TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 264.252 | Formula: C13H13FN2O3
H donors: 0 H acceptors: 2 LogP: 1.04 Rotable bonds: 0
Rule of 5 violations (Lipinski): 1
SMILES: CN1C(=O)N(C(=O)[C@@]21CCOc1c2cc(F)cc1)C
InChi: 1S/C13H13FN2O3/c1-15-11(17)13(16(2)12(15)18)5-6-19-10-4-3-8(14)7-9(10)13/h3-4,7H,5-6H2,1-2H3/t13-/m1/s1
InChiKey: AQNKOJKMIGXZOU-CYBMUJFWSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	flap endonuclease-1, putative	0.0031	0.0758	0.0438
Giardia lamblia	Flap structure-specific endonuclease	0.0031	0.0758	0.072
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0019	0.0334	0.0259
Schistosoma mansoni	tar DNA-binding protein	0.0052	0.1564	0.1827
Plasmodium vivax	flavodoxin domain containing protein	0.0178	0.6217	0.8742
Echinococcus granulosus	thioredoxin glutathione reductase	0.0056	0.1689	0.2013
Loa Loa (eye worm)	hypothetical protein	0.02	0.7063	0.723
Leishmania major	hypothetical protein, conserved	0.0077	0.2465	0.3343
Trypanosoma brucei	flap endonuclease-1 (FEN-1), putative	0.0031	0.0758	0.0872
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0019	0.0334	0.0259
Giardia lamblia	Hypothetical protein	0.0178	0.6217	1
Brugia malayi	diaphorase	0.0023	0.0463	0.0331
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0019	0.0334	0.0259
Schistosoma mansoni	NADH-cytochrome B5 reductase	0.0023	0.0463	0.0191
Schistosoma mansoni	tar DNA-binding protein	0.0052	0.1564	0.1827
Mycobacterium tuberculosis	Probable dehydrogenase	0.0127	0.4344	0.8837
Leishmania major	NADH-cytochrome b5 reductase, putative	0.0023	0.0463	0.0445
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0127	0.4344	0.8837
Toxoplasma gondii	flavodoxin domain-containing protein	0.0099	0.3311	1
Loa Loa (eye worm)	diaphorase	0.0023	0.0463	0.0473
Echinococcus multilocularis	tar DNA binding protein	0.0052	0.1564	0.1827
Trypanosoma cruzi	Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative	0.0077	0.2465	0.3343
Chlamydia trachomatis	sulfite reductase	0.0124	0.4215	1
Schistosoma mansoni	tar DNA-binding protein	0.0052	0.1564	0.1827
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0019	0.0334	0.0259
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0019	0.0334	0.0259
Treponema pallidum	flavodoxin	0.0077	0.2465	1
Brugia malayi	Thioredoxin reductase	0.0056	0.1689	0.1605
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.0925	0.0877
Giardia lamblia	Flavohemoprotein lateral transfer candidate	0.0023	0.0463	0.0218
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0052	0.1564	0.1601
Mycobacterium tuberculosis	Probable monooxygenase	0.0023	0.0463	0.0283
Trypanosoma cruzi	oxidoreductase-protein, putative	0.0023	0.0463	0.0445
Echinococcus granulosus	cytochrome b5 reductase 4	0.0023	0.0463	0.0191
Trypanosoma cruzi	cytochrome-b5 reductase, putative	0.0023	0.0463	0.0445
Loa Loa (eye worm)	cytochrome b5 reductase 4	0.0023	0.0463	0.0473
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	0.0031	0.0758	0.0872
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0019	0.0334	0.5
Leishmania major	p450 reductase, putative	0.02	0.7063	1
Leishmania major	nitrate reductase, putative	0.0023	0.0463	0.0445
Schistosoma mansoni	diflavin oxidoreductase	0.0099	0.3311	0.4424
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0019	0.0334	0.0259
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0019	0.0334	0.0259
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0019	0.0334	0.0259
Toxoplasma gondii	NADH-cytochrome b5 reductase 1, putative	0.0023	0.0463	0.0431
Plasmodium falciparum	ferredoxin--NADP reductase	0.0023	0.0463	0.0191
Echinococcus granulosus	flap endonuclease 1	0.0031	0.0758	0.0629
Leishmania major	NADH-cytochrome b5 reductase, putative	0.0023	0.0463	0.0445
Trypanosoma cruzi	NADH-cytochrome b5 reductase, putative	0.0023	0.0463	0.0445
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.0925	0.0877
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0127	0.4344	0.8837
Loa Loa (eye worm)	flavodoxin family protein	0.0077	0.2465	0.2523
Plasmodium vivax	SET domain protein, putative	0.0035	0.0925	0.0877
Giardia lamblia	Nitric oxide synthase, inducible	0.0178	0.6217	1
Trypanosoma cruzi	Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative	0.0077	0.2465	0.3343
Trypanosoma brucei	S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative	0.0077	0.2465	0.3343
Entamoeba histolytica	type A flavoprotein, putative	0.0077	0.2465	1
Plasmodium vivax	NADPH-cytochrome p450 reductase, putative	0.02	0.7063	1
Schistosoma mansoni	tar DNA-binding protein	0.0052	0.1564	0.1827
Trichomonas vaginalis	NADPH fad oxidoreductase, putative	0.0178	0.6217	0.6086
Plasmodium falciparum	nitric oxide synthase, putative	0.02	0.7063	1
Trypanosoma cruzi	trypanothione reductase, putative	0.0019	0.0334	0.0259
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0273	0.9769	1
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0019	0.0334	0.5
Loa Loa (eye worm)	CYP4Cod1	0.0015	0.0155	0.0159
Plasmodium falciparum	glutathione reductase	0.0056	0.1689	0.2013
Trichomonas vaginalis	set domain proteins, putative	0.0279	1	1
Mycobacterium ulcerans	monooxygenase	0.0023	0.0463	0.0445
Echinococcus granulosus	cytochrome b5 reductase 4	0.0023	0.0463	0.0191
Plasmodium vivax	glutathione reductase, putative	0.0056	0.1689	0.2013
Leishmania major	cytochrome-b5 reductase, putative	0.0023	0.0463	0.0445
Toxoplasma gondii	flap structure-specific endonuclease 1, putative	0.0031	0.0758	0.1422
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0019	0.0334	0.0198
Brugia malayi	Cytochrome b5-like Heme/Steroid binding domain containing protein	0.0023	0.0463	0.0331
Trypanosoma cruzi	NADPH-dependent FMN/FAD containing oxidoreductase, putative	0.02	0.7063	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.0925	0.0877
Trypanosoma cruzi	p450 reductase, putative	0.02	0.7063	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0023	0.0463	0.0283
Trypanosoma cruzi	reductase, putative	0.0023	0.0463	0.0445
Treponema pallidum	ferredoxin-NADP(+) reductase subunit alpha	0.0023	0.0463	0.0602
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0127	0.4344	0.8837
Echinococcus multilocularis	NADH cytochrome b5 reductase 3	0.0023	0.0463	0.0191
Mycobacterium ulcerans	formate dehydrogenase H FdhF	0.02	0.7063	1
Echinococcus granulosus	tar DNA binding protein	0.0052	0.1564	0.1827
Loa Loa (eye worm)	FAD binding domain-containing protein	0.0124	0.4215	0.4314
Plasmodium falciparum	flap endonuclease 1	0.0031	0.0758	0.0629
Leishmania major	reductase, putative	0.0023	0.0463	0.0445
Mycobacterium ulcerans	electron transfer protein FdxB	0.0023	0.0463	0.0445
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0245	0.874	0.8946
Trypanosoma brucei	NADH-cytochrome b5 reductase, putative	0.0023	0.0463	0.0445
Brugia malayi	follicle stimulating hormone receptor	0.0273	0.9769	1
Leishmania major	flap endonuclease-1 (FEN-1), putative	0.0031	0.0758	0.0872
Trypanosoma cruzi	cytochrome P450 reductase, putative	0.02	0.7063	1
Mycobacterium tuberculosis	Possible electron transfer protein FdxB	0.0023	0.0463	0.0283
Trypanosoma cruzi	trypanothione reductase, putative	0.0056	0.1689	0.222
Echinococcus multilocularis	cytochrome b5 reductase 4	0.0023	0.0463	0.0191
Trypanosoma brucei	NADH-cytochrome b5 reductase, putative	0.0023	0.0463	0.0445
Schistosoma mansoni	cytochrome B5	0.0023	0.0463	0.0191
Echinococcus granulosus	NADH cytochrome b5 reductase 3	0.0023	0.0463	0.0191
Entamoeba histolytica	type A flavoprotein, putative	0.0077	0.2465	1
Leishmania major	cytochrome-b5 reductase, putative	0.0023	0.0463	0.0445
Schistosoma mansoni	flap endonuclease-1	0.0028	0.0648	0.0466
Loa Loa (eye worm)	RNA binding protein	0.0052	0.1564	0.1601
Schistosoma mansoni	5-methyl tetrahydrofolate-homocysteine methyltransferase reductase	0.0124	0.4215	0.5767
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0019	0.0334	0.0259
Mycobacterium tuberculosis	Probable oxidoreductase	0.0141	0.4872	1
Trypanosoma cruzi	cytochrome-b5 reductase, putative	0.0023	0.0463	0.0445
Loa Loa (eye worm)	FAD binding domain-containing protein	0.02	0.7063	0.723
Chlamydia trachomatis	Na(+)-translocating NADH-quinone reductase subunit F	0.0023	0.0463	0.0331
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0023	0.0463	0.0445
Plasmodium vivax	thioredoxin reductase, putative	0.0056	0.1689	0.2013
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0019	0.0334	0.0259
Trypanosoma brucei	trypanothione reductase	0.0056	0.1689	0.222
Trichomonas vaginalis	NADPH cytochrome P450, putative	0.0077	0.2465	0.2204
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0035	0.0925	0.0877
Trypanosoma brucei	NADPH-dependent diflavin oxidoreductase 1	0.02	0.7063	1
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0019	0.0334	0.0259
Brugia malayi	glutathione reductase	0.0056	0.1689	0.1605
Plasmodium vivax	oxidoreductase NAD-binding domain containing protein	0.0023	0.0463	0.0191
Trypanosoma cruzi	NADH-dependent fumarate reductase, putative	0.0023	0.0463	0.0445
Trypanosoma cruzi	NADH-cytochrome b5 reductase, putative	0.0023	0.0463	0.0445
Echinococcus granulosus	NADPH cytochrome P450 reductase	0.02	0.7063	1
Brugia malayi	TAR-binding protein	0.0052	0.1564	0.1475
Toxoplasma gondii	ferredoxin NADP+ oxidoreductase FNR	0.0023	0.0463	0.0431
Trypanosoma cruzi	NADH-cytochrome b5 reductase, putative	0.0023	0.0463	0.0445
Loa Loa (eye worm)	flap endonuclease-1	0.0031	0.0758	0.0775
Trypanosoma cruzi	NADH-cytochrome b5 reductase, putative	0.0023	0.0463	0.0445
Trypanosoma cruzi	NADH-dependent fumarate reductase, putative	0.0023	0.0463	0.0445
Trypanosoma brucei	NADH-dependent fumarate reductase	0.0023	0.0463	0.0445
Brugia malayi	FAD binding domain containing protein	0.0124	0.4215	0.4229
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0056	0.1689	0.2985
Plasmodium vivax	flap endonuclease 1, putative	0.0031	0.0758	0.0629
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0019	0.0334	0.0259
Plasmodium vivax	ferredoxin--NADP reductase, putative	0.0023	0.0463	0.0191
Brugia malayi	Cytochrome P450 family protein	0.0015	0.0155	0.0012
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0056	0.1689	0.2013
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0035	0.0925	0.0877
Mycobacterium tuberculosis	Possible oxygenase	0.0023	0.0463	0.0283
Schistosoma mansoni	cytochrome P450 reductase	0.02	0.7063	1
Trypanosoma brucei	NADH-cytochrome b5 reductase-like protein	0.0023	0.0463	0.0445
Trypanosoma cruzi	NADH-dependent fumarate reductase, putative	0.0023	0.0463	0.0445
Plasmodium falciparum	S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative	0.0077	0.2465	0.3166
Brugia malayi	Cytochrome P450 family protein	0.0015	0.0155	0.0012
Trypanosoma cruzi	nitrate reductase, putative	0.0023	0.0463	0.0445
Echinococcus granulosus	histone lysine methyltransferase setb	0.0035	0.0925	0.0877
Trypanosoma brucei	nitrate reductase, putative	0.0023	0.0463	0.0445
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0019	0.0334	0.0259
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0019	0.0334	0.0259
Leishmania major	NADPH-cytochrome p450 reductase-like protein	0.02	0.7063	1
Trypanosoma brucei	NADH-cytochrome b5 reductase, putative	0.0023	0.0463	0.0445
Echinococcus multilocularis	NADPH dependent diflavin oxidoreductase 1	0.02	0.7063	1
Trypanosoma brucei	oxidoreductase-protein, putative	0.0023	0.0463	0.0445
Entamoeba histolytica	type A flavoprotein, putative	0.0077	0.2465	1
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0127	0.4344	0.8837
Toxoplasma gondii	flavodoxin domain-containing protein	0.0099	0.3311	1
Onchocerca volvulus		0.0035	0.0925	0.0484
Trypanosoma brucei	NADH-cytochrome b5 reductase, putative	0.0023	0.0463	0.0445
Loa Loa (eye worm)	thioredoxin reductase	0.0056	0.1689	0.1729
Trypanosoma brucei	NADPH-cytochrome p450 reductase, putative	0.02	0.7063	1
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0034	0.0876	0.0806
Echinococcus multilocularis	NADPH cytochrome P450 reductase	0.02	0.7063	1
Brugia malayi	Flap endonuclease-1	0.0031	0.0758	0.0638
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0019	0.0334	0.0259
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0035	0.0925	0.0877
Plasmodium vivax	hypothetical protein, conserved	0.0077	0.2465	0.3166
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0019	0.0334	0.0259
Loa Loa (eye worm)	glutathione reductase	0.0056	0.1689	0.1729
Leishmania major	trypanothione reductase	0.0056	0.1689	0.222
Brugia malayi	flavodoxin family protein	0.0077	0.2465	0.2411
Trypanosoma cruzi	NADH-cytochrome b5 reductase, putative	0.0023	0.0463	0.0445
Brugia malayi	RNA binding protein	0.0052	0.1564	0.1475
Echinococcus granulosus	methionine synthase reductase	0.0124	0.4215	0.5767
Mycobacterium ulcerans	oxygenase	0.0023	0.0463	0.0445
Trypanosoma brucei	NADPH--cytochrome P450 reductase, putative	0.02	0.7063	1
Mycobacterium tuberculosis	Hypothetical oxidoreductase	0.0023	0.0463	0.0283
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0141	0.4872	1
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0141	0.4872	1
Trypanosoma cruzi	p450 reductase, putative	0.0023	0.0463	0.0445
Trichomonas vaginalis	sulfite reductase, putative	0.02	0.7063	0.6962
Entamoeba histolytica	type A flavoprotein, putative	0.0077	0.2465	1
Trypanosoma brucei	NADH-cytochrome b5 reductase, putative	0.0023	0.0463	0.0445
Plasmodium falciparum	NADH-cytochrome b5 reductase, putative	0.0023	0.0463	0.0191
Mycobacterium ulcerans	flavodoxin reductase Hmp	0.0023	0.0463	0.0445
Entamoeba histolytica	type A flavoprotein, putative	0.0077	0.2465	1
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0141	0.4872	1
Trypanosoma brucei	NADPH--cytochrome P450 reductase, putative	0.02	0.7063	1
Echinococcus multilocularis	flap endonuclease 1	0.0031	0.0758	0.0629
Trypanosoma cruzi	NADH-dependent fumarate reductase, putative	0.0023	0.0463	0.0445
Echinococcus granulosus	NADPH dependent diflavin oxidoreductase 1	0.02	0.7063	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0015	0.0155	0.0159
Loa Loa (eye worm)	TAR-binding protein	0.0052	0.1564	0.1601
Trypanosoma cruzi	NADH-dependent fumarate reductase, putative	0.0023	0.0463	0.0445
Leishmania major	NADH-dependent fumarate reductase-like protein	0.0023	0.0463	0.0445
Trypanosoma brucei	NADH-dependent fumarate reductase, putative	0.0023	0.0463	0.0445
Trichomonas vaginalis	NADPH cytochrome P450, putative	0.0077	0.2465	0.2204
Trypanosoma brucei	NADH-dependent fumarate reductase	0.0023	0.0463	0.0445
Brugia malayi	Pre-SET motif family protein	0.0245	0.874	0.893
Trypanosoma cruzi	cytochrome P450 reductase, putative	0.02	0.7063	1
Trypanosoma brucei	NADH-cytochrome b5 reductase, putative	0.0023	0.0463	0.0445
Brugia malayi	RNA recognition motif domain containing protein	0.0052	0.1564	0.1475
Trypanosoma cruzi	NADH-cytochrome b5 reductase, putative	0.0023	0.0463	0.0445
Leishmania major	NADH-dependent fumarate reductase, putative	0.0023	0.0463	0.0445
Schistosoma mansoni	NADPH flavin oxidoreductase	0.0101	0.3368	0.4508
Plasmodium falciparum	thioredoxin reductase	0.0056	0.1689	0.2013
Echinococcus multilocularis	methionine synthase reductase	0.0124	0.4215	0.5767
Trypanosoma cruzi	NADPH--cytochrome P450 reductase, putative	0.0077	0.2465	0.3343
Brugia malayi	flavodoxin family protein	0.02	0.7063	0.7189
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0019	0.0334	0.0259
Loa Loa (eye worm)	cytochrome P450 family protein	0.0015	0.0155	0.0159
Mycobacterium tuberculosis	Probable reductase	0.0127	0.4344	0.8837
Trypanosoma cruzi	NADH-dependent fumarate reductase, putative	0.0023	0.0463	0.0445
Trypanosoma brucei	NADH-dependent fumarate reductase, putative	0.0023	0.0463	0.0445
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0925	0.0946
Plasmodium falciparum	NADPH--cytochrome P450 reductase, putative	0.0077	0.2465	0.3166
Mycobacterium ulcerans	flavodoxin oxidoreductase	0.0023	0.0463	0.0445
Leishmania major	oxidoreductase-like protein	0.0023	0.0463	0.0445
Trichomonas vaginalis	NADPH cytochrome P450, putative	0.0077	0.2465	0.2204
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0035	0.0925	0.1983
Brugia malayi	FAD binding domain containing protein	0.02	0.7063	0.7189
Brugia malayi	Pre-SET motif family protein	0.0035	0.0925	0.0811
Toxoplasma gondii	thioredoxin reductase	0.0056	0.1689	0.455
Trichomonas vaginalis	NADPH cytochrome P450, putative	0.0077	0.2465	0.2204
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0019	0.0334	0.0259
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0019	0.0334	0.0259
Schistosoma mansoni	tar DNA-binding protein	0.0052	0.1564	0.1827
Mycobacterium ulcerans	oxidoreductase	0.0023	0.0463	0.0445
Leishmania major	cytochrome P450 reductase, putative	0.0178	0.6217	0.8774
Leishmania major	NADH-cytochrome b5 reductase, putative	0.0023	0.0463	0.0445

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 0.0001 M	In vitro inhibitory activity of the compound towards partially purified human placenta aldose reductase	ChEMBL.	3121857

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2310844

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1581444