Detailed information for compound 1556475

Basic information

Technical information
  • TDR Targets ID: 1556475
  • Name: 2-(4-nitropyrazol-1-yl)-1-(4-phenylpiperazin- 1-yl)ethanone
  • MW: 315.327 | Formula: C15H17N5O3
  • H donors: 0 H acceptors: 4 LogP: 1.28 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCN(CC1)c1ccccc1)Cn1ncc(c1)[N+](=O)[O-]
  • InChi: 1S/C15H17N5O3/c21-15(12-19-11-14(10-16-19)20(22)23)18-8-6-17(7-9-18)13-4-2-1-3-5-13/h1-5,10-11H,6-9,12H2
  • InChiKey: LLCADEANQOMVJJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(4-nitro-1-pyrazolyl)-1-(4-phenyl-1-piperazinyl)ethanone
  • 1-[(4-nitro-1H-pyrazol-1-yl)acetyl]-4-phenylpiperazine
  • MLS001007974
  • SMR000498467
  • ZINC04811113

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0025 0.0463
Mycobacterium ulcerans putative transglutaminase-like protein 0.0324 0.2781 1
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0308 0.1107
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0056 0.0115
Trichomonas vaginalis peptide N-glycanase, putative 0.0324 0.2781 1
Echinococcus multilocularis Transglutaminase 0.0324 0.2781 1
Brugia malayi Pre-SET motif family protein 0.0034 0.0164 0.0591
Mycobacterium tuberculosis Conserved protein 0.0035 0.0172 0.062
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0025 0.0123
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0172 0.0536
Schistosoma mansoni hypothetical protein 0.0324 0.2781 0.2781
Loa Loa (eye worm) hypothetical protein 0.0035 0.0172 0.0859
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0172 0.0172
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0056 0.0203
Schistosoma mansoni Smad4 0.0016 0.0005 0.0005
Mycobacterium tuberculosis Long conserved protein 0.0324 0.2781 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0259 0.0259
Echinococcus granulosus integrin beta 2 0.015 0.1213 0.4362
Mycobacterium ulcerans transglutaminase family protein 0.0324 0.2781 1
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0075 0.0534 0.1921
Mycobacterium ulcerans lipase LipD 0.0035 0.0172 0.0536
Schistosoma mansoni smad1 5 8 and 0.0016 0.0005 0.0005
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0308 0.1107
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0056 0.0115
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0056 0.0203
Schistosoma mansoni hypothetical protein 0.0168 0.1371 0.1371
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0259 0.093
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0308 0.0308
Loa Loa (eye worm) hypothetical protein 0.0031 0.0137 0.0682
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0075 0.0534 0.2663
Mycobacterium ulcerans hypothetical protein 0.0324 0.2781 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0238 0.2006 1
Echinococcus multilocularis integrin beta 2 0.015 0.1213 0.4362
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0259 0.093
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0031 0.0137 0.0682
Echinococcus multilocularis transcription factor Dp 1 0.0043 0.025 0.0899
Onchocerca volvulus 0.0269 0.2282 0.8093
Trypanosoma brucei DNA polymerase eta, putative 0.0051 0.0317 0.5934
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0304 0.1092
Loa Loa (eye worm) hypothetical protein 0.0035 0.0172 0.0859
Echinococcus granulosus Transglutaminase 0.0324 0.2781 1
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0205 0.1703 0.1703
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0172 0.062
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0025 0.0089
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0056 0.0115
Mycobacterium ulcerans hypothetical protein 0.0324 0.2781 1
Brugia malayi Pre-SET motif family protein 0.0236 0.1988 0.7148
Giardia lamblia DINP protein human, muc B family 0.0022 0.0056 0.0115
Loa Loa (eye worm) hypothetical protein 0.0051 0.0317 0.158
Brugia malayi Smad1 0.0016 0.0005 0.0019
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0056 0.0203
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0056 0.1057
Trypanosoma brucei unspecified product 0.0022 0.0056 0.1057
Schistosoma mansoni ap endonuclease 0.0018 0.0025 0.0025
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0005 0.0027
Leishmania major DNA polymerase eta, putative 0.0036 0.0181 0.3385
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0025 0.1435
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0005 0.0027
Brugia malayi MH2 domain containing protein 0.0016 0.0005 0.0019
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0056 0.1057
Brugia malayi beta-lactamase family protein 0.0035 0.0172 0.062
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0056 0.1057
Onchocerca volvulus 0.0035 0.0172 0.0031
Mycobacterium leprae Conserved hypothetical protein 0.0324 0.2781 1
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0172 0.062
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0172 0.0536
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.0056 0.0622
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0172 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0153 0.0551
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0308 0.1028
Onchocerca volvulus 0.0035 0.0172 0.0031
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0308 0.1107
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0308 0.1028
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0308 0.1535
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0025 0.0463
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0308 0.1028
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0005 0.0019
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0056 0.1057
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0075 0.0534 1
Schistosoma mansoni smad1 5 8 and 0.0016 0.0005 0.0005
Mycobacterium tuberculosis Conserved protein 0.0324 0.2781 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0164 0.5338
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0308 0.5764
Loa Loa (eye worm) transcription factor SMAD2 0.0238 0.2006 1
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0075 0.0534 0.1921
Brugia malayi hypothetical protein 0.0031 0.0137 0.0492
Brugia malayi Thioredoxin family protein 0.0324 0.2781 1
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0308 0.1107
Trichomonas vaginalis set domain proteins, putative 0.0269 0.2282 0.819
Plasmodium vivax SET domain protein, putative 0.0034 0.0164 0.9537
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0075 0.0534 1
Brugia malayi MH2 domain containing protein 0.0238 0.2006 0.7215
Loa Loa (eye worm) Smad1 0.0016 0.0005 0.0027
Echinococcus granulosus smad 0.0016 0.0005 0.0019
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0534 1
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0308 0.1028
Echinococcus multilocularis smad 0.0016 0.0005 0.0019
Brugia malayi beta-lactamase family protein 0.0035 0.0172 0.062
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0005 0.0019
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0259 0.0259
Brugia malayi Integrin beta pat-3 precursor 0.0203 0.1687 0.6066
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0056 0.0203
Brugia malayi beta-lactamase 0.0035 0.0172 0.062
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0534 1
Trypanosoma brucei protein kinase, putative 0.005 0.0308 0.5764
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0056 0.1057
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0056 0.1057
Leishmania major hypothetical protein, conserved 0.0035 0.0172 0.3226
Loa Loa (eye worm) hypothetical protein 0.0035 0.0172 0.0859
Brugia malayi Kelch motif family protein 0.0031 0.0137 0.0492
Echinococcus granulosus Smad4 0.0016 0.0005 0.0019
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0304 0.1092
Brugia malayi MAP kinase sur-1 0.005 0.0308 0.1107
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0005 0.0005
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0025 0.0089
Mycobacterium tuberculosis Conserved protein 0.0035 0.0172 0.062
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0172 0.062
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0172 0.3226
Echinococcus multilocularis geminin 0.0168 0.1371 0.4929
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0164 0.0164
Brugia malayi ImpB/MucB/SamB family protein 0.0051 0.0317 0.114
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0308 0.5764
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0056 0.1057
Echinococcus multilocularis dna polymerase eta 0.0051 0.0317 0.114
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0172 0.062
Loa Loa (eye worm) beta-lactamase 0.0035 0.0172 0.0859
Mycobacterium tuberculosis Conserved hypothetical protein 0.0324 0.2781 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0025 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0056 0.1057
Loa Loa (eye worm) integrin beta-2 0.0203 0.1687 0.8407
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0056 0.1057
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0172 0.0536
Echinococcus granulosus transcription factor Dp 1 0.0043 0.025 0.0899
Schistosoma mansoni integrin beta subunit 0.0119 0.0935 0.0935
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0056 0.1057
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0056 0.1057
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0172 0.062
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0172 0.062
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0308 0.5764
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0308 0.5764
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0172 0.0859
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0056 0.0115
Onchocerca volvulus 0.0035 0.0172 0.0031
Brugia malayi MH1 domain containing protein 0.0016 0.0005 0.0019
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0534 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0308 0.5764
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0056 0.0281
Loa Loa (eye worm) hypothetical protein 0.0034 0.0163 0.0813
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0056 0.1057
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0036 0.0181 0.5874
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0164 0.0591
Mycobacterium ulcerans hypothetical protein 0.0035 0.0172 0.0536
Loa Loa (eye worm) hypothetical protein 0.0049 0.0304 0.1514
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0025 0.5
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0172 0.3226
Onchocerca volvulus 0.0324 0.2781 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0324 0.2781 1
Schistosoma mansoni smad 0.0016 0.0005 0.0005
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0172 0.0536
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0025 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0056 0.0203
Echinococcus granulosus dna polymerase eta 0.0051 0.0317 0.114
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0164 0.0591
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0005 0.0019
Echinococcus multilocularis Smad4 0.0016 0.0005 0.0019
Mycobacterium tuberculosis Conserved protein 0.0035 0.0172 0.062
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0172 0.0536
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0164 0.0164
Echinococcus granulosus geminin 0.0168 0.1371 0.4929
Brugia malayi MH2 domain containing protein 0.0016 0.0005 0.0019
Schistosoma mansoni smad1 5 8 and 0.0016 0.0005 0.0005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0259 0.0259
Schistosoma mansoni ap endonuclease 0.0018 0.0025 0.0025
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0308 0.5764
Trypanosoma cruzi DNA polymerase eta, putative 0.0051 0.0317 0.5934
Schistosoma mansoni DNA polymerase eta 0.0051 0.0317 0.0317
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0025 0.0463
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0259 0.1288
Trichomonas vaginalis esterase, putative 0.0035 0.0172 0.0536
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0172 0.062
Giardia lamblia Hypothetical protein 0.0324 0.2781 1
Leishmania major DNA polymerase kappa, putative 0.0022 0.0056 0.1057
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0005 0.0019
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0056 0.1057
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0172 0.0536
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0075 0.0534 0.1921
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0056 0.0203
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0056 0.0056
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0025 0.0089
Loa Loa (eye worm) hypothetical protein 0.0035 0.0172 0.0859
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0172 0.062
Schistosoma mansoni hypothetical protein 0.0034 0.0163 0.0163
Giardia lamblia Transglutaminase/protease, putative 0.0324 0.2781 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.0035 0.0172 0.0859
Loa Loa (eye worm) hypothetical protein 0.0035 0.0172 0.0859
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0172 0.3226
Loa Loa (eye worm) hypothetical protein 0.0034 0.0164 0.0819
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0075 0.0534 0.0534
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0163 0.0586
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.1861 0.6692
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0164 0.0164
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0056 0.1057
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0304 0.1514
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0259 0.093
Brugia malayi MH1 domain containing protein 0.0016 0.0005 0.0019
Leishmania major DNA polymerase eta, putative 0.0051 0.0317 0.5934
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0025 0.0089
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0056 0.1057
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0172 0.062
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0164 0.0164
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0056 0.1057
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0308 0.5764
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0308 1
Toxoplasma gondii exonuclease III APE 0.0018 0.0025 0.0803
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0056 0.1057
Echinococcus granulosus dna polymerase kappa 0.0022 0.0056 0.0203
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0164 0.0591
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0025 0.0463
Schistosoma mansoni hypothetical protein 0.0168 0.1371 0.1371
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0172 0.062
Toxoplasma gondii ABC1 family protein 0.0035 0.0172 0.5598
Mycobacterium ulcerans beta-lactamase 0.0035 0.0172 0.0536
Mycobacterium tuberculosis Hypothetical protein 0.0324 0.2781 1
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0172 0.0536
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0236 0.1988 0.9908
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0259 0.093
Trypanosoma cruzi DNA polymerase eta, putative 0.0036 0.0181 0.3385
Mycobacterium leprae Conserved hypothetical protein 0.0324 0.2781 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0056 0.0056
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0259 0.093
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0056 0.1057
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0308 0.1028

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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