Detailed information for compound 1550814

Basic information

Technical information
  • TDR Targets ID: 1550814
  • Name: 1-(3-chlorophenyl)-3-piperidin-1-ylpropan-1-o ne
  • MW: 251.752 | Formula: C14H18ClNO
  • H donors: 0 H acceptors: 1 LogP: 3.05 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc(c1)C(=O)CCN1CCCCC1
  • InChi: 1S/C14H18ClNO/c15-13-6-4-5-12(11-13)14(17)7-10-16-8-2-1-3-9-16/h4-6,11H,1-3,7-10H2
  • InChiKey: KALXKAGOMISNSJ-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 1-(3-chlorophenyl)-3-(1-piperidyl)propan-1-one
  • 1-(3-chlorophenyl)-3-piperidino-propan-1-one
  • 1-(3-chlorophenyl)-3-piperidin-1-yl-propan-1-one
  • 82935-06-6
  • NSC108957

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens snurportin 1 No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.002 0.009 0.023
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0384 0.0984
Onchocerca volvulus 0.0047 0.0384 0.0126
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0047 0.0384 0.0984
Brugia malayi G protein-coupled receptor 0.0047 0.0384 0.0531
Echinococcus granulosus snurportin 1 0.0372 0.3904 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0047 0.0384 0.0984
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0153 0.0392
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0047 0.0384 0.0984
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0494 0.1266
Brugia malayi Telomerase reverse transcriptase 0.0679 0.7235 1
Brugia malayi DNA polymerase I family protein 0.0048 0.0399 0.0551
Loa Loa (eye worm) hypothetical protein 0.0047 0.0384 0.0984
Schistosoma mansoni neuropeptide receptor 0.0047 0.0384 0.0984
Schistosoma mansoni adenoreceptor 0.0047 0.0384 0.0984
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0384 0.0984
Brugia malayi hypothetical protein 0.0047 0.0384 0.0531
Echinococcus multilocularis neuropeptide s receptor 0.0047 0.0384 0.0984
Loa Loa (eye worm) hypothetical protein 0.0047 0.0384 0.0984
Entamoeba histolytica hypothetical protein 0.0028 0.0181 0.0295
Loa Loa (eye worm) melatonin receptor type 1A 0.0047 0.0384 0.0984
Echinococcus granulosus alpha 1A adrenergic receptor 0.0047 0.0384 0.0984
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.009 0.0295
Brugia malayi G-protein coupled receptor 0.0047 0.0384 0.0531
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0153 0.0392
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.009 0.0295
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0384 0.0984
Brugia malayi hypothetical protein 0.0182 0.1853 0.2562
Loa Loa (eye worm) hypothetical protein 0.0047 0.0384 0.0984
Loa Loa (eye worm) hypothetical protein 0.0047 0.0384 0.0984
Loa Loa (eye worm) hypothetical protein 0.0047 0.0384 0.0984
Schistosoma mansoni ran 0.0026 0.0153 0.0392
Echinococcus multilocularis g protein coupled receptor 0.0047 0.0384 0.0984
Loa Loa (eye worm) glutathione reductase 0.0057 0.0494 0.1266
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1112 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.002 0.009 0.0295
Loa Loa (eye worm) hypothetical protein 0.0047 0.0384 0.0984
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0384 0.0984
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.1445 0.8502
Echinococcus granulosus neuropeptide receptor 0.0047 0.0384 0.0984
Schistosoma mansoni hypothetical protein 0.0047 0.0384 0.0984
Schistosoma mansoni opsin-like receptor 0.0047 0.0384 0.0984
Plasmodium falciparum glutathione reductase 0.0057 0.0494 0.1834
Brugia malayi Dopamine receptor protein 2 0.0047 0.0384 0.0531
Echinococcus multilocularis neuropeptide receptor 0.0047 0.0384 0.0984
Schistosoma mansoni myosin xvIII 0.0047 0.0384 0.0984
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0345 0.0883
Brugia malayi AKH receptor 0.0047 0.0384 0.0531
Brugia malayi RE15519p 0.0047 0.0384 0.0531
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.1445 0.8502
Onchocerca volvulus 0.0047 0.0384 0.0126
Loa Loa (eye worm) hypothetical protein 0.0047 0.0384 0.0984
Brugia malayi Melatonin receptor type 1A 0.0047 0.0384 0.0531
Echinococcus granulosus neuropeptide receptor 0.0047 0.0384 0.0984
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0153 0.0392
Mycobacterium ulcerans flavoprotein disulfide reductase 0.002 0.009 0.0184
Echinococcus multilocularis g protein coupled receptor 0.0047 0.0384 0.0984
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.0277 0.1831
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.004 0.0305 0.0782
Echinococcus granulosus neuropeptides capa receptor 0.0047 0.0384 0.0984
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0384 0.0984
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0047 0.0384 0.0984
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0494 0.2538
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0494 0.1266
Trypanosoma cruzi mitochondrial structure specific endonuclease I (SSE-1), putative 0.0119 0.116 0.4366
Echinococcus granulosus tm gpcr rhodopsin 0.0047 0.0384 0.0984
Brugia malayi RNA, U transporter 1 0.0099 0.0949 0.1311
Brugia malayi putative neuropeptide receptor 0.0047 0.0384 0.0531
Loa Loa (eye worm) TYRA-2 protein 0.0047 0.0384 0.0984
Loa Loa (eye worm) hypothetical protein 0.0047 0.0384 0.0984
Toxoplasma gondii thioredoxin reductase 0.0057 0.0494 0.1585
Entamoeba histolytica DNA-directed DNA polymerase, putative 0.0048 0.0399 0.2563
Loa Loa (eye worm) hypothetical protein 0.0047 0.0384 0.0984
Mycobacterium ulcerans 5'-3' exonuclease 0.0119 0.116 0.6776
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.1112 0.2848
Onchocerca volvulus 0.0047 0.0384 0.0126
Plasmodium vivax 5'-3' exonuclease, N-terminal resolvase-like domain, putative 0.0119 0.116 0.4366
Schistosoma mansoni hypothetical protein 0.0047 0.0384 0.0984
Schistosoma mansoni neuropeptide f receptor 76f 0.0047 0.0384 0.0984
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0384 0.0984
Echinococcus multilocularis neuropeptide Y receptor 0.0047 0.0384 0.0984
Trypanosoma cruzi mitochondrial DNA polymerase I protein A, putative 0.0048 0.0399 0.147
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0047 0.0384 0.0984
Echinococcus multilocularis neuropeptides capa receptor 0.0047 0.0384 0.0984
Echinococcus multilocularis g protein coupled receptor 0.0047 0.0384 0.0984
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.004 0.0305 0.0782
Brugia malayi Thioredoxin reductase 0.0057 0.0494 0.0683
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0015 0.0033 0.0046
Loa Loa (eye worm) hypothetical protein 0.0047 0.0384 0.0984
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1112 1
Mycobacterium tuberculosis Probable reductase 0.013 0.1287 0.7514
Schistosoma mansoni hypothetical protein 0.0205 0.2093 0.5361
Trypanosoma cruzi trypanothione reductase, putative 0.002 0.009 0.0295
Echinococcus multilocularis neuropeptides capa receptor 0.0047 0.0384 0.0984
Onchocerca volvulus 0.0047 0.0384 0.0126
Brugia malayi hypothetical protein 0.0047 0.0384 0.0531
Echinococcus granulosus neuropeptide receptor A26 0.0047 0.0384 0.0984
Echinococcus granulosus g protein coupled receptor 0.0047 0.0384 0.0984
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0153 0.0536
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0047 0.0384 0.0984
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0047 0.0384 0.0984
Mycobacterium tuberculosis Probable 5'-3' exonuclease 0.0119 0.116 0.6715
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0047 0.0384 0.0984
Plasmodium falciparum importin beta, putative 0.0035 0.0253 0.0915
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.1112 0.2848
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0181 0.0643
Schistosoma mansoni neuropeptide F-like receptor 0.0047 0.0384 0.0984
Loa Loa (eye worm) hypothetical protein 0.0047 0.0384 0.0984
Chlamydia trachomatis DNA polymerase I 0.0167 0.1683 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0047 0.0384 0.0984
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0384 0.0984
Loa Loa (eye worm) hypothetical protein 0.0047 0.0384 0.0984
Brugia malayi Tachykinin-like peptides receptor 99D 0.0047 0.0384 0.0531
Onchocerca volvulus 0.0047 0.0384 0.0126
Toxoplasma gondii RNA-directed DNA polymerase 0.0255 0.2641 1
Echinococcus multilocularis serotonin receptor 0.0047 0.0384 0.0984
Loa Loa (eye worm) hypothetical protein 0.0047 0.0384 0.0984
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.1112 0.0873
Loa Loa (eye worm) hypothetical protein 0.0047 0.0384 0.0984
Echinococcus multilocularis neuropeptide Y receptor 0.0047 0.0384 0.0984
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0047 0.0384 0.0531
Echinococcus granulosus tm gpcr rhodopsin 0.0047 0.0384 0.0984
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0047 0.0384 0.0531
Echinococcus granulosus allatostatin A receptor 0.0047 0.0384 0.0984
Loa Loa (eye worm) hypothetical protein 0.0047 0.0384 0.0984
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.009 0.0295
Leishmania major telomerase reverse transcriptase, putative 0.0255 0.2641 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0384 0.0984
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0047 0.0384 0.0984
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0255 0.2641 1
Onchocerca volvulus 0.0047 0.0384 0.0126
Schistosoma mansoni neuropeptide receptor 0.0047 0.0384 0.0984
Onchocerca volvulus 0.0047 0.0384 0.0126
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0047 0.0384 0.0984
Echinococcus granulosus peptide allatostatin:somatostatin 0.0047 0.0384 0.0984
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0253 0.0915
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0384 0.0984
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0047 0.0384 0.0984
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.1112 0.1537
Loa Loa (eye worm) hypothetical protein 0.0047 0.0384 0.0984
Echinococcus multilocularis geminin 0.0205 0.2093 0.5361
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.002 0.009 0.023
Echinococcus multilocularis neuropeptide receptor 0.0047 0.0384 0.0984
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0047 0.0384 0.0984
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0047 0.0384 0.0984
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0253 0.0639
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0384 0.0984
Loa Loa (eye worm) hypothetical protein 0.0047 0.0384 0.0984
Brugia malayi sulfakinin receptor protein 0.0047 0.0384 0.0531
Toxoplasma gondii 5'-3' exonuclease, N-terminal resolvase family domain-containing protein 0.0058 0.0505 0.1626
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1112 1
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0253 0.0648
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0047 0.0384 0.0984
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0153 0.0248
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0494 0.1834
Plasmodium falciparum thioredoxin reductase 0.0057 0.0494 0.1834
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0047 0.0384 0.0984
Echinococcus multilocularis fmrfamide receptor 0.0047 0.0384 0.0984
Trypanosoma cruzi cytochrome P450, putative 0.0017 0.006 0.0181
Schistosoma mansoni neuropeptide receptor 0.0047 0.0384 0.0984
Plasmodium falciparum plastid replication-repair enzyme 0.0048 0.0399 0.147
Echinococcus granulosus orexin receptor type 2 0.0047 0.0384 0.0984
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.1445 0.8502
Loa Loa (eye worm) hypothetical protein 0.0047 0.0384 0.0984
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.009 0.0295
Brugia malayi G protein-coupled receptor F59B2.13 0.0047 0.0384 0.0531
Trypanosoma brucei telomerase reverse transcriptase 0.0255 0.2641 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.004 0.0305 0.0782
Echinococcus granulosus DNA polymerase theta 0.0013 0.0012 0.0032
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0047 0.0384 0.0984
Echinococcus granulosus DNA polymerase subunit gamma 0.0013 0.0012 0.0032
Loa Loa (eye worm) hypothetical protein 0.0047 0.0384 0.0984
Trypanosoma brucei trypanothione reductase 0.0057 0.0494 0.1834
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0153 0.0248
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.1112 0.4183
Echinococcus granulosus neuropeptide Y receptor 0.0047 0.0384 0.0984
Onchocerca volvulus 0.0047 0.0384 0.0126
Schistosoma mansoni biogenic amine receptor 0.0047 0.0384 0.0984
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1112 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0384 0.0984
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0487 0.389
Mycobacterium ulcerans DNA polymerase I 0.0167 0.1683 1
Brugia malayi G-protein coupled receptor 0.0047 0.0384 0.0531
Echinococcus multilocularis G-protein coupled receptor, putative 0.0047 0.0384 0.0984
Giardia lamblia Telomerase catalytic subunit 0.0255 0.2641 1
Toxoplasma gondii helicase, putative 0.0048 0.0399 0.1211
Brugia malayi neuropeptide F receptor 0.0047 0.0384 0.0531
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0047 0.0384 0.0984
Echinococcus multilocularis somatostatin receptor 0.0047 0.0384 0.0984
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0047 0.0384 0.0984
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0494 0.1834
Echinococcus granulosus importin subunit beta 1 0.0035 0.0253 0.0648
Echinococcus granulosus fmrfamide receptor 0.0047 0.0384 0.0984
Echinococcus granulosus neuropeptide FF receptor 2 0.0047 0.0384 0.0984
Onchocerca volvulus 0.0047 0.0384 0.0126
Brugia malayi Importin beta-1 subunit 0.0035 0.0253 0.035
Brugia malayi GnHR receptor homolog 0.0047 0.0384 0.0531
Brugia malayi glutathione reductase 0.0057 0.0494 0.0683
Loa Loa (eye worm) hypothetical protein 0.0047 0.0384 0.0984
Trypanosoma cruzi cytochrome P450, putative 0.0017 0.006 0.0181
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0153 0.0212
Loa Loa (eye worm) hypothetical protein 0.0047 0.0384 0.0984
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0047 0.0384 0.0531
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0047 0.0384 0.0984
Brugia malayi follicle stimulating hormone receptor 0.0047 0.0384 0.0531
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0047 0.0384 0.0984
Brugia malayi Serotonin receptor 0.0047 0.0384 0.0531
Loa Loa (eye worm) hypothetical protein 0.0047 0.0384 0.0984
Loa Loa (eye worm) hypothetical protein 0.0047 0.0384 0.0984
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0384 0.0984
Schistosoma mansoni hypothetical protein 0.0205 0.2093 0.5361
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.1112 0.4183
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0047 0.0384 0.0984
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0181 0.0896
Brugia malayi Cytochrome P450 family protein 0.0017 0.006 0.0083
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0255 0.2641 1
Brugia malayi putative neuropeptide receptor NPR1 0.0047 0.0384 0.0531
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.009 0.0295
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.1287 0.7514
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.1287 0.7514
Onchocerca volvulus Neuropeptide F receptor homolog 0.0047 0.0384 0.0126
Loa Loa (eye worm) hypothetical protein 0.0047 0.0384 0.0984
Loa Loa (eye worm) hypothetical protein 0.0047 0.0384 0.0984
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0487 0.389
Leishmania major cytochrome p450-like protein 0.0017 0.006 0.0181
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.1112 1
Echinococcus multilocularis serotonin receptor 0.0047 0.0384 0.0984
Schistosoma mansoni opsin-like receptor 0.0047 0.0384 0.0984
Schistosoma mansoni neuropeptide F-like receptor 0.0047 0.0384 0.0984
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.1112 0.4183
Schistosoma mansoni DNA polymerase I 0.0048 0.0399 0.1022
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0384 0.0984
Echinococcus granulosus hypothetical protein 0.0047 0.0384 0.0984
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0384 0.0984
Schistosoma mansoni amine GPCR 0.0047 0.0384 0.0984
Brugia malayi DNA polymerase I family protein 0.0013 0.0012 0.0017
Echinococcus granulosus geminin 0.0205 0.2093 0.5361
Mycobacterium tuberculosis Probable DNA polymerase I PolA 0.0167 0.1683 1
Echinococcus multilocularis DNA polymerase theta 0.0013 0.0012 0.0032
Loa Loa (eye worm) hypothetical protein 0.0047 0.0384 0.0984
Echinococcus multilocularis allatostatin A receptor 0.0047 0.0384 0.0984
Onchocerca volvulus 0.0047 0.0384 0.0126
Brugia malayi hypothetical protein 0.0047 0.0384 0.0531
Loa Loa (eye worm) hypothetical protein 0.0047 0.0384 0.0984
Echinococcus granulosus 7tm_1 domain containing protein 0.0047 0.0384 0.0984
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.002 0.009 0.0184
Echinococcus multilocularis snurportin 1 0.0372 0.3904 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0017 0.006 0.0154
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.3904 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0047 0.0384 0.0984
Loa Loa (eye worm) hypothetical protein 0.0047 0.0384 0.0984
Plasmodium falciparum glutathione reductase 0.002 0.009 0.0295
Loa Loa (eye worm) hypothetical protein 0.0182 0.1853 0.4747
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0153 0.0536
Loa Loa (eye worm) neuropeptide F receptor 0.0047 0.0384 0.0984
Echinococcus granulosus sex peptide receptor 0.0047 0.0384 0.0984
Treponema pallidum DNA polymerase I (polA) 0.0167 0.1683 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.1112 0.2848
Brugia malayi hypothetical protein 0.0047 0.0384 0.0531
Trypanosoma brucei mitochondrial DNA polymerase I protein A, putative 0.0048 0.0399 0.147
Plasmodium falciparum 5'-3' exonuclease, N-terminal resolvase-like domain, putative 0.0119 0.116 0.4366
Onchocerca volvulus 0.0047 0.0384 0.0126
Loa Loa (eye worm) hypothetical protein 0.0047 0.0384 0.0984
Brugia malayi hypothetical protein 0.0047 0.0384 0.0531
Trypanosoma brucei polo-like protein kinase 0.0114 0.1112 0.4183
Echinococcus multilocularis neuropeptide receptor A26 0.0047 0.0384 0.0984
Echinococcus multilocularis neuropeptide FF receptor 2 0.0047 0.0384 0.0984
Echinococcus granulosus biogenic amine 5HT receptor 0.0047 0.0384 0.0984
Plasmodium vivax plastid replication-repair enzyme, putative 0.0048 0.0399 0.147
Brugia malayi hypothetical protein 0.0047 0.0384 0.0531
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.1112 0.2848
Echinococcus granulosus g-protein coupled receptor 0.0047 0.0384 0.0984
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0384 0.0984
Echinococcus granulosus neuropeptide s receptor 0.0047 0.0384 0.0984
Trypanosoma brucei mitochondrial DNA polymerase I protein A, putative 0.0048 0.0399 0.147
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0384 0.0984
Brugia malayi Dopamine receptor 0.0047 0.0384 0.0531
Brugia malayi Cytochrome P450 family protein 0.0017 0.006 0.0083
Schistosoma mansoni hypothetical protein 0.0047 0.0384 0.0984
Loa Loa (eye worm) hypothetical protein 0.0048 0.0399 0.1022
Schistosoma mansoni DNA polymerase gamma 0.0013 0.0012 0.0032
Loa Loa (eye worm) G-protein coupled receptor 0.0047 0.0384 0.0984
Schistosoma mansoni histamine h1 receptor 0.0047 0.0384 0.0984
Trypanosoma cruzi mitochondrial structure specific endonuclease I (SSE-1), putative 0.0119 0.116 0.4366
Schistosoma mansoni alpha-1 adrenergic receptor 0.0047 0.0384 0.0984
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0384 0.0984
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0384 0.0984
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0047 0.0384 0.0984
Trypanosoma brucei cytochrome P450, putative 0.0017 0.006 0.0181
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0047 0.0384 0.0984
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0047 0.0384 0.0984
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.1445 0.3976
Loa Loa (eye worm) hypothetical protein 0.0047 0.0384 0.0984
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0047 0.0384 0.0984
Loa Loa (eye worm) twinkle helicase 0.0036 0.0262 0.0671
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0047 0.0384 0.0531
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.009 0.0295
Schistosoma mansoni amine GPCR 0.0047 0.0384 0.0984
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0153 0.0536
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0047 0.0384 0.0984
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.1287 0.7514
Echinococcus granulosus serotonin receptor 0.0047 0.0384 0.0984
Brugia malayi hypothetical protein 0.0047 0.0384 0.0531
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0153 0.0536
Echinococcus multilocularis orexin receptor type 2 0.0047 0.0384 0.0984
Schistosoma mansoni hypothetical protein 0.0036 0.0262 0.0671
Trichomonas vaginalis DNA polymerase I, putative 0.0048 0.0399 0.3024
Loa Loa (eye worm) G-protein coupled receptor 0.0047 0.0384 0.0984
Loa Loa (eye worm) hypothetical protein 0.0047 0.0384 0.0984
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0047 0.0384 0.0984
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0153 0.0536
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.009 0.0295
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0384 0.0984
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0032
Echinococcus granulosus 7TM GPCR rhodopsin 0.0047 0.0384 0.0984
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0047 0.0384 0.0984
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0047 0.0384 0.0984
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1112 1
Onchocerca volvulus 0.0047 0.0384 0.0126
Onchocerca volvulus 0.0182 0.1853 0.1634
Echinococcus multilocularis twinkle protein, mitochondrial 0.0036 0.0262 0.0671
Loa Loa (eye worm) hypothetical protein 0.0047 0.0384 0.0984
Onchocerca volvulus 0.0047 0.0384 0.0126
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0047 0.0384 0.0984
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0253 0.0915
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0384 0.0984
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0047 0.0384 0.0984
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.1287 0.7514
Leishmania major trypanothione reductase 0.0057 0.0494 0.1834
Echinococcus granulosus dro:myosuppressin receptor 0.0047 0.0384 0.0984
Schistosoma mansoni biogenic amine receptor 0.0047 0.0384 0.0984
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.002 0.009 0.0184
Toxoplasma gondii DNA polymerase I domain-containing protein 0.0048 0.0399 0.1211
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.002 0.009 0.0295
Schistosoma mansoni opsin-like receptor 0.0047 0.0384 0.0984
Echinococcus multilocularis fmrfamide receptor 0.0047 0.0384 0.0984
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0047 0.0384 0.0126
Brugia malayi hypothetical protein 0.0047 0.0384 0.0531
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1112 1
Schistosoma mansoni amine GPCR 0.0047 0.0384 0.0984
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.1287 0.7514
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0015 0.0033 0.0046
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0047 0.0384 0.0984
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0181 0.0896
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.009 0.0295
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0047 0.0384 0.0984
Echinococcus granulosus tm gpcr rhodopsin 0.0047 0.0384 0.0984
Schistosoma mansoni hypothetical protein 0.0372 0.3904 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.0277 0.1831
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0384 0.0984
Echinococcus granulosus somatostatin receptor 0.0047 0.0384 0.0984
Echinococcus multilocularis sex peptide receptor 0.0047 0.0384 0.0984
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.009 0.0295
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.002 0.009 0.0295
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0047 0.0384 0.0984
Echinococcus granulosus biogenic amine 5HT receptor 0.0047 0.0384 0.0984
Loa Loa (eye worm) hypothetical protein 0.0047 0.0384 0.0984
Trypanosoma brucei mitochondrial structure specific endonuclease I (SSE-1), putative 0.0119 0.116 0.4366
Loa Loa (eye worm) hypothetical protein 0.0047 0.0384 0.0984
Loa Loa (eye worm) hypothetical protein 0.0047 0.0384 0.0984
Plasmodium vivax glutathione reductase, putative 0.0057 0.0494 0.1834
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.009 0.0295
Plasmodium falciparum thioredoxin reductase 0.002 0.009 0.0295
Loa Loa (eye worm) hypothetical protein 0.0047 0.0384 0.0984
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0047 0.0384 0.0531
Leishmania major importin beta-1 subunit, putative 0.0028 0.0181 0.0643
Brugia malayi hypothetical protein 0.0047 0.0384 0.0531
Loa Loa (eye worm) hypothetical protein 0.0047 0.0384 0.0984
Schistosoma mansoni amine GPCR 0.0047 0.0384 0.0984
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.002 0.009 0.0295
Brugia malayi Dopamine receptor protein 1 0.0047 0.0384 0.0531
Brugia malayi hypothetical protein 0.0047 0.0384 0.0531
Giardia lamblia Kinase, PLK 0.0114 0.1112 0.4006
Brugia malayi neuropeptide F receptor 0.0047 0.0384 0.0531
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0384 0.0984
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0384 0.0984
Schistosoma mansoni neuropeptide receptor 0.0047 0.0384 0.0984
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0047 0.0384 0.0984
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0384 0.0984
Plasmodium vivax importin-beta 2, putative 0.0035 0.0253 0.0915
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.002 0.009 0.0295
Loa Loa (eye worm) neuropeptide F receptor 0.0047 0.0384 0.0984
Loa Loa (eye worm) hypothetical protein 0.0047 0.0384 0.0984
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0384 0.0984
Echinococcus multilocularis g-protein coupled receptor 0.0047 0.0384 0.0984
Onchocerca volvulus 0.0047 0.0384 0.0126
Brugia malayi ORL1-like opioid receptor 0.0047 0.0384 0.0531
Echinococcus granulosus neuropeptides capa receptor 0.0047 0.0384 0.0984
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.002 0.009 0.023
Schistosoma mansoni biogenic amine receptor 0.0047 0.0384 0.0984
Loa Loa (eye worm) hypothetical protein 0.0047 0.0384 0.0984
Onchocerca volvulus 0.0047 0.0384 0.0126
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.009 0.0295
Loa Loa (eye worm) hypothetical protein 0.0035 0.0253 0.0648
Onchocerca volvulus 0.0047 0.0384 0.0126
Onchocerca volvulus 0.0047 0.0384 0.0126
Echinococcus granulosus g protein coupled receptor 0.0047 0.0384 0.0984
Loa Loa (eye worm) cytochrome P450 family protein 0.0017 0.006 0.0154
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.002 0.009 0.0124
Leishmania major GTP-binding protein, putative 0.0026 0.0153 0.0536
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0047 0.0384 0.0984
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0494 0.1266
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0047 0.0384 0.0984
Echinococcus granulosus G protein coupled receptor 139 0.0047 0.0384 0.0984
Loa Loa (eye worm) hypothetical protein 0.0047 0.0384 0.0984
Schistosoma mansoni biogenic amine (5HT) receptor 0.0047 0.0384 0.0984
Plasmodium falciparum telomerase reverse transcriptase 0.0255 0.2641 1
Leishmania major mitochondrial structure specific endonuclease I (SSE-1), putative 0.0119 0.116 0.4366
Loa Loa (eye worm) hypothetical protein 0.0047 0.0384 0.0984
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1112 1
Trypanosoma cruzi mitochondrial DNA polymerase I protein A, putative 0.0048 0.0399 0.147
Plasmodium vivax telomerase reverse transcriptase, putative 0.0255 0.2641 1
Schistosoma mansoni importin beta-1 0.0035 0.0253 0.0648
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.009 0.0295
Echinococcus multilocularis hypothetical protein 0.0013 0.0012 0.0032
Brugia malayi Serotonin receptor 0.0047 0.0384 0.0531
Echinococcus granulosus neuropeptide Y receptor 0.0047 0.0384 0.0984
Mycobacterium leprae PROBABLE DNA POLYMERASE I POLA 0.0167 0.1683 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0047 0.0384 0.0984
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0047 0.0384 0.0984
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0345 0.0883
Echinococcus multilocularis G protein coupled receptor 139 0.0047 0.0384 0.0984
Loa Loa (eye worm) CYP4Cod1 0.0017 0.006 0.0154
Echinococcus multilocularis dro:myosuppressin receptor 0.0047 0.0384 0.0984
Echinococcus granulosus g protein coupled receptor 0.0047 0.0384 0.0984
Wolbachia endosymbiont of Brugia malayi DNA polymerase I 0.0167 0.1683 1
Schistosoma mansoni amine GPCR 0.0047 0.0384 0.0984
Schistosoma mansoni hypothetical protein 0.0036 0.0262 0.0671
Brugia malayi larval opioid receptor 0.0047 0.0384 0.0531
Schistosoma mansoni ran 0.0026 0.0153 0.0392
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.002 0.009 0.0295
Loa Loa (eye worm) hypothetical protein 0.0047 0.0384 0.0984
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0181 0.0896
Loa Loa (eye worm) hypothetical protein 0.0034 0.0249 0.0637
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0384 0.0984
Trichomonas vaginalis ran, putative 0.0026 0.0153 0.0619
Schistosoma mansoni kinase 0.0058 0.0504 0.129
Loa Loa (eye worm) hypothetical protein 0.0047 0.0384 0.0984
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.002 0.009 0.0295
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.004 0.0305 0.0422
Leishmania major mitochondrial DNA polymerase I protein A, putative 0.0048 0.0399 0.147
Leishmania major acetoin dehydrogenase e3 component-like protein 0.002 0.009 0.0295
Schistosoma mansoni hypothetical protein 0.0047 0.0384 0.0984
Echinococcus granulosus twinkle protein mitochondrial 0.0036 0.0262 0.0671

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.3548 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 6.5131 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 10.6213 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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