Detailed information for compound 1582645

Basic information

Technical information
  • TDR Targets ID: 1582645
  • Name: 5-[(2S,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6- dimethyloxan-2-yl]oxy-2-phenyl-N-(phenylmethy l)benzamide
  • MW: 477.549 | Formula: C28H31NO6
  • H donors: 3 H acceptors: 3 LogP: 3.38 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CO[C@@H]1[C@@H](O)[C@@H](O)[C@H](OC1(C)C)Oc1ccc(c(c1)C(=O)NCc1ccccc1)c1ccccc1
  • InChi: 1S/C28H31NO6/c1-28(2)25(33-3)23(30)24(31)27(35-28)34-20-14-15-21(19-12-8-5-9-13-19)22(16-20)26(32)29-17-18-10-6-4-7-11-18/h4-16,23-25,27,30-31H,17H2,1-3H3,(H,29,32)/t23-,24+,25+,27-/m0/s1
  • InChiKey: LHAMLHSJSZJTLB-FCRYVSRXSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-[(2S,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyl-tetrahydropyran-2-yl]oxy-2-phenyl-N-(phenylmethyl)benzamide
  • 5-[[(2S,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyl-2-tetrahydropyranyl]oxy]-2-phenyl-N-(phenylmethyl)benzamide
  • N-(benzyl)-5-[(2S,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyl-tetrahydropyran-2-yl]oxy-2-phenyl-benzamide
  • 5-[(2S,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyl-oxan-2-yl]oxy-2-phenyl-N-(phenylmethyl)benzamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens snurportin 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0026 0.0477
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0397 0.0397
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0026 0.0477
Schistosoma mansoni cpg binding protein 0.0036 0.0243 0.0851
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0005 0.0004 0.0015
Brugia malayi MH1 domain containing protein 0.001 0.0041 0.0041
Brugia malayi kap beta 3 protein 0.0007 0.0018 0.0018
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.0041 0.0143
Echinococcus granulosus importin subunit beta 1 0.0035 0.0238 0.0832
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0166 0.0582
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0238 0.4943
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0032 0.0111
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.0522 0.1825
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0026 0.0477
Loa Loa (eye worm) hypothetical protein 0.0005 0.0008 0.0008
Trichomonas vaginalis helicase, putative 0.0008 0.0026 0.0477
Brugia malayi MH2 domain containing protein 0.001 0.0041 0.0041
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0047 0.0047
Plasmodium vivax importin-beta 2, putative 0.0035 0.0238 1
Loa Loa (eye worm) kap beta 3 protein 0.0007 0.0018 0.0018
Echinococcus multilocularis translational activator gcn1 0.0007 0.0018 0.0063
Echinococcus granulosus transportin 1 0.0007 0.0018 0.0063
Echinococcus granulosus Smad4 0.001 0.0041 0.0143
Schistosoma mansoni ran 0.0026 0.0166 0.0582
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0026 0.0477
Schistosoma mansoni smad1 5 8 and 0.001 0.0041 0.0143
Entamoeba histolytica hypothetical protein 0.0028 0.0187 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0187 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0397 0.1387
Brugia malayi MH1 domain containing protein 0.0005 0.0008 0.0008
Trichomonas vaginalis ran, putative 0.0026 0.0166 0.8795
Echinococcus multilocularis cpg binding protein 0.0036 0.0243 0.0851
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.0041 0.0041
Brugia malayi RNA, U transporter 1 0.0099 0.0737 0.0737
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0026 0.0477
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0048 0.0167
Echinococcus multilocularis importin 5 0.0007 0.0018 0.0063
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0187 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0397 0.1387
Schistosoma mansoni smad1 5 8 and 0.001 0.0041 0.0143
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0238 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0397 0.1387
Loa Loa (eye worm) CXXC zinc finger family protein 0.0034 0.0229 0.0229
Brugia malayi Smad1 0.001 0.0041 0.0041
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0166 0.0582
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.0041 0.0143
Loa Loa (eye worm) nuclear factor I 0.0005 0.0008 0.0008
Onchocerca volvulus 0.0034 0.0229 1
Loa Loa (eye worm) hypothetical protein 0.1289 1 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0026 0.0477
Leishmania major GTP-binding protein, putative 0.0026 0.0166 0.8795
Schistosoma mansoni hypothetical protein 0.0372 0.2859 1
Brugia malayi MH1 domain containing protein 0.001 0.0041 0.0041
Echinococcus granulosus importin 5 0.0007 0.0018 0.0063
Schistosoma mansoni ran 0.0026 0.0166 0.0582
Leishmania major importin beta-1 subunit, putative 0.0028 0.0187 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0026 0.0477
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.0041 0.0143
Echinococcus multilocularis smad 0.001 0.0041 0.0143
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0463 1
Echinococcus multilocularis Smad4 0.001 0.0041 0.0143
Brugia malayi MH1 domain containing protein 0.0005 0.0008 0.0008
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0166 0.6744
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0026 0.0477
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0032 0.0111
Schistosoma mansoni cpg binding protein 0.0036 0.0243 0.0851
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.2859 0.2859
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0166 0.0166
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0397 0.1387
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0026 0.0477
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0166 0.6744
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.0041 0.0143
Echinococcus multilocularis transportin 1 0.0007 0.0018 0.0063
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0166 0.5
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0026 0.0477
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0238 0.0832
Brugia malayi MH2 domain containing protein 0.001 0.0041 0.0041
Schistosoma mansoni Smad4 0.001 0.0041 0.0143
Entamoeba histolytica Ran family GTPase 0.0026 0.0166 0.8795
Schistosoma mansoni cpg binding protein 0.0034 0.0229 0.0799
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0032 0.0111
Schistosoma mansoni smad1 5 8 and 0.001 0.0041 0.0143
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0397 0.1387
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0026 0.0477
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0397 0.0397
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0026 0.0477
Echinococcus granulosus smad 0.001 0.0041 0.0143
Loa Loa (eye worm) MH2 domain-containing protein 0.014 0.1054 0.1054
Brugia malayi Importin beta-1 subunit 0.0035 0.0238 0.0238
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0026 0.0477
Loa Loa (eye worm) Smad1 0.001 0.0041 0.0041
Brugia malayi CXXC zinc finger family protein 0.0034 0.0229 0.0229
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0032 0.0111
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0026 0.0477
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0187 1
Echinococcus granulosus snurportin 1 0.0372 0.2859 1
Plasmodium falciparum importin beta, putative 0.0035 0.0238 1
Loa Loa (eye worm) histone methyltransferase 0.001 0.0048 0.0048
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0187 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0026 0.0477
Loa Loa (eye worm) NNMT/PNMT/TEMT family protein 0.1289 1 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0238 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0032 0.0111
Echinococcus granulosus cpg binding protein 0.0036 0.0243 0.0851
Schistosoma mansoni importin beta-1 0.0035 0.0238 0.0832
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.0041 0.0143
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0166 0.0166
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0048 0.0167
Schistosoma mansoni smad 0.001 0.0041 0.0143
Echinococcus granulosus translational activator gcn1 0.0007 0.0018 0.0063
Echinococcus multilocularis snurportin 1 0.0372 0.2859 1
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.0041 0.0041
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0166 0.6744
Brugia malayi MH2 domain containing protein 0.014 0.1054 0.1054
Loa Loa (eye worm) hypothetical protein 0.1289 1 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0238 0.0238
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0397 0.1387
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0026 0.0477
Loa Loa (eye worm) importin-beta domain-containing protein 0.0007 0.0018 0.0018
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0166 0.3334
Loa Loa (eye worm) transcription factor SMAD2 0.014 0.1054 0.1054
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0397 0.1387
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0026 0.0477
Schistosoma mansoni importin-beta 2 0.0007 0.0018 0.0063

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 6.5131 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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