Detailed information for compound 1594634

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 444.482 | Formula: C25H24N4O4
  • H donors: 2 H acceptors: 5 LogP: 3.91 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc2c(c1)cccc2)Nc1ccc(cc1)c1nnc(n1C)OCC(C(=O)O)(C)C
  • InChi: 1S/C25H24N4O4/c1-25(2,23(31)32)15-33-24-28-27-21(29(24)3)17-10-12-20(13-11-17)26-22(30)19-9-8-16-6-4-5-7-18(16)14-19/h4-14H,15H2,1-3H3,(H,26,30)(H,31,32)
  • InChiKey: ONAIAPRXRRJXAV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens diacylglycerol O-acyltransferase 1 Starlite/ChEMBL References
Mus musculus diacylglycerol O-acyltransferase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Diacylglycerol O-acyltransferase 1, putative Get druggable targets OG5_128200 All targets in OG5_128200
Neospora caninum sterol O-acyltransferase, putative Get druggable targets OG5_128200 All targets in OG5_128200
Candida albicans Acyl-CoA cholesterol acyltransferase Get druggable targets OG5_128200 All targets in OG5_128200
Cryptosporidium parvum diacylglycerol acyltransferase 1 Get druggable targets OG5_128200 All targets in OG5_128200
Brugia malayi diacylglycerol acyltransferase Get druggable targets OG5_128200 All targets in OG5_128200
Plasmodium yoelii acyl transferase-related Get druggable targets OG5_128200 All targets in OG5_128200
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha Get druggable targets OG5_128200 All targets in OG5_128200
Plasmodium knowlesi diacylglycerol O-acyltransferase, putative Get druggable targets OG5_128200 All targets in OG5_128200
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme Get druggable targets OG5_128200 All targets in OG5_128200
Schistosoma japonicum Diacylglycerol O-acyltransferase 1, putative Get druggable targets OG5_128200 All targets in OG5_128200
Echinococcus granulosus diacylglycerol O acyltransferase 1 Get druggable targets OG5_128200 All targets in OG5_128200
Babesia bovis diacylglycerol acyltransferase, putative Get druggable targets OG5_128200 All targets in OG5_128200
Neospora caninum diacylglycerol acyltransferase, putative Get druggable targets OG5_128200 All targets in OG5_128200
Plasmodium falciparum diacylglycerol O-acyltransferase Get druggable targets OG5_128200 All targets in OG5_128200
Plasmodium vivax diacylglycerol O-acyltransferase, putative Get druggable targets OG5_128200 All targets in OG5_128200
Cryptosporidium hominis acyl-CoA:diacylglycerol acyltransferase 1-related enzyme Get druggable targets OG5_128200 All targets in OG5_128200
Schistosoma mansoni diacylglycerol O-acyltransferase 1 Get druggable targets OG5_128200 All targets in OG5_128200
Plasmodium berghei diacylglycerol O-acyltransferase, putative Get druggable targets OG5_128200 All targets in OG5_128200
Candida albicans Acyl-CoA cholesterol acyltransferase Get druggable targets OG5_128200 All targets in OG5_128200
Schistosoma japonicum ko:K00635 diacylglycerol O-acyltransferase [EC2.3.1.20], putative Get druggable targets OG5_128200 All targets in OG5_128200
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128200 All targets in OG5_128200
Loa Loa (eye worm) diacylglycerol acyltransferase Get druggable targets OG5_128200 All targets in OG5_128200
Theileria parva diacylglycerol O-acyltransferase, putative Get druggable targets OG5_128200 All targets in OG5_128200
Echinococcus multilocularis diacylglycerol O acyltransferase 1 Get druggable targets OG5_128200 All targets in OG5_128200
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi RhoGAP domain containing protein 0.006 0.0096 0.0418
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0315 0.5084
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0084 0.0315 0.1378
Schistosoma mansoni serine/threonine protein kinase 0.0084 0.0315 0.1378
Brugia malayi hypothetical protein 0.0127 0.0691 0.3019
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0307 0.2289 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0096 0.0096
Onchocerca volvulus 0.006 0.0096 0.0078
Brugia malayi 6-phosphofructokinase 0.0116 0.0598 0.2612
Echinococcus multilocularis Rac GTPase activating protein 1 0.006 0.0096 0.0418
Loa Loa (eye worm) hhat protein 0.0052 0.0023 0.0023
Trichomonas vaginalis penicillin-binding protein, putative 0.0069 0.0176 0.2652
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0069 0.0176 0.0176
Brugia malayi protein kinase C II. 0.0144 0.0846 0.3694
Loa Loa (eye worm) hypothetical protein 0.006 0.0096 0.0096
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0084 0.0315 0.1378
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0062 0.0112 0.0489
Trypanosoma brucei rac serine-threonine kinase, putative 0.0084 0.0315 0.5084
Loa Loa (eye worm) hypothetical protein 0.006 0.0096 0.0096
Echinococcus multilocularis geminin 0.0142 0.0828 0.3616
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0052 0.0023 0.0102
Brugia malayi Hr1 repeat family protein 0.0084 0.0315 0.1378
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0052 0.0023 0.0102
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0052 0.0023 0.0102
Loa Loa (eye worm) hypothetical protein 0.006 0.0096 0.0096
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0315 0.5084
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0052 0.0023 0.0102
Entamoeba histolytica protein kinase, putative 0.0084 0.0315 0.5084
Brugia malayi Variant SH3 domain containing protein 0.006 0.0096 0.0418
Echinococcus granulosus o acyltransferase membrane bound domain 0.0052 0.0023 0.0102
Schistosoma mansoni diacylglycerol kinase theta 0.006 0.0096 0.0418
Loa Loa (eye worm) phosphofructokinase 0.0116 0.0598 0.0598
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0116 0.0598 1
Leishmania major hypothetical protein, conserved 0.0069 0.0176 0.2652
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.006 0.0096 0.0418
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0307 0.2289 0.2289
Entamoeba histolytica hypothetical protein 0.006 0.0096 0.126
Brugia malayi MBOAT family protein 0.0052 0.0023 0.0102
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0052 0.0023 0.0102
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0084 0.0315 0.1378
Echinococcus multilocularis serine:threonine protein kinase N2 0.0084 0.0315 0.1378
Echinococcus granulosus o acyltransferase membrane bound domain 0.0052 0.0023 0.0102
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0307 0.2289 1
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0315 0.5084
Echinococcus granulosus unc 13 munc13 0.006 0.0096 0.0418
Echinococcus multilocularis serine:threonine protein kinase N2 0.0084 0.0315 0.1378
Loa Loa (eye worm) transcription factor SMAD2 0.01 0.0455 0.0455
Brugia malayi Pleckstrin Homology Domain 0.006 0.0096 0.0418
Loa Loa (eye worm) hypothetical protein 0.0127 0.0691 0.0691
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0116 0.0598 0.1284
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0315 0.5084
Schistosoma mansoni hypothetical protein 0.0142 0.0828 0.3616
Brugia malayi p70 ribosomal S6 kinase beta 0.0084 0.0315 0.1378
Echinococcus granulosus serine:threonine protein kinase N2 0.0084 0.0315 0.1378
Loa Loa (eye worm) hypothetical protein 0.0069 0.0176 0.0176
Schistosoma mansoni serine/threonine protein kinase 0.0084 0.0315 0.1378
Echinococcus multilocularis serine:threonine protein kinase 38 0.0084 0.0315 0.1378
Brugia malayi phosphofructokinase 0.0116 0.0598 0.2612
Brugia malayi Protein kinase domain containing protein 0.0062 0.0112 0.0489
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0307 0.2289 1
Loa Loa (eye worm) raf kinase 0.006 0.0096 0.0096
Loa Loa (eye worm) 6-phosphofructokinase 0.0116 0.0598 0.0598
Echinococcus granulosus raf serine:threonine protein kinase 0.006 0.0096 0.0418
Schistosoma mansoni protein kinase C mu 0.006 0.0096 0.0418
Loa Loa (eye worm) RasGEF domain-containing protein 0.006 0.0096 0.0096
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0052 0.0023 0.0102
Brugia malayi diacylglycerol kinase 0.006 0.0096 0.0418
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.006 0.0096 0.0418
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0084 0.0315 0.0315
Entamoeba histolytica protein kinase, putative 0.0084 0.0315 0.5084
Loa Loa (eye worm) hypothetical protein 0.109 0.925 0.925
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0062 0.0112 0.0112
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0052 0.0023 0.0102
Loa Loa (eye worm) hypothetical protein 0.0069 0.0176 0.0176
Schistosoma mansoni hypothetical protein 0.0052 0.0023 0.0102
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0112 0.0489
Loa Loa (eye worm) hypothetical protein 0.109 0.925 0.925
Echinococcus multilocularis myotubularin protein 13 0.006 0.0096 0.0418
Echinococcus granulosus sterol O acyltransferase 1 0.0052 0.0023 0.0102
Loa Loa (eye worm) RhoGAP domain-containing protein 0.006 0.0096 0.0096
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.0598 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0069 0.0176 0.0768
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0084 0.0315 0.0315
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0144 0.0846 0.3694
Brugia malayi MBOAT family protein 0.0052 0.0023 0.0102
Schistosoma mansoni hypothetical protein 0.0142 0.0828 0.3616
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0315 0.5084
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0069 0.0176 0.0768
Brugia malayi Hhat protein 0.0052 0.0023 0.0102
Entamoeba histolytica diacylglycerol kinase, putative 0.006 0.0096 0.126
Brugia malayi Protein kinase domain containing protein 0.0084 0.0315 0.1378
Schistosoma mansoni unc-13 (munc13) 0.0061 0.011 0.0481
Loa Loa (eye worm) MBOAT family protein 0.0052 0.0023 0.0023
Schistosoma mansoni 6-phosphofructokinase 0.0116 0.0598 0.2612
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0315 0.5084
Trichomonas vaginalis esterase, putative 0.0069 0.0176 0.2652
Schistosoma mansoni protein kinase C mu 0.0062 0.0112 0.0489
Brugia malayi beta-lactamase 0.0069 0.0176 0.0768
Schistosoma mansoni protein kinase C 0.006 0.0096 0.0418
Schistosoma mansoni atypical protein kinase C 0.0144 0.0846 0.3694
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0144 0.0846 0.0846
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.006 0.0096 0.0418
Brugia malayi RhoGAP domain containing protein 0.006 0.0096 0.0418
Loa Loa (eye worm) MH2 domain-containing protein 0.01 0.0455 0.0455
Loa Loa (eye worm) AGC/AKT protein kinase 0.0084 0.0315 0.0315
Entamoeba histolytica protein kinase, putative 0.0084 0.0315 0.5084
Loa Loa (eye worm) AGC/PKN protein kinase 0.0084 0.0315 0.0315
Echinococcus granulosus myotubularin protein 13 0.006 0.0096 0.0418
Loa Loa (eye worm) hypothetical protein 0.0052 0.0023 0.0023
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.006 0.0096 0.0096
Echinococcus granulosus geminin 0.0142 0.0828 0.3616
Brugia malayi protein kinase C3,putative 0.0062 0.0112 0.0489
Toxoplasma gondii diacylglycerol kinase, putative 0.006 0.0096 0.0319
Brugia malayi Protein kinase c protein 2 0.0062 0.0112 0.0489
Loa Loa (eye worm) hypothetical protein 0.006 0.0096 0.0096
Onchocerca volvulus 0.109 0.925 1
Echinococcus multilocularis unc 13 (munc13) 0.006 0.0096 0.0418
Loa Loa (eye worm) 6-phosphofructokinase 0.0116 0.0598 0.0598
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0062 0.0112 0.0489
Schistosoma mansoni serine/threonine protein kinase 0.0144 0.0846 0.3694
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0307 0.2289 1
Echinococcus granulosus protein kinase C gamma type 0.0084 0.0315 0.1378
Brugia malayi diacylglycerol kinase 0.006 0.0096 0.0418
Schistosoma mansoni serine/threonine kinase 0.0084 0.0315 0.1378
Loa Loa (eye worm) MBOAT family protein 0.0052 0.0023 0.0023
Echinococcus granulosus 6 phosphofructokinase 0.0116 0.0598 0.2612
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.006 0.0096 0.0418
Schistosoma mansoni hypothetical protein 0.006 0.0096 0.0418
Loa Loa (eye worm) hypothetical protein 0.0069 0.0176 0.0176
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0112 0.0489
Echinococcus multilocularis 6 phosphofructokinase 0.0116 0.0598 0.2612
Loa Loa (eye worm) variant SH3 domain-containing protein 0.006 0.0096 0.0096
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0052 0.0023 0.0102
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0052 0.0023 0.0102
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0315 0.5084
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.006 0.0096 0.0418
Schistosoma mansoni serine/threonine protein kinase 0.0144 0.0846 0.3694
Echinococcus granulosus Rac GTPase activating protein 1 0.006 0.0096 0.0418
Entamoeba histolytica phosphofructokinase, putative 0.0116 0.0598 1
Loa Loa (eye worm) hypothetical protein 0.115 0.978 0.978
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0062 0.0112 0.0489
Echinococcus granulosus Diacylglycerol kinase theta 0.006 0.0096 0.0418
Brugia malayi Protein kinase domain containing protein 0.0084 0.0315 0.1378
Schistosoma mansoni serine/threonine protein kinase 0.0084 0.0315 0.1378
Leishmania major ATP-dependent phosphofructokinase 0.0116 0.0598 1
Loa Loa (eye worm) hypothetical protein 0.109 0.925 0.925
Brugia malayi MBOAT family protein 0.0052 0.0023 0.0102
Echinococcus multilocularis serine threonine protein kinase 0.0084 0.0315 0.1378
Schistosoma mansoni vav2 0.006 0.0096 0.0418
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.0598 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.0176 0.0176
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0439 0.3464 1
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0052 0.0023 0.0102
Onchocerca volvulus 0.0069 0.0176 0.0165
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0052 0.0023 0.0102
Echinococcus multilocularis Diacylglycerol kinase theta 0.006 0.0096 0.0418
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0069 0.0176 0.0768
Loa Loa (eye worm) hhat protein 0.0052 0.0023 0.0023
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0116 0.0598 1
Trypanosoma cruzi hypothetical protein, conserved 0.0069 0.0176 0.2652
Toxoplasma gondii ABC1 family protein 0.0069 0.0176 0.0672
Echinococcus multilocularis raf serine:threonine protein kinase 0.006 0.0096 0.0418
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0069 0.0176 0.0768
Loa Loa (eye worm) hypothetical protein 0.0069 0.0176 0.0176
Trichomonas vaginalis D-aminoacylase, putative 0.0069 0.0176 0.2652
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0084 0.0315 0.0315
Brugia malayi C1-like domain containing protein 0.0062 0.0112 0.0489
Loa Loa (eye worm) hypothetical protein 0.0052 0.0023 0.0023
Entamoeba histolytica phosphofructokinase, putative 0.0116 0.0598 1
Onchocerca volvulus 0.0069 0.0176 0.0165
Echinococcus multilocularis sterol O acyltransferase 1 0.0052 0.0023 0.0102
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0096 0.0418
Onchocerca volvulus 0.0069 0.0176 0.0165
Brugia malayi beta-lactamase family protein 0.0069 0.0176 0.0768
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0052 0.0023 0.0023
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0083 0.0299 0.4802
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.0598 1
Loa Loa (eye worm) MBOAT family protein 0.0052 0.0023 0.0023
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0052 0.0023 0.0102
Loa Loa (eye worm) AGC/NDR protein kinase 0.0084 0.0315 0.0315
Echinococcus granulosus protein kinase c epsilon type 0.0144 0.0846 0.3694
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0052 0.0023 0.0102
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0315 0.5084
Loa Loa (eye worm) hypothetical protein 0.0052 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.006 0.0096 0.0096
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.0598 1
Mycobacterium ulcerans 6-phosphofructokinase 0.0116 0.0598 1
Echinococcus granulosus N chimaerin 0.006 0.0096 0.0418
Echinococcus granulosus protein kinase c eta type 0.006 0.0096 0.0418
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0084 0.0315 0.1378
Echinococcus multilocularis protein kinase c iota type 0.0144 0.0846 0.3694
Echinococcus multilocularis protein kinase c epsilon type 0.0144 0.0846 0.3694
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0116 0.0598 1
Trypanosoma cruzi hypothetical protein, conserved 0.0069 0.0176 0.2652
Loa Loa (eye worm) hypothetical protein 0.0255 0.1831 0.1831
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0062 0.0112 0.0112
Brugia malayi MBOAT family protein 0.0052 0.0023 0.0102
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0116 0.0598 1
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0315 0.5084
Schistosoma mansoni diacylglycerol kinase theta 0.006 0.0096 0.0418
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0084 0.0315 0.1378
Schistosoma mansoni 6-phosphofructokinase 0.0116 0.0598 0.2612
Entamoeba histolytica phosphofructokinase, putative 0.0116 0.0598 1
Echinococcus multilocularis protein kinase c eta type 0.006 0.0096 0.0418
Entamoeba histolytica protein kinase, putative 0.0084 0.0315 0.5084
Schistosoma mansoni unc-13 (munc13) 0.006 0.0096 0.0418
Echinococcus multilocularis N chimaerin 0.006 0.0096 0.0418
Entamoeba histolytica diacylglycerol kinase, putative 0.006 0.0096 0.126
Brugia malayi diacylglycerol acyltransferase 0.0307 0.2289 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0069 0.0176 0.2652
Loa Loa (eye worm) hypothetical protein 0.006 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0052 0.0023 0.0023
Brugia malayi MH2 domain containing protein 0.01 0.0455 0.1987
Brugia malayi RhoGEF domain containing protein 0.006 0.0096 0.0418
Trichomonas vaginalis D-aminoacylase, putative 0.0069 0.0176 0.2652
Echinococcus granulosus protein kinase c iota type 0.0144 0.0846 0.3694
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0307 0.2289 1
Schistosoma mansoni sterol O-acyltransferase 1 0.0052 0.0023 0.0102
Brugia malayi Protein kinase domain containing protein 0.0084 0.0315 0.1378
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0307 0.2289 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0096 0.0096
Onchocerca volvulus 0.0127 0.0691 0.0724
Toxoplasma gondii AGC kinase 0.0084 0.0315 0.1289
Echinococcus granulosus C2 calcium dependent membrane targeting 0.006 0.0096 0.0418
Echinococcus granulosus Protein kinase C brain isozyme 0.0144 0.0846 0.3694
Schistosoma mansoni serine/threonine protein kinase 0.0144 0.0846 0.3694
Schistosoma mansoni rac gtpase activating protein 0.006 0.0096 0.0418
Schistosoma mansoni zinc finger protein 0.0052 0.0023 0.0102
Echinococcus granulosus o acyltransferase membrane bound domain 0.0052 0.0023 0.0102
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0052 0.0023 0.0102
Loa Loa (eye worm) beta-lactamase 0.0069 0.0176 0.0176
Onchocerca volvulus 0.006 0.0096 0.0078
Brugia malayi Ras association domain family 1 isoform A 0.006 0.0096 0.0418
Echinococcus granulosus NDR protein kinase 0.0084 0.0315 0.1378
Brugia malayi 6-phosphofructokinase 0.0116 0.0598 0.2612
Echinococcus multilocularis beta LACTamase domain containing family member 0.0069 0.0176 0.0768
Loa Loa (eye worm) hypothetical protein 0.006 0.0096 0.0096
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0315 0.5084
Loa Loa (eye worm) hypothetical protein 0.006 0.0096 0.0096
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0315 0.5084
Trichomonas vaginalis D-aminoacylase, putative 0.0069 0.0176 0.2652
Schistosoma mansoni serine/threonine protein kinase 0.0084 0.0315 0.1378
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0084 0.0315 0.0315
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0307 0.2289 0.5
Trypanosoma brucei hypothetical protein, conserved 0.0069 0.0176 0.2652
Loa Loa (eye worm) hypothetical protein 0.0069 0.0176 0.0176
Brugia malayi MBOAT family protein 0.0052 0.0023 0.0102
Loa Loa (eye worm) hypothetical protein 0.006 0.0096 0.0096
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0052 0.0023 0.0102
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0084 0.0315 0.1378
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0052 0.0023 0.0102
Onchocerca volvulus 0.006 0.0096 0.0078
Brugia malayi beta-lactamase family protein 0.0069 0.0176 0.0768

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.004 uM Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesis ChEMBL. 22217874
IC50 (binding) = 1.96 uM Inhibition of DGAT1-mediated triglyceride synthesis n mouse 3T3L1 cells ChEMBL. 22217874
permeability (ADMET) = 0.22 ucm/s Permeability from apical to basolateral side in human Caco2 cells ChEMBL. 22217874
permeability (ADMET) = 17.6 ucm/s Permeability from basolateral to apical side in human Caco2 cells ChEMBL. 22217874

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.