Detailed information for compound 1512734

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 318.329 | Formula: C18H14N4O2
  • H donors: 3 H acceptors: 4 LogP: 2.3 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccccc1Nc1nccc(n1)C1C(=O)Nc2c1cccc2
  • InChi: 1S/C18H14N4O2/c23-15-8-4-3-7-13(15)21-18-19-10-9-14(22-18)16-11-5-1-2-6-12(11)20-17(16)24/h1-10,16,23H,(H,20,24)(H,19,21,22)
  • InChiKey: LAWQCTXIAVNVKR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0031 0.0214
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.0034 0.0068 0.0462
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.007 0.0247 0.0795
Brugia malayi mbt repeat family protein 0.0048 0.0136 0.0917
Schistosoma mansoni hypothetical protein 0.0034 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0062 0.0208 0.1404
Brugia malayi PHD-finger family protein 0.0029 0.0044 0.0298
Leishmania major 4-coumarate:coa ligase-like protein 0.007 0.0247 0.9855
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0247 0.0795
Echinococcus granulosus thymidine phosphorylase 0.0647 0.3085 0.3085
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0071 0.0251 0.1854
Echinococcus granulosus lysine specific demethylase 6a 0.0025 0.0024 0.0024
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0071 0.0251 1
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0044 0.2676
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0053 0.0159 0.0511
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0143 0.0605 0.1957
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0155 0.0662 0.0662
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0071 0.0251 0.1854
Trichomonas vaginalis alpha-glucosidase, putative 0.0071 0.0251 0.1854
Mycobacterium ulcerans thymidine phosphorylase 0.0647 0.3085 1
Schistosoma mansoni hypothetical protein 0.0334 0.1543 0.1543
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.049 0.3309
Echinococcus multilocularis JmjC domain containing protein 4 0.0025 0.0024 0.0024
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0145 0.0465
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.0247 0.0795
Mycobacterium tuberculosis Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) 0.0647 0.3085 1
Echinococcus granulosus metabotropic glutamate receptor 2 0.0043 0.011 0.011
Trichomonas vaginalis protein kinase inhibitor, putative 0.0059 0.0192 0.1413
Brugia malayi Glycosyl hydrolases family 31 protein 0.0027 0.0031 0.0208
Echinococcus multilocularis lysosomal alpha glucosidase 0.0321 0.148 0.148
Loa Loa (eye worm) hypothetical protein 0.0053 0.0159 0.1077
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0136 0.0136
Brugia malayi Glycosyl hydrolases family 31 protein 0.0071 0.0251 0.1694
Mycobacterium ulcerans fatty-acid-CoA ligase 0.007 0.0247 0.0795
Echinococcus granulosus jumonji domain containing 1A 0.0025 0.0024 0.0024
Onchocerca volvulus 0.007 0.0247 0.3036
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0101 0.0101
Entamoeba histolytica acyl-coA synthetase, putative 0.007 0.0247 0.1827
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0143 0.0605 0.1957
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0155 0.0662 0.0662
Loa Loa (eye worm) hypothetical protein 0.0152 0.0647 0.4368
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0101 0.0101
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0002 0.0014
Loa Loa (eye worm) hypothetical protein 0.0025 0.0024 0.0163
Echinococcus granulosus peregrin 0.0029 0.0044 0.0044
Entamoeba histolytica acyl-CoA synthetase, putative 0.007 0.0247 0.1827
Schistosoma mansoni metabotropic glutamate receptor 0.0043 0.011 0.011
Brugia malayi jmjC domain containing protein 0.0094 0.0365 0.2466
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0188 0.0829 0.0829
Echinococcus multilocularis lysosomal alpha glucosidase 0.0321 0.148 0.148
Trichomonas vaginalis maltase-glucoamylase, putative 0.0071 0.0251 0.1854
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0031 0.0214
Onchocerca volvulus 0.0021 0.0002 0.0025
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1344 1
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0025 0.0024 0.0887
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0002 0.0014
Onchocerca volvulus 0.0186 0.0814 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0025 0.0024 0.0024
Brugia malayi mbt repeat family protein 0.0048 0.0136 0.0917
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0146 0.0989
Echinococcus multilocularis thymidine phosphorylase 0.0647 0.3085 0.3085
Echinococcus multilocularis peregrin 0.0029 0.0044 0.0044
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0044 0.0298
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0024 0.0163
Schistosoma mansoni alpha glucosidase 0.0071 0.0251 0.0251
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0136 0.1668
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0168 0.0168
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.0053 0.0159 0.1077
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.0048 0.0136 0.0917
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.007 0.0247 0.3075
Treponema pallidum fructose-bisphosphate aldolase 0.0293 0.1344 0.5
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.049 0.3309
Trypanosoma brucei glycosyl hydrolase-like protein 0.0027 0.0031 0.1154
Echinococcus granulosus lysine specific demethylase 5A 0.0094 0.0365 0.0365
Brugia malayi DnaJ domain containing protein 0.0059 0.0192 0.1295
Brugia malayi Glycosyl hydrolases family 31 protein 0.0321 0.148 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0002 0.0014
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0293 0.1344 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0044 0.0044
Echinococcus multilocularis phd:f box containing protein 0.0025 0.0024 0.0024
Brugia malayi AMP-binding enzyme family protein 0.007 0.0247 0.167
Schistosoma mansoni hypothetical protein 0.0334 0.1543 0.1543
Schistosoma mansoni alpha-glucosidase 0.0276 0.126 0.126
Schistosoma mansoni metabotropic glutamate receptor 0.0025 0.0022 0.0022
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0043 0.011 0.011
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0024 0.0163
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0002 0.0014
Echinococcus multilocularis serotonin receptor 0.0133 0.0556 0.0556
Echinococcus granulosus geminin 0.0334 0.1543 0.1543
Brugia malayi metabotropic glutamate receptor type 2 0.0025 0.0022 0.0149
Onchocerca volvulus 0.0048 0.0136 0.1668
Loa Loa (eye worm) hypothetical protein 0.0053 0.0159 0.1077
Loa Loa (eye worm) hypothetical protein 0.007 0.0247 0.167
Loa Loa (eye worm) hypothetical protein 0.0027 0.0031 0.0208
Schistosoma mansoni protein phosphatase 2C 0.0025 0.0024 0.0024
Brugia malayi jmjC domain containing protein 0.0025 0.0024 0.0163
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.0002 0.0002
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0813 0.3904 0.3904
Trichomonas vaginalis sucrase-isomaltase, putative 0.0071 0.0251 0.1854
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0071 0.0251 0.1694
Echinococcus granulosus dnaJ subfamily C 6 0.0059 0.0192 0.0192
Echinococcus multilocularis serotonin receptor 0.0133 0.0556 0.0556
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0027 0.0031 0.0214
Trichomonas vaginalis alpha-glucosidase, putative 0.0071 0.0251 0.1854
Brugia malayi Bromodomain containing protein 0.0029 0.0044 0.0298
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0251 1
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.0024 0.0887
Echinococcus granulosus biogenic amine 5HT receptor 0.0133 0.0556 0.0556
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0136 0.0917
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.0002 0.0002
Mycobacterium ulcerans anthranilate phosphoribosyltransferase 0.0182 0.0799 0.2585
Schistosoma mansoni hypothetical protein 0.0291 0.1332 0.1332
Loa Loa (eye worm) DnaJ domain-containing protein 0.0059 0.0192 0.1295
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0031 0.0214
Leishmania major alpha glucosidase II subunit, putative 0.0071 0.0251 1
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0188 0.0829 0.0829
Schistosoma mansoni biogenic amine (5HT) receptor 0.0133 0.0556 0.0556
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.0002 0.0014
Entamoeba histolytica acyl-CoA synthetase, putative 0.007 0.0247 0.1827
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0044 0.1693
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0031 0.0214
Schistosoma mansoni jumonji/arid domain-containing protein 0.0094 0.0365 0.0365
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1344 1
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0046 0.0127 0.0855
Trichomonas vaginalis alpha-glucosidase, putative 0.0071 0.0251 0.1854
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0025 0.0024 0.0024
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1344 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0168 0.0168
Plasmodium vivax acyl-CoA synthetase, putative 0.0053 0.0159 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0027 0.0031 0.0214
Brugia malayi jmjC domain containing protein 0.0155 0.0662 0.4474
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0025 0.0024 0.0024
Schistosoma mansoni hypothetical protein 0.0059 0.0192 0.0192
Schistosoma mansoni hypothetical protein 0.0029 0.0044 0.0044
Echinococcus multilocularis lysine specific demethylase 5A 0.0094 0.0365 0.0365
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0071 0.0251 0.1854
Plasmodium falciparum JmjC domain-containing protein, putative 0.0025 0.0024 0.1402
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0068 0.0462
Trichomonas vaginalis alpha-glucosidase, putative 0.0071 0.0251 0.1854
Schistosoma mansoni jumonji domain containing protein 0.0025 0.0024 0.0024
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0136 0.0136
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.0002 0.0014
Brugia malayi jmjC domain containing protein 0.0025 0.0024 0.0163
Brugia malayi jmjC domain containing protein 0.0025 0.0024 0.0163
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0293 0.1344 1
Leishmania major 4-coumarate:coa ligase-like protein 0.007 0.0247 0.9855
Schistosoma mansoni phosphatidylserine receptor 0.0025 0.0024 0.0024
Echinococcus granulosus phd:f box containing protein 0.0025 0.0024 0.0024
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0053 0.0159 0.1077
Schistosoma mansoni jumonji domain containing protein 0.0135 0.0565 0.0565
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0136 0.0136
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0053 0.0159 0.0511
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0002 0.0014
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0058 0.0184 0.0184
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0044 0.0044
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0168 0.0168
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0136 0.0136
Onchocerca volvulus 0.0021 0.0002 0.0025
Leishmania major glycosyl hydrolase-like protein 0.0027 0.0031 0.1154
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1344 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0168 0.1138
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0044 0.1693
Onchocerca volvulus 0.0152 0.0647 0.7942
Echinococcus multilocularis neutral alpha glucosidase AB 0.0071 0.0251 0.0251
Brugia malayi hypothetical protein 0.0152 0.0647 0.4368
Trypanosoma brucei glucosidase, putative 0.0071 0.0251 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0071 0.0251 0.1854
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0247 0.0795
Brugia malayi Metabotropic glutamate receptor precursor. 0.0051 0.015 0.1014
Plasmodium falciparum phd finger protein, putative 0.0029 0.0044 0.2676
Leishmania major hypothetical protein, conserved 0.0025 0.0024 0.0887
Echinococcus granulosus lysosomal alpha glucosidase 0.0321 0.148 0.148
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0027 0.0031 0.0378
Loa Loa (eye worm) hypothetical protein 0.007 0.0247 0.167
Onchocerca volvulus 0.0021 0.0002 0.0025
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0053 0.0159 0.5
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0025 0.0024 0.0887
Echinococcus multilocularis geminin 0.0334 0.1543 0.1543
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0145 0.0465
Giardia lamblia Fructose-bisphosphate aldolase 0.0293 0.1344 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0094 0.0365 0.0365
Loa Loa (eye worm) hypothetical protein 0.0066 0.0225 0.1517
Echinococcus granulosus metabotropic glutamate receptor 5 0.0062 0.0208 0.0208
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0146 0.0989
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.007 0.0247 0.167
Loa Loa (eye worm) hypothetical protein 0.0021 0.0002 0.0014
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.007 0.0247 0.0795
Echinococcus multilocularis dnaJ subfamily C 6 0.0059 0.0192 0.0192
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0321 0.148 1
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0025 0.0024 0.0887
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0002 0.0014
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.0002 0.0002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0145 0.0465
Onchocerca volvulus Alhambra homolog 0.0029 0.0044 0.0543
Brugia malayi jmjC domain containing protein 0.0025 0.0024 0.0163
Loa Loa (eye worm) glutamate receptor 0.0051 0.015 0.1014
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0027 0.0031 0.1154
Mycobacterium ulcerans hypothetical protein 0.007 0.0247 0.0795
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0136 0.0136
Mycobacterium leprae Probable anthranilate phosphoribosyltransferase TrpD 0.0182 0.0799 1
Brugia malayi AMP-binding enzyme family protein 0.007 0.0247 0.167
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0024 0.0163
Echinococcus multilocularis jumonji domain containing 1A 0.0025 0.0024 0.0024
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0027 0.0031 0.0214
Loa Loa (eye worm) jmjC domain-containing protein 0.0094 0.0365 0.2466
Loa Loa (eye worm) hypothetical protein 0.0133 0.0556 0.3756
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0031 0.0214
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0145 0.0465
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.007 0.0247 0.3075
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0027 0.0031 0.1154
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0197 0.1334
Schistosoma mansoni phd/f-box containing protein 0.0025 0.0024 0.0024
Loa Loa (eye worm) MBCTL1 0.0054 0.0168 0.1138
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.0024 0.0887
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0143 0.0605 0.7569
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0071 0.0251 0.1854
Plasmodium vivax JmjC domain containing protein 0.0025 0.0024 0.1402
Onchocerca volvulus 0.0021 0.0002 0.0025
Echinococcus granulosus neutral alpha glucosidase AB 0.0071 0.0251 0.0251
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1344 1
Mycobacterium tuberculosis Probable anthranilate phosphoribosyltransferase TrpD 0.0182 0.0799 0.2585
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0002 0.0014
Echinococcus granulosus JmjC domain containing protein 4 0.0025 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0053 0.0159 0.1077
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0146 0.0989
Loa Loa (eye worm) oxidoreductase 0.0021 0.0002 0.0014
Plasmodium falciparum acyl-CoA synthetase 0.0053 0.0159 1
Brugia malayi MH2 domain containing protein 0.012 0.049 0.3309
Loa Loa (eye worm) hypothetical protein 0.0133 0.0556 0.3756
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1344 1
Leishmania major 4-coumarate:coa ligase-like protein 0.007 0.0247 0.9855
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0168 0.1138
Loa Loa (eye worm) hypothetical protein 0.005 0.0146 0.0989
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.007 0.0247 0.0795
Schistosoma mansoni alpha-glucosidase 0.0276 0.126 0.126
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0247 0.0795
Brugia malayi AMP-binding enzyme family protein 0.007 0.0247 0.167
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0251 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1344 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.007 0.0247 0.0795
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0062 0.0208 0.0208
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1344 1
Echinococcus multilocularis lysine specific demethylase 6a 0.0025 0.0024 0.0024
Trichomonas vaginalis maltase-glucoamylase, putative 0.0027 0.0031 0.0214
Loa Loa (eye worm) hypothetical protein 0.0029 0.0044 0.0298
Loa Loa (eye worm) hypothetical protein 0.0025 0.0024 0.0163

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 52 % Competitive inhibition of recombinant TAK1-TAB1 assessed as [33P]gamma-ATP incorporation into substrate histone H1 peptide at 10 uM by filter plate assay ChEMBL. 21316225

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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