TDR Targets

Basic information

Technical information

TDR Targets ID: 1550985
Name: N'-(2-chloro-5-nitrophenyl)sulfonyl-N-pyridin -3-ylbenzenecarboximidamide
MW: 416.838 | Formula: C18H13ClN4O4S
H donors: 1 H acceptors: 5 LogP: 3.55 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cc1S(=O)(=O)NC(=Nc1cccnc1)c1ccccc1)[N+](=O)[O-]
InChi: 1S/C18H13ClN4O4S/c19-16-9-8-15(23(24)25)11-17(16)28(26,27)22-18(13-5-2-1-3-6-13)21-14-7-4-10-20-12-14/h1-12H,(H,21,22)
InChiKey: JIQXRAXRNQPDAB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N'-(2-chloro-5-nitro-phenyl)sulfonyl-N-(3-pyridyl)benzamidine
N'-(2-chloro-5-nitrophenyl)sulfonyl-N-(3-pyridyl)benzamidine
N'-(2-chloro-5-nitro-phenyl)sulfonyl-N-pyridin-3-yl-benzenecarboximidamide
T0511-1417

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references
Homo sapiens	Werner syndrome, RecQ helicase-like	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	Get druggable targets OG5_126644	All targets in OG5_126644
Echinococcus multilocularis	ATP dependent DNA helicase Q5	Get druggable targets OG5_126644	All targets in OG5_126644
Echinococcus multilocularis	bloom syndrome protein	Get druggable targets OG5_126644	All targets in OG5_126644
Trichomonas vaginalis	DNA helicase recq, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Theileria parva	hypothetical protein	Get druggable targets OG5_126644	All targets in OG5_126644
Loa Loa (eye worm)	RecQ helicase	Get druggable targets OG5_126644	All targets in OG5_126644
Candida albicans	DNA helicase	Get druggable targets OG5_126644	All targets in OG5_126644
Treponema pallidum	ATP-dependent DNA helicase	Get druggable targets OG5_126644	All targets in OG5_126644
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126644	All targets in OG5_126644
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	Get druggable targets OG5_126644	All targets in OG5_126644
Schistosoma japonicum	Bloom syndrome protein homolog, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Plasmodium berghei	ATP-dependent DNA helicase Q1, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Plasmodium berghei	ADP-dependent DNA helicase RecQ, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Theileria parva	DNA helicase, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Schistosoma mansoni	blooms syndrome DNA helicase	Get druggable targets OG5_126644	All targets in OG5_126644
Schistosoma japonicum	ko:K03654 ATP-dependent DNA helicase RecQ, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Loa Loa (eye worm)	ATP-dependent DNA helicase	Get druggable targets OG5_126644	All targets in OG5_126644
Cryptosporidium parvum	RecQ bloom helicase (RNA helicase+hrdc)	Get druggable targets OG5_126644	All targets in OG5_126644
Candida albicans	DNA helicase	Get druggable targets OG5_126644	All targets in OG5_126644
Neospora caninum	hypothetical protein	Get druggable targets OG5_126644	All targets in OG5_126644
Plasmodium knowlesi	ATP-dependent DNA helicase Q1, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126644	All targets in OG5_126644
Echinococcus granulosus	ATP dependent DNA helicase Q5	Get druggable targets OG5_126644	All targets in OG5_126644
Schistosoma mansoni	DNA helicase recq1	Get druggable targets OG5_126644	All targets in OG5_126644
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	Get druggable targets OG5_126644	All targets in OG5_126644
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126644	All targets in OG5_126644
Neospora caninum	hypothetical protein	Get druggable targets OG5_126644	All targets in OG5_126644
Cryptosporidium hominis	DEAD/DEAH box helicase	Get druggable targets OG5_126644	All targets in OG5_126644
Babesia bovis	ATP-dependent DNA helicase, RecQ family protein	Get druggable targets OG5_126644	All targets in OG5_126644
Leishmania donovani	ATP-dependent DEAD/H DNA helicase recQ, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Leishmania infantum	ATP-dependent DEAD/H DNA helicase recQ, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Entamoeba histolytica	recQ family DNA helicase	Get druggable targets OG5_126644	All targets in OG5_126644
Plasmodium knowlesi	ADP-dependent DNA helicase RecQ, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Giardia lamblia	Sgs1 DNA helicase, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Entamoeba histolytica	recQ family helicase, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Babesia bovis	ATP-dependent DNA helicase, RecQ family protein	Get druggable targets OG5_126644	All targets in OG5_126644
Leishmania braziliensis	ATP-dependent DEAD/H DNA helicase recQ, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Plasmodium falciparum	ATP-dependent DNA helicase Q1	Get druggable targets OG5_126644	All targets in OG5_126644
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Plasmodium yoelii	ATP-dependent DNA helicase-related	Get druggable targets OG5_126644	All targets in OG5_126644
Echinococcus granulosus	bloom syndrome protein	Get druggable targets OG5_126644	All targets in OG5_126644
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	Get druggable targets OG5_126644	All targets in OG5_126644
Trichomonas vaginalis	DNA helicase recq, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Trichomonas vaginalis	DNA helicase recq1, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Trypanosoma brucei gambiense	ATP-dependent DEAD/H DNA helicase recQ, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Leishmania mexicana	ATP-dependent DEAD/H DNA helicase recQ, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Echinococcus granulosus	ATP dependent DNA helicase Q1	Get druggable targets OG5_126644	All targets in OG5_126644
Plasmodium yoelii	ATP-dependent DNA helicase recQ-related	Get druggable targets OG5_126644	All targets in OG5_126644
Schistosoma mansoni	DNA helicase recq5	Get druggable targets OG5_126644	All targets in OG5_126644
Echinococcus multilocularis	ATP dependent DNA helicase Q1	Get druggable targets OG5_126644	All targets in OG5_126644
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	Get druggable targets OG5_126644	All targets in OG5_126644
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	Get druggable targets OG5_126644	All targets in OG5_126644
Brugia malayi	Bloom's syndrome protein homolog	Get druggable targets OG5_126644	All targets in OG5_126644

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0016	0.0711	0.1094
Echinococcus multilocularis	g protein coupled receptor	0.0016	0.0711	0.1094
Brugia malayi	sulfakinin receptor protein	0.0016	0.0711	0.0463
Echinococcus granulosus	neuropeptide receptor	0.0016	0.0711	0.1094
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0711	0.0711
Echinococcus granulosus	neuropeptide s receptor	0.0016	0.0711	0.1094
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0013	0.0517	0.5
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0016	0.0711	0.1641
Echinococcus granulosus	neuropeptides capa receptor	0.0016	0.0711	0.1094
Echinococcus granulosus	dro:myosuppressin receptor	0.0016	0.0711	0.1094
Brugia malayi	neuropeptide F receptor	0.0016	0.0711	0.0463
Trypanosoma cruzi	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0024	0.1261	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.0016	0.0711	0.0463
Echinococcus multilocularis	fmrfamide receptor	0.0016	0.0711	0.1094
Schistosoma mansoni	adenoreceptor	0.0016	0.0711	0.1641
Schistosoma mansoni	Smad4	0.001	0.0266	0.0614
Echinococcus granulosus	rhodopsin orphan GPCR	0.0016	0.0711	0.1094
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0016	0.0711	0.0463
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0016	0.0711	0.1094
Echinococcus multilocularis	neuropeptide Y receptor	0.0016	0.0711	0.1094
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.0012	0.042	0.0377
Schistosoma mansoni	brg-1 associated factor	0.0067	0.4335	1
Toxoplasma gondii	DNA topoisomerase domain-containing protein	0.0067	0.4335	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0016	0.0711	0.1094
Trypanosoma brucei	hypothetical protein, conserved	0.0024	0.1261	1
Brugia malayi	GnHR receptor homolog	0.0016	0.0711	0.0463
Leishmania major	hypothetical protein, conserved	0.0024	0.1261	1
Treponema pallidum	ATP-dependent DNA helicase	0.0006	0.0000000003529	0.5
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0711	0.0711
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.0012	0.042	0.0377
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0016	0.0711	0.1094
Loa Loa (eye worm)	G-protein coupled receptor	0.0016	0.0711	0.0711
Brugia malayi	hypothetical protein	0.0016	0.0711	0.0463
Echinococcus granulosus	fmrfamide receptor	0.0016	0.0711	0.1094
Loa Loa (eye worm)	CYP4Cod1	0.0013	0.0517	0.0517
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0016	0.0711	0.0711
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0711	0.0711
Echinococcus multilocularis	zinc finger protein Ran binding	0.0024	0.1261	0.2445
Schistosoma mansoni	myosin xvIII	0.0016	0.0711	0.1641
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0711	0.0711
Onchocerca volvulus	Ubiquitin thioesterase ZRANB1 homolog	0.0024	0.1261	0.1517
Schistosoma mansoni	amine GPCR	0.0016	0.0711	0.1641
Echinococcus granulosus	tm gpcr rhodopsin	0.0016	0.0711	0.1094
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0016	0.0711	0.1094
Echinococcus multilocularis	neuropeptides capa receptor	0.0016	0.0711	0.1094
Brugia malayi	Cytochrome P450 family protein	0.0013	0.0517	0.0261
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0016	0.0711	0.0711
Trichomonas vaginalis	DNA helicase recq1, putative	0.0029	0.1637	0.2636
Echinococcus granulosus	hypothetical protein	0.0016	0.0711	0.1094
Leishmania major	hypothetical protein, conserved	0.0024	0.1261	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0711	0.0711
Brugia malayi	hypothetical protein	0.0016	0.0711	0.0463
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0012	0.042	0.0968
Loa Loa (eye worm)	MH2 domain-containing protein	0.001	0.0266	0.0266
Echinococcus multilocularis	ring and YY1 binding protein	0.0024	0.1261	0.2445
Echinococcus granulosus	sex peptide receptor	0.0016	0.0711	0.1094
Onchocerca volvulus		0.0024	0.1261	0.1517
Loa Loa (eye worm)	hypothetical protein	0.0024	0.1261	0.1261
Brugia malayi	hypothetical protein	0.0016	0.0711	0.0463
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0711	0.0711
Brugia malayi	RE15519p	0.0016	0.0711	0.0463
Schistosoma mansoni	DNA helicase recq5	0.0012	0.042	0.0968
Trypanosoma cruzi	cytochrome P450, putative	0.0013	0.0517	0.41
Echinococcus multilocularis	fmrfamide receptor	0.0016	0.0711	0.1094
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0016	0.0711	0.1641
Trypanosoma brucei	mitochondrial RNA binding complex 1 subunit	0.0024	0.1261	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0016	0.0711	0.1094
Schistosoma mansoni	RNA binding protein	0.0024	0.1261	0.2909
Onchocerca volvulus		0.0024	0.1261	0.1517
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0711	0.0711
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0024	0.1261	0.1035
Brugia malayi	Dopamine receptor	0.0016	0.0711	0.0463
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0016	0.0711	0.1641
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0711	0.0711
Trichomonas vaginalis	DNA helicase recq, putative	0.0029	0.1637	0.2636
Echinococcus multilocularis	somatostatin receptor	0.0016	0.0711	0.1094
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0016	0.0711	0.1641
Loa Loa (eye worm)	hypothetical protein	0.0024	0.1261	0.1261
Schistosoma mansoni	histamine h1 receptor	0.0016	0.0711	0.1641
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0015	0.0671	0.2077
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0711	0.0711
Trypanosoma cruzi	cytochrome P450, putative	0.0013	0.0517	0.41
Echinococcus granulosus	neuropeptide Y receptor	0.0016	0.0711	0.1094
Schistosoma mansoni	neuropeptide receptor	0.0016	0.0711	0.1641
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0711	0.0711
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0016	0.0711	0.0463
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0016	0.0711	0.1641
Chlamydia trachomatis	DNA topoisomerase I	0.0067	0.4335	0.5
Brugia malayi	G-protein coupled receptor	0.0016	0.0711	0.0463
Echinococcus granulosus	g protein coupled receptor	0.0016	0.0711	0.1094
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.0067	0.4335	1
Schistosoma mansoni	smad	0.001	0.0266	0.0614
Trypanosoma brucei	hypothetical protein, conserved	0.0024	0.1261	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0016	0.0711	0.1094
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.0012	0.042	0.042
Brugia malayi	Cytochrome P450 family protein	0.0013	0.0517	0.0261
Loa Loa (eye worm)	brahma associated protein	0.0067	0.4335	0.4335
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0012	0.042	0.016
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0711	0.0711
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0016	0.0711	0.1094
Leishmania major	hypothetical protein, conserved	0.0024	0.1261	1
Brugia malayi	Serotonin receptor	0.0016	0.0711	0.0463
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0016	0.0711	0.1641
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0016	0.0711	0.1094
Schistosoma mansoni	growth hormone secretagogue receptor	0.0016	0.0711	0.1641
Brugia malayi	putative neuropeptide receptor	0.0016	0.0711	0.0463
Schistosoma mansoni	hypothetical protein	0.0016	0.0711	0.1641
Leishmania major	hypothetical protein, conserved	0.0024	0.1261	1
Schistosoma mansoni	fusion	0.0024	0.1261	0.2909
Echinococcus granulosus	zinc finger protein Ran binding	0.0024	0.1261	0.2445
Brugia malayi	Serotonin receptor	0.0016	0.0711	0.0463
Onchocerca volvulus		0.0067	0.4335	1
Plasmodium vivax	hypothetical protein, conserved	0.0067	0.4335	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0711	0.0711
Echinococcus multilocularis	bloom syndrome protein	0.0029	0.1637	0.3369
Trypanosoma cruzi	hypothetical protein, conserved	0.0024	0.1261	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0016	0.0711	0.0711
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0711	0.0711
Brugia malayi	neuropeptide F receptor	0.0016	0.0711	0.0463
Brugia malayi	ORL1-like opioid receptor	0.0016	0.0711	0.0463
Brugia malayi	G protein-coupled receptor	0.0016	0.0711	0.0463
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0016	0.0711	0.1641
Echinococcus granulosus	neuropeptide FF receptor 2	0.0016	0.0711	0.1094
Loa Loa (eye worm)	SWIB/MDM2 domain-containing protein	0.0067	0.4335	0.4335
Echinococcus multilocularis	Upstream activation factor subunit UAF30	0.0067	0.4335	1
Schistosoma mansoni	opsin-like receptor	0.0016	0.0711	0.1641
Echinococcus granulosus	serotonin receptor	0.0016	0.0711	0.1094
Schistosoma mansoni	TRABID protein (C64 family)	0.0024	0.1261	0.2909
Schistosoma mansoni	amine GPCR	0.0016	0.0711	0.1641
Schistosoma mansoni	neuropeptide receptor	0.0016	0.0711	0.1641
Loa Loa (eye worm)	hypothetical protein	0.0012	0.042	0.042
Trypanosoma brucei	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0024	0.1261	1
Schistosoma mansoni	biogenic amine receptor	0.0016	0.0711	0.1641
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0024	0.1261	1
Echinococcus granulosus	G protein coupled receptor 139	0.0016	0.0711	0.1094
Giardia lamblia	Sgs1 DNA helicase, putative	0.0012	0.042	0.5
Brugia malayi	hypothetical protein	0.0016	0.0711	0.0463
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0016	0.0711	0.1641
Schistosoma mansoni	hypothetical protein	0.0067	0.4335	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0711	0.0711
Echinococcus granulosus	biogenic amine 5HT receptor	0.0016	0.0711	0.1094
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0024	0.1261	0.1035
Chlamydia trachomatis	SWIB complex protein	0.0067	0.4335	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0016	0.0711	0.1094
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0016	0.0711	0.1641
Brugia malayi	follicle stimulating hormone receptor	0.0016	0.0711	0.0463
Echinococcus multilocularis	neuropeptide receptor	0.0016	0.0711	0.1094
Schistosoma mansoni	neuropeptide receptor	0.0016	0.0711	0.1641
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0016	0.0711	0.1094
Echinococcus multilocularis	neuropeptide s receptor	0.0016	0.0711	0.1094
Echinococcus multilocularis	serotonin receptor	0.0016	0.0711	0.1094
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0016	0.0711	0.1094
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0711	0.0711
Brugia malayi	hypothetical protein	0.0016	0.0711	0.0463
Leishmania major	hypothetical protein, conserved	0.0024	0.1261	1
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0024	0.1261	0.1035
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0016	0.0711	0.1641
Echinococcus granulosus	biogenic amine 5HT receptor	0.0016	0.0711	0.1094
Echinococcus multilocularis	dro:myosuppressin receptor	0.0016	0.0711	0.1094
Echinococcus granulosus	SWI:SNF matrix associated	0.0067	0.4335	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0243	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0711	0.0711
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0016	0.0711	0.1094
Schistosoma mansoni	blooms syndrome DNA helicase	0.0023	0.1201	0.277
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0019	0.0949	0.2189
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0016	0.0711	0.1094
Schistosoma mansoni	amine GPCR	0.0016	0.0711	0.1641
Brugia malayi	Dopamine receptor protein 2	0.0016	0.0711	0.0463
Echinococcus granulosus	g-protein coupled receptor	0.0016	0.0711	0.1094
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0016	0.0711	0.1094
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0016	0.0711	0.1641
Loa Loa (eye worm)	melatonin receptor type 1A	0.0016	0.0711	0.0711
Brugia malayi	larval opioid receptor	0.0016	0.0711	0.0463
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0016	0.0711	0.1094
Loa Loa (eye worm)	RecQ helicase	0.0029	0.1637	0.1637
Echinococcus multilocularis	neuropeptide Y receptor	0.0016	0.0711	0.1094
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0016	0.0711	0.1641
Entamoeba histolytica	recQ family helicase, putative	0.0015	0.0671	1
Brugia malayi	brahma associated protein 60 kDa	0.0067	0.4335	0.4234
Loa Loa (eye worm)	MH1 domain-containing protein	0.001	0.0266	0.0266
Loa Loa (eye worm)	TYRA-2 protein	0.0016	0.0711	0.0711
Loa Loa (eye worm)	neuropeptide F receptor	0.0016	0.0711	0.0711
Schistosoma mansoni	hypothetical protein	0.0016	0.0711	0.1641
Plasmodium falciparum	zinc finger Ran-binding domain-containing protein 2, putative	0.0024	0.1261	0.2149
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0016	0.0711	0.0463
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0711	0.0711
Onchocerca volvulus		0.0024	0.1261	0.1517
Echinococcus multilocularis	sex peptide receptor	0.0016	0.0711	0.1094
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0711	0.0711
Brugia malayi	brahma associated protein 60 kDa	0.0067	0.4335	0.4234
Echinococcus multilocularis	orexin receptor type 2	0.0016	0.0711	0.1094
Schistosoma mansoni	biogenic amine receptor	0.0016	0.0711	0.1641
Schistosoma mansoni	smad1 5 8 and	0.001	0.0266	0.0614
Echinococcus granulosus	tm gpcr rhodopsin	0.0016	0.0711	0.1094
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0016	0.0711	0.1094
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0016	0.0711	0.1094
Loa Loa (eye worm)	Smad1	0.001	0.0266	0.0266
Schistosoma mansoni	hypothetical protein	0.0016	0.0711	0.1641
Trypanosoma cruzi	hypothetical protein, conserved	0.0024	0.1261	1
Echinococcus multilocularis	SWI:SNF matrix associated	0.0067	0.4335	1
Echinococcus multilocularis	SWI:SNF matrix associated	0.0067	0.4335	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0016	0.0711	0.1641
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0016	0.0711	0.1094
Echinococcus granulosus	g protein coupled receptor	0.0016	0.0711	0.1094
Echinococcus multilocularis	neuropeptides capa receptor	0.0016	0.0711	0.1094
Loa Loa (eye worm)	neuropeptide F receptor	0.0016	0.0711	0.0711
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0711	0.0711
Brugia malayi	AKH receptor	0.0016	0.0711	0.0463
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0016	0.0711	0.1094
Echinococcus granulosus	Nuclear pore complex protein Nup153	0.0024	0.1261	0.2445
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0711	0.0711
Brugia malayi	hypothetical protein	0.0016	0.0711	0.0463
Echinococcus granulosus	rhodopsin orphan GPCR	0.0016	0.0711	0.1094
Echinococcus multilocularis	g protein coupled receptor	0.0016	0.0711	0.1094
Schistosoma mansoni	hypothetical protein	0.0067	0.4335	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0711	0.0711
Echinococcus granulosus	Upstream activation factor subunit UAF30	0.0067	0.4335	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0711	0.0711
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.9875	0.9875
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0016	0.0711	0.1094
Echinococcus granulosus	g protein coupled receptor	0.0016	0.0711	0.1094
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0016	0.0711	0.1641
Echinococcus multilocularis	serotonin receptor	0.0016	0.0711	0.1094
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0016	0.0711	0.1641
Echinococcus granulosus	Zinc finger RanBP2 type	0.0024	0.1261	0.2445
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0711	0.0711
Trypanosoma cruzi	WLM domain containing protein, putative	0.0024	0.1261	1
Schistosoma mansoni	hypothetical protein	0.0067	0.4335	1
Echinococcus granulosus	neuropeptide receptor A26	0.0016	0.0711	0.1094
Echinococcus granulosus	neuropeptides capa receptor	0.0016	0.0711	0.1094
Echinococcus multilocularis	neuropeptide receptor A26	0.0016	0.0711	0.1094
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0711	0.0711
Echinococcus granulosus	rhodopsin orphan GPCR	0.0016	0.0711	0.1094
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0711	0.0711
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0025	0.1385	0.2466
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0016	0.0711	0.1641
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0711	0.0711
Echinococcus granulosus	bloom syndrome protein	0.0029	0.1637	0.3369
Loa Loa (eye worm)	G-protein coupled receptor	0.0016	0.0711	0.0711
Loa Loa (eye worm)	cytochrome P450 family protein	0.0013	0.0517	0.0517
Brugia malayi	hypothetical protein	0.0016	0.0711	0.0463
Schistosoma mansoni	neuropeptide receptor	0.0016	0.0711	0.1641
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0711	0.0711
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0016	0.0711	0.1094
Echinococcus multilocularis	allatostatin A receptor	0.0016	0.0711	0.1094
Schistosoma mansoni	smad1 5 8 and	0.001	0.0266	0.0614
Echinococcus granulosus	allatostatin A receptor	0.0016	0.0711	0.1094
Echinococcus granulosus	7TM GPCR rhodopsin	0.0016	0.0711	0.1094
Schistosoma mansoni	hypothetical protein	0.0024	0.1261	0.2909
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0016	0.0711	0.1641
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0711	0.0711
Echinococcus multilocularis	g-protein coupled receptor	0.0016	0.0711	0.1094
Schistosoma mansoni	opsin-like receptor	0.0016	0.0711	0.1641
Brugia malayi	Melatonin receptor type 1A	0.0016	0.0711	0.0463
Echinococcus multilocularis	Zinc finger, RanBP2 type	0.0024	0.1261	0.2445
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0711	0.0711
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0711	0.0711
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0711	0.0711
Brugia malayi	YY1-associated factor 2	0.0024	0.1261	0.1035
Echinococcus multilocularis	SWI:SNF matrix associated	0.0067	0.4335	1
Echinococcus multilocularis	neuropeptide receptor	0.0016	0.0711	0.1094
Brugia malayi	hypothetical protein	0.0016	0.0711	0.0463
Schistosoma mansoni	smad1 5 8 and	0.001	0.0266	0.0614
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0016	0.0711	0.0711
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0016	0.0711	0.1094
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0016	0.0711	0.0463
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0711	0.0711
Echinococcus granulosus	ring and YY1 binding protein	0.0024	0.1261	0.2445
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.001	0.0266	0.0614
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0016	0.0711	0.1094
Toxoplasma gondii	ran binding protein	0.0024	0.1261	0.2909
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0016	0.0711	0.1641
Echinococcus granulosus	rhodopsin orphan GPCR	0.0016	0.0711	0.1094
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.0012	0.042	0.0377
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0016	0.0711	0.1641
Echinococcus multilocularis	g protein coupled receptor	0.0016	0.0711	0.1094
Brugia malayi	Dopamine receptor protein 1	0.0016	0.0711	0.0463
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0024	0.1261	1
Echinococcus granulosus	orexin receptor type 2	0.0016	0.0711	0.1094
Echinococcus granulosus	7tm_1 domain containing protein	0.0016	0.0711	0.1094
Schistosoma mansoni	amine GPCR	0.0016	0.0711	0.1641
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0016	0.0711	0.1094
Schistosoma mansoni	neuropeptide F-like receptor	0.0016	0.0711	0.1641
Echinococcus granulosus	rhodopsin orphan GPCR	0.0016	0.0711	0.1094
Echinococcus granulosus	somatostatin receptor	0.0016	0.0711	0.1094
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0016	0.0711	0.1094
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0016	0.0711	0.1641
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.0067	0.4335	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0711	0.0711
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0012	0.042	0.0968
Loa Loa (eye worm)	hypothetical protein	0.0024	0.1261	0.1261
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0016	0.0711	0.1094
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0016	0.0711	0.0463
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0024	0.1261	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0016	0.0711	0.0711
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0711	0.0711
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0024	0.1261	1
Brugia malayi	SWIB/MDM2 domain containing protein	0.0067	0.4335	0.4234
Schistosoma mansoni	neuropeptide f receptor 76f	0.0016	0.0711	0.1641
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.9875	0.9875
Echinococcus granulosus	tm gpcr rhodopsin	0.0016	0.0711	0.1094
Brugia malayi	hypothetical protein	0.0016	0.0711	0.0463
Schistosoma mansoni	biogenic amine receptor	0.0016	0.0711	0.1641
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0711	0.0711
Toxoplasma gondii	SWIB/MDM2 domain-containing protein	0.0067	0.4335	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0016	0.0711	0.1641
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0711	0.0711
Schistosoma mansoni	opsin-like receptor	0.0016	0.0711	0.1641
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0016	0.0711	0.1641
Loa Loa (eye worm)	cytochrome P450 family protein	0.0013	0.0517	0.0517
Loa Loa (eye worm)	hypothetical protein	0.0024	0.1261	0.1261
Echinococcus multilocularis	Nuclear pore complex protein Nup153	0.0024	0.1261	0.2445
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0016	0.0711	0.1094
Echinococcus granulosus	rhodopsin orphan GPCR	0.0016	0.0711	0.1094
Toxoplasma gondii	Zn-finger in Ran binding protein and others domain-containing protein	0.0024	0.1261	0.2909
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0016	0.0711	0.1094
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0015	0.0671	0.5325
Schistosoma mansoni	hypothetical protein	0.0016	0.0711	0.1641
Loa Loa (eye worm)	hypothetical protein	0.0024	0.1261	0.1261
Brugia malayi	Bloom's syndrome protein homolog	0.0029	0.1637	0.1427
Trypanosoma cruzi	hypothetical protein, conserved	0.0024	0.1261	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0016	0.0711	0.1094
Schistosoma mansoni	neuropeptide F-like receptor	0.0016	0.0711	0.1641
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0016	0.0711	0.1641
Plasmodium vivax	SWIB/MDM2 domain-containing protein, putative	0.0067	0.4335	1
Onchocerca volvulus		0.0024	0.1261	0.1517
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0024	0.1261	0.1035
Brugia malayi	putative neuropeptide receptor NPR1	0.0016	0.0711	0.0463
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0711	0.0711
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0016	0.0711	0.1094
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0016	0.0711	0.1094
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0016	0.0711	0.1641
Schistosoma mansoni	amine GPCR	0.0016	0.0711	0.1641
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0711	0.0711
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0016	0.0711	0.1094
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0016	0.0711	0.1094
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0711	0.0711
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0711	0.0711
Brugia malayi	MH2 domain containing protein	0.0144	0.9875	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0016	0.0711	0.1641
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0711	0.0711
Echinococcus granulosus	neuropeptide Y receptor	0.0016	0.0711	0.1094
Brugia malayi	G-protein coupled receptor	0.0016	0.0711	0.0463
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0016	0.0711	0.1094
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0016	0.0711	0.0463
Trypanosoma cruzi	WLM domain containing protein, putative	0.0024	0.1261	1
Echinococcus granulosus	neuropeptide receptor	0.0016	0.0711	0.1094
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0012	0.042	0.016
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0711	0.0711
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.0012	0.042	0.0377
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0711	0.0711
Schistosoma mansoni	DNA helicase recq1	0.0012	0.042	0.0968
Schistosoma mansoni	zinc finger protein	0.0024	0.1261	0.2909
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0711	0.0711
Brugia malayi	hypothetical protein	0.0016	0.0711	0.0463
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0711	0.0711
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0015	0.0671	0.2077
Trichomonas vaginalis	conserved hypothetical protein	0.0067	0.4335	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	12.5893 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	14.1254 uM	PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1880197

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1550985