Detailed information for compound 1611397

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 440.577 | Formula: C29H32N2O2
  • H donors: 0 H acceptors: 1 LogP: 5.21 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1N1CCN(CC1)CC1CCC(C1=O)(c1ccccc1)c1ccccc1
  • InChi: 1S/C29H32N2O2/c1-33-27-15-9-8-14-26(27)31-20-18-30(19-21-31)22-23-16-17-29(28(23)32,24-10-4-2-5-11-24)25-12-6-3-7-13-25/h2-15,23H,16-22H2,1H3
  • InChiKey: GRLMWWLAYDWUKA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0288 0.0497 0.0497
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0267 0.0444 0.8933
Trichomonas vaginalis PIKK family atypical protein kinase 0.1364 0.3267 0.3267
Echinococcus granulosus carbonic anhydrase II 0.0101 0.0017 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.2583 0.6403 0.6403
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0116 0.0055 0.5
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0288 0.0497 0.0672
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0267 0.0444 0.0444
Loa Loa (eye worm) hypothetical protein 0.0161 0.017 0.017
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0101 0.0017 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.398 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.033 0.0605 0.0605
Trichomonas vaginalis PIKK family atypical protein kinase 0.1375 0.3296 0.3296
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0116 0.0055 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.398 1 1
Trichomonas vaginalis immunophilin, putative 0.0116 0.0055 0.0055
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.01 0.0014 0.0014
Loa Loa (eye worm) FKBP5 protein 0.0116 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0394 0.077 0.077
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.011 0.004 0.004
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0288 0.0497 0.0497
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.1875 0.4582 0.4582
Trichomonas vaginalis PIKK family atypical protein kinase 0.3175 0.7927 0.7927
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.398 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.033 0.0605 0.0605
Onchocerca volvulus 0.0267 0.0444 0.5
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0288 0.0497 0.0672
Mycobacterium tuberculosis Conserved hypothetical protein 0.0267 0.0444 0.5
Entamoeba histolytica protein kinase rad3, putative 0.0772 0.1743 0.1743
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0267 0.0444 0.0444
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.033 0.0605 0.0605
Trichomonas vaginalis PIKK family atypical protein kinase 0.2169 0.534 0.534
Loa Loa (eye worm) phosphatidylinositol 3 0.1375 0.3296 0.3296
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0101 0.0017 0.0017
Loa Loa (eye worm) phosphatidylinositol 3 0.0267 0.0444 0.0444
Echinococcus multilocularis serine protein kinase ATM 0.0772 0.1743 0.1743
Toxoplasma gondii FATC domain-containing protein 0.0772 0.1743 0.2354
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0267 0.0444 0.0444
Trichomonas vaginalis PIKK family atypical protein kinase 0.3175 0.7927 0.7927
Loa Loa (eye worm) hypothetical protein 0.0772 0.1743 0.1743
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0267 0.0444 0.0444
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0288 0.0497 0.0497
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0424 0.0848 0.0848
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0116 0.0055 0.0055
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0101 0.0017 0.0017
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0267 0.0444 0.06
Loa Loa (eye worm) hypothetical protein 0.01 0.0014 0.0014
Loa Loa (eye worm) phosphatidylinositol 3 0.0267 0.0444 0.0444
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0148 0.0138 0.0138
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.3178 0.7936 0.7936
Echinococcus multilocularis Zinc finger, PHD finger 0.0288 0.0497 0.0497
Trypanosoma brucei carbonic anhydrase-like protein 0.0101 0.0017 0.0017
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0101 0.0017 0.0017
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.398 1 1
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0267 0.0444 0.0444
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0116 0.0055 0.0055
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0394 0.077 0.077
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.033 0.0605 0.0605
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.033 0.0605 0.0605
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.398 1 1
Echinococcus granulosus metabotropic glutamate receptor 5 0.0161 0.017 0.017
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1417 0.3402 0.3402
Trichomonas vaginalis PIKK family atypical protein kinase 0.2379 0.588 0.588
Trichomonas vaginalis PIKK family atypical protein kinase 0.1364 0.3267 0.3267
Trichomonas vaginalis PIKK family atypical protein kinase 0.3175 0.7927 0.7927
Trichomonas vaginalis PIKK family atypical protein kinase 0.0267 0.0444 0.0444
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1417 0.3402 0.3402
Schistosoma mansoni immunophilin 0.01 0.0014 0.0014
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0116 0.0055 0.0055
Leishmania major hypothetical protein, conserved 0.0362 0.0689 0.0689
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1417 0.3402 0.3402
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0288 0.0497 0.0497
Echinococcus granulosus metabotropic glutamate receptor 2 0.0109 0.0038 0.0038
Entamoeba histolytica hypothetical protein 0.0267 0.0444 0.0444
Trichomonas vaginalis PIKK family atypical protein kinase 0.2971 0.7404 0.7404
Trichomonas vaginalis PIKK family atypical protein kinase 0.2971 0.7404 0.7404
Loa Loa (eye worm) phosphatidylinositol 3 0.0267 0.0444 0.0444
Leishmania major carbonic anhydrase-like protein 0.0101 0.0017 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.2971 0.7404 0.7404
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0267 0.0444 0.0444
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0267 0.0444 0.0444
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0288 0.0497 0.0497
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0288 0.0497 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0466 0.0956 0.0956
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0116 0.0055 0.0055
Schistosoma mansoni hypothetical protein 0.0267 0.0444 0.0444
Loa Loa (eye worm) phosphatidylinositol 3 0.0267 0.0444 0.0444
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0466 0.0956 0.0956
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0109 0.0038 0.0038
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0116 0.0055 0.0055
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.398 1 1
Loa Loa (eye worm) hypothetical protein 0.0859 0.1968 0.1968
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0116 0.0055 0.0055
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0267 0.0444 0.0444
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0466 0.0956 0.0956
Mycobacterium leprae conserved hypothetical protein 0.0267 0.0444 0.5
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0783 0.1772 0.1772
Trichomonas vaginalis conserved hypothetical protein 0.0859 0.1968 0.1968
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0647 0.1421 0.1421
Trichomonas vaginalis PIKK family atypical protein kinase 0.0267 0.0444 0.0444
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.398 1 1
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0116 0.0055 0.0055
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0267 0.0444 0.0444
Plasmodium vivax hypothetical protein, conserved 0.0267 0.0444 0.8933
Trichomonas vaginalis PIKK family atypical protein kinase 0.2971 0.7404 0.7404
Trichomonas vaginalis PIKK family atypical protein kinase 0.267 0.6629 0.6629
Loa Loa (eye worm) glutamate receptor 0.0131 0.0092 0.0092
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0647 0.1421 0.1421
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0118 0.006 0.006
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0394 0.077 0.077
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0116 0.0055 0.0055
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.036 0.0683 0.0683
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0772 0.1743 0.1743
Trichomonas vaginalis PIKK family atypical protein kinase 0.0505 0.1055 0.1055
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0288 0.0497 0.0497
Trichomonas vaginalis PIKK family atypical protein kinase 0.2971 0.7404 0.7404
Entamoeba histolytica hypothetical protein 0.0772 0.1743 0.1743
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1375 0.3296 0.3296
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0772 0.1743 0.1743
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0267 0.0444 0.06
Trichomonas vaginalis PIKK family atypical protein kinase 0.2169 0.534 0.534
Trichomonas vaginalis PIKK family atypical protein kinase 0.3175 0.7927 0.7927
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0267 0.0444 0.0444
Schistosoma mansoni voltage-gated potassium channel 0.0129 0.0088 0.0088
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0267 0.0444 0.8933
Trichomonas vaginalis PIKK family atypical protein kinase 0.2166 0.5331 0.5331
Schistosoma mansoni hypothetical protein 0.0592 0.128 0.128
Trichomonas vaginalis PIKK family atypical protein kinase 0.0783 0.1772 0.1772
Echinococcus multilocularis fk506 binding protein 0.0116 0.0055 0.0055
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0402 0.0791 0.0791
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0116 0.0055 0.0055
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0267 0.0444 0.8933
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0116 0.0055 0.0055
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0267 0.0444 0.0444
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.01 0.0014 0.0014
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0116 0.0055 0.0055
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0118 0.006 0.006
Trypanosoma cruzi hypothetical protein, conserved 0.0095 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.1069 0.2509 0.2509
Trichomonas vaginalis PIKK family atypical protein kinase 0.2373 0.5863 0.5863
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0199 0.0268 0.0268
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0402 0.0791 0.0791
Loa Loa (eye worm) hypothetical protein 0.0505 0.1055 0.1055
Loa Loa (eye worm) hypothetical protein 0.0802 0.1821 0.1821
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0116 0.0055 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0592 0.128 0.128
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0772 0.1743 0.1743
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0309 0.0552 0.0552
Trichomonas vaginalis PIKK family atypical protein kinase 0.3388 0.8476 0.8476
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0288 0.0497 0.0497
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0288 0.0497 0.0497
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0116 0.0055 0.1109
Entamoeba histolytica hypothetical protein 0.0267 0.0444 0.0444
Leishmania major phosphatidylinositol 3-kinase, putative 0.0288 0.0497 0.0497
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.398 1 1
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0288 0.0497 0.0497
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1375 0.3296 0.3296
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0466 0.0956 0.0956
Leishmania major phosphatidylinositol 4-kinase, putative 0.0267 0.0444 0.0444
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0267 0.0444 0.0444
Trichomonas vaginalis PIKK family atypical protein kinase 0.2169 0.534 0.534
Trichomonas vaginalis PIKK family atypical protein kinase 0.2971 0.7404 0.7404
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0535 0.1134 0.1134
Schistosoma mansoni fkbp-rapamycin associated protein 0.0772 0.1743 0.1743
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0267 0.0444 0.8933
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0288 0.0497 0.0497
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0647 0.1421 0.1421
Trichomonas vaginalis PIKK family atypical protein kinase 0.3175 0.7927 0.7927
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0116 0.0055 0.0055
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0466 0.0956 0.0956
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.033 0.0605 0.0605
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0116 0.0055 0.0055
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0267 0.0444 0.06
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0101 0.0017 0.0017
Giardia lamblia Phosphatidylinositol 4-kinase 0.0267 0.0444 0.0444
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.398 1 1
Plasmodium vivax hypothetical protein 0.0267 0.0444 0.8933
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0116 0.0055 0.0055
Toxoplasma gondii target of rapamycin (TOR), putative 0.2971 0.7404 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0772 0.1743 0.1743
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0505 0.1055 0.1055
Trichomonas vaginalis PIKK family atypical protein kinase 0.2169 0.534 0.534
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0267 0.0444 0.0444
Trichomonas vaginalis PIKK family atypical protein kinase 0.2166 0.5331 0.5331
Leishmania major fk506-binding protein 1-like protein 0.0116 0.0055 0.0055
Entamoeba histolytica hypothetical protein 0.0424 0.0848 0.0848
Trichomonas vaginalis conserved hypothetical protein 0.0505 0.1055 0.1055
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.033 0.0605 0.0605
Trichomonas vaginalis PIKK family atypical protein kinase 0.2373 0.5863 0.5863
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0267 0.0444 0.0444
Schistosoma mansoni immunophilin 0.0116 0.0055 0.0055
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0466 0.0956 0.0956
Trichomonas vaginalis PIKK family atypical protein kinase 0.2379 0.588 0.588
Loa Loa (eye worm) phosphatidylinositol 3 0.0605 0.1313 0.1313
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0288 0.0497 0.0497
Brugia malayi FAT domain containing protein 0.0592 0.128 0.128
Loa Loa (eye worm) carbonic anhydrase 3 0.0101 0.0017 0.0017
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0859 0.1968 0.2658
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0101 0.0017 0.0017
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0116 0.0055 0.0055
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0116 0.0055 0.1109
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0267 0.0444 0.0444
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0352 0.0663 0.0663
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0161 0.017 0.017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0772 0.1743 0.1743
Schistosoma mansoni immunophilin 0.0116 0.0055 0.0055
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1417 0.3402 0.3402
Leishmania major peptidylprolyl isomerase-like protein 0.0116 0.0055 0.0055
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1364 0.3267 0.3267
Loa Loa (eye worm) hypothetical protein 0.0267 0.0444 0.0444
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1417 0.3402 0.3402
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0772 0.1743 0.1743
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.398 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0772 0.1743 0.1743
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0116 0.0055 0.0055
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0592 0.128 0.128
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0267 0.0444 0.0444
Trichomonas vaginalis PIKK family atypical protein kinase 0.2379 0.588 0.588
Leishmania major hypothetical protein, unknown function 0.0267 0.0444 0.0444
Trichomonas vaginalis PIKK family atypical protein kinase 0.2166 0.5331 0.5331
Loa Loa (eye worm) phosphatidylinositol 3 0.398 1 1
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0267 0.0444 0.0444
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0288 0.0497 0.0497
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1417 0.3402 0.3402
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0288 0.0497 0.0497
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0772 0.1743 0.1743
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0772 0.1743 0.1743
Loa Loa (eye worm) hypothetical protein 0.0592 0.128 0.128
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0267 0.0444 0.0444
Trypanosoma brucei target of rapamycin kinase 3, putative 0.3178 0.7936 0.7936
Trichomonas vaginalis fk506-binding protein, putative 0.0116 0.0055 0.0055
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0118 0.0061 0.0061
Trichomonas vaginalis PIKK family atypical protein kinase 0.398 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0129 0.0088 0.0088
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.398 1 1
Leishmania major phosphatidylinositol kinase related protein, putative 0.0267 0.0444 0.0444
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.011 0.004 0.004
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0394 0.077 0.077
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.033 0.0605 0.0605
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0267 0.0444 0.0444
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0267 0.0444 0.8933
Trichomonas vaginalis PIKK family atypical protein kinase 0.2971 0.7404 0.7404
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0772 0.1743 0.1743
Loa Loa (eye worm) hypothetical protein 0.0102 0.002 0.002
Echinococcus multilocularis carbonic anhydrase II 0.0101 0.0017 0.0017
Trypanosoma cruzi target of rapamycin kinase 3 0.3178 0.7936 0.7936
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0118 0.006 0.006
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0267 0.0444 0.0444
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0118 0.006 0.006
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0466 0.0956 0.0956
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.018 0.0221 0.0221
Loa Loa (eye worm) phosphatidylinositol kinase 0.0267 0.0444 0.0444
Brugia malayi Metabotropic glutamate receptor precursor. 0.0131 0.0092 0.0092
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0288 0.0497 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0267 0.0444 0.0444
Giardia lamblia Hypothetical protein 0.0267 0.0444 0.0444
Echinococcus granulosus serine protein kinase ATM 0.0772 0.1743 0.1743
Leishmania major phosphatidylinositol 3-kinase, putative 0.1364 0.3267 0.3267
Entamoeba histolytica hypothetical protein 0.0267 0.0444 0.0444
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0535 0.1134 0.1134
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.398 1 1
Echinococcus multilocularis 0.0267 0.0444 0.0444
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0288 0.0497 0.0497
Trichomonas vaginalis PIKK family atypical protein kinase 0.1364 0.3267 0.3267
Schistosoma mansoni metabotropic glutamate receptor 0.0109 0.0038 0.0038
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.1665 0.4041 0.4041
Onchocerca volvulus 0.0267 0.0444 0.5
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.398 1 1
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0101 0.0017 0.0017
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0288 0.0497 0.0497
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.033 0.0605 0.0605
Giardia lamblia GTOR 0.398 1 1
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0116 0.0055 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.1364 0.3267 0.3267
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0288 0.0497 0.0497
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0592 0.128 0.128
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0116 0.0055 0.5
Leishmania major phosphatidylinositol kinase, putative 0.0267 0.0444 0.0444

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.