Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Serotonin transporter | Starlite/ChEMBL | References |
Rattus norvegicus | Norepinephrine transporter | Starlite/ChEMBL | References |
Rattus norvegicus | Dopamine transporter | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0349 | 0.0258 | 0.5 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.1512 | 0.7083 | 0.7083 |
Loa Loa (eye worm) | hypothetical protein | 0.077 | 0.2728 | 0.2728 |
Echinococcus granulosus | integrin beta 2 | 0.1488 | 0.6944 | 1 |
Schistosoma mansoni | integrin alpha | 0.0981 | 0.3965 | 0.7575 |
Echinococcus multilocularis | integrin alpha ps | 0.044 | 0.0789 | 0.0795 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0349 | 0.0258 | 0.0258 |
Echinococcus multilocularis | integrin alpha ps | 0.044 | 0.0789 | 0.0795 |
Echinococcus multilocularis | integrin alpha 3 | 0.0752 | 0.2621 | 0.3535 |
Echinococcus granulosus | integrin alpha 3 | 0.0752 | 0.2621 | 0.3535 |
Loa Loa (eye worm) | hypothetical protein | 0.0541 | 0.1384 | 0.1384 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0349 | 0.0258 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0742 | 0.2563 | 0.2563 |
Echinococcus granulosus | integrin alpha ps | 0.044 | 0.0789 | 0.0795 |
Toxoplasma gondii | kringle domain-containing protein | 0.0349 | 0.0258 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0349 | 0.0258 | 0.0258 |
Schistosoma mansoni | integrin beta subunit | 0.1183 | 0.5152 | 1 |
Schistosoma mansoni | integrin alpha-ps | 0.044 | 0.0789 | 0.1086 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0981 | 0.3965 | 0.3965 |
Brugia malayi | Protein kinase domain containing protein | 0.0349 | 0.0258 | 0.0258 |
Brugia malayi | Kringle domain containing protein | 0.0349 | 0.0258 | 0.0258 |
Echinococcus multilocularis | integrin beta 2 | 0.1488 | 0.6944 | 1 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0349 | 0.0258 | 0.5 |
Onchocerca volvulus | 0.0349 | 0.0258 | 0.5 | |
Leishmania major | hypothetical protein, conserved | 0.0349 | 0.0258 | 0.5 |
Loa Loa (eye worm) | integrin beta-2 | 0.2009 | 1 | 1 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.0742 | 0.2563 | 0.2563 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.14 nM | 50% Inhibition against dopamine transporter (DAT) in rat striatal tissue by displacing [3H]WIN35,428 radioligand | ChEMBL. | 12190324 |
IC50 (binding) | = 10.8 nM | 50% Inhibition against Norepinephrin transpoter in rat cerebral cortex by displacing [3H]-nisoxatine radioligand | ChEMBL. | 12190324 |
IC50 (binding) | = 234 nM | 50% Inhibition against Serotonin transporter in rat midbrain tissue by displacing [3H]-paroxetine radioligand | ChEMBL. | 12190324 |
Ki (binding) | = 6.5 nM | Tested for the binding affinity towards Norepinephrin transpoter in rat cerebral cortex by displacing [3H]-nisoxatine radioligand | ChEMBL. | 12190324 |
Ki (binding) | = 21.3 nM | Tested for the binding affinity towards Serotonin transporter in rat midbrain tissue by displacing [3H]-paroxetine radioligand | ChEMBL. | 12190324 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.