 0.4441
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0875 0.2137
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0285 0.0285
Leishmania major cathepsin L-like protease 0.0331 0.406 1
Giardia lamblia Encystation-specific protease 0.0078 0.0875 0.2517
Giardia lamblia Cathepsin L precursor 0.0078 0.0875 0.2517
Brugia malayi calpain family protein 1 0.0053 0.056 0.0612
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0331 0.406 1
Schistosoma mansoni neuronal calcium sensor 0.0009 0.001 0.001
Trypanosoma cruzi kinesin, putative 0.0014 0.0073 0.007
Loa Loa (eye worm) calpain 0.002 0.0148 0.0162
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0331 0.406 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0331 0.406 1
Plasmodium falciparum serine repeat antigen 7 0.0078 0.0875 0.2137
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.008 0.0904 0.0904
Trypanosoma cruzi cysteine peptidase, putative 0.0331 0.406 0.4435
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0103 0.119 0.1301
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0148 0.0152
Loa Loa (eye worm) hypothetical protein 0.0078 0.0875 0.0957
Echinococcus granulosus cathepsin L cysteine protease 0.0181 0.2166 0.2369
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0078 0.0875 0.2137
Entamoeba histolytica cysteine proteinase, putative 0.0181 0.2166 0.5325
Onchocerca volvulus 0.0331 0.406 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0331 0.406 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0078 0.0875 0.2137
Plasmodium falciparum serine repeat antigen 6 0.0078 0.0875 0.2137
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0331 0.406 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0229 0.2769 0.3021
Toxoplasma gondii calcium-dependent protein kinase 0.0009 0.0015 0.0014
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0736 0.9142 1
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0875 0.2137
Schistosoma mansoni hypothetical protein 0.0031 0.0287 0.0314
Toxoplasma gondii cathepsin CPL 0.0331 0.406 1
Giardia lamblia Cathepsin L-like protease 0.0078 0.0875 0.2517
Schistosoma mansoni reticulocalbin 0.0009 0.001 0.001
Entamoeba histolytica cysteine protease, putative 0.0331 0.406 1
Entamoeba histolytica hypothetical protein 0.0078 0.0875 0.2137
Brugia malayi Papain family cysteine protease containing protein 0.0181 0.2166 0.2369
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.0009 0.001 0.001
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0001 0.0001
Plasmodium vivax vivapain-2 0.0331 0.406 1
Entamoeba histolytica cysteine protease, putative 0.0181 0.2166 0.5325
Echinococcus multilocularis centrin 2 0.0009 0.001 0.001
Brugia malayi cathepsin B-like cysteine proteinase 0.0736 0.9142 1
Schistosoma mansoni calpain-7 (C02 family) 0.002 0.0148 0.0162
Brugia malayi Matrixin family protein 0.0022 0.0175 0.0192
Loa Loa (eye worm) cysteine protease 0.0331 0.406 0.4441
Toxoplasma gondii cathepsin CPC1 0.0078 0.0875 0.2137
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0078 0.0875 0.2137
Plasmodium vivax hypothetical protein, conserved 0.0009 0.0015 0.0014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0331 0.406 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0331 0.406 1
Echinococcus granulosus calpain 5 0.002 0.0148 0.0162
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0331 0.406 1
Entamoeba histolytica cysteine protease, putative 0.0181 0.2166 0.5325
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0331 0.406 1
Giardia lamblia Cysteine protease 0.0078 0.0875 0.2517
Echinococcus granulosus cathepsin L cysteine proteinase 0.0331 0.406 0.4441
Schistosoma mansoni reticulocalbin 0.0009 0.0015 0.0017
Trypanosoma cruzi cysteine proteinase, putative 0.0181 0.2166 0.2362
Loa Loa (eye worm) hypothetical protein 0.0078 0.0875 0.0957
Echinococcus multilocularis dnaJ subfamily B 0.0401 0.4938 0.4938
Echinococcus granulosus neurocalcin 0.0009 0.001 0.001
Entamoeba histolytica cysteine proteinase, putative 0.0229 0.2769 0.6812
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0331 0.406 1
Schistosoma mansoni hypothetical protein 0.0031 0.0291 0.0318
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0078 0.0875 0.0957
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0875 0.2137
Loa Loa (eye worm) hypothetical protein 0.0078 0.0875 0.0957
Onchocerca volvulus Cathepsin L homolog 0.0331 0.406 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0078 0.0875 0.0957
Leishmania major cathepsin L-like protease 0.0331 0.406 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0253 0.0276
Loa Loa (eye worm) calpain 5 0.0014 0.0073 0.008
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.0009 0.001 0.001
Echinococcus granulosus cathepsin l1 0.0229 0.2769 0.3029
Loa Loa (eye worm) EF hand family protein 0.0009 0.001 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0331 0.406 1
Echinococcus multilocularis cysteine protease 0.0331 0.406 0.406
Loa Loa (eye worm) hypothetical protein 0.0078 0.0875 0.0957
Echinococcus granulosus tachykinin peptides receptor 99D 0.0589 0.73 0.7985
Onchocerca volvulus Cathepsin F homolog 0.0331 0.406 1
Plasmodium vivax calpain, putative 0.002 0.0148 0.0342
Giardia lamblia Cathepsin L precursor 0.0078 0.0875 0.2517
Leishmania major cysteine peptidase A (CPA) 0.0331 0.406 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0331 0.406 1
Giardia lamblia Cathepsin L precursor 0.0078 0.0875 0.2517
Echinococcus granulosus programmed cell death protein 0.0009 0.001 0.001
Plasmodium falciparum serine repeat antigen 5 0.0078 0.0875 0.2137
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0181 0.2166 0.2362
Trypanosoma brucei calpain-like protein, putative 0.002 0.0148 0.0342
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0181 0.2166 0.2369
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0022 0.0024
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0331 0.406 1
Trypanosoma cruzi cruzipain precursor, putative 0.0103 0.119 0.1292
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0078 0.0875 0.2137
Loa Loa (eye worm) hypothetical protein 0.0009 0.001 0.001
Brugia malayi fibroinase precursor 0.0078 0.0875 0.0957
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0331 0.406 1
Echinococcus granulosus cathepsin L 0.0078 0.0875 0.0957
Loa Loa (eye worm) hypothetical protein 0.0736 0.9142 1
Giardia lamblia Hypothetical protein 0.0078 0.0875 0.2517
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.2546 0.2785
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0148 0.0152
Entamoeba histolytica cysteine proteinase, putative 0.0331 0.406 1
Trypanosoma cruzi kinesin, putative 0.0014 0.0073 0.007
Brugia malayi cathepsin F-like cysteine proteinase 0.0078 0.0875 0.0957
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0078 0.0875 0.2137
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0331 0.406 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0281 0.3432 0.3754
Schistosoma mansoni cathepsin s 0.0103 0.119 0.1301
Brugia malayi Cathepsin L-like precursor 0.0229 0.2769 0.3029
Onchocerca volvulus 0.0078 0.0875 0.2137
Schistosoma mansoni hypothetical protein 0.0401 0.4938 0.5402
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0331 0.406 1
Trypanosoma brucei antigen, putative 0.002 0.0148 0.0342
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.008 0.0904 0.0988
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0331 0.406 0.4441
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0331 0.406 1
Onchocerca volvulus 0.0331 0.406 1
Trypanosoma brucei calpain-like protein, putative 0.002 0.0148 0.0342
Onchocerca volvulus Matrilysin homolog 0.0022 0.0175 0.0409
Entamoeba histolytica protein kinase, putative 0.0014 0.0073 0.0157
Trypanosoma cruzi major cysteine proteinase, putative 0.0078 0.0875 0.0948
Schistosoma mansoni cathepsin F (C01 family) 0.0331 0.406 0.4441
Giardia lamblia Cathepsin B precursor 0.0281 0.3432 1
Entamoeba histolytica cysteine protease, putative 0.0078 0.0875 0.2137
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0331 0.406 1
Loa Loa (eye worm) hypothetical protein 0.0103 0.119 0.1301
Brugia malayi Hemopexin family protein 0.0031 0.0291 0.0318
Schistosoma mansoni neuronal calcium sensor 0.0009 0.001 0.001
Trypanosoma brucei calmodulin, putative 0.0009 0.0015 0.0014
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0287 0.0287
Onchocerca volvulus Matrilysin homolog 0.0049 0.0512 0.124
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0875 0.2137
Brugia malayi EF hand family protein 0.0009 0.001 0.001
Entamoeba histolytica cysteine protease, putative 0.0181 0.2166 0.5325
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.1026 0.1122
Schistosoma mansoni cathepsin F (C01 family) 0.0229 0.2769 0.3029
Mycobacterium ulcerans hydrolase 0.0027 0.0235 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0229 0.2769 0.6812
Brugia malayi Cathepsin L-like precursor 0.0331 0.406 0.4441
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.1026 0.1026
Schistosoma mansoni neuronal calcium sensor 0.0009 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0022 0.0175 0.0192
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0875 0.2137
Trypanosoma cruzi cruzipain precursor, putative 0.0331 0.406 0.4435
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0263 0.0288
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0001 0.0001
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.1127 0.1233
Brugia malayi EF hand family protein 0.0009 0.0015 0.0017
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0078 0.0875 0.2137
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0331 0.406 1
Brugia malayi Pre-SET motif family protein 0.0211 0.2546 0.2785
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.1026 0.1122
Leishmania major cathepsin L-like protease 0.0331 0.406 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0148 0.0152
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.002 0.0148 0.0342
Onchocerca volvulus 0.0331 0.406 1
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0078 0.0875 0.2137
Schistosoma mansoni hypothetical protein 0.0031 0.0287 0.0314
Echinococcus granulosus sarcoplasmic calcium binding protein 0.0009 0.001 0.001
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0078 0.0875 0.2137
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.1026 0.1122
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0078 0.0875 0.0957
Trichomonas vaginalis calmodulin, putative 0.0009 0.0015 0.0014
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0663 0.0725
Echinococcus granulosus cathepsin b 0.0736 0.9142 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0287 0.0314
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0331 0.406 1
Loa Loa (eye worm) matrix metalloproteinase 0.0022 0.0175 0.0192
Giardia lamblia Cysteine protease 0.0078 0.0875 0.2517
Echinococcus multilocularis calumenin 0.0009 0.0015 0.0015
Echinococcus multilocularis programmed cell death protein 0.0009 0.001 0.001
Plasmodium falciparum serine repeat antigen 4 0.0078 0.0875 0.2137
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0285 0.0312
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0285 0.0312
Entamoeba histolytica cysteine protease, putative 0.0181 0.2166 0.5325
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.1026 0.1122
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0148 0.0152
Onchocerca volvulus 0.0331 0.406 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0331 0.406 1
Echinococcus multilocularis GPCR, family 2 0.0031 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.0022 0.0175 0.0192
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0331 0.406 0.4441
Echinococcus granulosus GPCR family 2 0.0031 0.0287 0.0314
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0078 0.0875 0.2137
Trypanosoma cruzi cysteine peptidase, putative 0.0181 0.2166 0.2362
Echinococcus granulosus calpain 0.002 0.0148 0.0162
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0287 0.0314
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0027 0.0235 0.0257
Brugia malayi cathepsin L-like cysteine proteinase 0.0078 0.0875 0.0957
Loa Loa (eye worm) hypothetical protein 0.0022 0.0175 0.0192
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0181 0.2166 0.5325
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0148 0.0152
Schistosoma mansoni centrin-related 0.0009 0.001 0.001
Trypanosoma cruzi calpain cysteine peptidase, putative 0.002 0.0148 0.0152
Schistosoma mansoni cpg binding protein 0.003 0.0273 0.0298
Leishmania major cathepsin L-like protease 0.0331 0.406 1
Loa Loa (eye worm) cathepsin B 0.0281 0.3432 0.3754
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0589 0.73 0.73
Loa Loa (eye worm) hypothetical protein 0.0047 0.0485 0.053
Giardia lamblia Cathepsin B precursor 0.0281 0.3432 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0078 0.0875 0.0957
Brugia malayi Cathepsin L-like precursor 0.0103 0.119 0.1301
Entamoeba histolytica grainin, putative 0.0009 0.0015 0.0014

Activities

Activity type Activity value Assay description Source Reference
ED150 (functional) = 12.3 mg kg-1 Effective dose against aconitine-induced arrhythmia after intravenal administration in anesthetized rats ChEMBL. 3806567
LD50 (ADMET) = 119 mg kg-1 Acute toxicity determined after intravenal administration in mice ChEMBL. 3806567
LD50 (ADMET) = 119 mg kg-1 Acute toxicity determined after intravenal administration in mice ChEMBL. 3806567
No. of positive cases (functional) = 5 Incidence of arrhythmias in rats after a intravenal administration at 4mg/kg, expressed as no. of positive cases out of no. of tested cases (10) ChEMBL. 3806567
Relative potency (functional) = 0.97 Relative potency with reference to quinidine ChEMBL. 3806567
Therapeutic index (ADMET) = 9.7 Therapeutic index calculated as the ratio of LD50 in mice to ED 150 in rat when administered intravenously ChEMBL. 3806567

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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