Detailed information for compound 1523284

Basic information

Technical information
  • TDR Targets ID: 1523284
  • Name: 3-[5-(4-bromophenyl)-1-(carbamothioylamino)py rrol-2-yl]propanoic acid
  • MW: 368.249 | Formula: C14H14BrN3O2S
  • H donors: 2 H acceptors: 2 LogP: 2.88 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)CCc1ccc(n1N=C(S)N)c1ccc(cc1)Br
  • InChi: 1S/C14H14BrN3O2S/c15-10-3-1-9(2-4-10)12-7-5-11(6-8-13(19)20)18(12)17-14(16)21/h1-5,7H,6,8H2,(H,19,20)(H3,16,17,21)
  • InChiKey: RFAJSNFWGQAIEA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[5-(4-bromophenyl)-1-(carbamothioylamino)-2-pyrrolyl]propanoic acid
  • 3-[5-(4-bromophenyl)-1-(thiocarbamoylamino)pyrrol-2-yl]propionic acid
  • STK112445
  • 3-[1-[(aminocarbothioyl)amino]-5-(4-bromophenyl)-1H-pyrrol-2-yl]propanoic acid
  • MLS000540061
  • SMR000162045
  • AH-487/41733581

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens glutaminase Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 9 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) glutaminase 2 Get druggable targets OG5_129245 All targets in OG5_129245
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis glutaminase, putative Get druggable targets OG5_129245 All targets in OG5_129245
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Loa Loa (eye worm) glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi glutaminase DH11.1 Get druggable targets OG5_129245 All targets in OG5_129245
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 cytochrome P450, family 2, subfamily C, polypeptide 9 490 aa 441 aa 21.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tubulin subunit alpha 0.0158 0.1842 0.1842
Entamoeba histolytica tubulin alpha chain, putative 0.046 0.7293 0.3607
Leishmania major beta tubulin 0.0611 1 1
Trypanosoma cruzi zeta tubulin, putative 0.0487 0.7771 0.7755
Echinococcus multilocularis tubulin subunit beta 0.0611 1 1
Schistosoma mansoni tubulin subunit beta 0.0611 1 1
Echinococcus granulosus tubulin alpha chain 0.046 0.7293 0.7293
Leishmania major epsilon tubulin, putative 0.0375 0.5757 0.5598
Loa Loa (eye worm) tubulin alpha 2 0.0117 0.1107 0.1107
Plasmodium vivax tubulin epsilon chain, putative 0.0375 0.5757 0.4799
Brugia malayi glutaminase DH11.1 0.033 0.4947 0.4947
Leishmania major alpha tubulin 0.046 0.7293 0.7191
Trichomonas vaginalis tubulin epsilon chain, putative 0.046 0.7293 0.6681
Loa Loa (eye worm) tubulin alpha 2 0.0303 0.4457 0.4457
Echinococcus granulosus tubulin beta 1 chain 0.0611 1 1
Schistosoma mansoni tubulin subunit alpha 0.046 0.7293 0.7293
Echinococcus multilocularis tubulin alpha chain 0.046 0.7293 0.7293
Entamoeba histolytica tubulin family protein 0.0611 1 1
Echinococcus granulosus tubulin alpha chain 0.046 0.7293 0.7293
Trypanosoma brucei alpha tubulin 0.046 0.7293 0.7191
Trichomonas vaginalis tubulin, putative 0.0189 0.2416 0.0704
Trypanosoma cruzi epsilon tubulin, putative 0.0375 0.5757 0.5726
Trypanosoma brucei alpha tubulin 0.046 0.7293 0.7191
Echinococcus multilocularis Tubulin alpha 1 chain 0.046 0.7293 0.7293
Trypanosoma cruzi cruzipain precursor, putative 0.0075 0.0362 0.0292
Trypanosoma brucei epsilon tubulin 0.0375 0.5757 0.5598
Plasmodium falciparum alpha tubulin 2 0.046 0.7293 0.6681
Brugia malayi follicle stimulating hormone receptor 0.0274 0.3929 0.3929
Giardia lamblia Beta tubulin 0.0611 1 1
Entamoeba histolytica tubulin family protein 0.0611 1 1
Echinococcus multilocularis peroxisome assembly protein 26 0.046 0.7293 0.7293
Schistosoma mansoni tubulin subunit beta 0.0611 1 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0611 1 1
Echinococcus multilocularis hypothetical protein 0.046 0.7293 0.7293
Loa Loa (eye worm) tubulin alpha chain 0.046 0.7293 0.7293
Echinococcus granulosus tubulin alpha 1C chain 0.046 0.7293 0.7293
Trypanosoma cruzi cysteine peptidase, putative 0.0075 0.0362 0.0292
Trichomonas vaginalis tubulin, putative 0.0186 0.2355 0.0629
Trypanosoma brucei epsilon tubulin 0.0375 0.5757 0.5598
Plasmodium falciparum tubulin gamma chain 0.0376 0.5765 0.4809
Trypanosoma cruzi tubulin delta chain 0.0355 0.5389 0.5355
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0274 0.3929 0.3929
Trichomonas vaginalis tubulin alpha chain, putative 0.0611 1 1
Giardia lamblia Beta tubulin 0.0611 1 1
Brugia malayi Tubulin alpha chain 0.0158 0.1842 0.1842
Schistosoma mansoni alpha tubulin 0.046 0.7293 0.7293
Echinococcus multilocularis tubulin alpha chain 0.046 0.7293 0.7293
Trichomonas vaginalis tubulin beta chain, putative 0.046 0.7293 0.6681
Trypanosoma brucei alpha tubulin 0.046 0.7293 0.7191
Echinococcus multilocularis tubulin gamma 1 chain 0.0376 0.5765 0.5765
Echinococcus granulosus beta tubulin 0.0611 1 1
Leishmania major beta tubulin 0.0611 1 1
Plasmodium vivax tubulin beta chain, putative 0.0611 1 1
Brugia malayi tubulin alpha-2 chain 0.046 0.7293 0.7293
Trichomonas vaginalis tubulin, putative 0.0611 1 1
Loa Loa (eye worm) hypothetical protein 0.0193 0.2475 0.2475
Echinococcus granulosus tubulin subunit TubB 0.046 0.7293 0.7293
Leishmania major alpha tubulin 0.046 0.7293 0.7191
Echinococcus multilocularis Tubulin alpha 1 chain 0.046 0.7293 0.7293
Leishmania major beta tubulin 0.0611 1 1
Echinococcus granulosus peroxisome assembly protein 26 0.046 0.7293 0.7293
Echinococcus granulosus tubulin epsilon chain 0.0375 0.5757 0.5757
Leishmania major beta tubulin 0.0611 1 1
Schistosoma mansoni tubulin subunit beta 0.0611 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0075 0.0362 0.0292
Loa Loa (eye worm) BEN-1 protein 0.0611 1 1
Schistosoma mansoni tubulin subunit alpha 0.046 0.7293 0.7293
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0274 0.3943 0.2576
Toxoplasma gondii beta-tubulin, putative 0.0611 1 1
Leishmania major alpha tubulin 0.046 0.7293 0.7191
Echinococcus multilocularis tubulin alpha 0.0344 0.5191 0.5191
Schistosoma mansoni tubulin subunit alpha 0.046 0.7293 0.7293
Trichomonas vaginalis tubulin beta chain, putative 0.046 0.7293 0.6681
Leishmania major beta tubulin 0.0611 1 1
Loa Loa (eye worm) tubulin beta-2A chain 0.0611 1 1
Giardia lamblia Beta tubulin 0.0611 1 1
Brugia malayi Tubulin alpha chain 0.046 0.7293 0.7293
Trichomonas vaginalis tubulin beta chain, putative 0.046 0.7293 0.6681
Schistosoma mansoni alpha tubulin 0.046 0.7293 0.7293
Echinococcus granulosus tubulin alpha chain 0.046 0.7293 0.7293
Trichomonas vaginalis tubulin alpha chain, putative 0.0186 0.2355 0.0629
Schistosoma mansoni tubulin subunit delta 0.0158 0.1842 0.1842
Loa Loa (eye worm) tubulin beta chain 0.0611 1 1
Toxoplasma gondii alpha-tubulin I, putative 0.046 0.7293 0.6434
Trypanosoma brucei zeta tubulin, putative 0.0487 0.7771 0.7688
Trypanosoma brucei beta tubulin 0.0611 1 1
Echinococcus granulosus tubulin alpha chain 0.046 0.7293 0.7293
Entamoeba histolytica tubulin alpha-1 chain 0.046 0.7293 0.3607
Leishmania major beta tubulin 0.0611 1 1
Leishmania major alpha tubulin 0.046 0.7293 0.7191
Trypanosoma brucei tubulin gamma chain 0.0376 0.5765 0.5606
Schistosoma mansoni tubulin subunit beta 0.0611 1 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0611 1 1
Trypanosoma brucei alpha tubulin 0.046 0.7293 0.7191
Echinococcus multilocularis Tubulin beta 2C chain 0.0611 1 1
Trypanosoma cruzi tubulin gamma chain 0.0376 0.5765 0.5735
Echinococcus granulosus tubulin subunit beta 0.0611 1 1
Toxoplasma gondii alpha tubulin TUBA1 0.046 0.7293 0.6434
Echinococcus granulosus Tubulin alpha 1 chain 0.046 0.7293 0.7293
Echinococcus multilocularis Tubulin beta 2C chain 0.0611 1 1
Plasmodium falciparum alpha tubulin 1 0.046 0.7293 0.6681
Leishmania major beta tubulin 0.0611 1 1
Brugia malayi alpha-tubulin 0.046 0.7293 0.7293
Brugia malayi Cytochrome P450 family protein 0.0058 0.0053 0.0053
Trichomonas vaginalis tubulin beta chain, putative 0.046 0.7293 0.6681
Leishmania major alpha tubulin 0.046 0.7293 0.7191
Loa Loa (eye worm) cytochrome P450 family protein 0.0058 0.0053 0.0053
Trichomonas vaginalis tubulin, putative 0.0186 0.2355 0.0629
Leishmania major alpha tubulin 0.046 0.7293 0.7191
Echinococcus multilocularis tubulin delta chain 0.0158 0.1842 0.1842
Echinococcus granulosus Tubulin alpha 1 chain 0.046 0.7293 0.7293
Trypanosoma brucei beta tubulin 0.0611 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.046 0.7293 0.6681
Brugia malayi Tubulin alpha-2 chain 0.046 0.7293 0.7293
Echinococcus granulosus tubulin beta 4A class IVa 0.0611 1 1
Echinococcus multilocularis beta tubulin 0.0611 1 1
Echinococcus multilocularis tubulin alpha 3 chain 0.046 0.7293 0.7293
Leishmania major delta tubulin, putative 0.0355 0.5389 0.5216
Plasmodium falciparum tubulin epsilon chain, putative 0.0375 0.5757 0.4799
Brugia malayi Tubulin gamma chain 0.0376 0.5765 0.5765
Trypanosoma brucei epsilon tubulin 0.0344 0.5191 0.5011
Schistosoma mansoni tubulin subunit gamma 0.0376 0.5765 0.5765
Echinococcus granulosus alpha tubulin 0.046 0.7293 0.7293
Loa Loa (eye worm) tubulin beta-4 chain 0.0611 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.0186 0.2355 0.0629
Schistosoma mansoni tubulin subunit epsilon 0.0375 0.5757 0.5757
Loa Loa (eye worm) tubulin beta-1 chain 0.0611 1 1
Leishmania major alpha tubulin 0.046 0.7293 0.7191
Trypanosoma brucei beta tubulin 0.0611 1 1
Leishmania major alpha tubulin 0.046 0.7293 0.7191
Echinococcus granulosus Tubulin beta 2C chain 0.0611 1 1
Trypanosoma brucei beta tubulin 0.0344 0.5191 0.5011
Treponema pallidum cell division protein FtsZ 0.0158 0.1842 0.5
Echinococcus multilocularis tubulin alpha 3 chain 0.046 0.7293 0.7293
Loa Loa (eye worm) glutaminase 2 0.033 0.4947 0.4947
Leishmania major alpha tubulin 0.046 0.7293 0.7191
Brugia malayi Tubulin alpha-2 chain 0.046 0.7293 0.7293
Trypanosoma cruzi alpha tubulin, putative 0.046 0.7293 0.7273
Brugia malayi hypoxia-induced factor 1 0.0178 0.2206 0.2206
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0069 0.0244 0.0174
Echinococcus granulosus Tubulin beta 2C chain 0.0611 1 1
Echinococcus granulosus tubulin alpha 3 chain 0.046 0.7293 0.7293
Trichomonas vaginalis tubulin gamma chain, putative 0.0611 1 1
Echinococcus multilocularis tubulin alpha chain 0.046 0.7293 0.7293
Brugia malayi tubulin alpha chain - mouse 0.046 0.7293 0.7293
Plasmodium vivax tubulin alpha chain, putative 0.046 0.7293 0.6681
Trichomonas vaginalis tubulin gamma chain, putative 0.0376 0.5765 0.4809
Echinococcus granulosus tubulin delta chain 0.0158 0.1842 0.1842
Echinococcus multilocularis Tubulin beta 2C chain 0.0611 1 1
Brugia malayi beta-tubulin, identical 0.0611 1 1
Loa Loa (eye worm) alpha-tubulin 0.046 0.7293 0.7293
Schistosoma mansoni glutaminase 0.033 0.4947 0.4947
Trypanosoma cruzi zeta tubulin, putative 0.0487 0.7771 0.7755
Echinococcus granulosus tubulin gamma 1 chain 0.0376 0.5765 0.5765
Leishmania major alpha tubulin 0.046 0.7293 0.7191
Leishmania major zeta tubulin, putative 0.0487 0.7771 0.7688
Leishmania major beta tubulin 0.0611 1 1
Echinococcus granulosus tubulin alpha chain 0.046 0.7293 0.7293
Echinococcus granulosus Tubulin beta 2C chain 0.0611 1 1
Leishmania major beta tubulin 0.0611 1 1
Leishmania major beta tubulin 0.0611 1 1
Trypanosoma brucei tubulin delta chain 0.0355 0.5389 0.5216
Toxoplasma gondii beta-1 tubulin, putative 0.0611 1 1
Brugia malayi hypothetical protein 0.0193 0.2475 0.2475
Trypanosoma brucei beta tubulin 0.0611 1 1
Mycobacterium ulcerans glutaminase 0.033 0.4947 1
Trypanosoma cruzi tubulin delta chain 0.0355 0.5389 0.5355
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0186 0.2355 0.0629
Echinococcus granulosus Tubulin beta 2C chain 0.0611 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.0611 1 1
Schistosoma mansoni tubulin subunit beta 0.0611 1 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.046 0.7293 0.7293
Leishmania major alpha tubulin 0.046 0.7293 0.7191
Echinococcus granulosus tubulin alpha 3 chain 0.046 0.7293 0.7293
Echinococcus granulosus tubulin alpha 1C chain 0.046 0.7293 0.7293
Echinococcus multilocularis tubulin alpha 1C chain 0.046 0.7293 0.7293
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0303 0.4457 0.3205
Toxoplasma gondii beta tubulin 0.0611 1 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0375 0.5757 0.4799
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0344 0.5191 0.3666
Trichomonas vaginalis tubulin epsilon chain, putative 0.0611 1 1
Echinococcus multilocularis tubulin beta 1 chain 0.0611 1 1
Loa Loa (eye worm) hypothetical protein 0.0303 0.4457 0.4457
Schistosoma mansoni tubulin subunit beta 0.0158 0.1842 0.1842
Leishmania major beta tubulin 0.0611 1 1
Leishmania major beta tubulin 0.0611 1 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0611 1 1
Loa Loa (eye worm) tubulin alpha chain 0.046 0.7293 0.7293
Loa Loa (eye worm) glutaminase 0.033 0.4947 0.4947
Loa Loa (eye worm) tubulin beta chain 0.0158 0.1842 0.1842
Loa Loa (eye worm) BEN-1 protein 0.0611 1 1
Leishmania major beta tubulin 0.0611 1 1
Brugia malayi PAS domain containing protein 0.0057 0.004 0.004
Schistosoma mansoni alpha tubulin 0.046 0.7293 0.7293
Leishmania major beta tubulin 0.0611 1 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.046 0.7293 0.6681
Echinococcus multilocularis tubulin alpha chain 0.046 0.7293 0.7293
Echinococcus multilocularis tubulin alpha chain 0.046 0.7293 0.7293
Giardia lamblia Alpha-tubulin 0.046 0.7293 0.6681
Giardia lamblia Epsilon tubulin 0.0189 0.2408 0.0694
Trichomonas vaginalis tubulin beta chain, putative 0.046 0.7293 0.6681
Echinococcus multilocularis beta tubulin 0.0611 1 1
Onchocerca volvulus 0.0186 0.2355 0.5
Loa Loa (eye worm) hypothetical protein 0.0274 0.3943 0.3943
Schistosoma mansoni single-minded 0.0057 0.004 0.004
Echinococcus granulosus Tubulin alpha 1 chain 0.046 0.7293 0.7293
Loa Loa (eye worm) hypoxia-induced factor 1 0.0178 0.2206 0.2206
Echinococcus granulosus tubulin alpha 0.0344 0.5191 0.5191
Schistosoma mansoni aryl hydrocarbon receptor 0.0057 0.004 0.004
Loa Loa (eye worm) alpha-tubulin 0.046 0.7293 0.7293
Plasmodium vivax tubulin alpha chain, putative 0.046 0.7293 0.6681
Plasmodium falciparum tubulin beta chain 0.0611 1 1
Plasmodium vivax tubulin gamma chain, putative 0.0376 0.5765 0.4809
Brugia malayi Cell division protein ftsZ 0.0158 0.1842 0.1842
Brugia malayi Tubulin beta chain 0.0186 0.2355 0.2355
Leishmania major beta tubulin 0.0611 1 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0186 0.2355 0.0629
Loa Loa (eye worm) tubulin alpha 2 0.0303 0.4457 0.4457
Giardia lamblia Alpha-tubulin 0.046 0.7293 0.6681
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0355 0.5389 0.3926
Trichomonas vaginalis tubulin alpha chain, putative 0.0186 0.2355 0.0629
Mycobacterium tuberculosis Cell division protein FtsZ 0.0158 0.1842 0.5
Schistosoma mansoni tubulin subunit beta 0.0611 1 1
Leishmania major alpha tubulin 0.046 0.7293 0.7191
Leishmania major gamma-tubulin 0.0376 0.5765 0.5606
Echinococcus granulosus beta tubulin 0.0611 1 1
Loa Loa (eye worm) tubulin alpha-2 chain 0.046 0.7293 0.7293
Trichomonas vaginalis tubulin alpha chain, putative 0.0344 0.5191 0.4105
Echinococcus granulosus Tubulin beta 2C chain 0.0611 1 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.046 0.7293 0.6681
Echinococcus multilocularis tubulin alpha 1C chain 0.046 0.7293 0.7293
Trichomonas vaginalis glutaminase, putative 0.033 0.4947 0.3807
Loa Loa (eye worm) tubulin alpha-3 chain 0.0274 0.3943 0.3943
Leishmania major beta tubulin 0.0611 1 1
Loa Loa (eye worm) beta-tubulin 0.0611 1 1
Trypanosoma cruzi epsilon tubulin, putative 0.0375 0.5757 0.5726
Brugia malayi Tubulin beta chain 0.0158 0.1842 0.1842
Loa Loa (eye worm) hypothetical protein 0.046 0.7293 0.7293
Trypanosoma cruzi beta tubulin, putative 0.0611 1 1
Giardia lamblia Gamma tubulin 0.0376 0.5765 0.4809
Trypanosoma brucei alpha tubulin, putative 0.0186 0.2355 0.2068
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0611 1 1
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0158 0.1842 0.5
Echinococcus multilocularis tubulin subunit TubB 0.046 0.7293 0.7293
Trypanosoma cruzi cysteine peptidase, putative 0.0075 0.0362 0.0292
Leishmania major beta tubulin 0.0611 1 1
Echinococcus multilocularis tubulin epsilon chain 0.0375 0.5757 0.5757
Trypanosoma brucei zeta tubulin 0.0487 0.7771 0.7688
Leishmania major beta tubulin 0.0611 1 1
Mycobacterium leprae cell division protein FtsZ 0.0158 0.1842 0.5
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0303 0.4457 0.4457
Loa Loa (eye worm) tubulin gamma chain 0.0376 0.5765 0.5765

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 14.12537545 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 35.48133892 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (functional) 0.8913 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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