TDR Targets

Basic information

Technical information

TDR Targets ID: 1583481
Name: N'-(2-fluorophenyl)-N'-methyl-N-(12-oxo-7,8,9 ,10-tetrahydro-6H-azepino[2,1-b]quinazolin-2- yl)propanediamide
MW: 422.452 | Formula: C23H23FN4O3
H donors: 1 H acceptors: 3 LogP: 2.67 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(CC(=O)N(c1ccccc1F)C)Nc1ccc2c(c1)c(=O)n1c(n2)CCCCC1
InChi: 1S/C23H23FN4O3/c1-27(19-8-5-4-7-17(19)24)22(30)14-21(29)25-15-10-11-18-16(13-15)23(31)28-12-6-2-3-9-20(28)26-18/h4-5,7-8,10-11,13H,2-3,6,9,12,14H2,1H3,(H,25,29)
InChiKey: GESTYORCTRAHAU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N'-(2-fluorophenyl)-N-(12-keto-7,8,9,10-tetrahydro-6H-azepino[2,1-b]quinazolin-2-yl)-N'-methyl-malonamide
C865-0104
NCGC00113758-01

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0217	0.1225	1
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0084	0.0413	0.0583
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0217	0.1225	0.4952
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0084	0.0413	0.337
Giardia lamblia	Cathepsin B precursor	0.0084	0.0413	0.1669
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0018	0.0008	0.0012
Brugia malayi	Niemann-Pick C1 protein precursor	0.0088	0.0434	0.0613
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0084	0.0413	0.337
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0084	0.0413	0.337
Brugia malayi	Papain family cysteine protease containing protein	0.0217	0.1225	0.1731
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0048	0.0193	1
Plasmodium vivax	vivapain-3	0.0084	0.0413	0.337
Toxoplasma gondii	cathepsin CPL	0.0217	0.1225	0.4952
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0081	0.0391	0.0552
Trypanosoma cruzi	cruzipain precursor, putative	0.0217	0.1225	0.1731
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0084	0.0413	0.337
Entamoeba histolytica	cysteine proteinase, putative	0.0084	0.0413	0.337
Entamoeba histolytica	cysteine protease, putative	0.0217	0.1225	1
Entamoeba histolytica	cysteine protease, putative	0.0084	0.0413	0.337
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0434	0.0613
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0217	0.1225	0.4952
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0084	0.0413	0.0583
Echinococcus granulosus	expressed conserved protein	0.0082	0.0401	0.0567
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0217	0.1225	1
Loa Loa (eye worm)	hypothetical protein	0.1176	0.7078	1
Plasmodium vivax	serine-repeat antigen (SERA)	0.0084	0.0413	0.337
Trypanosoma brucei	carbonic anhydrase-like protein	0.0172	0.0947	0.3828
Schistosoma mansoni	transcription factor LCR-F1	0.0032	0.0094	0.0132
Brugia malayi	cathepsin B-like cysteine proteinase	0.1176	0.7078	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0018	0.0008	0.0012
Plasmodium falciparum	serine repeat antigen 9	0.0084	0.0413	0.337
Entamoeba histolytica	cysteine protease, putative	0.0084	0.0413	0.337
Onchocerca volvulus		0.0217	0.1225	1
Entamoeba histolytica	cysteine proteinase, putative	0.0084	0.0413	0.337
Loa Loa (eye worm)	hypothetical protein	0.0217	0.1225	0.1731
Brugia malayi	Cathepsin L-like precursor	0.0217	0.1225	0.1731
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0217	0.1225	0.4952
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0084	0.0413	0.337
Loa Loa (eye worm)	hypothetical protein	0.0217	0.1225	0.1731
Echinococcus granulosus	cathepsin L	0.0084	0.0413	0.0583
Giardia lamblia	Cathepsin B precursor	0.0422	0.2474	1
Leishmania major	cathepsin L-like protease	0.0217	0.1225	0.4952
Schistosoma mansoni	patched 1	0.0038	0.0128	0.018
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0422	0.2474	0.3496
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0217	0.1225	1
Mycobacterium ulcerans	hypothetical protein	0.0048	0.0193	1
Giardia lamblia	Cathepsin L precursor	0.0084	0.0413	0.1669
Plasmodium falciparum	serine repeat antigen 6	0.0084	0.0413	0.337
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0172	0.0947	0.1338
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0413	0.0583
Plasmodium falciparum	serine repeat antigen 8	0.0084	0.0413	0.337
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0084	0.0413	0.1669
Plasmodium vivax	vivapain-2	0.0217	0.1225	1
Brugia malayi	Papain family cysteine protease containing protein	0.0084	0.0413	0.0583
Schistosoma mansoni	hypothetical protein	0.0018	0.0008	0.0012
Echinococcus multilocularis	cathepsin L cysteine protease	0.0217	0.1225	0.1225
Echinococcus multilocularis	carbonic anhydrase	0.0081	0.0391	0.0391
Schistosoma mansoni	cathepsin F (C01 family)	0.0217	0.1225	0.1731
Brugia malayi	cathepsin L-like precursor	0.0217	0.1225	0.1731
Echinococcus granulosus	cathepsin l1	0.0217	0.1225	0.1731
Schistosoma mansoni	cathepsin S (C01 family)	0.0084	0.0413	0.0583
Entamoeba histolytica	cysteine proteinase, putative	0.0084	0.0413	0.337
Giardia lamblia	Cysteine protease	0.0084	0.0413	0.1669
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0193	0.0273
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0118	0.0167
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0217	0.1225	0.4952
Giardia lamblia	Cysteine protease	0.0084	0.0413	0.1669
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0422	0.2474	1
Onchocerca volvulus	Cathepsin F homolog	0.0217	0.1225	1
Echinococcus granulosus	cathepsin L	0.0084	0.0413	0.0583
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0084	0.0413	0.1669
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0413	0.0583
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0057	0.0247	0.0349
Schistosoma mansoni	hypothetical protein	0.0043	0.016	0.0226
Giardia lamblia	Encystation-specific protease	0.0084	0.0413	0.1669
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0084	0.0413	0.1669
Entamoeba histolytica	cysteine protease, putative	0.0084	0.0413	0.337
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0048	0.0193	1
Onchocerca volvulus		0.0217	0.1225	1
Trichomonas vaginalis	conserved hypothetical protein	0.0084	0.0413	0.1669
Leishmania major	cathepsin L-like protease	0.0217	0.1225	0.4952
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0048	0.0193	1
Giardia lamblia	Hypothetical protein	0.0084	0.0413	0.1669
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0084	0.0413	0.1669
Echinococcus granulosus	GPCR family 2	0.0018	0.0008	0.0012
Schistosoma mansoni	cellular tumor antigen P53	0.006	0.0262	0.0371
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0036	0.0118	0.5
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0084	0.0413	0.0583
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0084	0.0413	0.1669
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0048	0.0193	0.5
Loa Loa (eye worm)	hypothetical protein	0.0217	0.1225	0.1731
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0217	0.1225	0.4952
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0038	0.0128	0.018
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0084	0.0413	0.0583
Loa Loa (eye worm)	hypothetical protein	0.0217	0.1225	0.1731
Echinococcus granulosus	carbonic anhydrase	0.0081	0.0391	0.0552
Brugia malayi	Papain family cysteine protease containing protein	0.0084	0.0413	0.0583
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0118	0.0167
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0036	0.0118	0.613
Plasmodium falciparum	serine repeat antigen 4	0.0084	0.0413	0.337
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0193	0.0273
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0084	0.0413	0.337
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0084	0.0413	0.1669
Echinococcus granulosus	cysteine protease	0.0084	0.0413	0.0583
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0084	0.0413	0.0583
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0084	0.0413	0.1669
Schistosoma mansoni	hypothetical protein	0.0032	0.0094	0.0132
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0084	0.0413	0.0583
Brugia malayi	AMP-binding enzyme family protein	0.0048	0.0193	0.0273
Leishmania major	cathepsin L-like protease	0.0217	0.1225	0.4952
Schistosoma mansoni	hypothetical protein	0.0039	0.0137	0.0193
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0084	0.0413	0.0583
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0084	0.0413	0.1669
Trypanosoma cruzi	cysteine peptidase, putative	0.0217	0.1225	0.1731
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0217	0.1225	0.4952
Entamoeba histolytica	hypothetical protein	0.0032	0.0094	0.0763
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0032	0.0094	0.0094
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0172	0.0947	0.1338
Loa Loa (eye worm)	cysteine protease	0.0217	0.1225	0.1731
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0081	0.0391	0.0552
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0084	0.0413	0.337
Schistosoma mansoni	hypothetical protein	0.0036	0.0119	0.0169
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0084	0.0413	0.0583
Schistosoma mansoni	cathepsin B (C01 family)	0.0084	0.0413	0.0583
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0217	0.1225	0.4952
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0084	0.0413	0.0583
Trichomonas vaginalis	conserved hypothetical protein	0.0084	0.0413	0.1669
Entamoeba histolytica	cysteine protease, putative	0.0084	0.0413	0.337
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0048	0.0193	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1176	0.7078	1
Schistosoma mansoni	hypothetical protein	0.0081	0.0391	0.0552
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0247	0.0349
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0008	0.0012
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0081	0.0391	0.0552
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0088	0.0434	0.354
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0018	0.0008	0.0012
Schistosoma mansoni	hypothetical protein	0.0036	0.0119	0.0169
Leishmania major	cathepsin L-like protease	0.0217	0.1225	0.4952
Echinococcus granulosus	carbonic anhydrase	0.0081	0.0391	0.0552
Echinococcus multilocularis	expressed conserved protein	0.0082	0.0401	0.0401
Brugia malayi	Cathepsin L-like precursor	0.0217	0.1225	0.1731
Brugia malayi	Papain family cysteine protease containing protein	0.0084	0.0413	0.0583
Echinococcus multilocularis	sterol regulatory element binding protein	0.0038	0.0128	0.0128
Echinococcus multilocularis	protein patched	0.0038	0.0128	0.0128
Echinococcus multilocularis	protein dispatched 1	0.0043	0.016	0.016
Brugia malayi	MH2 domain containing protein	0.0106	0.0548	0.0774
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0137	0.0193
Loa Loa (eye worm)	carbonic anhydrase 3	0.0172	0.0947	0.1338
Onchocerca volvulus		0.0048	0.0193	0.0307
Schistosoma mansoni	carbonic anhydrase-related	0.0081	0.0391	0.0552
Leishmania major	4-coumarate:coa ligase-like protein	0.0048	0.0193	0.078
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0217	0.1225	0.4952
Entamoeba histolytica	hypothetical protein	0.0032	0.0094	0.0763
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0084	0.0413	0.1669
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0217	0.1225	0.4952
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0034	0.0106	0.5505
Plasmodium vivax	serine-repeat antigen (SERA)	0.0084	0.0413	0.337
Trypanosoma cruzi	cysteine peptidase, putative	0.0217	0.1225	0.1731
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0084	0.0413	0.0583
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0217	0.1225	0.1731
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0048	0.0193	0.1575
Echinococcus multilocularis	cathepsin b	0.1176	0.7078	0.7078
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0217	0.1225	0.1731
Schistosoma mansoni	hypothetical protein	0.0036	0.0119	0.0169
Brugia malayi	Cathepsin L-like precursor	0.0217	0.1225	0.1731
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0217	0.1225	0.4952
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0217	0.1225	0.4952
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0036	0.0118	0.613
Entamoeba histolytica	cysteine protease, putative	0.0084	0.0413	0.337
Plasmodium vivax	acyl-CoA synthetase, putative	0.0036	0.0118	0.0965
Echinococcus multilocularis	carbonic anhydrase	0.0081	0.0391	0.0391
Echinococcus granulosus	tumor protein p63	0.0408	0.239	0.3376
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0057	0.0247	0.0349
Brugia malayi	AMP-binding enzyme family protein	0.0048	0.0193	0.0273
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0084	0.0413	0.1669
Toxoplasma gondii	cathepsin CPC2	0.0084	0.0413	0.1669
Mycobacterium ulcerans	acyl-CoA synthetase	0.0048	0.0193	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0106	0.0548	0.0774
Echinococcus granulosus	sterol regulatory element binding protein	0.0038	0.0128	0.018
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0018	0.0008	0.0012
Schistosoma mansoni	hypothetical protein	0.0018	0.0008	0.0012
Plasmodium falciparum	serine repeat antigen 1	0.0084	0.0413	0.337
Entamoeba histolytica	cysteine proteinase, putative	0.0084	0.0413	0.337
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0057	0.0247	0.0349
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0422	0.2474	0.3496
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.0172	0.0947	0.1338
Giardia lamblia	Cathepsin L-like protease	0.0084	0.0413	0.1669
Loa Loa (eye worm)	hypothetical protein	0.0211	0.1185	0.1675
Brugia malayi	Cathepsin L-like precursor	0.0217	0.1225	0.1731
Leishmania major	cathepsin L-like protease	0.0217	0.1225	0.4952
Plasmodium falciparum	carbonic anhydrase	0.0081	0.0391	0.3187
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0089	0.0442	0.0625
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0084	0.0413	0.0583
Entamoeba histolytica	cysteine protease, putative	0.0084	0.0413	0.337
Loa Loa (eye worm)	ctsf protein	0.0217	0.1225	0.1731
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0413	0.0583
Entamoeba histolytica	cysteine protease, putative	0.0084	0.0413	0.337
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0048	0.0193	0.1575
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0034	0.0106	0.5505
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0084	0.0413	0.337
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0084	0.0413	0.1669
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0413	0.0583
Echinococcus multilocularis	GPCR, family 2	0.0018	0.0008	0.0008
Entamoeba histolytica	cysteine proteinase, putative	0.0217	0.1225	1
Schistosoma mansoni	hypothetical protein	0.0018	0.0008	0.0012
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0217	0.1225	0.4952
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0084	0.0413	0.1669
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0128	0.0516
Plasmodium vivax	vivapain-2	0.0217	0.1225	1
Plasmodium falciparum	serine repeat antigen 2	0.0084	0.0413	0.337
Schistosoma mansoni	carbonic anhydrase	0.0081	0.0391	0.0552
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0084	0.0413	0.1669
Onchocerca volvulus		0.0217	0.1225	1
Entamoeba histolytica	hypothetical protein	0.0032	0.0094	0.0763
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0084	0.0413	0.1669
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0172	0.0947	0.1338
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0172	0.0947	0.1338
Loa Loa (eye worm)	cathepsin B	0.0422	0.2474	0.3496
Toxoplasma gondii	hypothetical protein	0.0081	0.0391	0.1579
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0084	0.0413	0.337
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0172	0.0947	0.1338
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0032	0.0094	0.0132
Plasmodium falciparum	serine repeat antigen 5	0.0084	0.0413	0.337
Plasmodium falciparum	acyl-CoA synthetase	0.0036	0.0118	0.0965
Echinococcus multilocularis	carbonic anhydrase II	0.0172	0.0947	0.0947
Onchocerca volvulus	Cathepsin L homolog	0.0217	0.1225	1
Giardia lamblia	Cathepsin L precursor	0.0084	0.0413	0.1669
Echinococcus multilocularis	Niemann Pick C1 protein	0.0125	0.0664	0.0664
Echinococcus granulosus	Protein patched homolog 1	0.0038	0.0128	0.018
Plasmodium falciparum	serine repeat antigen 7	0.0084	0.0413	0.337
Trypanosoma cruzi	cysteine proteinase, putative	0.0084	0.0413	0.0583
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0084	0.0413	0.0583
Entamoeba histolytica	cysteine proteinase 1, putative	0.0084	0.0413	0.337
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0018	0.0008	0.0008
Giardia lamblia	Cathepsin B precursor	0.0084	0.0413	0.1669
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0217	0.1225	0.4952
Echinococcus granulosus	cathepsin b	0.1176	0.7078	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0217	0.1225	0.1225
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0084	0.0413	0.1669
Entamoeba histolytica	cysteine protease, putative	0.0084	0.0413	0.337
Schistosoma mansoni	carbonic anhydrase-related	0.0081	0.0391	0.0552
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.1176	0.7078	1
Brugia malayi	CHE-14 protein	0.0038	0.0128	0.018
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0217	0.1225	0.4952
Giardia lamblia	Cathepsin B precursor	0.0422	0.2474	1
Echinococcus granulosus	cathepsin l1	0.0217	0.1225	0.1731
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0217	0.1225	0.4952
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0217	0.1225	0.4952
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0193	0.0273
Brugia malayi	Cathepsin L-like precursor	0.0217	0.1225	0.1731
Brugia malayi	Cathepsin L-like precursor	0.0217	0.1225	0.1731
Schistosoma mansoni	hypothetical protein	0.0036	0.0119	0.0169
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0084	0.0413	0.1669
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0084	0.0413	0.337
Entamoeba histolytica	cysteine protease, putative	0.0084	0.0413	0.337
Echinococcus multilocularis	survival motor neuron protein 1	0.0211	0.1185	0.1185
Trypanosoma cruzi	cysteine peptidase, putative	0.0217	0.1225	0.1731
Brugia malayi	hypothetical protein	0.0032	0.0094	0.0132
Giardia lamblia	Cathepsin B precursor	0.0084	0.0413	0.1669
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0413	0.0583
Giardia lamblia	Cathepsin L-like protease	0.0084	0.0413	0.1669
Onchocerca volvulus		0.0084	0.0413	0.2372
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0084	0.0413	0.337
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0048	0.0193	1
Giardia lamblia	Cathepsin B precursor	0.0084	0.0413	0.1669
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0084	0.0413	0.0583
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0217	0.1225	0.4952
Schistosoma mansoni	carbonic anhydrase-related	0.0081	0.0391	0.0552
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0217	0.1225	0.1225
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0217	0.1225	0.4952
Brugia malayi	Papain family cysteine protease containing protein	0.0084	0.0413	0.0583
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0217	0.1225	0.4952
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0084	0.0413	0.1669
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0217	0.1225	0.4952
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0217	0.1225	0.4952
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0217	0.1225	0.4952
Schistosoma mansoni	cathepsin F (C01 family)	0.0217	0.1225	0.1731
Giardia lamblia	Cathepsin L precursor	0.0084	0.0413	0.1669
Toxoplasma gondii	cathepsin CPC1	0.0084	0.0413	0.1669
Brugia malayi	Cathepsin L-like precursor	0.0217	0.1225	0.1731
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0217	0.1225	0.1731
Onchocerca volvulus		0.0217	0.1225	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0084	0.0413	0.1669
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0084	0.0413	0.337
Trypanosoma cruzi	cysteine proteinase, putative	0.0084	0.0413	0.0583
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0217	0.1225	0.4952
Entamoeba histolytica	cysteine protease, putative	0.0084	0.0413	0.337
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0084	0.0413	0.0583
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0084	0.0413	0.1669
Mycobacterium ulcerans	acyl-CoA synthetase	0.0048	0.0193	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0217	0.1225	0.4952
Trypanosoma cruzi	cysteine protease, putative	0.0084	0.0413	0.0583
Entamoeba histolytica	cysteine protease, putative	0.0084	0.0413	0.337
Leishmania major	4-coumarate:coa ligase-like protein	0.0048	0.0193	0.078
Brugia malayi	Papain family cysteine protease containing protein	0.0084	0.0413	0.0583
Brugia malayi	Cathepsin L-like precursor	0.0217	0.1225	0.1731
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0084	0.0413	0.0583
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0048	0.0193	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0217	0.1225	0.4952
Giardia lamblia	Cysteine protease	0.0084	0.0413	0.1669
Entamoeba histolytica	acyl-coA synthetase, putative	0.0048	0.0193	0.1575
Entamoeba histolytica	cysteine protease, putative	0.0084	0.0413	0.337
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0118	0.0167
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0217	0.1225	1
Onchocerca volvulus		0.0217	0.1225	1
Schistosoma mansoni	hypothetical protein	0.0018	0.0008	0.0012
Entamoeba histolytica	hypothetical protein	0.0032	0.0094	0.0763
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0217	0.1225	0.4952
Echinococcus granulosus	Niemann Pick C1 protein	0.0125	0.0664	0.0938
Onchocerca volvulus		0.006	0.0262	0.0958
Leishmania major	cathepsin L-like protease	0.0217	0.1225	0.4952
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0391	0.0552
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0084	0.0413	0.1669
Schistosoma mansoni	cathepsin F (C01 family)	0.0217	0.1225	0.1731
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0081	0.0391	0.0552
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0391	0.0552
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0128	0.018
Entamoeba histolytica	cysteine proteinase, putative	0.0217	0.1225	1
Leishmania major	cathepsin L-like protease	0.0217	0.1225	0.4952
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1176	0.7078	1
Onchocerca volvulus	Cathepsin L homolog	0.0084	0.0413	0.2372
Mycobacterium ulcerans	acyl-CoA synthetase	0.0048	0.0193	1
Plasmodium vivax	unspecified product	0.0084	0.0413	0.337
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0217	0.1225	0.4952
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0084	0.0413	0.337
Schistosoma mansoni	cathepsin C	0.0084	0.0413	0.0583
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0172	0.0947	0.1338
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0048	0.0193	0.5
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0084	0.0413	0.1669
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0018	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0413	0.0583
Echinococcus multilocularis	cathepsin L	0.0084	0.0413	0.0413
Toxoplasma gondii	cathepsin B	0.0422	0.2474	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0217	0.1225	0.4952
Trypanosoma cruzi	major cysteine proteinase, putative	0.0084	0.0413	0.0583
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0118	0.0167
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0217	0.1225	0.4952
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0217	0.1225	0.4952
Schistosoma mansoni	survival motor neuron protein	0.0043	0.016	0.0226
Giardia lamblia	Cathepsin B precursor	0.0084	0.0413	0.1669
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0034	0.0106	0.5505
Leishmania major	cysteine peptidase A (CPA)	0.0217	0.1225	0.4952
Leishmania major	carbonic anhydrase-like protein	0.0172	0.0947	0.3828
Echinococcus granulosus	cathepsin b	0.1176	0.7078	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0084	0.0413	0.0583
Plasmodium vivax	unspecified product	0.0084	0.0413	0.337
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0081	0.0391	0.0552
Giardia lamblia	Cathepsin L precursor	0.0084	0.0413	0.1669
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0084	0.0413	0.337
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0084	0.0413	0.0583
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0217	0.1225	0.1731
Echinococcus granulosus	carbonic anhydrase	0.0081	0.0391	0.0552
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0081	0.0391	0.0552
Giardia lamblia	Hypothetical protein	0.0084	0.0413	0.1669
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0084	0.0413	0.1669
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0084	0.0413	0.0583
Leishmania major	4-coumarate:coa ligase-like protein	0.0048	0.0193	0.078
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0084	0.0413	0.1669
Entamoeba histolytica	cysteine protease, putative	0.0084	0.0413	0.337
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1176	0.7078	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0391	0.0552
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0084	0.0413	0.337
Onchocerca volvulus		0.0217	0.1225	1
Entamoeba histolytica	cysteine protease, putative	0.0084	0.0413	0.337
Echinococcus multilocularis	tumor protein p63	0.0408	0.239	0.239
Brugia malayi	latrophilin 2 splice variant baaae	0.0039	0.0137	0.0193
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0217	0.1225	0.4952
Trypanosoma cruzi	cysteine peptidase, putative	0.0084	0.0413	0.0583
Echinococcus granulosus	carbonic anhydrase II	0.0172	0.0947	0.1338
Loa Loa (eye worm)	MH2 domain-containing protein	0.0106	0.0548	0.0774
Brugia malayi	hypothetical protein	0.0211	0.1185	0.1675
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0217	0.1225	0.1731
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0084	0.0413	0.1669
Echinococcus multilocularis	cathepsin b	0.1176	0.7078	0.7078
Entamoeba histolytica	cysteine protease, putative	0.0084	0.0413	0.337
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0217	0.1225	0.1731
Plasmodium falciparum	serine repeat antigen 3	0.0084	0.0413	0.337
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0217	0.1225	0.4952
Plasmodium vivax	vivapain-1	0.0084	0.0413	0.337
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0034	0.0106	0.5505
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1176	0.7078	1
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0017	0	0.5
Brugia malayi	Latrophilin receptor protein 2	0.0018	0.0008	0.0012
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0217	0.1225	0.4952
Brugia malayi	cathepsin L precursor	0.0084	0.0413	0.0583
Loa Loa (eye worm)	hypothetical protein	0.006	0.0262	0.0371
Brugia malayi	cathepsin F-like cysteine proteinase	0.0084	0.0413	0.0583
Entamoeba histolytica	cysteine proteinase, putative	0.0217	0.1225	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0217	0.1225	0.4952
Giardia lamblia	Cathepsin L precursor	0.0084	0.0413	0.1669
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0217	0.1225	0.1225
Leishmania major	cathepsin L-like protease	0.0217	0.1225	0.4952
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0084	0.0413	0.1669
Loa Loa (eye worm)	fibroinase	0.0217	0.1225	0.1731
Echinococcus granulosus	Niemann Pick C1 protein	0.0088	0.0434	0.0613
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0084	0.0413	0.0583
Entamoeba histolytica	cysteine proteinase 2	0.0084	0.0413	0.337
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0217	0.1225	0.4952
Onchocerca volvulus	Cathepsin L homolog	0.0217	0.1225	1
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0043	0.016	0.0226
Echinococcus multilocularis	Niemann Pick C1 protein	0.0088	0.0434	0.0434
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0422	0.2474	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0084	0.0413	0.1669
Onchocerca volvulus		0.0217	0.1225	1
Echinococcus multilocularis	carbonic anhydrase	0.0081	0.0391	0.0391
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0179	0.0254
Entamoeba histolytica	cysteine protease, putative	0.0084	0.0413	0.337
Giardia lamblia	Cathepsin L precursor	0.0084	0.0413	0.1669
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0217	0.1225	0.4952
Brugia malayi	fibroinase precursor	0.0084	0.0413	0.0583
Brugia malayi	cathepsin L-like cysteine proteinase	0.0084	0.0413	0.0583
Entamoeba histolytica	hypothetical protein	0.0084	0.0413	0.337
Echinococcus granulosus	survival motor neuron protein 1	0.0211	0.1185	0.1675
Entamoeba histolytica	cysteine protease, putative	0.0084	0.0413	0.337
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0118	0.0167
Echinococcus multilocularis	cysteine protease	0.0217	0.1225	0.1225
Entamoeba histolytica	cysteine protease, putative	0.0084	0.0413	0.337
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0217	0.1225	0.4952
Echinococcus multilocularis	cathepsin L	0.0084	0.0413	0.0413
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0017	0	0.5
Brugia malayi	AMP-binding enzyme family protein	0.0048	0.0193	0.0273
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0084	0.0413	0.337
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0217	0.1225	0.4952
Entamoeba histolytica	cysteine protease, putative	0.0084	0.0413	0.337
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0422	0.2474	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0217	0.1225	0.1731
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0084	0.0413	0.0583
Echinococcus granulosus	cathepsin L cysteine protease	0.0084	0.0413	0.0583
Echinococcus multilocularis	cysteine protease	0.0217	0.1225	0.1225
Giardia lamblia	Cysteine protease	0.0084	0.0413	0.1669
Giardia lamblia	Cathepsin B precursor	0.0422	0.2474	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1887223

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1583481