Detailed information for compound 1535534

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 288.342 | Formula: C16H20N2O3
  • H donors: 1 H acceptors: 1 LogP: 2.64 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1CCCC(=NNC(=O)C2COc3c(O2)cccc3)C1
  • InChi: 1S/C16H20N2O3/c1-11-5-4-6-12(9-11)17-18-16(19)15-10-20-13-7-2-3-8-14(13)21-15/h2-3,7-8,11,15H,4-6,9-10H2,1H3,(H,18,19)
  • InChiKey: XUAMEZPLBCCPFZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi SPARC precursor 0.0019 0.0006 0.0147
Loa Loa (eye worm) thymidylate synthase 0.0381 0.0306 0.8148
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0058 0.0038 0.1063
Schistosoma mansoni thyroid hormone receptor 0.0027 0.0012 0.0331
Loa Loa (eye worm) hypothetical protein 0.0027 0.0012 0.0314
Echinococcus granulosus GTP binding nuclear protein Ran 0.0015 0.0002 0.0066
Mycobacterium ulcerans AcrR family transcriptional regulator 1.2028 1 1
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0003 0.0076
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0028 0.0013 0.0161
Plasmodium vivax histone deacetylase 1, putative 0.0414 0.0334 0.7668
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0019 0.0006 0.0147
Giardia lamblia Histone deacetylase 0.0414 0.0334 1
Brugia malayi hypothetical protein 0.0181 0.014 0.3729
Trypanosoma cruzi Zn-finger in ubiquitin-hydrolases and other protein, putative 0.004 0.0023 0.0478
Brugia malayi beta-lactamase family protein 0.0042 0.0024 0.0649
Brugia malayi BRCA1-associated protein 2 containing protein 0.004 0.0023 0.0613
Brugia malayi sodium-independent organic anion transporter family protein 0.0028 0.0013 0.0346
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.0071 0.2067
Onchocerca volvulus Putative organic anion transporter 0.0028 0.0013 0.0424
Loa Loa (eye worm) hypothetical protein 0.0042 0.0024 0.065
Schistosoma mansoni hypothetical protein 0.0014 0.0001 0.0023
Echinococcus multilocularis protein patched 0.0042 0.0024 0.0304
Schistosoma mansoni cpg binding protein 0.0022 0.0008 0.0221
Brugia malayi hypothetical protein 0.0119 0.0089 0.2362
Brugia malayi secreted modular calcium-binding protein 1 0.0019 0.0006 0.0147
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0035 0.0441
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase 5, putative 0.004 0.0023 0.0624
Leishmania major hypothetical protein, conserved 0.0042 0.0024 0.0509
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.004 0.0023 0.0647
Loa Loa (eye worm) glutamate receptor 0.0016 0.0003 0.0068
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0536 0.0435 1
Onchocerca volvulus 0.0042 0.0024 0.0797
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0004 0.0046
Toxoplasma gondii histone deacetylase HDAC2 0.0414 0.0334 0.7668
Leishmania major hypothetical protein, conserved 0.004 0.0023 0.0478
Loa Loa (eye worm) hypothetical protein 0.0028 0.0013 0.0346
Schistosoma mansoni importin beta-1 0.0021 0.0007 0.0195
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0041 0.0506
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0024 0.0509
Schistosoma mansoni hypothetical protein 0.0169 0.013 0.3642
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0004 0.0095
Brugia malayi RNA, U transporter 1 0.006 0.0039 0.1043
Trypanosoma cruzi histone deacetylase, putative 0.04 0.0323 0.7397
Brugia malayi histone deacetylase 1 (HD1) 0.0414 0.0334 0.8898
Echinococcus granulosus histone deacetylase 6 0.04 0.0323 0.9057
Mycobacterium tuberculosis Conserved protein 0.0042 0.0024 0.0021
Onchocerca volvulus 0.0042 0.0024 0.0797
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.0023 0.0613
Entamoeba histolytica hypothetical protein 0.0072 0.005 0.1423
Schistosoma mansoni hypothetical protein 0.0224 0.0176 0.4945
Trichomonas vaginalis histone deacetylase, putative 0.0414 0.0334 1
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0536 0.0435 1
Echinococcus granulosus dnaJ subfamily B 0.0298 0.0237 0.6667
Schistosoma mansoni cpg binding protein 0.0022 0.0008 0.0221
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0041 0.1142
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0381 0.0306 0.8595
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.0001 0.001
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase 13, putative 0.004 0.0023 0.0478
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.0024 0.0303
Loa Loa (eye worm) histone deacetylase 1 0.0414 0.0334 0.8898
Onchocerca volvulus 0.0042 0.0024 0.0797
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0038 0.0014
Loa Loa (eye worm) hypothetical protein 0.0019 0.0006 0.0147
Plasmodium vivax U4/U6.U5 tri-snRNP-associated protein 2, putative 0.004 0.0023 0.0478
Echinococcus multilocularis dihydrofolate reductase 0.0155 0.0119 0.1474
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0014 0.0001 0.0035
Schistosoma mansoni hypothetical protein 0.0031 0.0016 0.0439
Trypanosoma cruzi histone deacetylase, putative 0.0216 0.0169 0.3858
Schistosoma mansoni histone deacetylase 0.0414 0.0334 0.9387
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0086 0.2294
Brugia malayi ecdysteroid receptor 0.0027 0.0012 0.0314
Brugia malayi CHE-14 protein 0.0042 0.0024 0.065
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0023 0.0478
Plasmodium vivax histone deacetylase, putative 0.04 0.0323 0.7397
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.0012 0.0314
Loa Loa (eye worm) hypothetical protein 0.0019 0.0006 0.0147
Trypanosoma cruzi MFS transporter, putative 0.0028 0.0013 0.0246
Echinococcus multilocularis histone deacetylase 7 0.04 0.0323 0.401
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 1.2028 1 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0027 0.0012 0.0331
Brugia malayi Steroid receptor seven-up type 2 0.0027 0.0012 0.0314
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0003 0.0008
Loa Loa (eye worm) ubiquitin specific peptidase 39 0.004 0.0023 0.0613
Loa Loa (eye worm) hypothetical protein 0.0042 0.0024 0.0649
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.006 0.0039 0.0486
Loa Loa (eye worm) hypothetical protein 0.0028 0.0013 0.0346
Echinococcus granulosus histone deacetylase 6 0.0441 0.0356 1
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0024 0.0686
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0181 0.014 0.3183
Echinococcus granulosus histone deacetylase 1 0.0414 0.0334 0.9387
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0023 0.0624
Schistosoma mansoni follistatin 0.0019 0.0006 0.0155
Echinococcus multilocularis cpg binding protein 0.0022 0.0008 0.0098
Trypanosoma cruzi importin beta-1 subunit, putative 0.0017 0.0004 0.003
Schistosoma mansoni histone deacetylase hda2 0.0441 0.0356 1
Trichomonas vaginalis histone deacetylase, putative 0.0414 0.0334 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0042 0.0024 0.0021
Brugia malayi Dihydrofolate reductase 0.0155 0.0119 0.3157
Plasmodium vivax JmjC domain containing protein 0.0016 0.0003 0.0008
Brugia malayi histone deacetylase 11 0.0216 0.0169 0.4508
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0034 0.0017 0.0216
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.0023 0.0613
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0015 0.0288
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0028 0.0013 0.0365
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0004 0.0095
Echinococcus granulosus phd:f box containing protein 0.0016 0.0003 0.0076
Brugia malayi jmjC domain containing protein 0.0016 0.0003 0.0072
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0003 0.0034
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0003 0.0008
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0049 0.003 0.0379
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0017 0.0004 0.0039
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0024 0.0664
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0072
Trichomonas vaginalis brca1-associated protein, putative 0.004 0.0023 0.0624
Brugia malayi prostaglandin transporter 0.0028 0.0013 0.0346
Brugia malayi Nuclear hormone receptor-like 1 0.0014 0.0001 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.0012 0.0314
Loa Loa (eye worm) hypothetical protein 0.0028 0.0013 0.0346
Loa Loa (eye worm) hypothetical protein 0.003 0.0015 0.0394
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0023 0.0478
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase 13, putative 0.004 0.0023 0.0478
Loa Loa (eye worm) hypothetical protein 0.0027 0.0012 0.0314
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0224 0.0176 0.4687
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.014 0.415
Echinococcus granulosus snurportin 1 0.0224 0.0176 0.4945
Echinococcus granulosus dihydrofolate reductase 0.0155 0.0119 0.333
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0024 0.065
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0019 0.0006 0.0147
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0006 0.0074
Trypanosoma brucei histone deacetylase 1 0.0414 0.0334 0.7668
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0027 0.0012 0.0314
Loa Loa (eye worm) hypothetical protein 0.0031 0.0016 0.0416
Loa Loa (eye worm) hypothetical protein 0.0414 0.0334 0.8898
Schistosoma mansoni ran 0.0015 0.0002 0.0066
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0027 0.0012 0.0147
Schistosoma mansoni organic anion transporter 0.0028 0.0013 0.0365
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0017 0.0004 0.0039
Echinococcus multilocularis histone deacetylase 0.04 0.0323 0.401
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0027 0.0012 0.0314
Loa Loa (eye worm) hypothetical protein 0.0119 0.0089 0.2362
Mycobacterium ulcerans TetR family transcriptional regulator 1.2028 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0024 0.0664
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0027 0.0012 0.0314
Echinococcus multilocularis agrin 0.0019 0.0006 0.0069
Brugia malayi nuclear receptor RXR 0.0014 0.0001 0.0034
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0536 0.0435 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0012 0.0331
Schistosoma mansoni histone deacetylase 0.0414 0.0334 0.9387
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0027 0.0012 0.0331
Onchocerca volvulus 0.0019 0.0006 0.0181
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0027 0.0012 0.0331
Brugia malayi Histone deacetylase family protein 0.04 0.0323 0.8586
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0016 0.0194
Echinococcus granulosus geminin 0.0169 0.013 0.3642
Onchocerca volvulus Putative organic anion transporter 0.0028 0.0013 0.0424
Schistosoma mansoni brca1-associated protein (brap2) 0.004 0.0023 0.0647
Echinococcus granulosus histone deacetylase 8 0.0216 0.0169 0.4755
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.0012 0.0314
Brugia malayi hypothetical protein 0.0028 0.0013 0.0346
Echinococcus multilocularis histone deacetylase 6 0.04 0.0323 0.401
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0006 0.0074
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0014 0.0001 0.0016
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.004 0.1125
Trichomonas vaginalis histone deacetylase, putative 0.0414 0.0334 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0027 0.0012 0.0314
Leishmania major histone deacetylase, putative 0.04 0.0323 0.7397
Trichomonas vaginalis histone deacetylase, putative 0.0414 0.0334 1
Echinococcus granulosus BRCA1 associated protein 0.004 0.0023 0.0647
Mycobacterium tuberculosis Hypothetical protein 0.0181 0.014 0.0137
Leishmania major hypothetical protein, conserved 0.003 0.0015 0.0288
Loa Loa (eye worm) hypothetical protein 0.0028 0.0013 0.0346
Brugia malayi hypothetical protein 0.0014 0.0001 0.0034
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0004 0.01
Schistosoma mansoni coup transcription factor 0.0027 0.0012 0.0331
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.004 0.0023 0.0624
Echinococcus multilocularis histone deacetylase 6 0.0441 0.0356 0.4428
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0004 0.0028
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0004 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0024 0.0666
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0003 0.0076
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 22 0.004 0.0023 0.0647
Brugia malayi Metabotropic glutamate receptor precursor. 0.004 0.0023 0.0606
Schistosoma mansoni histone deacetylase 4 5 0.04 0.0323 0.9057
Echinococcus multilocularis histone deacetylase 1 0.0414 0.0334 0.4156
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.005 0.0617
Brugia malayi jmjC domain containing protein 0.0016 0.0003 0.0072
Echinococcus multilocularis ecdysone induced protein 78C 0.0027 0.0012 0.0147
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0004 0.0028
Plasmodium falciparum histone deacetylase, putative 0.04 0.0323 0.7397
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0028 0.0013 0.0161
Schistosoma mansoni hypothetical protein 0.0041 0.0023 0.0651
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0014 0.0001 0.0034
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0414 0.0334 1
Brugia malayi hypothetical protein 0.002 0.0006 0.0155
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.0001 0.0023
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.0012 0.0331
Loa Loa (eye worm) hypothetical protein 0.0098 0.0071 0.1888
Loa Loa (eye worm) hypothetical protein 0.0042 0.0024 0.0649
Toxoplasma gondii protease inhibitor PI2 0.0019 0.0006 0.0074
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0035 0.0995
Schistosoma mansoni hypothetical protein 0.0031 0.0016 0.0439
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0024 0.0664
Loa Loa (eye worm) hypothetical protein 0.0028 0.0013 0.0346
Loa Loa (eye worm) hypothetical protein 0.0068 0.0046 0.1225
Onchocerca volvulus 0.0021 0.0007 0.0225
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0027 0.0012 0.0331
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0268 0.0213 0.0209
Brugia malayi follicle stimulating hormone receptor 0.0464 0.0376 1
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0015 0.0288
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0023 0.0624
Loa Loa (eye worm) hypothetical protein 0.0028 0.0013 0.0346
Trypanosoma brucei histone deacetylase 3 0.04 0.0323 0.7397
Plasmodium falciparum histone deacetylase 2 0.04 0.0323 0.7397
Loa Loa (eye worm) BRCA1-associated protein 2 containing protein 0.004 0.0023 0.0613
Mycobacterium ulcerans thymidylate synthase 0.0381 0.0306 0.0282
Entamoeba histolytica histone deacetylase, putative 0.0414 0.0334 1
Echinococcus granulosus thymidylate synthase 0.0381 0.0306 0.8595
Trichomonas vaginalis histone deacetylase, putative 0.0414 0.0334 1
Brugia malayi dihydrofolate reductase family protein 0.0155 0.0119 0.3157
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0035 0.0995
Onchocerca volvulus 0.0028 0.0013 0.0424
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0036 0.002 0.0523
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0155 0.0119 0.0094
Brugia malayi beta-lactamase family protein 0.0042 0.0024 0.0649
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.004 0.0023 0.0647
Echinococcus multilocularis expressed conserved protein 0.0092 0.0066 0.0821
Schistosoma mansoni hypothetical protein 0.0298 0.0237 0.6667
Schistosoma mansoni thyroid hormone receptor 0.0027 0.0012 0.0331
Brugia malayi jmjC domain containing protein 0.0061 0.004 0.1067
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0003 0.0008
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0058 0.0038 0.0034
Schistosoma mansoni hypothetical protein 0.0068 0.0046 0.1292
Plasmodium falciparum U4/U6.U5 tri-snRNP-associated protein 2, putative 0.004 0.0023 0.0478
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0038 0.1063
Loa Loa (eye worm) beta-lactamase 0.0042 0.0024 0.0649
Mycobacterium tuberculosis Probable esterase LipL 0.0042 0.0024 0.0021
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0003 0.0076
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.0023 0.0613
Echinococcus multilocularis geminin 0.0169 0.013 0.1613
Echinococcus granulosus Niemann Pick C1 protein 0.014 0.0106 0.2974
Toxoplasma gondii UBA/TS-N domain-containing protein 0.004 0.0023 0.0478
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0041 0.0886
Brugia malayi thymidylate synthase 0.0381 0.0306 0.8148
Trypanosoma cruzi histone deacetylase, putative 0.0216 0.0169 0.3858
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 14 0.004 0.0023 0.0624
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.0024 0.0685
Brugia malayi nuclear hormone receptor 0.0027 0.0012 0.0314
Toxoplasma gondii transporter, major facilitator family protein 0.0028 0.0013 0.0246
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0027 0.0012 0.0314
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0027 0.0012 0.0331
Echinococcus multilocularis thymidylate synthase 0.0381 0.0306 0.3806
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.0804 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0024 0.0685
Schistosoma mansoni metabotropic glutamate receptor 0.002 0.0006 0.016
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0004 0.0028
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0004 0.0044
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0003 0.0072
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0004 0.0028
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0072 0.1921
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0464 0.0376 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.0012 0.0314
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0003 0.0076
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0041 0.0016
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0034
Echinococcus granulosus histone deacetylase 7 0.04 0.0323 0.9057
Trypanosoma cruzi histone deacetylase, putative 0.04 0.0323 0.7397
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.0071 0.1888
Brugia malayi hypothetical protein 0.0072 0.005 0.132
Toxoplasma gondii histone lysine methyltransferase SET1 0.004 0.0022 0.0465
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0004 0.0028
Echinococcus granulosus Solute carrier organic anion transporter family 0.0028 0.0013 0.0365
Echinococcus multilocularis FTZ F1 alpha 0.0027 0.0012 0.0147
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0003 0.0072
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0012 0.0147
Entamoeba histolytica hypothetical protein 0.0017 0.0004 0.0039
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0041 0.0016
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0155 0.0119 0.0094
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0027 0.0012 0.0147
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0035 0.0995
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0003 0.0034
Onchocerca volvulus Huntingtin homolog 0.0119 0.0089 0.2899
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0414 0.0334 1
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0024 0.0686
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0046 0.1225
Loa Loa (eye worm) hypothetical protein 0.0042 0.0024 0.0649
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0003 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.0012 0.0314
Echinococcus multilocularis histone deacetylase 8 0.0216 0.0169 0.2105
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0004 0.0028
Loa Loa (eye worm) hypothetical protein 0.0119 0.0089 0.2362
Schistosoma mansoni hypothetical protein 0.0041 0.0023 0.0651
Loa Loa (eye worm) hypothetical protein 0.0049 0.003 0.0811
Mycobacterium tuberculosis Probable lipase LipD 0.0042 0.0024 0.0021
Echinococcus multilocularis follistatin 0.0019 0.0006 0.0069
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0072 0.1921
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.0024 0.0649
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0015 0.0288
Echinococcus granulosus follistatin 0.0019 0.0006 0.0155
Trichomonas vaginalis importin beta-1, putative 0.0017 0.0004 0.0039
Trypanosoma brucei histone deacetylase 2 0.0216 0.0169 0.3858
Trypanosoma cruzi Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.004 0.0023 0.0478
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0035 0.0995
Trichomonas vaginalis BRCA1-associated protein, putative 0.004 0.0023 0.0624
Loa Loa (eye worm) steroid hormone receptor 0.0027 0.0012 0.0314
Echinococcus granulosus u4:u6.u5 tri snrnp associated protein 2 0.004 0.0023 0.0647
Brugia malayi histone deacetylase 3 (HD3) 0.0414 0.0334 0.8898
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0016 0.0439
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.0003 0.0008
Echinococcus multilocularis dnaJ subfamily B 0.0298 0.0237 0.2952
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0004 0.01
Onchocerca volvulus Uncharacterized RING finger protein homolog 0.004 0.0023 0.0753
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0086 0.2294
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0003 0.0076
Echinococcus granulosus lysine specific demethylase 5A 0.0061 0.004 0.1125
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0004 0.0044
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0012 0.0147
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0024 0.0664
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0006 0.0074
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0006 0.0074
Brugia malayi CXXC zinc finger family protein 0.0021 0.0007 0.0183
Mycobacterium tuberculosis Conserved protein 0.0042 0.0024 0.0021
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.0071 0.1992
Echinococcus granulosus histone deacetylase 6 0.04 0.0323 0.9057
Plasmodium vivax importin-beta 2, putative 0.0021 0.0007 0.0107
Trypanosoma cruzi histone deacetylase 1, putative 0.0414 0.0334 0.7668
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.004 0.1125
Onchocerca volvulus 0.0028 0.0013 0.0424
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0006 0.0147
Schistosoma mansoni steroid hormone receptor ad4bp 0.0027 0.0012 0.0331
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.0038 0.1008
Loa Loa (eye worm) hypothetical protein 0.0042 0.0024 0.0649
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0024 0.0509
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.0024 0.0649
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0016 0.0416
Schistosoma mansoni histone deacetylase hda2 0.0216 0.0169 0.4755
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0027 0.0012 0.0314
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0004 0.0044
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.0035 0.0921
Echinococcus multilocularis lysine specific demethylase 5A 0.006 0.0039 0.0486
Schistosoma mansoni histone deacetylase 1 2 3 0.0216 0.0169 0.4755
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0003 0.0008
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0027 0.0012 0.0147
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0027 0.0012 0.0314
Schistosoma mansoni hypothetical protein 0.0031 0.0016 0.0439
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.006 0.0039 0.1097
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0038 0.0014
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0027 0.0012 0.0331
Leishmania major histone deacetylase, putative 0.0414 0.0334 0.7668
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0004 0.0028
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0185
Onchocerca volvulus 0.0028 0.0013 0.0424
Onchocerca volvulus 0.0028 0.0013 0.0424
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0004 0.0044
Toxoplasma gondii ubiquitin specific protease 39 isoform 2, putative 0.004 0.0023 0.0478
Leishmania major histone deacetylase, putative 0.04 0.0323 0.7397
Loa Loa (eye worm) hypothetical protein 0.0051 0.0032 0.086
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0038 0.0471
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0536 0.0435 1
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0015 0.0288
Echinococcus granulosus metabotropic glutamate receptor 2 0.0034 0.0017 0.0487
Leishmania major hypothetical protein, conserved 0.0016 0.0003 0.0008
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0003 0.0034
Loa Loa (eye worm) hypothetical protein 0.0224 0.0176 0.4692
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0072
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0024 0.0664
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0027 0.0012 0.0331
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0003 0.0072
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.004 0.1067
Plasmodium vivax hypothetical protein, conserved 0.004 0.0023 0.0478
Schistosoma mansoni hypothetical protein 0.0169 0.013 0.3642
Schistosoma mansoni organic anion transporter 0.0028 0.0013 0.0365
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0035 0.0441
Trypanosoma brucei histone deacetylase, putative 0.04 0.0323 0.7397
Loa Loa (eye worm) histone deacetylase 0.04 0.0323 0.8586
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0019 0.0006 0.0147
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 5 0.004 0.0023 0.0286
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.0072 0.2028
Onchocerca volvulus Histone deacetylase 10 homolog 0.0216 0.0169 0.5532
Onchocerca volvulus Huntingtin homolog 0.0119 0.0089 0.2899
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0027 0.0012 0.0331
Brugia malayi jmjC domain containing protein 0.0016 0.0003 0.0072
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0041 0.0886
Trypanosoma brucei histone deacetylase 4 0.04 0.0323 0.7397
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0034
Loa Loa (eye worm) hypothetical protein 0.0019 0.0006 0.0147
Loa Loa (eye worm) histone deacetylase 11 0.0216 0.0169 0.4508
Schistosoma mansoni RAR-like nuclear receptor 0.0027 0.0012 0.0331
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0003 0.0008
Brugia malayi isocitrate dehydrogenase 0.0017 0.0004 0.0095
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0003 0.0034
Echinococcus multilocularis importin subunit beta 1 0.0021 0.0007 0.0086
Loa Loa (eye worm) agrin synaptic family protein 0.0019 0.0006 0.0147
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0015 0.0002 0.0062
Brugia malayi hypothetical protein 0.0028 0.0013 0.0346
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0024 0.0685
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0023 0.0624
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0027 0.0012 0.0147
Echinococcus multilocularis snurportin 1 0.0224 0.0176 0.2189
Trypanosoma cruzi Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.004 0.0023 0.0478
Trypanosoma cruzi histone deacetylase, putative 0.04 0.0323 0.7397
Loa Loa (eye worm) histone deacetylase 3 0.0414 0.0334 0.8898
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 22 0.004 0.0023 0.0286
Trichomonas vaginalis esterase, putative 0.0042 0.0024 0.0664
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0023 0.0624
Echinococcus multilocularis BRCA1 associated protein 0.004 0.0023 0.0286
Echinococcus granulosus histone deacetylase 3 0.0414 0.0334 0.9387
Mycobacterium ulcerans transcriptional regulator 1.2028 1 1
Echinococcus multilocularis protein dispatched 1 0.0048 0.0029 0.0365
Toxoplasma gondii histone deacetylase HDAC1 0.04 0.0323 0.7397
Loa Loa (eye worm) hypothetical protein 0.0019 0.0006 0.0147
Entamoeba histolytica hypothetical protein 0.0072 0.005 0.1423
Leishmania major importin beta-1 subunit, putative 0.0017 0.0004 0.003
Plasmodium vivax histone deacetylase 2, putative 0.04 0.0323 0.7397
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0536 0.0435 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0012 0.0331
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0016 0.0416
Echinococcus granulosus importin subunit beta 1 0.0021 0.0007 0.0195
Loa Loa (eye worm) hypothetical protein 0.0027 0.0012 0.0314
Echinococcus granulosus metabotropic glutamate receptor 5 0.0049 0.003 0.0855
Loa Loa (eye worm) hypothetical protein 0.0216 0.0169 0.4508
Plasmodium falciparum importin beta, putative 0.0021 0.0007 0.0107
Echinococcus multilocularis GPCR, family 2 0.0031 0.0016 0.0194
Onchocerca volvulus 0.0027 0.0012 0.0385
Brugia malayi Importin beta-1 subunit 0.0021 0.0007 0.0185
Schistosoma mansoni cpg binding protein 0.0021 0.0007 0.0193
Brugia malayi steroid hormone receptor 0.0027 0.0012 0.0314
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0536 0.0435 1
Brugia malayi MH2 domain containing protein 0.0116 0.0086 0.2294
Echinococcus granulosus GPCR family 2 0.0031 0.0016 0.0439
Loa Loa (eye worm) hypothetical protein 0.0028 0.0013 0.0346
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0072
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0027 0.0012 0.0314
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0004 0.0028
Schistosoma mansoni retinoic acid receptor RXR 0.0027 0.0012 0.0331
Brugia malayi Nuclear hormone receptor-like 1 0.0014 0.0001 0.0034
Brugia malayi sodium-independent organic anion transporter family protein 0.0028 0.0013 0.0346
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.004 0.0023 0.0613
Mycobacterium tuberculosis Probable hydrolase 0.0042 0.0024 0.0021
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0028 0.0013 0.0346
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0015 0.0002 0.0062
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0023 0.0624
Entamoeba histolytica hypothetical protein 0.0072 0.005 0.1423
Loa Loa (eye worm) hypothetical protein 0.0027 0.0012 0.0314
Leishmania major histone deacetylase, putative 0.0414 0.0334 0.7668
Brugia malayi beta-lactamase 0.0042 0.0024 0.0649
Trypanosoma brucei importin beta-1 subunit, putative 0.0021 0.0007 0.0107
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0044 0.0026 0.0741
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0072 0.1921
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0004 0.0104
Brugia malayi hypothetical protein 0.0014 0.0001 0.0034
Loa Loa (eye worm) hypothetical protein 0.0184 0.0143 0.3798
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0045 0.0027 0.0767
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0027 0.0012 0.0314
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0023 0.0478
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.005 0.1392
Schistosoma mansoni jumonji domain containing protein 0.006 0.0039 0.1097
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0042 0.0024 0.0021
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0015 0.0288
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0003 0.0076
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.004 0.0023 0.0647
Brugia malayi Histone deacetylase 1 0.0414 0.0334 0.8898
Brugia malayi hypothetical protein 0.003 0.0015 0.0394
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0381 0.0306 0.0303
Echinococcus granulosus agrin 0.0019 0.0006 0.0155
Entamoeba histolytica hypothetical protein 0.0072 0.005 0.1423
Mycobacterium tuberculosis Probable lipase LipE 0.0042 0.0024 0.0021
Trypanosoma cruzi histone deacetylase 1, putative 0.0414 0.0334 0.7668
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.004 0.0023 0.0613
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0042 0.0024 0.0021
Loa Loa (eye worm) hypothetical protein 0.0099 0.0072 0.1921
Loa Loa (eye worm) hypothetical protein 0.0027 0.0012 0.0314
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0014 0.0001 0.0035
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0027 0.0012 0.0314
Schistosoma mansoni histone deacetylase 4 5 0.04 0.0323 0.9057
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.004 0.0023 0.0624
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.005 0.1392
Loa Loa (eye worm) histone deacetylase 7A 0.04 0.0323 0.8586
Echinococcus granulosus cpg binding protein 0.0022 0.0008 0.0221
Giardia lamblia Hypothetical protein 0.004 0.0023 0.0624
Echinococcus multilocularis histone deacetylase 3 0.0414 0.0334 0.4156
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.0071 0.0882
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0003 0.0076
Toxoplasma gondii HEAT repeat-containing protein 0.0021 0.0007 0.0107
Brugia malayi photoreceptor-specific nuclear receptor 0.0027 0.0012 0.0314
Schistosoma mansoni hypothetical protein 0.0041 0.0023 0.0651
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0024 0.0304
Echinococcus granulosus histone deacetylase 0.04 0.0323 0.9057
Onchocerca volvulus Putative organic anion transporter 0.0028 0.0013 0.0424
Trypanosoma brucei Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.004 0.0023 0.0478
Loa Loa (eye worm) hypothetical protein 0.0027 0.0012 0.0314
Echinococcus granulosus expressed conserved protein 0.0092 0.0066 0.1853
Loa Loa (eye worm) glutamate receptor 0.004 0.0023 0.0606
Echinococcus multilocularis expressed protein 0.0019 0.0006 0.0069
Plasmodium falciparum histone deacetylase 1 0.0414 0.0334 0.7668
Brugia malayi Histone deacetylase family protein 0.04 0.0323 0.8586
Onchocerca volvulus Protein ultraspiracle homolog 0.0027 0.0012 0.0385
Chlamydia trachomatis dihydrofolate reductase 0.0155 0.0119 0.5
Onchocerca volvulus 0.0381 0.0306 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0034
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0414 0.0334 1
Toxoplasma gondii histone deacetylase HDAC5 0.0216 0.0169 0.3858
Mycobacterium tuberculosis Conserved protein 0.0042 0.0024 0.0021
Schistosoma mansoni dihydrofolate reductase 0.0155 0.0119 0.333
Echinococcus multilocularis Niemann Pick C1 protein 0.014 0.0106 0.1317
Schistosoma mansoni agrin 0.0019 0.0006 0.0155
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0381 0.0306 0.0282
Schistosoma mansoni brca1-associated protein (brap2) 0.004 0.0023 0.0647
Echinococcus multilocularis u4:u6.u5 tri snrnp associated protein 2 0.004 0.0023 0.0286
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0023 0.0478
Loa Loa (eye worm) hypothetical protein 0.0042 0.0024 0.0649
Brugia malayi nuclear receptor NHR-88 0.0027 0.0012 0.0314
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0027 0.0012 0.0314
Trypanosoma brucei importin beta-1 subunit, putative 0.0021 0.0007 0.0107
Schistosoma mansoni metabotropic glutamate receptor 0.0034 0.0017 0.0487
Echinococcus multilocularis histone deacetylase 6 0.04 0.0323 0.401
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0024 0.0509
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0015 0.0002 0.0029
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0004 0.0044
Trypanosoma brucei Zn-finger in ubiquitin-hydrolases and other protein, putative 0.004 0.0023 0.0478
Onchocerca volvulus 0.0028 0.0013 0.0424
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0034
Schistosoma mansoni hypothetical protein 0.0041 0.0023 0.0651
Echinococcus granulosus ecdysone induced protein 78C 0.0027 0.0012 0.0331
Toxoplasma gondii ABC1 family protein 0.0042 0.0024 0.0509
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0015 0.0288
Loa Loa (eye worm) hypothetical protein 0.0027 0.0012 0.0314
Echinococcus multilocularis thyroid hormone receptor alpha 0.0027 0.0012 0.0147
Loa Loa (eye worm) hypothetical protein 0.0027 0.0012 0.0314
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0019 0.0006 0.0147
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0041 0.0037
Schistosoma mansoni hypothetical protein 0.0031 0.0016 0.0439
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0035 0.0943
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0027 0.0012 0.0331
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0024 0.0509
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0058 0.0038 0.082
Loa Loa (eye worm) CXXC zinc finger family protein 0.0021 0.0007 0.0183
Brugia malayi metabotropic glutamate receptor type 2 0.002 0.0006 0.0152
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0041 0.1142
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0041 0.1142
Trichomonas vaginalis histone deacetylase, putative 0.0414 0.0334 1
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0012 0.0314
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0016 0.0416
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0014 0.0001 0.0035
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0034
Toxoplasma gondii Zn-finger in ubiquitin-hydrolases domain-containing protein 0.004 0.0023 0.0478
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0155 0.0119 0.0115
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.0012 0.0314
Schistosoma mansoni ran 0.0015 0.0002 0.0066
Brugia malayi jmjC domain containing protein 0.006 0.0039 0.104
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0015 0.0288
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0035 0.0943
Schistosoma mansoni patched 1 0.0042 0.0024 0.0686
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0016 0.0439
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0027 0.0012 0.0314
Loa Loa (eye worm) hypothetical protein 0.0042 0.0024 0.0649
Leishmania major hypothetical protein, conserved 0.004 0.0023 0.0478
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0027 0.0012 0.0385
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.004 0.0023 0.0478
Onchocerca volvulus Bile acid receptor homolog 0.0027 0.0012 0.0385
Brugia malayi sodium-independent organic anion transporter family protein 0.0028 0.0013 0.0346
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0027 0.0012 0.0314
Toxoplasma gondii histone deacetylase HDAC4 0.0216 0.0169 0.3858
Echinococcus granulosus FTZ F1 alpha 0.0027 0.0012 0.0331
Loa Loa (eye worm) dihydrofolate reductase 0.0155 0.0119 0.3157
Schistosoma mansoni nuclear hormone receptor 0.0027 0.0012 0.0331
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0016 0.0194
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0027 0.0012 0.0331
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0035 0.0995
Plasmodium vivax histone deacetylase, putative 0.0216 0.0169 0.3858
Toxoplasma gondii histone deacetylase HDAC3 0.0414 0.0334 0.7668
Schistosoma mansoni hypothetical protein 0.0072 0.005 0.1392
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0027 0.0012 0.0314
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.004 0.0023 0.0613
Brugia malayi jmjC domain containing protein 0.0016 0.0003 0.0072
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0041 0.0016

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.9953 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.6234 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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