Detailed information for compound 1543021

Basic information

Technical information
  • TDR Targets ID: 1543021
  • Name: 6-[1-[2-(methyl-phenylamino)-2-oxoethyl]-2,4- dioxothieno[3,2-d]pyrimidin-3-yl]-N-[(4-methy lphenyl)methyl]hexanamide
  • MW: 532.654 | Formula: C29H32N4O4S
  • H donors: 1 H acceptors: 4 LogP: 4.09 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(NCc1ccc(cc1)C)CCCCCn1c(=O)c2sccc2n(c1=O)CC(=O)N(c1ccccc1)C
  • InChi: 1S/C29H32N4O4S/c1-21-12-14-22(15-13-21)19-30-25(34)11-7-4-8-17-32-28(36)27-24(16-18-38-27)33(29(32)37)20-26(35)31(2)23-9-5-3-6-10-23/h3,5-6,9-10,12-16,18H,4,7-8,11,17,19-20H2,1-2H3,(H,30,34)
  • InChiKey: AJXCHTYGBCCVDD-UHFFFAOYSA-N  


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Synonyms

  • 6-[1-[2-(methyl-phenyl-amino)-2-oxo-ethyl]-2,4-dioxo-thieno[3,2-d]pyrimidin-3-yl]-N-[(4-methylphenyl)methyl]hexanamide
  • 6-[1-[2-(methyl-phenylamino)-2-oxoethyl]-2,4-dioxo-3-thieno[3,2-d]pyrimidinyl]-N-[(4-methylphenyl)methyl]hexanamide
  • 6-[2,4-diketo-1-[2-keto-2-(methyl-phenyl-amino)ethyl]thieno[3,2-d]pyrimidin-3-yl]-N-(4-methylbenzyl)hexanamide
  • C241-2050
  • NCGC00105942-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0017 0.0193 0.4264
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0023 0.031 0.7349
Plasmodium falciparum lysine--tRNA ligase 0.0027 0.0391 0.0368
Plasmodium falciparum calcium-dependent protein kinase 2 0.0037 0.0589 0.0568
Echinococcus granulosus solute carrier family 22 0.0017 0.0193 0.0765
Plasmodium falciparum proline--tRNA ligase 0.0042 0.0693 0.0671
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0765
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0422 1
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0458 0.066
Trypanosoma cruzi hexose transporter 0.0038 0.0598 0.8588
Trypanosoma cruzi hexose transporter, putative 0.0038 0.0598 0.8588
Brugia malayi major facilitator superfamily protein 0.0017 0.0193 0.0765
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0422 1
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0598 0.2587
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0765
Plasmodium falciparum hexose transporter 0.0121 0.2247 0.2229
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0027 0.0391 0.667
Trichomonas vaginalis sugar transport protein, putative 0.0017 0.0193 0.0765
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0193 0.0765
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0017 0.0193 0.4264
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0037 0.0589 0.2545
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0422 1
Brugia malayi hypothetical protein 0.0017 0.0193 0.0765
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0037 0.0589 0.0568
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0279 0.6617
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0196 0.3719 0.5611
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0589 0.2545
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0598 0.2587
Trypanosoma brucei glucose transporter, putative 0.0038 0.0598 0.8588
Onchocerca volvulus 0.0017 0.0193 0.4264
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.0127 0.0465
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0279 0.0257
Brugia malayi Major Facilitator Superfamily protein 0.0017 0.0193 0.0765
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0037 0.0589 0.086
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0598 0.2587
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0765
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0422 0.1794
Onchocerca volvulus 0.0017 0.0193 0.4264
Plasmodium falciparum protein kinase 7 0.0342 0.6609 0.6601
Loa Loa (eye worm) hypothetical protein 0.0037 0.0589 0.2545
Plasmodium falciparum mitogen-activated protein kinase 2 0.0196 0.3719 0.3704
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0765
Plasmodium vivax calcium-dependent protein kinase, putative 0.0037 0.0589 0.0568
Plasmodium vivax proline--tRNA ligase, putative 0.0042 0.0693 0.0671
Plasmodium falciparum calcium-dependent protein kinase 5 0.0037 0.0589 0.0568
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0193 0.0765
Loa Loa (eye worm) hypothetical protein 0.0017 0.0193 0.0765
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0027 0.0391 0.9211
Brugia malayi lysyl-tRNA synthetase 0.0027 0.0391 0.1653
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.0023 0.0546
Echinococcus granulosus General substrate transporter 0.0104 0.1911 0.8489
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0121 0.2247 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0256 0.6071
Loa Loa (eye worm) hypothetical protein 0.0029 0.0422 0.1794
Chlamydia trachomatis lysine--tRNA ligase 0.0027 0.0391 1
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0765
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0422 1
Loa Loa (eye worm) major facilitator superfamily transporter 0.0017 0.0193 0.0765
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0422 0.5957
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0121 0.2247 1
Onchocerca volvulus 0.0017 0.0193 0.4264
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0765
Echinococcus multilocularis solute carrier family 22 0.0017 0.0193 0.0765
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0589 0.2545
Brugia malayi hypothetical protein 0.003 0.0458 0.1955
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0765
Loa Loa (eye worm) hypothetical protein 0.0017 0.0193 0.0765
Onchocerca volvulus 0.0017 0.0193 0.4264
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0279 0.6421
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0422 1
Entamoeba histolytica protein kinase, putative 0.0037 0.0589 1
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0193 0.254
Toxoplasma gondii lysine-tRNA ligase 0.0027 0.0391 0.0558
Leishmania major glucose transporter/membrane transporter D2, putative 0.0038 0.0598 0.8588
Loa Loa (eye worm) hypothetical protein 0.0017 0.0193 0.0765
Loa Loa (eye worm) hypothetical protein 0.0017 0.0193 0.0765
Trypanosoma brucei glucose transporter 2A 0.0038 0.0598 0.8588
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0279 0.0257
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0765
Trypanosoma brucei glucose transporter 1E 0.0038 0.0598 0.8588
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0422 0.7241
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.0023 0.0546
Onchocerca volvulus 0.0017 0.0193 0.4264
Leishmania major hypothetical protein, conserved 0.003 0.0458 0.649
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0017 0.0193 0.254
Onchocerca volvulus 0.0017 0.0193 0.4264
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0042 0.0693 1
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0765
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0589 0.2545
Onchocerca volvulus 0.0017 0.0193 0.4264
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0256 0.6071
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0023 0.031 0.5211
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0037 0.0589 0.2545
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0193 0.0765
Brugia malayi Major Facilitator Superfamily protein 0.0017 0.0193 0.0765
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0042 0.0693 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0422 0.7241
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0589 0.2545
Echinococcus multilocularis synaptic vesicle 2 protein 0.0017 0.0193 0.0765
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0279 0.6027
Loa Loa (eye worm) hypothetical protein 0.0017 0.0193 0.0765
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0458 0.0436
Plasmodium falciparum calcium-dependent protein kinase 4 0.0037 0.0589 0.0568
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0589 0.2545
Schistosoma mansoni protein kinase 0.0037 0.0589 0.2545
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0765
Plasmodium falciparum calcium-dependent protein kinase 1 0.0037 0.0589 0.0568
Leishmania major glucose transporter, lmgt1 0.0038 0.0598 0.8588
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0765
Giardia lamblia Lysyl-tRNA synthetase 0.0027 0.0391 0.5182
Trichomonas vaginalis glucose transporter, putative 0.0017 0.0193 0.0765
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0037 0.0589 0.0568
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0765
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0193 0.0765
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.0023 0.0546
Loa Loa (eye worm) hypothetical protein 0.0021 0.0279 0.1152
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0121 0.2247 1
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0013 0.011 0.219
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.0127 0.0465
Echinococcus granulosus lysyl tRNA synthetase 0.0027 0.0391 0.1653
Leishmania major lysyl-tRNA synthetase, putative 0.0027 0.0391 0.5487
Onchocerca volvulus 0.0017 0.0193 0.4264
Echinococcus multilocularis solute carrier family 22 0.0017 0.0193 0.0765
Onchocerca volvulus Putative transporter 0.0017 0.0193 0.4264
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0422 1
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0196 0.3719 0.3704
Loa Loa (eye worm) sugar transporter 0.0017 0.0193 0.0765
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0765
Echinococcus granulosus solute carrier family 22 0.0017 0.0193 0.0765
Toxoplasma gondii transporter, major facilitator family protein 0.0017 0.0193 0.0258
Brugia malayi hypothetical protein 0.0017 0.0193 0.0765
Leishmania major myo-inositol/proton symporter (MIT) 0.0017 0.0193 0.254
Schistosoma mansoni glucose transport protein 0.0121 0.2247 1
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0036 0.0574 0.2478
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0422 1
Onchocerca volvulus 0.0017 0.0193 0.4264
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0042 0.0693 0.1017
Onchocerca volvulus 0.0017 0.0193 0.4264
Loa Loa (eye worm) hypothetical protein 0.0021 0.0279 0.1152
Plasmodium vivax CDK-related protein kinase 6, putative 0.0514 1 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0193 0.0765
Mycobacterium ulcerans sugar transporter 0.0017 0.0193 0.4264
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0765
Plasmodium vivax hexose transporter 0.0121 0.2247 0.2229
Loa Loa (eye worm) hypothetical protein 0.0017 0.0193 0.0765
Trypanosoma brucei glucose transporter, putative 0.0038 0.0598 0.8588
Echinococcus multilocularis General substrate transporter 0.0104 0.1911 0.8489
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0037 0.0589 0.0568
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.0023 0.0546
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0121 0.2247 1
Schistosoma mansoni protein kinase 0.0037 0.0589 0.2545
Brugia malayi Cam kinase protein 1 0.0037 0.0589 0.2545
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0765
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0017 0.0193 0.4577
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0042 0.0693 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0422 0.1794
Brugia malayi Major Facilitator Superfamily protein 0.0017 0.0193 0.0765
Brugia malayi hypothetical protein 0.002 0.0245 0.0998
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0458 0.0436
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0036 0.0574 0.2478
Leishmania major protein kinase, putative 0.0037 0.0589 0.8448
Entamoeba histolytica protein kinase, putative 0.0037 0.0589 1
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0042 0.0693 1
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0765
Loa Loa (eye worm) hypothetical protein 0.0036 0.0574 0.2478
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0036 0.0574 0.2478
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0036 0.0574 0.2478
Toxoplasma gondii facilitative glucose transporter GT1 0.0121 0.2247 0.3377
Trypanosoma brucei glucose transporter, putative 0.0038 0.0598 0.8588
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0036 0.0574 1
Schistosoma mansoni sugar transporter 0.0017 0.0193 0.0765
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0765
Loa Loa (eye worm) hypothetical protein 0.0021 0.0279 0.1152
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0765
Echinococcus multilocularis calcium dependent protein kinase 0.0035 0.0544 0.2341
Loa Loa (eye worm) hypothetical protein 0.0029 0.0422 0.1794
Toxoplasma gondii sugar transporter ST3 0.0017 0.0193 0.0258
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0256 0.6071
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0765
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0023 0.0546
Loa Loa (eye worm) sugar transporter 0.0121 0.2247 1
Schistosoma mansoni glucose transporter 0.0017 0.0193 0.0765
Brugia malayi hypothetical protein 0.0017 0.0193 0.0765
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0121 0.2247 1
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0765
Treponema pallidum prolyl-tRNA synthetase 0.0013 0.011 0.5
Trypanosoma brucei glucose transporter, putative 0.0038 0.0598 0.8588
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0027 0.0391 0.1653
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0458 0.649
Trypanosoma cruzi hexose transporter, putative 0.0038 0.0598 0.8588
Loa Loa (eye worm) hypothetical protein 0.0036 0.0574 0.2478
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0765
Loa Loa (eye worm) hypothetical protein 0.0027 0.0391 0.1653
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0121 0.2247 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0422 0.1794
Mycobacterium ulcerans hypothetical protein 0.0029 0.0422 1
Mycobacterium ulcerans integral membrane transport protein 0.0017 0.0193 0.4264
Loa Loa (eye worm) hypothetical protein 0.0017 0.0193 0.0765
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0037 0.0589 0.086
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0037 0.0589 0.8448
Trypanosoma brucei sugar transporter, putative 0.0017 0.0193 0.254
Onchocerca volvulus 0.0017 0.0193 0.4264
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0027 0.0391 0.9211
Schistosoma mansoni lysyl-tRNA synthetase 0.0027 0.0391 0.1653
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0765
Loa Loa (eye worm) hypothetical protein 0.0017 0.0193 0.0765
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0458 0.649
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0589 0.2545
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0037 0.0589 0.2545
Schistosoma mansoni glucose transport protein 0.0121 0.2247 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0023 0.0546
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0017 0.0193 0.0765
Loa Loa (eye worm) hypothetical protein 0.0017 0.0193 0.0765
Toxoplasma gondii protein kinase, putative 0.0342 0.6609 1
Schistosoma mansoni glucose transport protein 0.0121 0.2247 1
Trypanosoma brucei glucose transporter, putative 0.0038 0.0598 0.8588
Leishmania major glucose transporter, lmgt3 0.0038 0.0598 0.8588
Trypanosoma brucei glucose transporter, putative 0.0038 0.0598 0.8588
Echinococcus granulosus synaptic vesicle 2 protein 0.0017 0.0193 0.0765
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0037 0.0589 0.2545
Trichomonas vaginalis glucose transporter, putative 0.0038 0.0598 0.2587
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0765
Schistosoma mansoni hypothetical protein 0.0121 0.2247 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0121 0.2247 1
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0015 0.0151 0.0577
Leishmania major hypothetical protein, conserved 0.0017 0.0193 0.254
Trypanosoma cruzi hexose transporter, putative 0.0038 0.0598 0.8588
Schistosoma mansoni sugar transporter 0.0017 0.0193 0.0765
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.0023 0.0546
Plasmodium vivax sugar transporter, putative 0.0017 0.0193 0.0171
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0256 0.6071
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0422 0.5957
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0042 0.0693 1
Onchocerca volvulus 0.0017 0.0193 0.4264
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0765
Toxoplasma gondii sugar transporter ST2 0.0017 0.0193 0.0258
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0037 0.0589 0.2545
Brugia malayi Sugar transporter family protein 0.0121 0.2247 1
Echinococcus granulosus calcium dependent protein kinase 0.0035 0.0544 0.2341
Echinococcus multilocularis solute carrier family 22 0.0017 0.0193 0.0765
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0027 0.0391 0.5487
Plasmodium falciparum calcium-dependent protein kinase 3 0.0037 0.0589 0.0568
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0121 0.2247 1
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0037 0.0589 0.2545
Loa Loa (eye worm) major facilitator superfamily transporter 0.0017 0.0193 0.0765
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0765
Giardia lamblia Prolyl-tRNA synthetase 0.0036 0.0574 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0193 0.0765
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0027 0.0391 0.5487
Schistosoma mansoni lysyl-tRNA synthetase 0.0027 0.0391 0.1653
Loa Loa (eye worm) hypothetical protein 0.0017 0.0193 0.0765
Loa Loa (eye worm) hypothetical protein 0.0017 0.0193 0.0765
Onchocerca volvulus 0.0017 0.0193 0.4264
Loa Loa (eye worm) hypothetical protein 0.0017 0.0193 0.0765
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0036 0.0574 0.2478
Echinococcus granulosus Sugar transporter ERD6 protein 0.0017 0.0193 0.0765
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0017 0.0193 0.0765
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0037 0.0589 0.2545
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0023 0.0546
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0023 0.0546
Echinococcus multilocularis lysyl tRNA synthetase 0.0027 0.0391 0.1653
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0765
Trypanosoma brucei glucose transporter, putative 0.0038 0.0598 0.8588
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0023 0.031 0.7349
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0422 1
Schistosoma mansoni hypothetical protein 0.0014 0.0127 0.0465
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0193 0.0765
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0765
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0036 0.0574 0.2478
Onchocerca volvulus 0.0017 0.0193 0.4264
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.0023 0.0546
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0422 0.7052
Onchocerca volvulus 0.0029 0.0422 1
Trypanosoma cruzi hexose transporter, putative 0.0021 0.0262 0.3572
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0036 0.0574 0.2478
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0765
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0036 0.0574 0.9738
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0422 0.5957
Loa Loa (eye worm) hypothetical protein 0.003 0.0458 0.1955
Trypanosoma brucei THT1 - hexose transporter, putative 0.0038 0.0598 0.8588
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.2247 1
Trypanosoma cruzi sugar transporter, putative 0.0017 0.0193 0.254
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0598 0.2587
Trichomonas vaginalis myo-inositol transporter, putative 0.0017 0.0193 0.0765
Loa Loa (eye worm) hypothetical protein 0.003 0.044 0.1873
Trypanosoma brucei THT1 - hexose transporter, putative 0.0038 0.0598 0.8588
Onchocerca volvulus 0.0017 0.0193 0.4264
Plasmodium vivax lysine--tRNA ligase, putative 0.0027 0.0391 0.0368
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0325 0.1357
Echinococcus granulosus solute carrier family 22 0.0017 0.0193 0.0765
Entamoeba histolytica hypothetical protein 0.0027 0.0391 0.6495
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0422 0.7052
Echinococcus multilocularis solute carrier family 22 0.0017 0.0193 0.0765
Schistosoma mansoni protein kinase 0.0037 0.0589 0.2545
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0765
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0422 0.7052
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0765
Loa Loa (eye worm) hypothetical protein 0.0021 0.0279 0.1152
Brugia malayi Sugar transporter family protein 0.0017 0.0193 0.0765
Leishmania major glucose transporter, lmgt2 0.0038 0.0598 0.8588
Schistosoma mansoni sugar transporter 0.0017 0.0193 0.0765
Trypanosoma brucei THT1 - hexose transporter, putative 0.0038 0.0598 0.8588
Schistosoma mansoni sugar transporter 0.0017 0.0193 0.0765
Loa Loa (eye worm) hypothetical protein 0.0021 0.0279 0.1152
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0017 0.0193 0.5
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0017 0.0193 0.0171
Brugia malayi major facilitator superfamily protein 0.0017 0.0193 0.0765
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0765
Toxoplasma gondii sugar transporter ST1 0.0017 0.0193 0.0258
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0017 0.0193 0.4577
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0598 0.2587
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0765
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0422 1
Echinococcus granulosus solute carrier family 22 0.0017 0.0193 0.0765
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0765
Loa Loa (eye worm) hypothetical protein 0.0029 0.0422 0.1794
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0458 0.0436
Trypanosoma brucei glucose transporter, putative 0.0038 0.0598 0.8588
Loa Loa (eye worm) hypothetical protein 0.0017 0.0193 0.0765
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0037 0.0589 0.086
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.0023 0.0546
Brugia malayi Sugar transporter family protein 0.0017 0.0193 0.0765
Trichomonas vaginalis glucose transporter, putative 0.0038 0.0598 0.2587
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0458 0.649
Onchocerca volvulus 0.0017 0.0193 0.4264
Trypanosoma cruzi glucose transporter, putative 0.0017 0.0193 0.254
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0765
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0765

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.6234 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 10.691 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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