Detailed information for compound 1611394

Basic information

Technical information
  • TDR Targets ID: 1611394
  • Name: 1-[5-[8-(5-piperidin-1-yl-1,3,4-oxadiazol-2-y l)octyl]-1,3,4-oxadiazol-2-yl]piperidine
  • MW: 416.56 | Formula: C22H36N6O2
  • H donors: 0 H acceptors: 4 LogP: 5.35 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: C(CCCc1nnc(o1)N1CCCCC1)CCCCc1nnc(o1)N1CCCCC1
  • InChi: 1S/C22H36N6O2/c1(3-7-13-19-23-25-21(29-19)27-15-9-5-10-16-27)2-4-8-14-20-24-26-22(30-20)28-17-11-6-12-18-28/h1-18H2
  • InChiKey: QSAAYCMBTXGCHP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[5-[8-[5-(1-piperidyl)-1,3,4-oxadiazol-2-yl]octyl]-1,3,4-oxadiazol-2-yl]piperidine
  • 1-[5-[8-(5-piperidino-1,3,4-oxadiazol-2-yl)octyl]-1,3,4-oxadiazol-2-yl]piperidine
  • AIDS152599
  • NSC697182
  • AIDS-152599
  • NCI60_034651
  • 1-(5-(8-(5-(1-Piperidinyl)-1,3,4-oxadiazol-2-yl)octyl)-1,3,4-oxadiazol-2-yl)piperidine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) FKBP5 protein 0.0178 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.004 0.0011 0.0011
Echinococcus multilocularis voltage gated potassium channel 0.0047 0.0021 0.0019
Loa Loa (eye worm) phosphatidylinositol 3 0.052 0.0623 0.0623
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0154 0.0157 0.0155
Loa Loa (eye worm) MH2 domain-containing protein 0.0126 0.0121 0.0121
Loa Loa (eye worm) AGC/AKT protein kinase 0.0033 0.0003 0.0003
Onchocerca volvulus 0.052 0.0623 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1524 0.1901 0.19
Trichomonas vaginalis conserved hypothetical protein 0.1164 0.1442 0.1441
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0666 0.0808 0.0807
Trichomonas vaginalis immunophilin, putative 0.0178 0.0188 0.0186
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0178 0.0188 0.0188
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.052 0.0623 0.0579
Trichomonas vaginalis PIKK family atypical protein kinase 0.628 0.7958 0.7958
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0003 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.4279 0.5409 0.5408
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.052 0.0623 0.0623
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0003 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.4272 0.5401 0.54
Leishmania major hypothetical protein, unknown function 0.052 0.0623 0.0443
Loa Loa (eye worm) hypothetical protein 0.1512 0.1886 0.1886
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0032 0.0002 0.0002
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.2687 0.3383 0.3381
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0542 0.0651 0.0649
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.081 0.0992 0.099
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.1512 0.1886 0.1884
Trichomonas vaginalis PIKK family atypical protein kinase 0.5875 0.7443 0.7442
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.062 0.0751 0.0574
Schistosoma mansoni immunophilin 0.0154 0.0157 0.0155
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0657 0.0797 0.0796
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0178 0.0188 0.0142
Echinococcus granulosus serine protein kinase ATM 0.1512 0.1886 0.1884
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0178 0.0188 0.0188
Trichomonas vaginalis PIKK family atypical protein kinase 0.5875 0.7443 0.7442
Trichomonas vaginalis PIKK family atypical protein kinase 0.5288 0.6695 0.6695
Entamoeba histolytica hypothetical protein 0.052 0.0623 0.0623
Schistosoma mansoni hypothetical protein 0.1164 0.1442 0.1441
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.052 0.0623 0.9387
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.7883 1 1
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0178 0.0188 0.0186
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1524 0.1901 0.1901
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0735 0.0897 0.0897
Echinococcus multilocularis 0.052 0.0623 0.0621
Leishmania major phosphatidylinositol 4-kinase, putative 0.052 0.0623 0.0443
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.052 0.0623 0.0837
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.1164 0.1442 0.1441
Trichomonas vaginalis conserved hypothetical protein 0.1684 0.2105 0.2103
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0003 0.0001
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0021 0.0019
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1684 0.2105 0.2828
Loa Loa (eye worm) phosphatidylinositol 3 0.7883 1 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0178 0.0188 0.0142
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.052 0.0623 0.062
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0178 0.0188 0.5
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0735 0.0897 0.0895
Brugia malayi MH2 domain containing protein 0.0126 0.0121 0.0121
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0032 0.0002 0.0002
Schistosoma mansoni jumonji domain containing protein 0.0077 0.0059 0.0057
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0735 0.0897 0.0897
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.052 0.0623 0.0621
Trichomonas vaginalis PIKK family atypical protein kinase 0.052 0.0623 0.0621
Trichomonas vaginalis PIKK family atypical protein kinase 0.5875 0.7443 0.7442
Echinococcus multilocularis Zinc finger, PHD finger 0.0542 0.0651 0.0649
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0542 0.0651 0.0649
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.052 0.0623 0.0579
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0011 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.5875 0.7443 0.7442
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.052 0.0623 0.0837
Giardia lamblia Phosphatidylinositol 4-kinase 0.052 0.0623 0.0443
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0051 0.0049
Trichomonas vaginalis PIKK family atypical protein kinase 0.5875 0.7443 0.7442
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.2732 0.344 0.3439
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0025 0.0023
Brugia malayi jmjC domain containing protein 0.0097 0.0084 0.0084
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0542 0.0651 0.0651
Echinococcus multilocularis fk506 binding protein 0.0178 0.0188 0.0186
Leishmania major hypothetical protein, conserved 0.0623 0.0754 0.0577
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2732 0.344 0.3409
Mycobacterium leprae conserved hypothetical protein 0.052 0.0623 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.628 0.7958 0.7958
Trichomonas vaginalis PIKK family atypical protein kinase 0.2675 0.3368 0.3366
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0588 0.0709 0.0709
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.7883 1 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0588 0.0709 0.0706
Trichomonas vaginalis PIKK family atypical protein kinase 0.4712 0.5961 0.596
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.2732 0.344 0.3439
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0195 0.0209 0.0209
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0178 0.0188 0.0142
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0003 0.0001
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.7883 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.052 0.0623 0.0623
Echinococcus granulosus chromobox protein 1 0.0071 0.0051 0.0049
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0006 0.0006
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0657 0.0797 0.0797
Trypanosoma brucei target of rapamycin kinase 3, putative 0.6286 0.7966 0.7966
Schistosoma mansoni chromobox protein 0.0071 0.0051 0.0049
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0542 0.0651 0.0875
Entamoeba histolytica protein kinase, putative 0.0033 0.0003 0.0003
Schistosoma mansoni voltage-gated potassium channel 0.0179 0.0189 0.0187
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.052 0.0623 0.9387
Onchocerca volvulus 0.005 0.0025 0.0391
Entamoeba histolytica hypothetical protein 0.069 0.0839 0.0839
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0178 0.0188 0.5
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0542 0.0651 1
Loa Loa (eye worm) phosphatidylinositol 3 0.052 0.0623 0.0623
Loa Loa (eye worm) heterochromatin protein 1 0.0071 0.0051 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.628 0.7958 0.7958
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.052 0.0623 0.0579
Echinococcus multilocularis serine protein kinase ATM 0.1512 0.1886 0.1884
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.052 0.0623 0.0621
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1512 0.1886 0.1848
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0588 0.0709 0.0707
Trichomonas vaginalis PIKK family atypical protein kinase 0.4279 0.5409 0.5408
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.1512 0.1886 0.1884
Plasmodium vivax hypothetical protein, conserved 0.052 0.0623 0.9387
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0047 0.0021 0.0019
Echinococcus multilocularis chromobox protein 1 0.0071 0.0051 0.0049
Leishmania major phosphatidylinositol 3-related kinase, putative 0.2687 0.3383 0.3256
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0542 0.0651 0.0651
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.7883 1 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.052 0.0623 0.0621
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0588 0.0709 0.0709
Onchocerca volvulus 0.052 0.0623 1
Entamoeba histolytica hypothetical protein 0.1512 0.1886 0.1886
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.052 0.0623 0.0621
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0097 0.0084 0.0082
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0657 0.0797 0.0796
Loa Loa (eye worm) hypothetical protein 0.0154 0.0157 0.0157
Trichomonas vaginalis PIKK family atypical protein kinase 0.628 0.7958 0.7958
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0542 0.0651 0.0649
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.372 0.4698 0.4697
Loa Loa (eye worm) hypothetical protein 0.005 0.0025 0.0025
Trypanosoma cruzi hypothetical protein, conserved 0.0103 0.0091 0.0045
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.7883 1 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.7883 1 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0038 0.0038
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0154 0.0157 0.0155
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0588 0.0709 0.0707
Trichomonas vaginalis PIKK family atypical protein kinase 0.2687 0.3383 0.3382
Loa Loa (eye worm) hypothetical protein 0.0051 0.0025 0.0025
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.2675 0.3368 0.3366
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0542 0.0651 0.0607
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0215 0.0234 0.0234
Loa Loa (eye worm) phosphatidylinositol 3 0.052 0.0623 0.0623
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0164 0.0169 0.0168
Trichomonas vaginalis PIKK family atypical protein kinase 0.5116 0.6476 0.6476
Brugia malayi jmjC domain containing protein 0.0036 0.0006 0.0006
Entamoeba histolytica hypothetical protein 0.052 0.0623 0.0623
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0542 0.0651 0.0651
Loa Loa (eye worm) phosphatidylinositol 3 0.052 0.0623 0.0623
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0178 0.0188 0.0186
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0006 0.0004
Entamoeba histolytica protein kinase, putative 0.0033 0.0003 0.0003
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0542 0.0651 0.0649
Brugia malayi chromobox protein homolog 3 0.004 0.0011 0.0011
Leishmania major phosphatidylinositol 3-kinase, putative 0.2675 0.3368 0.3241
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0164 0.0169 0.0168
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.7883 1 1
Loa Loa (eye worm) hypothetical protein 0.0992 0.1223 0.1223
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0542 0.0651 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0068 0.0047 0.0047
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0021 0.0019
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.7883 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0588 0.0709 0.0707
Loa Loa (eye worm) hypothetical protein 0.0078 0.006 0.006
Trichomonas vaginalis PIKK family atypical protein kinase 0.2675 0.3368 0.3366
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0542 0.0651 0.0649
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.052 0.0623 0.0623
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.3287 0.4146 0.4145
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.093 0.1145 0.1144
Loa Loa (eye worm) hypothetical protein 0.0047 0.0021 0.0021
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0015 0.0237
Loa Loa (eye worm) hypothetical protein 0.052 0.0623 0.0623
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.7883 1 1
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.052 0.0623 0.9387
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.1512 0.1886 0.1884
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.052 0.0623 0.0579
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.052 0.0623 0.9387
Brugia malayi Protein kinase domain containing protein 0.0033 0.0003 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.2675 0.3368 0.3366
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0542 0.0651 0.0649
Echinococcus granulosus voltage gated potassium channel 0.0047 0.0021 0.0019
Schistosoma mansoni immunophilin 0.0178 0.0188 0.0186
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.052 0.0623 0.0621
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0735 0.0897 0.0895
Echinococcus multilocularis tumor protein p63 0.0343 0.0398 0.0396
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0178 0.0188 0.0186
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0011 0.0009
Echinococcus granulosus chromobox protein 1 0.0071 0.0051 0.0049
Echinococcus multilocularis chromobox protein 1 0.0071 0.0051 0.0049
Toxoplasma gondii FATC domain-containing protein 0.1512 0.1886 0.2534
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.052 0.0623 0.0579
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0178 0.0188 0.0188
Trypanosoma cruzi target of rapamycin kinase 3 0.6286 0.7966 0.7957
Giardia lamblia Hypothetical protein 0.052 0.0623 0.0443
Toxoplasma gondii target of rapamycin (TOR), putative 0.5875 0.7443 1
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0015 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.7883 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.052 0.0623 0.0621
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0588 0.0709 0.0665
Loa Loa (eye worm) hypothetical protein 0.0657 0.0797 0.0797
Leishmania major phosphatidylinositol kinase related protein, putative 0.052 0.0623 0.0443
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0097 0.0084 0.0082
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0003 0.0001
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0178 0.0188 0.0186
Trichomonas vaginalis PIKK family atypical protein kinase 0.7883 1 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.6286 0.7966 0.7927
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0178 0.0188 0.0188
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0164 0.0169 0.0169
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.052 0.0623 0.0837
Trichomonas vaginalis conserved hypothetical protein 0.0992 0.1223 0.1222
Trichomonas vaginalis PIKK family atypical protein kinase 0.1512 0.1886 0.1884
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1512 0.1886 0.1886
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.2732 0.344 0.344
Leishmania major phosphatidylinositol 3-kinase, putative 0.0542 0.0651 0.0472
Giardia lamblia GTOR 0.7883 1 1
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0542 0.0651 0.0649
Loa Loa (eye worm) phosphatidylinositol kinase 0.052 0.0623 0.0623
Brugia malayi Cyclic-nucleotide gated cation channel 0.0032 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0032 0.0002 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.4272 0.5401 0.54
Trichomonas vaginalis PIKK family atypical protein kinase 0.4712 0.5961 0.596
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.052 0.0623 0.0621
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0006 0.0004
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.1164 0.1442 0.1441
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0015 0.0013
Schistosoma mansoni phosphatidylinositol 4-kinase 0.052 0.0623 0.0621
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1512 0.1886 0.1848
Plasmodium vivax hypothetical protein 0.052 0.0623 0.9387
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2732 0.344 0.3409
Trichomonas vaginalis fk506-binding protein, putative 0.0178 0.0188 0.0186
Echinococcus granulosus serine:threonine protein kinase SMG1 0.1512 0.1886 0.1884
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.7883 1 1
Loa Loa (eye worm) transcription factor SMAD2 0.0126 0.0121 0.0121
Entamoeba histolytica protein kinase rad3, putative 0.1512 0.1886 0.1886
Trichomonas vaginalis PIKK family atypical protein kinase 0.2675 0.3368 0.3366
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0178 0.0188 0.0185
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.2732 0.344 0.3439
Loa Loa (eye worm) hypothetical protein 0.1684 0.2105 0.2105
Brugia malayi Heterochromatin protein 1 0.0071 0.0051 0.0051
Schistosoma mansoni voltage-gated potassium channel 0.0179 0.0189 0.0187
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0612 0.074 0.074
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.052 0.0623 0.0621
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0153 0.0156 0.0154
Schistosoma mansoni immunophilin 0.0178 0.0188 0.0186
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0051 0.0049
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0735 0.0897 0.0854
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0006 0.0004
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0542 0.0651 0.0649
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0992 0.1223 0.1182
Trichomonas vaginalis PIKK family atypical protein kinase 0.4712 0.5961 0.596
Brugia malayi FAT domain containing protein 0.1164 0.1442 0.1442
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.093 0.1145 0.1144
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.069 0.0839 0.0839
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0178 0.0188 0.0185
Trichomonas vaginalis PIKK family atypical protein kinase 0.4272 0.5401 0.54
Plasmodium falciparum phosphatidylinositol 4-kinase 0.052 0.0623 0.9387
Schistosoma mansoni hypothetical protein 0.052 0.0623 0.0621
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0178 0.0188 0.0188
Trichomonas vaginalis PIKK family atypical protein kinase 0.4683 0.5925 0.5924
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0588 0.0709 0.0707
Trichomonas vaginalis PIKK family atypical protein kinase 0.5875 0.7443 0.7442
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0003 0.0001
Entamoeba histolytica hypothetical protein 0.052 0.0623 0.0623
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0164 0.0169 0.0169
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.7883 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.4279 0.5409 0.5408
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.081 0.0992 0.099
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1512 0.1886 0.1886
Schistosoma mansoni chromobox protein 0.0071 0.0051 0.0049
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.052 0.0623 0.062
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0178 0.0188 0.0186
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0588 0.0709 0.0709
Loa Loa (eye worm) hypothetical protein 0.0142 0.0142 0.0142
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0735 0.0897 0.0854
Leishmania major phosphatidylinositol kinase, putative 0.052 0.0623 0.0443
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0542 0.0651 0.0649
Trichomonas vaginalis PIKK family atypical protein kinase 0.628 0.7958 0.7958
Loa Loa (eye worm) hypothetical protein 0.1164 0.1442 0.1442
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.052 0.0623 0.0621
Trichomonas vaginalis PIKK family atypical protein kinase 0.4279 0.5409 0.5408
Trichomonas vaginalis PIKK family atypical protein kinase 0.5875 0.7443 0.7442
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.093 0.1145 0.1144
Trichomonas vaginalis PIKK family atypical protein kinase 0.1512 0.1886 0.1884
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0003 0.0001
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.052 0.0623 0.0621
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0735 0.0897 0.0895
Mycobacterium tuberculosis Conserved hypothetical protein 0.052 0.0623 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.052 0.0623 0.0623
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0178 0.0188 0.0142
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0542 0.0651 0.0875
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0542 0.0651 0.0607
Trichomonas vaginalis PIKK family atypical protein kinase 0.672 0.8518 0.8518
Loa Loa (eye worm) phosphatidylinositol 3 0.2687 0.3383 0.3383
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0542 0.0651 0.0472
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0542 0.0651 0.0651
Trichomonas vaginalis PIKK family atypical protein kinase 0.7883 1 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0006 0.0004
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0565 0.068 0.0502
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0013 0.0011
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0047 0.0021 0.0021
Schistosoma mansoni fkbp-rapamycin associated protein 0.1512 0.1886 0.1884
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0666 0.0808 0.0807
Echinococcus granulosus tumor protein p63 0.0343 0.0398 0.0396
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0013 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0992 0.1223 0.1222
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0153 0.0156 0.0154
Loa Loa (eye worm) phosphatidylinositol 3 0.0885 0.1088 0.1088
Loa Loa (eye worm) hypothetical protein 0.1597 0.1994 0.1994
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0047 0.0021 0.0019
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0178 0.0188 0.0186
Trichomonas vaginalis PIKK family atypical protein kinase 0.4683 0.5925 0.5924
Trichomonas vaginalis PIKK family atypical protein kinase 0.2117 0.2656 0.2655
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0011 0.0175

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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