TDR Targets

Basic information

Technical information

TDR Targets ID: 1533051
Name: ethyl 1-phenyl-5-pyridin-4-ylpyrazole-4-carbo xylate
MW: 293.32 | Formula: C17H15N3O2
H donors: 0 H acceptors: 3 LogP: 2.7 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)c1cnn(c1c1ccncc1)c1ccccc1
InChi: 1S/C17H15N3O2/c1-2-22-17(21)15-12-19-20(14-6-4-3-5-7-14)16(15)13-8-10-18-11-9-13/h3-12H,2H2,1H3
InChiKey: LGXLXTXAHSGKFY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

ethyl 1-phenyl-5-(4-pyridyl)pyrazole-4-carboxylate
1-phenyl-5-(4-pyridyl)-4-pyrazolecarboxylic acid ethyl ester
1-phenyl-5-(4-pyridyl)pyrazole-4-carboxylic acid ethyl ester
ethyl 1-phenyl-5-pyridin-4-yl-pyrazole-4-carboxylate

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references
Homo sapiens	K(lysine) acetyltransferase 2A	Starlite/ChEMBL	No references
Homo sapiens	geminin, DNA replication inhibitor	Starlite/ChEMBL	No references
Homo sapiens	glycoprotein hormones, alpha polypeptide	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Plasmodium berghei	histone acetyltransferase GCN5, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Babesia bovis	histone acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Neospora caninum	Bromodomain containing protein, related	Get druggable targets OG5_127781	All targets in OG5_127781
Cryptosporidium parvum	GCN5 like acetylase + bromodomain	Get druggable targets OG5_127781	All targets in OG5_127781
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	Get druggable targets OG5_127781	All targets in OG5_127781
Giardia lamblia	Histone acetyltransferase GCN5	Get druggable targets OG5_127781	All targets in OG5_127781
Cryptosporidium hominis	histone acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	Get druggable targets OG5_127781	All targets in OG5_127781
Theileria parva	histone acetyltransferase Gcn5, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Candida albicans	bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Entamoeba histolytica	acetyltransferase, GNAT family	Get druggable targets OG5_127781	All targets in OG5_127781
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	histone acetyltransferase KAT2B	Get druggable targets OG5_127781	All targets in OG5_127781
Plasmodium falciparum	histone acetyltransferase GCN5	Get druggable targets OG5_127781	All targets in OG5_127781
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Plasmodium knowlesi	histone acetyltransferase GCN5, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	acetyltransferase, GNAT family protein	Get druggable targets OG5_127781	All targets in OG5_127781
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	ko:K06062 p300/CBP-associated factor, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Loa Loa (eye worm)	acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Plasmodium yoelii	histone acetyltransferase GCN5-related	Get druggable targets OG5_127781	All targets in OG5_127781
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	Get druggable targets OG5_127781	All targets in OG5_127781
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Candida albicans	bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	Get druggable targets OG5_127781	All targets in OG5_127781
Echinococcus granulosus	histone acetyltransferase KAT2B	Get druggable targets OG5_127781	All targets in OG5_127781
Neospora caninum	hypothetical protein	Get druggable targets OG5_127781	All targets in OG5_127781
Plasmodium vivax	histone acetyltransferase GCN5, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Toxoplasma gondii	intraflagellar transport protein 172, putative	glycoprotein hormones, alpha polypeptide	116 aa	94 aa	26.6 %
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %
Brugia malayi	Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X	geminin, DNA replication inhibitor	209 aa	176 aa	27.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	glucosidase, putative	0.0038	0.0052	1
Onchocerca volvulus	Poor gastrulation protein homolog	0.0045	0.0084	0.144
Onchocerca volvulus	Alhambra homolog	0.003	0.0019	0.0328
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0036	0.0043	0.0382
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0033	0.0032	0.0232
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0033	0.0032	0.0032
Loa Loa (eye worm)	acetyltransferase	0.0175	0.0661	0.4724
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0098	0.032	0.032
Schistosoma mansoni	hypothetical protein	0.0036	0.0043	0.0043
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0033	0.0032	0.0291
Brugia malayi	Latrophilin receptor protein 2	0.0036	0.0043	0.0382
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0129	0.1161
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0051	0.0113	0.0113
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0033	0.0032	0.0032
Toxoplasma gondii	PHD-finger domain-containing protein	0.003	0.0019	0.1672
Schistosoma mansoni	sex comb on midleg homolog	0.005	0.0105	0.0105
Treponema pallidum	fructose-bisphosphate aldolase	0.0305	0.1236	0.5
Toxoplasma gondii	LsmAD domain-containing protein	0.0028	0.0009	0.0724
Loa Loa (eye worm)	transcription factor SMAD2	0.0124	0.0437	0.312
Brugia malayi	AMP-binding enzyme family protein	0.0052	0.0115	0.1032
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0305	0.1236	1
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0051	0.0113	1
Echinococcus granulosus	GPCR family 2	0.0036	0.0043	0.0043
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0149	0.0545	0.762
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0052	0.0115	0.0221
Schistosoma mansoni	jumonji domain containing protein	0.014	0.0507	0.0507
Brugia malayi	nuclear hormone receptor	0.0033	0.0032	0.0291
Echinococcus granulosus	FTZ F1 alpha	0.0033	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0084	0.0601
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0033	0.0032	0.0291
Echinococcus granulosus	neutral alpha glucosidase AB	0.0038	0.0052	0.0052
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0039	0.0057	0.5
Echinococcus multilocularis	lysosomal alpha glucosidase	0.017	0.0638	0.0638
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0115	0.0822
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0051	0.0113	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0028	0.0009	0.1652
Brugia malayi	acetyltransferase, GNAT family protein	0.0175	0.0661	0.5929
Echinococcus multilocularis	lysine specific demethylase 5A	0.0098	0.032	0.032
Schistosoma mansoni	RAR-like nuclear receptor	0.0033	0.0032	0.0032
Brugia malayi	ecdysteroid receptor	0.0033	0.0032	0.0291
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0033	0.0032	0.0232
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0033	0.0032	0.0032
Schistosoma mansoni	metabotropic glutamate receptor	0.0232	0.0915	0.0915
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0305	0.1236	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0033	0.0032	0.0232
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0051	0.0113	0.0516
Loa Loa (eye worm)	PHD-finger family protein	0.003	0.0019	0.0137
Echinococcus multilocularis	lysosomal alpha glucosidase	0.017	0.0638	0.0638
Loa Loa (eye worm)	jmjC domain-containing protein	0.0026	0	0.0003
Onchocerca volvulus		0.0158	0.0583	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0052	0.0115	1
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0057	0.0135	0.0135
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0129	0.0129
Loa Loa (eye worm)	mbt repeat family protein	0.005	0.0105	0.075
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0057	0.0135	0.0135
Brugia malayi	Receptor family ligand binding region containing protein	0.0071	0.02	0.1792
Brugia malayi	jmjC domain containing protein	0.0026	0	0.0003
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0033	0.0032	0.0291
Schistosoma mansoni	alpha glucosidase	0.0038	0.0052	0.0052
Loa Loa (eye worm)	hypothetical protein	0.003	0.0019	0.0137
Brugia malayi	jmjC domain containing protein	0.0026	0	0.0003
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0033	0.0032	0.0032
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0129	0.0129
Schistosoma mansoni	retinoic acid receptor RXR	0.0033	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0026	0	0.0003
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0033	0.0032	0.0032
Onchocerca volvulus		0.005	0.0105	0.1799
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.005	0.0105	0.1799
Loa Loa (eye worm)	metabotropic GABA-B receptor subtype 2	0.0071	0.02	0.1427
Echinococcus granulosus	GPCR family 3 C terminal	0.0045	0.0084	0.0084
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.0232	0.0915	0.0915
Brugia malayi	jmjC domain containing protein	0.0026	0	0.0003
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0149	0.0545	0.1876
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0033	0.0032	0.0032
Brugia malayi	jmjC domain containing protein	0.0161	0.0598	0.5364
Schistosoma mansoni	hypothetical protein	0.0036	0.0043	0.0043
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0129	0.0129
Brugia malayi	mbt repeat family protein	0.005	0.0105	0.0941
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0033	0.0032	0.0291
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0115	0.0822
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0129	0.0129
Brugia malayi	nuclear receptor NHR-88	0.0033	0.0032	0.0291
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.017	0.0638	0.4559
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0033	0.0032	0.0032
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0196	0.0754	0.0754
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0032	0.0232
Plasmodium vivax	acyl-CoA synthetase, putative	0.0039	0.0057	0.5014
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0033	0.0032	0.0032
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0052	1
Onchocerca volvulus	Protein ultraspiracle homolog	0.0033	0.0032	0.0556
Leishmania major	hypothetical protein, conserved	0.0028	0.0009	0.074
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0038	0.0052	0.4554
Echinococcus multilocularis	polycomb protein SCMH1	0.005	0.0105	0.0105
Schistosoma mansoni	hypothetical protein	0.0036	0.0043	0.0043
Echinococcus multilocularis	GPCR, family 3, C terminal	0.0045	0.0084	0.0084
Leishmania major	hypothetical protein, conserved	0.0026	0	0.0033
Plasmodium falciparum	acyl-CoA synthetase	0.0039	0.0057	0.6037
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0129	0.0129
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0038	0.0052	0.0462
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0033	0.0032	0.0291
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0113	0.0384	0.3449
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0175	0.0661	0.0661
Mycobacterium leprae	Probable anthranilate phosphoribosyltransferase TrpD	0.0179	0.0679	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0036	0.0043	0.0043
Schistosoma mansoni	sex comb on midleg homolog	0.005	0.0105	0.0105
Mycobacterium ulcerans	thymidine phosphorylase	0.0634	0.2699	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0032	0.0232
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0052	0.0115	0.0221
Brugia malayi	hypothetical protein	0.0158	0.0583	0.5232
Echinococcus multilocularis	FTZ F1 alpha	0.0033	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0057	0.0405
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0933	0.4024	0.4024
Entamoeba histolytica	acetyltransferase, GNAT family	0.0047	0.0094	0.0758
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0384	0.2748
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0033	0.0032	0.0291
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0033	0.0032	0.0291
Echinococcus granulosus	histone acetyltransferase KAT2B	0.017	0.0639	0.0639
Plasmodium falciparum	ataxin-2 like protein, putative	0.0028	0.0009	0.0872
Schistosoma mansoni	hypothetical protein	0.0045	0.0084	0.0084
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0129	0.0129
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0033	0.0032	0.0032
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0113	0.0384	0.3449
Schistosoma mansoni	microtubule-associated protein tau	0.228	1	1
Schistosoma mansoni	hypothetical protein	0.0077	0.0226	0.0226
Plasmodium falciparum	phd finger protein, putative	0.003	0.0019	0.2013
Loa Loa (eye worm)	hypothetical protein	0.0026	0	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0043	0.0304
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0196	0.0754	0.0754
Schistosoma mansoni	coup transcription factor	0.0033	0.0032	0.0032
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0033	0.0032	0.0232
Brugia malayi	latrophilin 2 splice variant baaae	0.0077	0.0226	0.2029
Leishmania major	4-coumarate:coa ligase-like protein	0.0052	0.0115	1
Echinococcus granulosus	jumonji domain containing protein	0.0042	0.0072	0.0072
Brugia malayi	metabotropic GABA-B receptor subtype 2	0.0045	0.0084	0.0754
Mycobacterium ulcerans	hypothetical protein	0.0052	0.0115	0.0221
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0051	0.0113	0.0516
Schistosoma mansoni	hypothetical protein	0.0036	0.0043	0.0043
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0052	0.0115	0.0255
Echinococcus multilocularis	PHD finger protein rhinoceros	0.003	0.0019	0.0019
Brugia malayi	PHD-finger family protein	0.003	0.0019	0.0172
Schistosoma mansoni	hypothetical protein	0.0365	0.1503	0.1503
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0032	0.0232
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0057	0.0405
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0033	0.0032	0.0032
Echinococcus granulosus	ecdysone induced protein 78C	0.0033	0.0032	0.0032
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0026	0	0.0073
Mycobacterium ulcerans	acyl-CoA synthetase	0.0052	0.0115	0.0221
Brugia malayi	AMP-binding enzyme family protein	0.0052	0.0115	0.1032
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0305	0.1236	1
Echinococcus granulosus	PHD finger protein rhinoceros	0.003	0.0019	0.0019
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0038	0.0052	0.0052
Brugia malayi	AMP-binding enzyme family protein	0.0052	0.0115	0.1032
Brugia malayi	MH2 domain containing protein	0.0124	0.0437	0.3916
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0175	0.0661	0.0661
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0057	0.0135	0.0135
Trypanosoma cruzi	PAB1-binding protein , putative	0.0028	0.0009	0.1652
Echinococcus granulosus	SAM and MBT domain containing protein	0.005	0.0105	0.0105
Brugia malayi	jmjC domain containing protein	0.0098	0.032	0.2867
Echinococcus granulosus	geminin	0.0365	0.1503	0.1503
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0032	0.0232
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.003	0.0019	0.0019
Brugia malayi	photoreceptor-specific nuclear receptor	0.0033	0.0032	0.0291
Echinococcus multilocularis	thymidine phosphorylase	0.0634	0.2699	0.2699
Loa Loa (eye worm)	hypothetical protein	0.0158	0.0583	0.4169
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	0.0315	0.1283	0.1283
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0036	0.0043	0.0043
Schistosoma mansoni	alpha-glucosidase	0.0146	0.0533	0.0533
Leishmania major	alpha glucosidase II subunit, putative	0.0038	0.0052	0.448
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0057	0.0405
Onchocerca volvulus		0.0033	0.0032	0.0556
Mycobacterium tuberculosis	Probable anthranilate phosphoribosyltransferase TrpD	0.0179	0.0679	0.2382
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0038	0.0052	0.0417
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0033	0.0032	0.0032
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0113	0.0384	0.2748
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0033	0.0032	0.0032
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0039	0.0057	0.0035
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0033	0.0032	0.0291
Brugia malayi	hypothetical protein	0.0028	0.0009	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0071	0.02	0.1427
Giardia lamblia	Fructose-bisphosphate aldolase	0.0305	0.1236	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0033	0.0032	0.0291
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0033	0.0032	0.0032
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0033	0.0032	0.0232
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0033	0.0032	0.0291
Brugia malayi	metabotropic glutamate receptor type 2	0.0135	0.0484	0.4342
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0033	0.0032	0.0291
Brugia malayi	mbt repeat family protein	0.005	0.0105	0.0941
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0033	0.0032	0.0232
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.005	0.0105	0.0105
Brugia malayi	Steroid receptor seven-up type 2	0.0033	0.0032	0.0291
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0305	0.1236	1
Plasmodium vivax	hypothetical protein, conserved	0.003	0.0019	0.1672
Loa Loa (eye worm)	jmjC domain-containing protein	0.0026	0	0.0003
Loa Loa (eye worm)	glutamate receptor	0.0277	0.1115	0.7968
Loa Loa (eye worm)	glutamate receptor	0.0109	0.0368	0.2633
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0135	0.0968
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0305	0.1236	1
Entamoeba histolytica	acyl-coA synthetase, putative	0.0052	0.0115	0.093
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0305	0.1236	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0033	0.0032	0.0291
Brugia malayi	jmjC domain containing protein	0.0026	0	0.0003
Brugia malayi	steroid hormone receptor	0.0033	0.0032	0.0291
Plasmodium vivax	ataxin-2 like protein, putative	0.0028	0.0009	0.0724
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0052	0.0115	0.093
Loa Loa (eye worm)	hypothetical protein	0.005	0.0105	0.075
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0052	0.0115	0.093
Leishmania major	4-coumarate:coa ligase-like protein	0.0052	0.0115	1
Loa Loa (eye worm)	MBCTL1	0.0057	0.0135	0.0968
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.0341	0.1399	0.1399
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0052	0.0115	0.0255
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0033	0.0032	0.0556
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0033	0.0032	0.0291
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0052	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0036	0.0043	0.0304
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0057	0.0135	0.0135
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0036	0.0043	0.0043
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0026	0	0.0073
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0033	0.0032	0.0232
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0052	0.0115	0.0221
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0033	0.0032	0.0291
Loa Loa (eye worm)	jmjC domain-containing protein	0.0026	0	0.0003
Mycobacterium ulcerans	anthranilate phosphoribosyltransferase	0.0179	0.0679	0.2354
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0032	0.0232
Loa Loa (eye worm)	receptor family ligand binding region containing protein	0.0071	0.02	0.1427
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0057	0.0405
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0033	0.0032	0.0032
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0305	0.1236	1
Brugia malayi	metabotropic glutamate receptor subtype 5a (mGluR5a), putative	0.0251	0.0999	0.8962
Loa Loa (eye worm)	hypothetical protein	0.0341	0.1399	1
Onchocerca volvulus		0.0098	0.032	0.5489
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0149	0.0545	0.1847
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0033	0.0032	0.0032
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0033	0.0032	0.0032
Schistosoma mansoni	hypothetical protein	0.003	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0032	0.0232
Plasmodium falciparum	histone acetyltransferase GCN5	0.0047	0.0094	1
Echinococcus granulosus	metabotropic glutamate receptor 2	0.0232	0.0915	0.0915
Echinococcus granulosus	thymidine phosphorylase	0.0634	0.2699	0.2699
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0033	0.0032	0.0032
Giardia lamblia	Histone acetyltransferase GCN5	0.0047	0.0094	0.0612
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0038	0.0052	0.0417
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0009	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0115	0.0822
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0057	0.0135	0.1215
Loa Loa (eye worm)	jmjC domain-containing protein	0.0063	0.0163	0.1163
Echinococcus multilocularis	microtubule associated protein 2	0.228	1	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.0098	0.032	0.2284
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0098	0.032	0.032
Loa Loa (eye worm)	MH2 domain-containing protein	0.0124	0.0437	0.312
Schistosoma mansoni	thyroid hormone receptor	0.0033	0.0032	0.0032
Schistosoma mansoni	hypothetical protein	0.0365	0.1503	0.1503
Echinococcus granulosus	polycomb protein SCMH1	0.005	0.0105	0.0105
Echinococcus granulosus	metabotropic glutamate receptor 5	0.0341	0.1399	0.1399
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0051	0.0113	1
Echinococcus multilocularis	GPCR, family 2	0.0036	0.0043	0.0043
Mycobacterium ulcerans	acyl-CoA synthetase	0.0052	0.0115	0.0221
Echinococcus granulosus	histone acetyltransferase MYST2	0.0057	0.0135	0.0135
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0033	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0057	0.0405
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0052	0.0115	0.0221
Mycobacterium tuberculosis	Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase)	0.0634	0.2699	1
Echinococcus granulosus	peregrin	0.0035	0.0038	0.0038
Echinococcus multilocularis	SAM and MBT domain containing protein	0.005	0.0105	0.0105
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0032	0.0232
Schistosoma mansoni	nuclear hormone receptor	0.0033	0.0032	0.0032
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0033	0.0032	0.0032
Echinococcus granulosus	lysine specific demethylase 5A	0.0098	0.032	0.032
Echinococcus multilocularis	peregrin	0.0035	0.0038	0.0038
Onchocerca volvulus		0.0052	0.0115	0.1972
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0161	0.0598	0.0598
Onchocerca volvulus	Metabotropic glutamate receptor homolog	0.0045	0.0084	0.144
Echinococcus multilocularis	ecdysone induced protein 78C	0.0033	0.0032	0.0032
Echinococcus granulosus	lysosomal alpha glucosidase	0.017	0.0638	0.0638
Schistosoma mansoni	metabotropic glutamate receptor	0.0135	0.0484	0.0484
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0305	0.1236	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0032	0.0232
Loa Loa (eye worm)	steroid hormone receptor	0.0033	0.0032	0.0232
Mycobacterium ulcerans	acyl-CoA synthetase	0.0052	0.0115	0.0221
Plasmodium falciparum	ataxin-2 like protein, putative	0.0028	0.0009	0.0872
Brugia malayi	Bromodomain containing protein	0.0035	0.0038	0.0343
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0277	0.1115	1
Brugia malayi	Glycosyl hydrolases family 31 protein	0.017	0.0638	0.5722
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0033	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0188	0.1344
Trypanosoma brucei	PAB1-binding protein , putative	0.0028	0.0009	0.1591
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0036	0.0043	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0226	0.1617
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0033	0.0032	0.0032
Echinococcus multilocularis	jumonji domain containing protein	0.0042	0.0072	0.0072
Toxoplasma gondii	PHD-finger domain-containing protein	0.003	0.0019	0.1672
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0305	0.1236	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0129	0.0129
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0161	0.0598	0.0598
Schistosoma mansoni	alpha-glucosidase	0.0146	0.0533	0.0533
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0305	0.1236	1
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0038	0.0052	0.0368
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0129	0.0925
Onchocerca volvulus	Bile acid receptor homolog	0.0033	0.0032	0.0556
Schistosoma mansoni	hypothetical protein	0.0302	0.1226	0.1226
Echinococcus multilocularis	geminin	0.0365	0.1503	0.1503
Schistosoma mansoni	thyroid hormone receptor	0.0033	0.0032	0.0032

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	1 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	1.6511 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	2.8184 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398]	ChEMBL.	No reference
Potency (functional)	2.8184 uM	PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	2.9093 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1724766

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1533051