TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 600.979 | Formula: C27H24ClF3N8O3
H donors: 2 H acceptors: 4 LogP: 5.63 Rotable bonds: 10
Rule of 5 violations (Lipinski): 2
SMILES: CC(Oc1cc(Cl)cc2c1n(C)/c(=N/c1ccc(cc1)OC(F)(F)F)/n2Cc1ccc(cc1)C(=O)Nc1nnn[nH]1)C
InChi: 1S/C27H24ClF3N8O3/c1-15(2)41-22-13-18(28)12-21-23(22)38(3)26(32-19-8-10-20(11-9-19)42-27(29,30)31)39(21)14-16-4-6-17(7-5-16)24(40)33-25-34-36-37-35-25/h4-13,15H,14H2,1-3H3,(H2,33,34,35,36,37,40)/b32-26-
InChiKey: FGBOTPMNHNVKKB-FSRJSHLRSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glucagon receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon receptor	477 aa	457 aa	25.4 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	sodium and chloride dependent glycine	0.0058	0.0538	0.0605
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0036	0.0251	0.0217
Echinococcus granulosus	Ribosomal protein S1 RNA binding domain	0.003	0.0173	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0027
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0019	0.0035	0.0027
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 3	0.0106	0.1156	0.1125
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.0088	0.0234
Giardia lamblia	Kinase, CMGC MAPK	0.005	0.0431	1
Schistosoma mansoni	hypothetical protein	0.0078	0.0788	0.0905
Echinococcus multilocularis	Ribosomal protein S1, RNA binding domain	0.003	0.0173	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0027
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	0.003	0.0173	0.0139
Echinococcus multilocularis	glutamate receptor subunit protein glur	0.003	0.0173	0.0139
Echinococcus multilocularis	vesicular acetylcholine transporter	0.0667	0.8354	0.8348
Brugia malayi	PAS domain containing protein	0.0048	0.0403	0.0443
Brugia malayi	latrophilin 2 splice variant baaae	0.0078	0.0788	0.0905
Plasmodium vivax	hypothetical protein, conserved	0.0058	0.0538	1
Schistosoma mansoni	hypothetical protein	0.0036	0.0251	0.026
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0058	0.0538	0.0605
Mycobacterium ulcerans	putative regulatory protein	0.0035	0.0243	0.062
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0027
Loa Loa (eye worm)	G-protein coupled receptor	0.0019	0.0035	0.0027
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0114	0.125	0.1484
Echinococcus granulosus	glutamate receptor ionotropic kainate 3	0.003	0.0173	0.0166
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.0088	0.0202
Echinococcus granulosus	vesicular acetylcholine transporter	0.0667	0.8354	1
Brugia malayi	Latrophilin receptor protein 2	0.0036	0.0251	0.026
Echinococcus multilocularis	GPCR, family 2	0.0036	0.0251	0.0217
Schistosoma mansoni	glutamate receptor NMDA	0.0045	0.0369	0.0402
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0027
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0367	0.0333
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0027
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0036	0.0251	0.026
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.005	0.0431	0.0254
Leishmania major	hypothetical protein, conserved	0.0158	0.1818	0.2786
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0343	0.42	0.5021
Loa Loa (eye worm)	hypothetical protein	0.016	0.1849	0.2201
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0343	0.42	0.5007
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0367	0.0399
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0058	0.0538	0.6915
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0058	0.0538	0.0605
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0027
Echinococcus granulosus	nmda type glutamate receptor	0.0106	0.1156	0.1348
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0096	0.1029	0.2576
Trypanosoma brucei	protein kinase, putative	0.005	0.0431	0.0254
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0036	0.0251	0.0217
Loa Loa (eye worm)	neuropeptide F receptor	0.0019	0.0035	0.0027
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0038	0.0278	0.5055
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0058	0.0538	1
Brugia malayi	ERG2 and Sigma1 receptor like protein	0.0373	0.4578	0.5461
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0538	0.063
Echinococcus granulosus	mitogen activated protein kinase 3	0.005	0.0431	0.0476
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0367	0.0399
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0114	0.125	0.1461
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0088	0.5
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0367	0.0425
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0058	0.0538	1
Schistosoma mansoni	hypothetical protein	0.0158	0.1818	0.2144
Schistosoma mansoni	sodium/chloride dependent transporter	0.0059	0.0544	0.0612
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0058	0.0538	0.0505
Schistosoma mansoni	hypothetical protein	0.003	0.0173	0.0166
Echinococcus multilocularis	Niemann Pick C1 protein	0.0138	0.1561	0.1531
Loa Loa (eye worm)	glutamate receptor 2	0.003	0.0173	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0538	0.063
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0027
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.005	0.0431	0.0254
Onchocerca volvulus		0.0058	0.0538	0.0605
Loa Loa (eye worm)	serotonin transporter b	0.0343	0.42	0.5021
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0431	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0117	0.1292	0.1535
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0538	0.063
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0114	0.125	0.1484
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0058	0.0538	0.0505
Mycobacterium tuberculosis	Probable phytoene synthase PhyA	0.0158	0.1818	0.486
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0027
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0056	0.0513	0.0575
Echinococcus granulosus	glutamate NMDA receptor subunit	0.003	0.0173	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0538	0.063
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0058	0.0538	0.0605
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0045	0.0369	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0788	0.093
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0045	0.0369	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0343	0.42	0.5021
Loa Loa (eye worm)	vesicular acetylcholine transporter unc-17	0.0667	0.8354	1
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0017	0.0012	0.0033
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0431	1
Echinococcus multilocularis	NMDA receptor	0.003	0.0173	0.0139
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0058	0.0538	0.0605
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0027
Loa Loa (eye worm)	G-protein coupled receptor	0.0019	0.0035	0.0027
Mycobacterium ulcerans	hypothetical protein	0.0308	0.3741	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0114	0.125	0.1461
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0027
Echinococcus multilocularis	mitogen activated protein kinase 3	0.005	0.0431	0.0397
Echinococcus granulosus	GPCR family 2	0.0036	0.0251	0.026
Echinococcus multilocularis	Squalene phytoene synthase	0.0158	0.1818	0.179
Plasmodium falciparum	amino acid transporter, putative	0.0058	0.0538	1
Mycobacterium tuberculosis	Probable glutamine-binding lipoprotein GlnH (GLNBP)	0.0077	0.0772	0.2065
Echinococcus multilocularis	serotonin transporter	0.0343	0.42	0.418
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0027
Echinococcus multilocularis	sterol regulatory element binding protein	0.0041	0.0321	0.0287
Schistosoma mansoni	single-minded	0.0048	0.0403	0.0443
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0045	0.0369	0.0402
Brugia malayi	Niemann-Pick C1 protein precursor	0.0096	0.1029	0.1195
Schistosoma mansoni	patched 1	0.0041	0.0321	0.0344
Brugia malayi	CHE-14 protein	0.0041	0.0321	0.0344
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0038	0.0278	0.0292
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0058	0.0538	0.0605
Loa Loa (eye worm)	hypothetical protein	0.0373	0.4578	0.5473
Loa Loa (eye worm)	norepinephrine transporter	0.0343	0.42	0.5021
Loa Loa (eye worm)	TYRA-2 protein	0.0019	0.0035	0.0027
Schistosoma mansoni	hypothetical protein	0.004	0.0302	0.0321
Echinococcus granulosus	mitogen activated protein kinase	0.005	0.0431	0.0476
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0058	0.0538	0.0605
Trypanosoma cruzi	squalene synthase, putative	0.0507	0.6299	1
Mycobacterium tuberculosis	Conserved protein	0.0308	0.3741	1
Echinococcus granulosus	sodium and chloride dependent glycine	0.0058	0.0538	0.0605
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0027
Echinococcus granulosus	muscleblind protein	0.0146	0.167	0.1966
Echinococcus granulosus	Protein patched homolog 1	0.0041	0.0321	0.0344
Chlamydia trachomatis	glutamine binding protein	0.0077	0.0772	1
Loa Loa (eye worm)	hypothetical protein	0.0191	0.2237	0.2667
Schistosoma mansoni	glutamate receptor NMDA	0.003	0.0173	0.0166
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0367	0.0399
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0056	0.0513	0.1343
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0056	0.0513	0.0575
Schistosoma mansoni	sphingoid long chain base kinase	0.0308	0.3741	0.4455
Schistosoma mansoni	aryl hydrocarbon receptor	0.0048	0.0403	0.0443
Brugia malayi	Muscleblind-like protein	0.0146	0.167	0.1966
Onchocerca volvulus		0.0023	0.0088	0.0064
Toxoplasma gondii	hypothetical protein	0.0058	0.0538	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0027
Leishmania major	C-8 sterol isomerase-like protein	0.0373	0.4578	0.723
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0036	0.0251	0.0287
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.0373	0.4578	0.7142
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0045	0.0369	0.0402
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0041	0.0321	0.037
Onchocerca volvulus		0.0058	0.0538	0.0605
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0058	0.0538	0.0505
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0088	0.5
Trypanosoma cruzi	phytoene synthase, putative	0.0158	0.1818	0.2558
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0027
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0019	0.0035	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0088	0.009
Echinococcus granulosus	Niemann Pick C1 protein	0.0096	0.1029	0.1195
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.005	0.0431	0.5876
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0027
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0088	0.0234
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0027
Brugia malayi	MAP kinase sur-1	0.005	0.0431	0.0476
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0019	0.0035	0.0027
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0321	0.2825
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0058	0.0538	0.0605
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0058	0.0538	0.0605
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.005	0.0431	0.0254
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0045	0.0369	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0146	0.167	0.1987
Mycobacterium ulcerans	glutamine-binding lipoprotein GlnH	0.0077	0.0772	0.2039
Schistosoma mansoni	hypothetical protein	0.004	0.0302	0.0321
Schistosoma mansoni	sodium/chloride dependent transporter	0.0058	0.0538	0.0605
Brugia malayi	hypoxia-induced factor 1	0.0148	0.1689	0.1989
Echinococcus granulosus	glutamate receptor ionotropic kainate	0.003	0.0173	0.0166
Echinococcus granulosus	glutamate receptor subunit protein glur	0.003	0.0173	0.0166
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0056	0.0513	0.1343
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0036	0.0251	0.026
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0027
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0058	0.0538	0.0605
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0058	0.0538	0.063
Echinococcus multilocularis	sphingosine kinase 1	0.0308	0.3741	0.3719
Echinococcus multilocularis	expressed conserved protein	0.0091	0.0954	0.0922
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0058	0.0538	0.0605
Echinococcus granulosus	serotonin transporter	0.0343	0.42	0.5007
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.005	0.0431	0.0254
Echinococcus multilocularis	nmda type glutamate receptor	0.0106	0.1156	0.1125
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0431	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0088	0.0202
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0441	0.0514
Schistosoma mansoni	hypothetical protein	0.0036	0.0251	0.026
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0058	0.0538	0.063
Echinococcus granulosus	sterol regulatory element binding protein	0.0041	0.0321	0.0344
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0367	0.0399
Loa Loa (eye worm)	transcription factor SMAD2	0.0117	0.1292	0.1535
Leishmania major	squalene synthase, putative	0.0507	0.6299	1
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0038	0.0278	0.5055
Echinococcus multilocularis	geminin	0.0522	0.6494	0.6482
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0056	0.0513	0.048
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0027
Chlamydia trachomatis	arginine ABC transporter substrate-binding protein ArtJ	0.0077	0.0772	1
Schistosoma mansoni	vesicular acetylcholine transporter	0.0667	0.8354	1
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0038	0.0278	0.0713
Plasmodium vivax	amine transporter, putative	0.0058	0.0538	1
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.0088	0.0202
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.0088	0.0202
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0038	0.0278	0.0319
Trypanosoma cruzi	squalene synthase, putative	0.0507	0.6299	1
Brugia malayi	hypothetical protein	0.016	0.1849	0.218
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0538	0.063
Plasmodium falciparum	transporter, putative	0.0058	0.0538	1
Loa Loa (eye worm)	hypothetical protein	0.0308	0.3741	0.447
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.005	0.0431	0.0552
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0088	0.0064
Echinococcus multilocularis	muscleblind protein 1	0.0146	0.167	0.1641
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0036	0.0251	0.026
Echinococcus granulosus	Squalene phytoene synthase	0.0158	0.1818	0.2144
Echinococcus multilocularis	mitogen activated protein kinase	0.005	0.0431	0.0397
Brugia malayi	MH2 domain containing protein	0.0117	0.1292	0.1512
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0088	0.0064
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0058	0.0538	0.0605
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.005	0.0431	0.0552
Onchocerca volvulus		0.0058	0.0538	0.0605
Brugia malayi	Glutamate receptor 1 precursor	0.003	0.0173	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0027
Schistosoma mansoni	ATP-binding cassette transporter	0.003	0.0173	0.0166
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.0088	0.0202
Brugia malayi	hypothetical protein	0.0058	0.0538	0.0605
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0058	0.0538	0.0605
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0027
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0019	0.0035	0.0027
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0058	0.0538	0.0505
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0056	0.0513	0.0685
Schistosoma mansoni	hypothetical protein	0.0036	0.0251	0.026
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0058	0.0538	0.0605
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0367	0.0333
Echinococcus granulosus	glutamate receptor 2	0.0045	0.0369	0.0402
Toxoplasma gondii	hypothetical protein	0.0058	0.0538	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0027
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0058	0.0538	0.0505
Echinococcus multilocularis	protein patched	0.0041	0.0321	0.0287
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0343	0.42	0.5007
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0027
Loa Loa (eye worm)	neuropeptide F receptor	0.0019	0.0035	0.0027
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0148	0.1689	0.201
Schistosoma mansoni	serine/threonine protein kinase	0.005	0.0431	0.0476
Mycobacterium ulcerans	phytoene synthase, CrtB	0.0158	0.1818	0.4843
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0038	0.0278	0.5
Echinococcus multilocularis	glutamate receptor ionotropic kainate	0.003	0.0173	0.0139
Schistosoma mansoni	hypothetical protein	0.0522	0.6494	0.7765
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0088	0.009
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0058	0.0538	1
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.005	0.0431	0.0502
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0038	0.0278	0.0521
Echinococcus granulosus	sphingosine kinase 1	0.0308	0.3741	0.4455
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0431	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0027
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0098	0.1048	0.1218
Schistosoma mansoni	glutamate receptor AMPA	0.003	0.0173	0.0166
Brugia malayi	Glutamate receptor 2 precursor	0.003	0.0173	0.0166
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein	0.0077	0.0772	0.1261
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0045	0.0369	0.0402
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0027
Brugia malayi	Cytochrome P450 family protein	0.0026	0.0119	0.0101
Echinococcus granulosus	single minded 2	0.0035	0.0243	0.0251
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0045	0.0369	0.0336
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein (hisJ)	0.0077	0.0772	0.1261
Loa Loa (eye worm)	glutamate receptor 1	0.003	0.0173	0.0193
Schistosoma mansoni	glutamate receptor kainate	0.003	0.0173	0.0166
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0058	0.0538	0.0605
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1029	0.1219
Brugia malayi	vesicular acetylcholine transporter unc-17	0.0667	0.8354	1
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0038	0.0278	0.0743
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0088	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0088	0.009
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0367	0.0399
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0038	0.0278	0.0306
Echinococcus multilocularis	protein dispatched 1	0.0047	0.0396	0.0363
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0058	0.0538	0.0605
Schistosoma mansoni	glutamate receptor kainate	0.003	0.0173	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0251	0.0287
Schistosoma mansoni	hypothetical protein	0.0036	0.0251	0.026
Onchocerca volvulus		0.0343	0.42	0.5007
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0027
Echinococcus multilocularis	glutamate receptor 2	0.003	0.0173	0.0139
Schistosoma mansoni	ap endonuclease	0.0038	0.0278	0.0292
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0038	0.0278	0.0244
Schistosoma mansoni	hypothetical protein	0.004	0.0302	0.0321
Loa Loa (eye worm)	melatonin receptor type 1A	0.0019	0.0035	0.0027
Echinococcus multilocularis	glutamate receptor 2	0.0045	0.0369	0.0336
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0056	0.0513	0.1371
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0027
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0053	0.0464	0.0542
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0058	0.0538	0.0605
Trypanosoma brucei	C-8 sterol isomerase, putative	0.0373	0.4578	0.7142
Brugia malayi	exodeoxyribonuclease III family protein	0.0038	0.0278	0.0292
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0367	0.0399
Loa Loa (eye worm)	cytochrome P450 family protein	0.0026	0.0119	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0027
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0045	0.0369	0.0402
Echinococcus granulosus	expressed conserved protein	0.0091	0.0954	0.1105
Echinococcus multilocularis	Niemann Pick C1 protein	0.0096	0.1029	0.0998
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0027
Onchocerca volvulus	NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog	0.0158	0.1818	0.2144
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0538	0.063
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0027
Echinococcus granulosus	geminin	0.0522	0.6494	0.7765
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0538	0.063
Schistosoma mansoni	sphingosine kinase A B	0.0308	0.3741	0.4455
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0088	0.0202
Brugia malayi	bHLH-PAS transcription factor	0.0035	0.0243	0.0251
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0058	0.0538	0.0605
Loa Loa (eye worm)	hypothetical protein	0.0343	0.42	0.5021
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0027
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0343	0.42	0.5021
Echinococcus multilocularis	transfer RNA-Lys	0.0035	0.0243	0.021
Schistosoma mansoni	sodium/chloride dependent transporter	0.0343	0.42	0.5007
Echinococcus granulosus	Niemann Pick C1 protein	0.0138	0.1561	0.1834
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0056	0.0513	0.0575
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0027
Schistosoma mansoni	ap endonuclease	0.0038	0.0278	0.0292
Onchocerca volvulus	Vesicular acetylcholine transporter homolog	0.0667	0.8354	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0321	0.037
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0088	0.0202
Schistosoma mansoni	glutamate receptor AMPA	0.003	0.0173	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0027
Treponema pallidum	sodium- and chloride- dependent transporter	0.0343	0.42	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0027
Schistosoma mansoni	glutamate receptor kainate	0.003	0.0173	0.0166
Schistosoma mansoni	hypothetical protein	0.0522	0.6494	0.7765
Schistosoma mansoni	hypothetical protein	0.004	0.0302	0.0321
Loa Loa (eye worm)	hypothetical protein	0.0146	0.167	0.1987
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.005	0.0431	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0027
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0088	0.0202
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0019	0.0035	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0027
Entamoeba histolytica	hypothetical protein, conserved	0.0308	0.3741	1
Loa Loa (eye worm)	hypothetical protein	0.0158	0.1818	0.2165
Trypanosoma brucei	squalene synthase, putative	0.0507	0.6299	1
Echinococcus multilocularis	muscleblind protein	0.0146	0.167	0.1641
Onchocerca volvulus		0.0035	0.0243	0.0251

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 9.3 nM	Displacement of [125I]glucagon from human GCGR expressed in CHO cells after 4 to 12 hrs by scintillation counting	ChEMBL.	22001094
IC50 (functional)	= 29 nM	Antagonist activity at human GCGR expressed in CHO cells assessed as inhibition of glucagon-induced [125I]cAMP accumulation after 30 mins by scintillation counting	ChEMBL.	22001094

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1922838

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1565842