TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 523.599 | Formula: C24H33N3O8S
H donors: 2 H acceptors: 6 LogP: 0.76 Rotable bonds: 9
Rule of 5 violations (Lipinski): 2
SMILES: COCCN(S(=O)(=O)c1c(C)noc1C)C[C@H](CN1CCCC2(C1)CC(=O)c1c(O2)ccc(c1)O)O
InChi: 1S/C24H33N3O8S/c1-16-23(17(2)35-25-16)36(31,32)27(9-10-33-3)14-19(29)13-26-8-4-7-24(15-26)12-21(30)20-11-18(28)5-6-22(20)34-24/h5-6,11,19,28-29H,4,7-10,12-15H2,1-3H3/t19-,24?/m0/s1
InChiKey: PDAQYFOOWGQKFR-XGLRFROISA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	v-akt murine thymoma viral oncogene homolog 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	serine threonine protein kinase nrc	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma brucei gambiense	rac serine-threonine kinase, putative,protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Brugia malayi	p70 ribosomal S6 kinase beta	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma cruzi	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma brucei	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	PH domain containing protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	Sodium/potassium-transporting ATPase subunit beta-1, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	Glutaredoxin protein 5	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	rac serine:threonine kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	Glutaredoxin protein 5	Get druggable targets OG5_126635	All targets in OG5_126635
Candida albicans	likely protein kinase similar to S. cerevisiae YPK2 (YMR104C)	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium berghei	rac-beta serine/threonine protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Loa Loa (eye worm)	AGC/AKT protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	Get druggable targets OG5_126635	All targets in OG5_126635
Neospora caninum	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1), related	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	serine/threonine protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma cruzi	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	ko:K08792 serum/glucocorticoid regulated kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	RAC serine/threonine-protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma cruzi	Protein kinase B	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	ko:K04456 RAC serine/threonine-protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium yoelii	kinase Akt/PKB-related	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma mansoni	serine/threonine-protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	protein kinase 2, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	ko:K07390 monothiol glutaredoxin, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium knowlesi	RAC-beta serine/threonine protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	Get druggable targets OG5_126635	All targets in OG5_126635
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma congolense	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Toxoplasma gondii	AGC kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Candida albicans	protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma mansoni	serine/threonine-protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	PH domain containing protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Giardia lamblia	Kinase, AGC PKA	Get druggable targets OG5_126635	All targets in OG5_126635

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0151	0.0743
Leishmania major	glycerol uptake protein, putative	0.0349	0.2037	1
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0151	0.0743
Trypanosoma brucei	glycerol uptake protein, putative	0.0349	0.2037	1
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0349	0.2037	0.2016
Echinococcus multilocularis	lysophospholipid acyltransferase 7	0.0349	0.2037	0.2016
Brugia malayi	Cytochrome P450 family protein	0.0029	0.0085	0.0072
Toxoplasma gondii	acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha	0.1376	0.8316	1
Trichomonas vaginalis	conserved hypothetical protein	0.0349	0.2037	1
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0025	0.0057	0.0032
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0028	0.0074	0.0077
Echinococcus granulosus	Glutaredoxin protein 5	0.0025	0.0057	0.0032
Loa Loa (eye worm)	cytochrome P450 family protein	0.0062	0.0284	0.0259
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.002	0.0026	0.5
Loa Loa (eye worm)	CYP4Cod1	0.0029	0.0085	0.0059
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0151	0.0743
Echinococcus granulosus	lysophospholipid acyltransferase 7	0.0349	0.2037	0.2016
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.002	0.0026	0.5
Trypanosoma cruzi	GUP1, putative	0.0349	0.2037	1
Loa Loa (eye worm)	diacylglycerol acyltransferase	0.1376	0.8316	0.8312
Loa Loa (eye worm)	cytochrome P450 family protein	0.0029	0.0085	0.0059
Leishmania major	glycerol uptake protein, putative	0.0349	0.2037	1
Trypanosoma cruzi	glycerol uptake protein, putative	0.0349	0.2037	1
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.002	0.0026	0.5
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0038	0.0136	0.0111
Trichomonas vaginalis	porcupine, putative	0.0349	0.2037	1
Echinococcus multilocularis	nervana 2	0.0025	0.0057	0.0032
Echinococcus multilocularis	sterol O acyltransferase 1	0.1652	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.002	0.0026	0.5
Echinococcus granulosus	serine/threonine protein kinase	0.0028	0.0074	0.0048
Brugia malayi	Cytochrome P450 family protein	0.0029	0.0085	0.0072
Brugia malayi	MBOAT family protein	0.0349	0.2037	0.2426
Echinococcus multilocularis	rac serine:threonine kinase	0.0028	0.0074	0.0048
Brugia malayi	MBOAT family protein	0.0349	0.2037	0.2426
Echinococcus multilocularis	diacylglycerol O acyltransferase 1	0.1376	0.8316	0.8312
Echinococcus granulosus	Membrane bound O acyl transferase MBOAT	0.0349	0.2037	0.2016
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0349	0.2037	1
Trichomonas vaginalis	conserved hypothetical protein	0.0349	0.2037	1
Loa Loa (eye worm)	hypothetical protein	0.0349	0.2037	0.2016
Entamoeba histolytica	hypothetical protein	0.0349	0.2037	1
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0151	0.0743
Schistosoma mansoni	leukocyte receptor cluster (lrc) member 4 protein	0.0349	0.2037	0.2016
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.002	0.0026	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0349	0.2037	1
Loa Loa (eye worm)	hypothetical protein	0.1028	0.6186	0.6176
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.002	0.0026	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.002	0.0026	0.5
Echinococcus granulosus	membrane bound acyltransferase:hhat	0.0349	0.2037	0.2016
Loa Loa (eye worm)	AGC/AKT protein kinase	0.004	0.0151	0.0126
Entamoeba histolytica	hypothetical protein, conserved	0.0349	0.2037	1
Loa Loa (eye worm)	MBOAT family protein	0.0349	0.2037	0.2016
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0349	0.2037	1
Brugia malayi	p70 ribosomal S6 kinase beta	0.0038	0.0136	0.0133
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0349	0.2037	0.2016
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0028	0.0074	0.0077
Entamoeba histolytica	protein kinase, putative	0.004	0.0151	0.0467
Brugia malayi	MBOAT family protein	0.0349	0.2037	0.2426
Echinococcus granulosus	diacylglycerol O acyltransferase 1	0.1376	0.8316	0.8312
Loa Loa (eye worm)	hypothetical protein	0.1303	0.7869	0.7864
Plasmodium vivax	diacylglycerol O-acyltransferase, putative	0.1376	0.8316	1
Echinococcus granulosus	nervana 2	0.0025	0.0057	0.0032
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0025	0.0059	0.0033
Echinococcus multilocularis	nervana 2	0.0025	0.0057	0.0032
Trypanosoma cruzi	cytochrome P450, putative	0.0029	0.0085	0.0295
Loa Loa (eye worm)	hypothetical protein	0.0349	0.2037	0.2016
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0349	0.2037	0.2016
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.002	0.0026	0.5
Schistosoma mansoni	serine/threonine-protein kinase	0.0028	0.0074	0.0048
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0349	0.2037	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0029	0.0085	0.0059
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.002	0.0026	0.5
Entamoeba histolytica	protein kinase, putative	0.0038	0.0136	0.039
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0349	0.2037	0.2016
Schistosoma mansoni	zinc finger protein	0.0349	0.2037	0.2016
Brugia malayi	Protein kinase domain containing protein	0.004	0.0151	0.0151
Giardia lamblia	Kinase, AGC PKA	0.0025	0.0059	0.5
Schistosoma mansoni	serine/threonine-protein kinase	0.0028	0.0074	0.0048
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0151	0.0743
Echinococcus granulosus	protein cysteine N palmitoyltransferase	0.0349	0.2037	0.2016
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0028	0.0074	0.024
Treponema pallidum	alginate O-acetylation protein (algI)	0.0349	0.2037	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.002	0.0026	0.5
Trypanosoma cruzi	cytochrome P450, putative	0.0029	0.0085	0.0295
Echinococcus multilocularis	membrane bound acyltransferase:hhat	0.0349	0.2037	0.2016
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0151	0.0743
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0151	0.0743
Onchocerca volvulus		0.0349	0.2037	0.5
Schistosoma mansoni	hypothetical protein	0.0349	0.2037	0.2016
Trypanosoma cruzi	glycerol uptake protein, putative	0.0349	0.2037	1
Plasmodium falciparum	diacylglycerol O-acyltransferase	0.1376	0.8316	1
Trypanosoma cruzi	GUP1, putative	0.0349	0.2037	1
Loa Loa (eye worm)	membrane bound O-acyltransferase domain containing 1	0.0349	0.2037	0.2016
Toxoplasma gondii	AGC kinase	0.0038	0.0136	0.0133
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.002	0.0026	0.5
Loa Loa (eye worm)	hhat protein	0.0349	0.2037	0.2016
Echinococcus granulosus	nervana 2	0.0025	0.0057	0.0032
Leishmania major	glycerol uptake protein, putative	0.0349	0.2037	1
Loa Loa (eye worm)	hypothetical protein	0.1652	1	1
Echinococcus granulosus	serine threonine protein kinase nrc	0.0025	0.0059	0.0033
Echinococcus multilocularis	Glutaredoxin protein 5	0.0025	0.0057	0.0032
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0349	0.2037	0.2016
Mycobacterium leprae	putative cytochrome p450	0.002	0.0026	0.5
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.002	0.0026	0.5
Brugia malayi	Cytochrome P450 family protein	0.0062	0.0284	0.0312
Loa Loa (eye worm)	hypothetical protein	0.0349	0.2037	0.2016
Brugia malayi	MBOAT family protein	0.0349	0.2037	0.2426
Loa Loa (eye worm)	hhat protein	0.0349	0.2037	0.2016
Trypanosoma brucei	glycerol uptake protein, putative	0.0349	0.2037	1
Schistosoma mansoni	diacylglycerol O-acyltransferase 1	0.1376	0.8316	0.8312
Leishmania major	glycerol uptake protein, putative	0.0349	0.2037	1
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0349	0.2037	0.2016
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0025	0.0059	0.0165
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.002	0.0026	0.5
Schistosoma mansoni	sterol O-acyltransferase 1	0.1652	1	1
Echinococcus multilocularis	protein cysteine N palmitoyltransferase	0.0349	0.2037	0.2016
Brugia malayi	MBOAT family protein	0.0349	0.2037	0.2426
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.002	0.0026	0.5
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0025	0.0057	0.0032
Leishmania major	glycerol uptake protein, putative	0.0349	0.2037	1
Trypanosoma brucei	cytochrome P450, putative	0.0029	0.0085	0.0295
Toxoplasma gondii	hypothetical protein	0.0349	0.2037	0.2426
Loa Loa (eye worm)	MBOAT family protein	0.0349	0.2037	0.2016
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0029	0.0085	1
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.002	0.0026	0.5
Brugia malayi	diacylglycerol acyltransferase	0.1376	0.8316	1
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.002	0.0026	0.5
Echinococcus multilocularis	Membrane bound O acyl transferase, MBOAT	0.0349	0.2037	0.2016
Leishmania major	cytochrome p450-like protein	0.0029	0.0085	0.0295
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0349	0.2037	0.2016
Trypanosoma cruzi	glycerol uptake protein, putative	0.0349	0.2037	1
Brugia malayi	Hhat protein	0.0349	0.2037	0.2426
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0349	0.2037	0.2016
Mycobacterium leprae	Conserved hypothetical protein	0.002	0.0026	0.5
Trypanosoma brucei	rac serine-threonine kinase, putative	0.004	0.0151	0.0624
Loa Loa (eye worm)	MBOAT family protein	0.0349	0.2037	0.2016
Entamoeba histolytica	protein kinase, putative	0.004	0.0151	0.0467
Leishmania major	hypothetical protein, conserved	0.0349	0.2037	1
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.002	0.0026	0.5
Entamoeba histolytica	vacuolar protein sorting 26	0.0349	0.2037	1
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0349	0.2037	0.2016
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.002	0.0026	0.5
Toxoplasma gondii	acyl-CoA:diacylglycerol acyltransferase 1-related enzyme	0.1376	0.8316	1
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.002	0.0026	0.5
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0025	0.0059	0.0033
Trypanosoma cruzi	Protein kinase B	0.0028	0.0074	0.024
Schistosoma mansoni	membrane-bound acyltransferase/hhat	0.0349	0.2037	0.2016
Trichomonas vaginalis	transmembrane protein nessy, putative	0.0349	0.2037	1
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.002	0.0026	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 2.1 uM	Inhibition of AKT1 by IMAP assay	ChEMBL.	21392984
IC50 (binding)	= 6.5 uM	Inhibition of AKT1 by IMAP assay	ChEMBL.	21392984
IC50 (binding)	> 25 uM	Inhibition of AKT1 in human LNCaP cells assessed as PRAS40 phosphorylation at Thr246 after 1.5 hrs	ChEMBL.	21392984
IC50 (binding)	= 40 uM	Inhibition of AKT1 by IMAP assay	ChEMBL.	21392984
Inhibition (binding)		Inhibition of AKT2 by IMAP assay	ChEMBL.	21392984
Inhibition (binding)		Inhibition of AKT3 by IMAP assay	ChEMBL.	21392984

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1761069

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1525215