Detailed information for compound 1623165

Basic information

Technical information
  • TDR Targets ID: 1623165
  • Name: 6-Cyano-N-(2,6-dimethylphenyl)-5-oxo-6-phenyl hexanamide
  • MW: 334.412 | Formula: C21H22N2O2
  • H donors: 1 H acceptors: 3 LogP: 3.36 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC(c1ccccc1)C(=O)CCCC(=O)Nc1c(C)cccc1C
  • InChi: 1S/C21H22N2O2/c1-15-8-6-9-16(2)21(15)23-20(25)13-7-12-19(24)18(14-22)17-10-4-3-5-11-17/h3-6,8-11,18H,7,12-13H2,1-2H3,(H,23,25)
  • InChiKey: UABACJFPWNRKAW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-cyano-N-(2,6-dimethylphenyl)-5-oxo-6-phenyl-hexanamide
  • 6-cyano-N-(2,6-dimethylphenyl)-5-keto-6-phenyl-hexanamide
  • AIDS-131722
  • AIDS131722
  • NSC624474
  • NCI60_007415

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.026 0.061 0.061
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.026 0.061 0.061
Trichomonas vaginalis PIKK family atypical protein kinase 0.2998 0.7428 0.7428
Entamoeba histolytica hypothetical protein 0.0762 0.1861 0.1847
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.026 0.061 0.061
Trichomonas vaginalis fk506-binding protein, putative 0.0055 0.0098 0.0098
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.026 0.061 0.0595
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0055 0.0098 0.0082
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0762 0.1861 0.1861
Loa Loa (eye worm) hypothetical protein 0.0066 0.0127 0.0127
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.026 0.061 0.0595
Trichomonas vaginalis PIKK family atypical protein kinase 0.3207 0.7946 0.7946
Trichomonas vaginalis PIKK family atypical protein kinase 0.2177 0.5382 0.5382
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.026 0.061 0.0595
Trichomonas vaginalis PIKK family atypical protein kinase 0.2174 0.5374 0.5374
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.026 0.061 0.0564
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0762 0.1861 0.1861
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1352 0.3329 0.3262
Entamoeba histolytica protein kinase, putative 0.0035 0.0049 0.0033
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.026 0.061 1
Echinococcus multilocularis serine protein kinase ATM 0.0762 0.1861 0.1861
Loa Loa (eye worm) hypothetical protein 0.0589 0.143 0.143
Onchocerca volvulus 0.026 0.061 0.5
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0055 0.0098 0.0082
Echinococcus granulosus Glutaredoxin protein 5 0.0021 0.0016 0.0016
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0055 0.0098 0.0049
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0022 0.0017 0.0017
Schistosoma mansoni hypothetical protein 0.026 0.061 0.061
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0047 0.008 0.008
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.026 0.061 0.061
Trichomonas vaginalis PIKK family atypical protein kinase 0.2998 0.7428 0.7428
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.026 0.061 0.0767
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.026 0.061 0.061
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.026 0.061 0.0595
Trichomonas vaginalis PIKK family atypical protein kinase 0.2998 0.7428 0.7428
Leishmania major hypothetical protein, unknown function 0.026 0.061 0.0517
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.026 0.061 0.061
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0033 0.0044 0.0044
Trichomonas vaginalis PIKK family atypical protein kinase 0.2998 0.7428 0.7428
Loa Loa (eye worm) hypothetical protein 0.085 0.2078 0.2078
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.4031 1 1
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0055 0.0098 0.0082
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.026 0.061 0.0595
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0055 0.0098 0.0082
Trichomonas vaginalis PIKK family atypical protein kinase 0.026 0.061 0.061
Entamoeba histolytica protein kinase, putative 0.0035 0.0049 0.0033
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0049 0.0049
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.026 0.061 0.061
Mycobacterium leprae conserved hypothetical protein 0.026 0.061 0.5
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.4031 1 1
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0055 0.0098 0.0098
Trichomonas vaginalis PIKK family atypical protein kinase 0.0762 0.1861 0.1861
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.026 0.061 0.061
Giardia lamblia Hypothetical protein 0.026 0.061 0.0595
Leishmania major phosphatidylinositol 3-kinase, putative 0.026 0.061 0.0517
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.026 0.061 0.0595
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0589 0.143 0.143
Trichomonas vaginalis conserved hypothetical protein 0.085 0.2078 0.2078
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0022 0.0016 0.0016
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0071 0.014 0.014
Trichomonas vaginalis PIKK family atypical protein kinase 0.2704 0.6695 0.6695
Toxoplasma gondii target of rapamycin (TOR), putative 0.2998 0.7428 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.026 0.061 0.061
Schistosoma mansoni hypothetical protein 0.0589 0.143 0.143
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.026 0.061 0.0767
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0055 0.0098 0.0082
Entamoeba histolytica hypothetical protein 0.026 0.061 0.0595
Loa Loa (eye worm) phosphatidylinositol 3 0.026 0.061 0.061
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.026 0.061 0.0595
Trypanosoma cruzi Protein kinase B 0.0024 0.0022 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.3207 0.7946 0.7946
Plasmodium falciparum phosphatidylinositol 3-kinase 0.026 0.061 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0762 0.1861 0.1847
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.026 0.061 0.0564
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0762 0.1861 0.1821
Trypanosoma brucei target of rapamycin kinase 3, putative 0.321 0.7954 0.7944
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0049 0.0049
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.026 0.061 0.061
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0076 0.0152 0.0152
Leishmania major phosphatidylinositol kinase related protein, putative 0.026 0.061 0.0517
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0022 0.0016 0.0016
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.4031 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.026 0.061 0.061
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.026 0.061 0.061
Trichomonas vaginalis PIKK family atypical protein kinase 0.2409 0.596 0.596
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1352 0.3329 0.3329
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0076 0.0152 0.0152
Schistosoma mansoni immunophilin 0.0055 0.0098 0.0098
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.4031 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.026 0.061 0.0595
Entamoeba histolytica PH domain containing protein kinase, putative 0.0024 0.0022 0.0005
Giardia lamblia Phosphatidylinositol 4-kinase 0.026 0.061 0.0595
Echinococcus multilocularis voltage gated potassium channel 0.0022 0.0017 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.1352 0.3329 0.3329
Loa Loa (eye worm) phosphatidylinositol 3 0.026 0.061 0.061
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0049 0.0049
Trichomonas vaginalis PIKK family atypical protein kinase 0.1352 0.3329 0.3329
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.026 0.061 0.061
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0055 0.0098 0.1379
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.026 0.061 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.3207 0.7946 0.7946
Leishmania major phosphatidylinositol 3-kinase, putative 0.1352 0.3329 0.3262
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0024 0.0022 0.0005
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1352 0.3329 0.3329
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.026 0.061 1
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0076 0.0152 0.0152
Schistosoma mansoni immunophilin 0.0055 0.0098 0.0098
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.026 0.061 0.061
Trichomonas vaginalis PIKK family atypical protein kinase 0.2617 0.6479 0.6479
Entamoeba histolytica hypothetical protein 0.026 0.061 0.0595
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.026 0.061 0.061
Brugia malayi Protein kinase domain containing protein 0.0035 0.0049 0.0049
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.4031 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.4031 1 1
Echinococcus multilocularis rac serine:threonine kinase 0.0024 0.0022 0.0022
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0055 0.0098 0.0098
Trichomonas vaginalis PIKK family atypical protein kinase 0.1352 0.3329 0.3329
Loa Loa (eye worm) hypothetical protein 0.026 0.061 0.061
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0049 0.0049
Mycobacterium tuberculosis Conserved hypothetical protein 0.026 0.061 0.5
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0055 0.0098 0.0098
Trichomonas vaginalis PIKK family atypical protein kinase 0.3207 0.7946 0.7946
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.1907 0.4709 0.4683
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.026 0.061 0.061
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0022 0.0017 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.2177 0.5382 0.5382
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.026 0.061 0.0595
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0762 0.1861 0.1847
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0017 0.0017
Plasmodium falciparum phosphatidylinositol 4-kinase 0.026 0.061 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1352 0.3329 0.3318
Echinococcus granulosus serine/threonine protein kinase 0.0024 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.026 0.061 0.061
Loa Loa (eye worm) phosphatidylinositol kinase 0.026 0.061 0.061
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.026 0.061 0.061
Loa Loa (eye worm) phosphatidylinositol 3 0.4031 1 1
Plasmodium vivax hypothetical protein, conserved 0.026 0.061 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0762 0.1861 0.1847
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.026 0.061 0.0517
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0017
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.026 0.061 0.0767
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0071 0.014 0.014
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.026 0.061 0.061
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.017 0.017
Echinococcus multilocularis Zinc finger, PHD finger 0.026 0.061 0.061
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0055 0.0098 0.0098
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0021 0.0016 0.0016
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.026 0.061 0.061
Echinococcus granulosus serine threonine protein kinase nrc 0.0022 0.0016 0.0016
Echinococcus granulosus nervana 2 0.0021 0.0016 0.0016
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.026 0.061 0.061
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.4031 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.026 0.061 0.0595
Entamoeba histolytica protein kinase rad3, putative 0.0762 0.1861 0.1847
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.026 0.061 0.0595
Leishmania major hypothetical protein, conserved 0.026 0.061 0.0517
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1352 0.3329 0.3329
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.026 0.061 0.0767
Schistosoma mansoni serine/threonine-protein kinase 0.0024 0.0022 0.0022
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.4031 1 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0022 0.0017 0.0017
Onchocerca volvulus 0.026 0.061 0.5
Loa Loa (eye worm) AGC/AKT protein kinase 0.0035 0.0049 0.0049
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1352 0.3329 0.3296
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.026 0.061 0.0595
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.026 0.061 0.0595
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.1674 0.4132 0.4103
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.026 0.061 1
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0055 0.0098 0.5
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.026 0.061 0.061
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1352 0.3329 0.3296
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0055 0.0098 0.0098
Giardia lamblia GTOR 0.4031 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0502 0.1213 0.1213
Schistosoma mansoni fkbp-rapamycin associated protein 0.0762 0.1861 0.1861
Loa Loa (eye worm) phosphatidylinositol 3 0.026 0.061 0.061
Loa Loa (eye worm) phosphatidylinositol 3 0.1352 0.3329 0.3329
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.026 0.061 0.061
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.4031 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.026 0.061 0.061
Trichomonas vaginalis PIKK family atypical protein kinase 0.2174 0.5374 0.5374
Trichomonas vaginalis PIKK family atypical protein kinase 0.2409 0.596 0.596
Schistosoma mansoni phosphatidylinositol 4-kinase 0.026 0.061 0.061
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.321 0.7954 0.7934
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0055 0.0098 0.0098
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0055 0.0098 0.0082
Leishmania major phosphatidylinositol 4-kinase, putative 0.026 0.061 0.0517
Loa Loa (eye worm) hypothetical protein 0.0502 0.1213 0.1213
Trichomonas vaginalis PIKK family atypical protein kinase 0.0762 0.1861 0.1861
Echinococcus multilocularis nervana 2 0.0021 0.0016 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.4031 1 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.026 0.061 0.061
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.026 0.061 0.061
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.026 0.061 0.0595
Leishmania major phosphatidylinositol kinase, putative 0.026 0.061 0.0517
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0049 0.0049
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0055 0.0098 0.1379
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.4031 1 1
Entamoeba histolytica protein kinase, putative 0.0033 0.0044 0.0027
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0049 0.0049
Echinococcus granulosus serine protein kinase ATM 0.0762 0.1861 0.1861
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.026 0.061 0.0595
Loa Loa (eye worm) FKBP5 protein 0.0055 0.0098 0.0098
Trypanosoma cruzi target of rapamycin kinase 3 0.321 0.7954 0.7951
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.026 0.061 0.061
Trichomonas vaginalis PIKK family atypical protein kinase 0.2998 0.7428 0.7428
Trichomonas vaginalis PIKK family atypical protein kinase 0.2998 0.7428 0.7428
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.026 0.061 0.061
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0055 0.0098 0.0098
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.4031 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2177 0.5382 0.5382
Echinococcus multilocularis 0.026 0.061 0.061
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0762 0.1861 0.1861
Brugia malayi p70 ribosomal S6 kinase beta 0.0033 0.0044 0.0044
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0055 0.0098 0.0082
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.026 0.061 0.061
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.026 0.061 0.061
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.026 0.061 0.0595
Loa Loa (eye worm) hypothetical protein 0.0047 0.008 0.008
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.026 0.061 0.0564
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.026 0.061 0.0595
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.026 0.061 0.061
Trichomonas vaginalis conserved hypothetical protein 0.0502 0.1213 0.1213
Brugia malayi FAT domain containing protein 0.0589 0.143 0.143
Trichomonas vaginalis PIKK family atypical protein kinase 0.2409 0.596 0.596
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.026 0.061 0.061
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.026 0.061 0.061
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0055 0.0098 0.0082
Trichomonas vaginalis PIKK family atypical protein kinase 0.2174 0.5374 0.5374
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.026 0.061 0.061
Trichomonas vaginalis PIKK family atypical protein kinase 0.2385 0.5901 0.5901
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.026 0.061 1
Echinococcus multilocularis fk506 binding protein 0.0055 0.0098 0.0098
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.026 0.061 0.061
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0049 0.0049
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0762 0.1861 0.1861
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1352 0.3329 0.3318
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0055 0.0098 0.0098
Trichomonas vaginalis PIKK family atypical protein kinase 0.1352 0.3329 0.3329
Toxoplasma gondii non-specific serine/threonine protein kinase 0.085 0.2078 0.2755
Entamoeba histolytica PH domain containing protein kinase, putative 0.0024 0.0022 0.0005
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0076 0.0152 0.0152
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.026 0.061 0.061
Schistosoma mansoni phosphatidylinositol 4-kinase 0.026 0.061 0.061
Trichomonas vaginalis immunophilin, putative 0.0055 0.0098 0.0098
Schistosoma mansoni immunophilin 0.0047 0.008 0.008
Schistosoma mansoni serine/threonine-protein kinase 0.0024 0.0022 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0589 0.143 0.143
Echinococcus multilocularis Glutaredoxin protein 5 0.0021 0.0016 0.0016
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.026 0.061 0.0564
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0762 0.1861 0.1861
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1352 0.3329 0.3329
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.026 0.061 0.0595
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0055 0.0098 0.5
Loa Loa (eye worm) hypothetical protein 0.0762 0.1861 0.1861
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.4031 1 1
Entamoeba histolytica hypothetical protein 0.026 0.061 0.0595
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.017 0.017
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0021 0.0016 0.0016
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0502 0.1213 0.1199
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0047 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0822 0.2008 0.2008
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.026 0.061 0.061
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0055 0.0098 0.0098
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0017 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.2385 0.5901 0.5901
Echinococcus granulosus nervana 2 0.0021 0.0016 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.1082 0.2656 0.2656
Loa Loa (eye worm) phosphatidylinositol 3 0.026 0.061 0.061
Echinococcus multilocularis nervana 2 0.0021 0.0016 0.0016
Echinococcus granulosus voltage gated potassium channel 0.0022 0.0017 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0762 0.1861 0.1861
Plasmodium vivax hypothetical protein 0.026 0.061 1
Entamoeba histolytica hypothetical protein 0.026 0.061 0.0595
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.026 0.061 0.061
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.026 0.061 0.0595
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0055 0.0098 0.0049
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.026 0.061 0.061
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.026 0.061 0.061
Trichomonas vaginalis PIKK family atypical protein kinase 0.3442 0.8532 0.8532
Trichomonas vaginalis PIKK family atypical protein kinase 0.1352 0.3329 0.3329
Trichomonas vaginalis PIKK family atypical protein kinase 0.026 0.061 0.061
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.026 0.061 0.061
Trichomonas vaginalis PIKK family atypical protein kinase 0.4031 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.3207 0.7946 0.7946
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.026 0.061 0.0767
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0589 0.143 0.143
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.026 0.061 0.0595
Trichomonas vaginalis PIKK family atypical protein kinase 0.2998 0.7428 0.7428
Trichomonas vaginalis PIKK family atypical protein kinase 0.2177 0.5382 0.5382
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.026 0.061 0.061
Toxoplasma gondii FATC domain-containing protein 0.0762 0.1861 0.2461

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -6 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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