Detailed information for compound 1623700

Basic information

Technical information
  • TDR Targets ID: 1623700
  • Name: 4,6'-dimethyl-2,2'-spirobi[3H-indene]-1,1'-di one
  • MW: 276.329 | Formula: C19H16O2
  • H donors: 0 H acceptors: 2 LogP: 3.95 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc2c(c1)C(=O)C1(C2)Cc2c(C1=O)cccc2C
  • InChi: 1S/C19H16O2/c1-11-6-7-13-9-19(18(21)15(13)8-11)10-16-12(2)4-3-5-14(16)17(19)20/h3-8H,9-10H2,1-2H3
  • InChiKey: KEMIKYAGTJQKPA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4,6'-dimethyl-2,2'-spirobi[indane]-1,1'-dione
  • 4,6'-dimethyl-2,2'-spirobi[indane]-1,1'-quinone
  • NCI60_027457
  • 2,2'-Spirobi[2H-indene]-1,1'(3'H,3H)-dione, 4,6'-dimethyl-
  • AIDS-147452
  • AIDS147452
  • NSC677073

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major beta tubulin 0.1563 0.3275 1
Trichomonas vaginalis sugar transporter, putative 0.0845 0.1741 0.531
Brugia malayi map kinase activated protein kinase protein 2 0.0186 0.0329 0.037
Loa Loa (eye worm) hypothetical protein 0.0921 0.1902 0.5807
Schistosoma mansoni opsin-like receptor 0.0921 0.1902 0.19
Schistosoma mansoni alpha-1 adrenergic receptor 0.0921 0.1902 0.19
Brugia malayi sulfakinin receptor protein 0.0921 0.1902 0.215
Loa Loa (eye worm) hypothetical protein 0.0921 0.1902 0.5807
Loa Loa (eye worm) sugar transporter 0.0845 0.1741 0.5314
Echinococcus granulosus rhodopsin orphan GPCR 0.0921 0.1902 0.1902
Brugia malayi Major Facilitator Superfamily protein 0.0845 0.1741 0.1967
Mycobacterium ulcerans sugar transporter 0.0845 0.1741 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0053 0.0044 0.0044
Onchocerca volvulus 0.0921 0.1902 0.8655
Trichomonas vaginalis sugar transporter, putative 0.0845 0.1741 0.531
Trichomonas vaginalis tubulin alpha chain, putative 0.1563 0.3275 1
Echinococcus multilocularis G protein coupled receptor 139 0.4705 1 1
Plasmodium vivax histone deacetylase, putative 0.0213 0.0388 0.0763
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0845 0.1741 1
Brugia malayi proprotein convertase 2 0.0089 0.0122 0.0135
Toxoplasma gondii histone deacetylase HDAC1 0.0213 0.0388 0.1165
Trypanosoma brucei beta tubulin 0.1563 0.3275 1
Trichomonas vaginalis sugar transporter, putative 0.0845 0.1741 0.531
Schistosoma mansoni histone deacetylase 0.0237 0.0438 0.0435
Echinococcus multilocularis tyrosine protein kinase csk 0.0034 0.0005 0.0005
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0921 0.1902 0.19
Loa Loa (eye worm) hypothetical protein 0.0921 0.1902 0.5807
Echinococcus granulosus Tubulin beta 2C chain 0.1563 0.3275 0.3275
Echinococcus multilocularis synaptic vesicle 2 protein 0.0845 0.1741 0.1741
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0921 0.1902 0.215
Echinococcus granulosus tyrosine protein kinase Fyn 0.0053 0.0044 0.0044
Echinococcus multilocularis Tubulin beta 2C chain 0.1563 0.3275 0.3275
Brugia malayi Cytochrome P450 family protein 0.0055 0.005 0.0053
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0921 0.1902 0.5807
Echinococcus granulosus histone deacetylase 0.0213 0.0388 0.0388
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0028 0.0063
Echinococcus granulosus neuropeptide Y receptor 0.0921 0.1902 0.1902
Onchocerca volvulus 0.0845 0.1741 0.791
Echinococcus multilocularis rhodopsin orphan GPCR 0.0921 0.1902 0.1902
Schistosoma mansoni glucose transport protein 0.0845 0.1741 0.1738
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0921 0.1902 0.1902
Echinococcus multilocularis Furin 1 0.0034 0.0003 0.0003
Brugia malayi hypothetical protein 0.0921 0.1902 0.215
Giardia lamblia Beta tubulin 0.1563 0.3275 1
Echinococcus granulosus Tubulin beta 2C chain 0.1563 0.3275 0.3275
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0028 0.0071
Loa Loa (eye worm) hypothetical protein 0.0921 0.1902 0.5807
Loa Loa (eye worm) G-protein coupled receptor 0.0921 0.1902 0.5807
Leishmania major beta tubulin 0.1563 0.3275 1
Echinococcus multilocularis neuropeptide Y receptor 0.0921 0.1902 0.1902
Brugia malayi hypothetical protein 0.0921 0.1902 0.215
Schistosoma mansoni sugar transporter 0.0845 0.1741 0.1738
Trichomonas vaginalis glucose transporter, putative 0.0845 0.1741 0.531
Loa Loa (eye worm) hypothetical protein 0.0921 0.1902 0.5807
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0921 0.1902 0.1902
Onchocerca volvulus 0.0921 0.1902 0.8655
Loa Loa (eye worm) hypothetical protein 0.0237 0.0438 0.1338
Schistosoma mansoni amine GPCR 0.0921 0.1902 0.19
Onchocerca volvulus 0.0921 0.1902 0.8655
Schistosoma mansoni opsin-like receptor 0.0921 0.1902 0.19
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0845 0.1741 0.1741
Leishmania major beta tubulin 0.1563 0.3275 1
Loa Loa (eye worm) hypothetical protein 0.0921 0.1902 0.5807
Schistosoma mansoni amine GPCR 0.0921 0.1902 0.19
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0921 0.1902 0.1902
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0028 0.0063
Leishmania major histone deacetylase, putative 0.0213 0.0388 0.1165
Echinococcus granulosus tm gpcr rhodopsin 0.0921 0.1902 0.1902
Schistosoma mansoni biogenic amine (5HT) receptor 0.0921 0.1902 0.19
Loa Loa (eye worm) hypothetical protein 0.0845 0.1741 0.5314
Echinococcus granulosus peptide allatostatin:somatostatin 0.0921 0.1902 0.1902
Loa Loa (eye worm) BEN-1 protein 0.1563 0.3275 1
Loa Loa (eye worm) hypothetical protein 0.0921 0.1902 0.5807
Echinococcus multilocularis allatostatin A receptor 0.1057 0.2193 0.2193
Leishmania major beta tubulin 0.1563 0.3275 1
Leishmania major beta tubulin 0.1563 0.3275 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0053 0.0044 0.0044
Echinococcus granulosus g-protein coupled receptor 0.0921 0.1902 0.1902
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0845 0.1741 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0921 0.1902 0.1902
Echinococcus multilocularis sodium channel protein 0.0199 0.0358 0.0358
Plasmodium vivax tubulin beta chain, putative 0.1563 0.3275 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0053 0.0044 0.0044
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0053 0.0044 0.0044
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0845 0.1741 0.5308
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0028 0.0071
Trichomonas vaginalis histone deacetylase, putative 0.0237 0.0438 0.1329
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0921 0.1902 0.19
Echinococcus granulosus solute carrier family 22 0.0845 0.1741 0.1741
Loa Loa (eye worm) neuropeptide F receptor 0.0921 0.1902 0.5807
Giardia lamblia Beta tubulin 0.1563 0.3275 1
Loa Loa (eye worm) hypothetical protein 0.0921 0.1902 0.5807
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0921 0.1902 0.8655
Trichomonas vaginalis sugar transporter, putative 0.0845 0.1741 0.531
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0921 0.1902 0.19
Brugia malayi putative neuropeptide receptor NPR1 0.0921 0.1902 0.215
Brugia malayi major facilitator superfamily protein 0.0845 0.1741 0.1967
Onchocerca volvulus 0.0845 0.1741 0.791
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0086 0.0116 0.0345
Trypanosoma brucei beta tubulin 0.1563 0.3275 1
Schistosoma mansoni neuropeptide receptor 0.4705 1 1
Trichomonas vaginalis sugar transporter, putative 0.0845 0.1741 0.531
Trichomonas vaginalis tubulin, putative 0.1563 0.3275 1
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0053 0.0044 0.0044
Echinococcus granulosus rhodopsin orphan GPCR 0.0921 0.1902 0.1902
Loa Loa (eye worm) hypothetical protein 0.0921 0.1902 0.5807
Trypanosoma brucei histone deacetylase, putative 0.0213 0.0388 0.1172
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0034 0.0003 0.0001
Schistosoma mansoni hypothetical protein 0.0921 0.1902 0.19
Loa Loa (eye worm) histone deacetylase 11 0.0102 0.0149 0.0456
Schistosoma mansoni amine GPCR 0.0921 0.1902 0.19
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0845 0.1741 0.1741
Trichomonas vaginalis sugar transporter, putative 0.0845 0.1741 0.531
Giardia lamblia Beta tubulin 0.1563 0.3275 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0921 0.1902 0.19
Trichomonas vaginalis sugar transporter, putative 0.0845 0.1741 0.531
Schistosoma mansoni myosin xvIII 0.0921 0.1902 0.19
Echinococcus granulosus tyrosine protein kinase csk 0.0034 0.0005 0.0005
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0845 0.1741 1
Leishmania major beta tubulin 0.1563 0.3275 1
Trypanosoma brucei histone deacetylase 1 0.0237 0.0438 0.1326
Trypanosoma brucei beta tubulin 0.1563 0.3275 1
Brugia malayi Melatonin receptor type 1A 0.0921 0.1902 0.215
Loa Loa (eye worm) hypothetical protein 0.0845 0.1741 0.5314
Brugia malayi Sugar transporter family protein 0.0845 0.1741 0.1967
Trypanosoma cruzi histone deacetylase, putative 0.0213 0.0388 0.1165
Trichomonas vaginalis sugar transporter, putative 0.0845 0.1741 0.531
Loa Loa (eye worm) hypothetical protein 0.0049 0.0036 0.0109
Trichomonas vaginalis sugar transporter, putative 0.0845 0.1741 0.531
Loa Loa (eye worm) proprotein convertase 2 0.0034 0.0003 0.001
Loa Loa (eye worm) hypothetical protein 0.0845 0.1741 0.5314
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0921 0.1902 0.19
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0921 0.1902 0.19
Trypanosoma brucei histone deacetylase 4 0.0213 0.0388 0.1172
Trypanosoma cruzi histone deacetylase 1, putative 0.0237 0.0438 0.1319
Echinococcus granulosus histone deacetylase 6 0.0219 0.0401 0.0401
Echinococcus granulosus histone deacetylase 7 0.0213 0.0388 0.0388
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0036 0.0037
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0237 0.0438 0.1329
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0186 0.0329 0.0329
Echinococcus multilocularis somatostatin receptor 0.0921 0.1902 0.1902
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0921 0.1902 0.215
Loa Loa (eye worm) hypothetical protein 0.0921 0.1902 0.5807
Plasmodium falciparum histone deacetylase 1 0.0237 0.0438 0.0175
Giardia lamblia Histone deacetylase 0.0237 0.0438 0.1219
Echinococcus multilocularis c src tyrosine kinase 0.0055 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0845 0.1741 0.5314
Loa Loa (eye worm) major facilitator superfamily transporter 0.0845 0.1741 0.5314
Echinococcus multilocularis tyrosine protein kinase Srms 0.0042 0.0022 0.0022
Loa Loa (eye worm) histone deacetylase 1 0.0237 0.0438 0.1338
Echinococcus multilocularis 0.0114 0.0176 0.0176
Loa Loa (eye worm) hypothetical protein 0.0118 0.0183 0.0559
Mycobacterium ulcerans integral membrane transport protein 0.0845 0.1741 1
Leishmania major beta tubulin 0.1563 0.3275 1
Schistosoma mansoni hypothetical protein 0.0921 0.1902 0.19
Loa Loa (eye worm) hypothetical protein 0.0921 0.1902 0.5807
Echinococcus granulosus neuropeptides capa receptor 0.0921 0.1902 0.1902
Echinococcus granulosus biogenic amine 5HT receptor 0.0921 0.1902 0.1902
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0845 0.1741 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0845 0.1741 0.531
Loa Loa (eye worm) hypothetical protein 0.0921 0.1902 0.5807
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0086 0.0116 0.0345
Loa Loa (eye worm) histone deacetylase 7A 0.0213 0.0388 0.1184
Brugia malayi beta-tubulin, identical 0.1563 0.3275 0.3705
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0921 0.1902 0.19
Onchocerca volvulus 0.0845 0.1741 0.791
Trypanosoma cruzi beta tubulin, putative 0.1563 0.3275 1
Onchocerca volvulus Putative transporter 0.0845 0.1741 0.791
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0028 0.0071
Leishmania major glucose transporter, lmgt1 0.0845 0.1741 0.5304
Echinococcus granulosus Furin 1 0.0034 0.0003 0.0003
Echinococcus granulosus beta tubulin 0.1563 0.3275 0.3275
Echinococcus granulosus solute carrier family 22 0.0845 0.1741 0.1741
Echinococcus granulosus tyrosine protein kinase Fyn 0.0053 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0056 0.0051 0.0155
Schistosoma mansoni glucose transport protein 0.0845 0.1741 0.1738
Echinococcus multilocularis tyrosine protein kinase Abl 0.0102 0.015 0.015
Trichomonas vaginalis myo-inositol transporter, putative 0.0845 0.1741 0.531
Brugia malayi hypothetical protein 0.0921 0.1902 0.215
Loa Loa (eye worm) hypothetical protein 0.0921 0.1902 0.5807
Schistosoma mansoni tubulin subunit beta 0.1563 0.3275 0.3273
Echinococcus granulosus neuropeptides capa receptor 0.0921 0.1902 0.1902
Echinococcus multilocularis 0.0035 0.0007 0.0007
Trichomonas vaginalis sugar transporter, putative 0.0845 0.1741 0.531
Onchocerca volvulus 0.0845 0.1741 0.791
Loa Loa (eye worm) hypothetical protein 0.0921 0.1902 0.5807
Brugia malayi GnHR receptor homolog 0.4161 0.8836 1
Echinococcus granulosus Tubulin beta 2C chain 0.1563 0.3275 0.3275
Brugia malayi Histone deacetylase family protein 0.0213 0.0388 0.0436
Trichomonas vaginalis conserved hypothetical protein 0.0845 0.1741 0.531
Toxoplasma gondii histone deacetylase HDAC5 0.0102 0.0149 0.0435
Trichomonas vaginalis conserved hypothetical protein 0.0845 0.1741 0.531
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0199 0.0358 0.1073
Brugia malayi Dopamine receptor 0.0921 0.1902 0.215
Onchocerca volvulus 0.0845 0.1741 0.791
Brugia malayi Histone deacetylase 1 0.0237 0.0438 0.0493
Schistosoma mansoni amine GPCR 0.0921 0.1902 0.19
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0921 0.1902 0.1902
Loa Loa (eye worm) tubulin beta-2A chain 0.1563 0.3275 1
Trichomonas vaginalis sugar transporter, putative 0.0845 0.1741 0.531
Schistosoma mansoni sugar transporter 0.0845 0.1741 0.1738
Loa Loa (eye worm) hypothetical protein 0.0845 0.1741 0.5314
Schistosoma mansoni tubulin subunit beta 0.1563 0.3275 0.3273
Echinococcus multilocularis rhodopsin orphan GPCR 0.0921 0.1902 0.1902
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0199 0.0358 0.0358
Trichomonas vaginalis DNA polymerase eta, putative 0.0045 0.0028 0.0075
Loa Loa (eye worm) hypothetical protein 0.0921 0.1902 0.5807
Leishmania major beta tubulin 0.1563 0.3275 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0921 0.1902 0.19
Leishmania major beta tubulin 0.1563 0.3275 1
Onchocerca volvulus 0.0845 0.1741 0.791
Brugia malayi hypothetical protein 0.0921 0.1902 0.215
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0921 0.1902 0.19
Schistosoma mansoni furin-1 (S08 family) 0.0062 0.0064 0.0061
Schistosoma mansoni tubulin subunit beta 0.1563 0.3275 0.3273
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0035 0.0007 0.0008
Echinococcus granulosus Tubulin beta 2C chain 0.1563 0.3275 0.3275
Loa Loa (eye worm) hypothetical protein 0.0845 0.1741 0.5314
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0845 0.1741 0.1741
Plasmodium vivax histone deacetylase 1, putative 0.0237 0.0438 0.0924
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0921 0.1902 0.1902
Loa Loa (eye worm) cytochrome P450 family protein 0.0055 0.005 0.0152
Echinococcus granulosus neuroendocrine convertase 2 0.0089 0.0122 0.0122
Loa Loa (eye worm) TK/CSK protein kinase 0.0034 0.0005 0.0016
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0053 0.0044 0.0044
Leishmania major beta tubulin 0.1563 0.3275 1
Loa Loa (eye worm) TK protein kinase 0.0042 0.0022 0.0069
Trichomonas vaginalis histone deacetylase, putative 0.0237 0.0438 0.1329
Loa Loa (eye worm) hypothetical protein 0.0921 0.1902 0.5807
Echinococcus granulosus nuclear receptor co repressor related ncor 0.0272 0.0515 0.0515
Trypanosoma cruzi hexose transporter, putative 0.0845 0.1741 0.5304
Toxoplasma gondii histone deacetylase HDAC4 0.0102 0.0149 0.0435
Loa Loa (eye worm) hypothetical protein 0.0921 0.1902 0.5807
Brugia malayi polk-prov protein 0.0034 0.0004 0.0002
Echinococcus granulosus alpha 1A adrenergic receptor 0.0921 0.1902 0.1902
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0921 0.1902 0.19
Trichomonas vaginalis sugar transporter, putative 0.0845 0.1741 0.531
Onchocerca volvulus 0.0921 0.1902 0.8655
Echinococcus multilocularis rhodopsin orphan GPCR 0.0921 0.1902 0.1902
Loa Loa (eye worm) hypothetical protein 0.0845 0.1741 0.5314
Loa Loa (eye worm) neuropeptide F receptor 0.0921 0.1902 0.5807
Loa Loa (eye worm) hypothetical protein 0.0921 0.1902 0.5807
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0845 0.1741 0.4685
Onchocerca volvulus 0.0845 0.1741 0.791
Brugia malayi major facilitator superfamily protein 0.0845 0.1741 0.1967
Trichomonas vaginalis tubulin epsilon chain, putative 0.1563 0.3275 1
Echinococcus multilocularis beta tubulin 0.1563 0.3275 0.3275
Trypanosoma cruzi histone deacetylase, putative 0.0213 0.0388 0.1165
Brugia malayi Serotonin receptor 0.0921 0.1902 0.215
Trypanosoma brucei glucose transporter, putative 0.0845 0.1741 0.5308
Schistosoma mansoni histone deacetylase 4 5 0.0213 0.0388 0.0385
Trichomonas vaginalis sugar transporter, putative 0.0845 0.1741 0.531
Echinococcus granulosus tyrosine protein kinase Src42A 0.004 0.0016 0.0016
Echinococcus granulosus c src tyrosine kinase 0.0055 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.1057 0.2193 0.6696
Schistosoma mansoni tubulin subunit beta 0.1563 0.3275 0.3273
Brugia malayi follicle stimulating hormone receptor 0.0921 0.1902 0.215
Trichomonas vaginalis sugar transporter, putative 0.0845 0.1741 0.531
Echinococcus multilocularis neuropeptide receptor A26 0.0921 0.1902 0.1902
Echinococcus granulosus fmrfamide receptor 0.0921 0.1902 0.1902
Brugia malayi G protein-coupled receptor F59B2.13 0.0921 0.1902 0.215
Loa Loa (eye worm) hypothetical protein 0.0921 0.1902 0.5807
Echinococcus granulosus g protein coupled receptor 0.0921 0.1902 0.1902
Onchocerca volvulus 0.0845 0.1741 0.791
Echinococcus multilocularis rhodopsin orphan GPCR 0.0921 0.1902 0.1902
Echinococcus granulosus neuropeptide Y receptor 0.0921 0.1902 0.1902
Onchocerca volvulus 0.1057 0.2193 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0045 0.0028 0.0075
Brugia malayi neuropeptide F receptor 0.0921 0.1902 0.215
Leishmania major beta tubulin 0.1563 0.3275 1
Trichomonas vaginalis sugar transporter, putative 0.0845 0.1741 0.531
Trichomonas vaginalis tubulin gamma chain, putative 0.1563 0.3275 1
Onchocerca volvulus 0.0845 0.1741 0.791
Brugia malayi Dopamine receptor protein 2 0.0921 0.1902 0.215
Trypanosoma brucei beta tubulin 0.1563 0.3275 1
Echinococcus granulosus tubulin beta 1 chain 0.1563 0.3275 0.3275
Echinococcus multilocularis dnaJ subfamily B 0.123 0.2565 0.2565
Trichomonas vaginalis histone deacetylase, putative 0.0237 0.0438 0.1329
Brugia malayi Cytochrome P450 family protein 0.0055 0.005 0.0053
Loa Loa (eye worm) cytochrome P450 0.0035 0.0007 0.0022
Brugia malayi hypothetical protein 0.0921 0.1902 0.215
Echinococcus granulosus tm gpcr rhodopsin 0.0921 0.1902 0.1902
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0042 0.0022 0.0022
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0921 0.1902 0.5807
Brugia malayi Dopamine receptor protein 1 0.0921 0.1902 0.215
Echinococcus multilocularis tyrosine protein kinase csk 0.0034 0.0005 0.0005
Echinococcus granulosus dnaJ subfamily B 0.123 0.2565 0.2565
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0921 0.1902 0.1902
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0921 0.1902 0.19
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0086 0.0116 0.0116
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0186 0.0329 0.0329
Loa Loa (eye worm) hypothetical protein 0.0921 0.1902 0.5807
Onchocerca volvulus 0.0921 0.1902 0.8655
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0921 0.1902 0.19
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0921 0.1902 0.1902
Onchocerca volvulus 0.0921 0.1902 0.8655
Echinococcus granulosus histone deacetylase 6 0.0213 0.0388 0.0388
Schistosoma mansoni tyrosine kinase 0.0053 0.0044 0.0042
Echinococcus multilocularis rhodopsin orphan GPCR 0.0921 0.1902 0.1902
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0921 0.1902 0.1902
Echinococcus multilocularis histone deacetylase 1 0.0237 0.0438 0.0438
Trypanosoma brucei DNA polymerase IV, putative 0.0045 0.0028 0.0071
Loa Loa (eye worm) hypothetical protein 0.0033 0.0003 0.0008
Loa Loa (eye worm) histone deacetylase 3 0.0237 0.0438 0.1338
Schistosoma mansoni sugar transporter 0.0845 0.1741 0.1738
Echinococcus granulosus Tubulin beta 2C chain 0.1563 0.3275 0.3275
Echinococcus granulosus serotonin receptor 0.0921 0.1902 0.1902
Echinococcus granulosus tyrosine protein kinase Src64B 0.0053 0.0044 0.0044
Trichomonas vaginalis sugar transporter, putative 0.0845 0.1741 0.531
Echinococcus multilocularis fmrfamide receptor 0.0921 0.1902 0.1902
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0053 0.0044 0.0044
Trypanosoma brucei glucose transporter, putative 0.0845 0.1741 0.5308
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0186 0.0329 0.1005
Brugia malayi Major Facilitator Superfamily protein 0.0845 0.1741 0.1967
Brugia malayi Serotonin receptor 0.0921 0.1902 0.215
Echinococcus granulosus Solute carrier family 22 5 0.2256 0.4759 0.4759
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0845 0.1741 0.1738
Schistosoma mansoni hypothetical protein 0.123 0.2565 0.2562
Brugia malayi protein-tyrosine kinase 0.0042 0.0022 0.0022
Trypanosoma cruzi histone deacetylase 1, putative 0.0237 0.0438 0.1319
Trichomonas vaginalis conserved hypothetical protein 0.0845 0.1741 0.531
Echinococcus multilocularis neuropeptides capa receptor 0.0921 0.1902 0.1902
Brugia malayi histone deacetylase 3 (HD3) 0.0237 0.0438 0.0493
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0921 0.1902 0.19
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0028 0.0071
Loa Loa (eye worm) major facilitator superfamily transporter 0.0845 0.1741 0.5314
Trichomonas vaginalis sugar transport protein, putative 0.0845 0.1741 0.531
Echinococcus multilocularis g protein coupled receptor 0.0921 0.1902 0.1902
Loa Loa (eye worm) hypothetical protein 0.0845 0.1741 0.5314
Leishmania major histone deacetylase, putative 0.0237 0.0438 0.1319
Toxoplasma gondii histone deacetylase HDAC2 0.0237 0.0438 0.1319
Echinococcus multilocularis histone deacetylase 0.0213 0.0388 0.0388
Trichomonas vaginalis histone deacetylase, putative 0.0237 0.0438 0.1329
Echinococcus multilocularis dro:myosuppressin receptor 0.0921 0.1902 0.1902
Schistosoma mansoni sugar transporter 0.0845 0.1741 0.1738
Leishmania major beta tubulin 0.1563 0.3275 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0921 0.1902 0.1902
Toxoplasma gondii beta tubulin 0.1563 0.3275 1
Schistosoma mansoni hypothetical protein 0.0921 0.1902 0.19
Echinococcus granulosus neuropeptide receptor 0.0921 0.1902 0.1902
Leishmania major glucose transporter, lmgt3 0.0845 0.1741 0.5304
Loa Loa (eye worm) hypothetical protein 0.0921 0.1902 0.5807
Onchocerca volvulus Neuropeptide F receptor homolog 0.0921 0.1902 0.8655
Loa Loa (eye worm) hypothetical protein 0.0111 0.017 0.0519
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0921 0.1902 0.1902
Trichomonas vaginalis glucose transporter, putative 0.0845 0.1741 0.531
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0053 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0034 0.0004 0.0013
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0921 0.1902 0.1902
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0921 0.1902 0.1902
Echinococcus granulosus biogenic amine 5HT receptor 0.0921 0.1902 0.1902
Schistosoma mansoni histone deacetylase 0.0237 0.0438 0.0435
Echinococcus granulosus orexin receptor type 2 0.0921 0.1902 0.1902
Echinococcus multilocularis orexin receptor type 2 0.0921 0.1902 0.1902
Trichomonas vaginalis sugar transporter, putative 0.0845 0.1741 0.531
Brugia malayi Cytochrome P450 family protein 0.0182 0.0322 0.0361
Echinococcus multilocularis g-protein coupled receptor 0.0921 0.1902 0.1902
Loa Loa (eye worm) hypothetical protein 0.0921 0.1902 0.5807
Echinococcus granulosus beta tubulin 0.1563 0.3275 0.3275
Echinococcus multilocularis histone deacetylase 6 0.0213 0.0388 0.0388
Brugia malayi endoprotease bli-4 precursor 0.0142 0.0235 0.0263
Loa Loa (eye worm) hypothetical protein 0.0921 0.1902 0.5807
Brugia malayi Sugar transporter family protein 0.0845 0.1741 0.1967
Loa Loa (eye worm) hypothetical protein 0.0081 0.0106 0.0323
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0921 0.1902 0.19
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0036 0.0037
Trypanosoma brucei THT1 - hexose transporter, putative 0.0845 0.1741 0.5308
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0053 0.0044 0.0044
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0237 0.0438 0.1329
Echinococcus granulosus allatostatin A receptor 0.1057 0.2193 0.2193
Trichomonas vaginalis sugar transporter, putative 0.0845 0.1741 0.531
Plasmodium falciparum tubulin beta chain 0.1563 0.3275 1
Trypanosoma cruzi hexose transporter, putative 0.0845 0.1741 0.5304
Echinococcus granulosus hypothetical protein 0.0921 0.1902 0.1902
Brugia malayi ORL1-like opioid receptor 0.0921 0.1902 0.215
Trichomonas vaginalis conserved hypothetical protein 0.0845 0.1741 0.531
Trichomonas vaginalis glucose transporter, putative 0.0845 0.1741 0.531
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0845 0.1741 0.1741
Schistosoma mansoni histone deacetylase hda2 0.0102 0.0149 0.0147
Schistosoma mansoni growth hormone secretagogue receptor 0.0921 0.1902 0.19
Loa Loa (eye worm) melatonin receptor type 1A 0.0921 0.1902 0.5807
Brugia malayi hypothetical protein 0.0921 0.1902 0.215
Leishmania major cytochrome p450-like protein 0.0055 0.005 0.013
Echinococcus multilocularis neuropeptide FF receptor 2 0.0921 0.1902 0.1902
Trypanosoma cruzi cytochrome P450, putative 0.0055 0.005 0.013
Loa Loa (eye worm) hypothetical protein 0.0921 0.1902 0.5807
Leishmania major beta tubulin 0.1563 0.3275 1
Echinococcus granulosus G protein coupled receptor 139 0.0921 0.1902 0.1902
Trichomonas vaginalis sugar transporter, putative 0.0845 0.1741 0.531
Onchocerca volvulus 0.0921 0.1902 0.8655
Trypanosoma brucei THT1 - hexose transporter, putative 0.0845 0.1741 0.5308
Trichomonas vaginalis sugar transporter, putative 0.0845 0.1741 0.531
Leishmania major beta tubulin 0.1563 0.3275 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0921 0.1902 0.1902
Echinococcus multilocularis solute carrier family 22 0.0845 0.1741 0.1741
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0921 0.1902 0.1902
Brugia malayi histone deacetylase 11 0.0102 0.0149 0.0166
Echinococcus multilocularis fmrfamide receptor 0.0921 0.1902 0.1902
Schistosoma mansoni hypothetical protein 0.0921 0.1902 0.19
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0028 0.0071
Loa Loa (eye worm) hypothetical protein 0.0921 0.1902 0.5807
Loa Loa (eye worm) hypothetical protein 0.0921 0.1902 0.5807
Echinococcus multilocularis neuropeptide s receptor 0.0921 0.1902 0.1902
Brugia malayi histone deacetylase 1 (HD1) 0.0237 0.0438 0.0493
Leishmania major histone deacetylase, putative 0.0237 0.0438 0.1319
Trichomonas vaginalis sugar transporter, putative 0.0845 0.1741 0.531
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0921 0.1902 0.1902
Trichomonas vaginalis sugar transporter, putative 0.0845 0.1741 0.531
Brugia malayi hypothetical protein 0.0845 0.1741 0.1967
Toxoplasma gondii transporter, major facilitator family protein 0.0845 0.1741 0.5304
Brugia malayi Tyrosine-protein kinase abl-1 0.0127 0.0203 0.0227
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0036 0.0109
Brugia malayi larval opioid receptor 0.0921 0.1902 0.215
Echinococcus granulosus furin 0.0142 0.0235 0.0235
Onchocerca volvulus 0.0921 0.1902 0.8655
Onchocerca volvulus 0.0921 0.1902 0.8655
Schistosoma mansoni glucose transporter 0.0845 0.1741 0.1738
Brugia malayi Sugar transporter family protein 0.0845 0.1741 0.1967
Trichomonas vaginalis sugar transporter, putative 0.0845 0.1741 0.531
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0845 0.1741 0.1741
Entamoeba histolytica tubulin family protein 0.1563 0.3275 1
Trichomonas vaginalis sugar transporter, putative 0.0845 0.1741 0.531
Brugia malayi SRC-1 0.0053 0.0044 0.0047
Echinococcus granulosus histone deacetylase 1 0.0237 0.0438 0.0438
Echinococcus granulosus 7TM GPCR rhodopsin 0.0921 0.1902 0.1902
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0921 0.1902 0.1902
Trypanosoma brucei glucose transporter, putative 0.0845 0.1741 0.5308
Echinococcus granulosus Sugar transporter ERD6 protein 0.0845 0.1741 0.1741
Onchocerca volvulus 0.0921 0.1902 0.8655
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0053 0.0044 0.0044
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0845 0.1741 1
Loa Loa (eye worm) sugar transporter 0.0845 0.1741 0.5314
Trypanosoma brucei DNA polymerase IV, putative 0.0045 0.0028 0.0071
Schistosoma mansoni histone deacetylase hda2 0.0219 0.0401 0.0398
Brugia malayi hypothetical protein 0.0921 0.1902 0.215
Trichomonas vaginalis conserved hypothetical protein 0.0845 0.1741 0.531
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0028 0.0071
Loa Loa (eye worm) tubulin beta-1 chain 0.1563 0.3275 1
Onchocerca volvulus 0.0845 0.1741 0.791
Loa Loa (eye worm) TK/ABL protein kinase 0.0219 0.04 0.122
Loa Loa (eye worm) TYRA-2 protein 0.0921 0.1902 0.5807
Echinococcus granulosus g protein coupled receptor 0.0921 0.1902 0.1902
Trichomonas vaginalis histone deacetylase, putative 0.0237 0.0438 0.1329
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0237 0.0438 0.1329
Echinococcus granulosus histone deacetylase 8 0.0102 0.0149 0.0149
Trypanosoma brucei histone deacetylase 2 0.0102 0.0149 0.0443
Echinococcus multilocularis tyrosine protein kinase Src42A 0.004 0.0016 0.0016
Echinococcus multilocularis g protein coupled receptor 0.0921 0.1902 0.1902
Schistosoma mansoni neuropeptide F-like receptor 0.0921 0.1902 0.19
Trypanosoma cruzi hexose transporter, putative 0.0845 0.1741 0.5304
Brugia malayi neuropeptide F receptor 0.0921 0.1902 0.215
Echinococcus multilocularis tubulin, beta 4A class IVa 0.1563 0.3275 0.3275
Onchocerca volvulus 0.0921 0.1902 0.8655
Onchocerca volvulus 0.0921 0.1902 0.8655
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0028 0.0071
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0028 0.0071
Echinococcus multilocularis neuroendocrine convertase 2 0.0089 0.0122 0.0122
Echinococcus multilocularis tyrosine protein kinase Blk 0.0042 0.0022 0.0022
Echinococcus granulosus neuropeptide FF receptor 2 0.0921 0.1902 0.1902
Toxoplasma gondii histone deacetylase HDAC3 0.0237 0.0438 0.1319
Trypanosoma brucei THT1 - hexose transporter, putative 0.0845 0.1741 0.5308
Brugia malayi Tubulin beta-1 chain 0.1563 0.3275 0.3705
Echinococcus granulosus cytochrome P450 2K1 0.0035 0.0007 0.0007
Echinococcus multilocularis G-protein coupled receptor, putative 0.0921 0.1902 0.1902
Echinococcus granulosus dna polymerase kappa 0.0045 0.0028 0.0028
Plasmodium vivax sugar transporter, putative 0.0845 0.1741 0.5091
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0028 0.0063
Plasmodium vivax histone deacetylase 2, putative 0.0213 0.0388 0.0763
Trypanosoma brucei unspecified product 0.0038 0.0012 0.0024
Trypanosoma cruzi histone deacetylase, putative 0.0102 0.0149 0.0435
Loa Loa (eye worm) hypothetical protein 0.0921 0.1902 0.5807
Brugia malayi SH2 domain containing protein 0.0045 0.0028 0.0028
Trichomonas vaginalis tubulin beta chain, putative 0.1563 0.3275 1
Toxoplasma gondii beta-1 tubulin, putative 0.1563 0.3275 1
Onchocerca volvulus 0.0921 0.1902 0.8655
Echinococcus granulosus solute carrier family 22 0.0845 0.1741 0.1741
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0086 0.0116 0.0116
Echinococcus granulosus tachykinin peptides receptor 99D 0.0921 0.1902 0.1902
Schistosoma mansoni opsin-like receptor 0.0921 0.1902 0.19
Trichomonas vaginalis sugar transporter, putative 0.0845 0.1741 0.531
Echinococcus granulosus tyrosine protein kinase csk 0.0034 0.0005 0.0005
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0921 0.1902 0.5807
Brugia malayi G-protein coupled receptor 0.0921 0.1902 0.215
Echinococcus multilocularis tubulin subunit beta 0.1563 0.3275 0.3275
Toxoplasma gondii beta-tubulin, putative 0.1563 0.3275 1
Brugia malayi putative neuropeptide receptor 0.0921 0.1902 0.215
Schistosoma mansoni amine GPCR 0.0921 0.1902 0.19
Loa Loa (eye worm) hypothetical protein 0.0921 0.1902 0.5807
Loa Loa (eye worm) hypothetical protein 0.0921 0.1902 0.5807
Echinococcus multilocularis neuropeptide receptor 0.4705 1 1
Schistosoma mansoni tubulin subunit beta 0.1563 0.3275 0.3273
Brugia malayi neuroendocrine convertase 1 precursor 0.0089 0.0122 0.0135
Brugia malayi hypothetical protein 0.0921 0.1902 0.215
Echinococcus granulosus tubulin subunit beta 0.1563 0.3275 0.3275
Echinococcus granulosus histone deacetylase 3 0.0237 0.0438 0.0438
Leishmania major glucose transporter/membrane transporter D2, putative 0.0845 0.1741 0.5304
Echinococcus granulosus sex peptide receptor 0.0921 0.1902 0.1902
Echinococcus multilocularis histone deacetylase 6 0.0213 0.0388 0.0388
Trypanosoma cruzi glucose transporter, putative 0.0845 0.1741 0.5304
Echinococcus granulosus tyrosine protein kinase ABL1 0.0219 0.04 0.04
Trypanosoma cruzi sugar transporter, putative 0.0845 0.1741 0.5304
Plasmodium vivax hexose transporter 0.0845 0.1741 0.5091
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0921 0.1902 0.19
Loa Loa (eye worm) hypothetical protein 0.0921 0.1902 0.5807
Trichomonas vaginalis sugar transporter, putative 0.0845 0.1741 0.531
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0921 0.1902 0.19
Echinococcus multilocularis histone deacetylase 8 0.0102 0.0149 0.0149
Toxoplasma gondii sugar transporter ST3 0.0845 0.1741 0.5304
Brugia malayi hypothetical protein 0.0845 0.1741 0.1967
Trichomonas vaginalis sugar transporter, putative 0.0845 0.1741 0.531
Echinococcus granulosus tyrosine protein kinase Blk 0.0042 0.0022 0.0022
Echinococcus granulosus 7tm_1 domain containing protein 0.0921 0.1902 0.1902
Loa Loa (eye worm) hypothetical protein 0.0921 0.1902 0.5807
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0845 0.1741 0.1741
Loa Loa (eye worm) hypothetical protein 0.0845 0.1741 0.5314
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0845 0.1741 0.1741
Schistosoma mansoni biogenic amine receptor 0.0921 0.1902 0.19
Trichomonas vaginalis sugar transporter, putative 0.0845 0.1741 0.531
Echinococcus granulosus neuropeptide receptor A26 0.0921 0.1902 0.1902
Echinococcus granulosus solute carrier family 22 0.0845 0.1741 0.1741
Brugia malayi Tyrosine-protein kinase abl-1 0.0102 0.015 0.0167
Trypanosoma cruzi hexose transporter, putative 0.0845 0.1741 0.5304
Leishmania major beta tubulin 0.1563 0.3275 1
Leishmania major glucose transporter, lmgt2 0.0845 0.1741 0.5304
Brugia malayi G protein-coupled receptor 0.0921 0.1902 0.215
Entamoeba histolytica tubulin family protein 0.1563 0.3275 1
Brugia malayi Histone deacetylase family protein 0.0213 0.0388 0.0436
Echinococcus granulosus tyrosine protein kinase csk 0.0034 0.0005 0.0005
Echinococcus multilocularis g protein coupled receptor 0.0921 0.1902 0.1902
Loa Loa (eye worm) cytochrome P450 family protein 0.0055 0.005 0.0152
Schistosoma mansoni neuropeptide f receptor 76f 0.0921 0.1902 0.19
Trypanosoma brucei glucose transporter 2A 0.0845 0.1741 0.5308
Trichomonas vaginalis sugar transporter, putative 0.0845 0.1741 0.531
Trichomonas vaginalis conserved hypothetical protein 0.0845 0.1741 0.531
Echinococcus granulosus somatostatin receptor 0.0921 0.1902 0.1902
Brugia malayi celfurPC protein 0.0114 0.0176 0.0197
Echinococcus multilocularis tyrosine protein kinase csk 0.0034 0.0005 0.0005
Leishmania major beta tubulin 0.1563 0.3275 1
Trypanosoma brucei glucose transporter, putative 0.0845 0.1741 0.5308
Loa Loa (eye worm) hypothetical protein 0.0845 0.1741 0.5314
Trichomonas vaginalis histone deacetylase, putative 0.0237 0.0438 0.1329
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0845 0.1741 0.1741
Echinococcus multilocularis nuclear receptor co repressor related (ncor) 0.0272 0.0515 0.0515
Trichomonas vaginalis sugar transporter, putative 0.0845 0.1741 0.531
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0921 0.1902 0.19
Echinococcus granulosus tyrosine kinase 0.0042 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0845 0.1741 0.5314
Loa Loa (eye worm) hypothetical protein 0.0921 0.1902 0.5807
Echinococcus multilocularis histone deacetylase 7 0.0213 0.0388 0.0388
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0921 0.1902 0.215
Loa Loa (eye worm) hypothetical protein 0.0845 0.1741 0.5314
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0053 0.0044 0.0044
Trichomonas vaginalis sugar transporter, putative 0.0845 0.1741 0.531
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0921 0.1902 0.19
Onchocerca volvulus 0.0921 0.1902 0.8655
Echinococcus multilocularis serotonin receptor 0.0921 0.1902 0.1902
Schistosoma mansoni neuropeptide receptor 0.0921 0.1902 0.19
Echinococcus multilocularis histone deacetylase 6 0.0219 0.0401 0.0401
Onchocerca volvulus Histone deacetylase 10 homolog 0.0102 0.0149 0.0561
Mycobacterium leprae putative cytochrome p450 0.0035 0.0007 0.5
Loa Loa (eye worm) beta-tubulin 0.1563 0.3275 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0845 0.1741 0.1741
Loa Loa (eye worm) hypothetical protein 0.0142 0.0235 0.0718
Leishmania major beta tubulin 0.1563 0.3275 1
Mycobacterium ulcerans DNA polymerase IV 0.0045 0.0028 0.0119
Loa Loa (eye worm) hypothetical protein 0.0921 0.1902 0.5807
Schistosoma mansoni histone deacetylase 1 2 3 0.0102 0.0149 0.0147
Echinococcus granulosus rhodopsin orphan GPCR 0.0921 0.1902 0.1902
Loa Loa (eye worm) hypothetical protein 0.0921 0.1902 0.5807
Onchocerca volvulus 0.0845 0.1741 0.791
Loa Loa (eye worm) hypothetical protein 0.0921 0.1902 0.5807
Trypanosoma cruzi histone deacetylase, putative 0.0102 0.0149 0.0435
Loa Loa (eye worm) hypothetical protein 0.0921 0.1902 0.5807
Schistosoma mansoni histone deacetylase 4 5 0.0213 0.0388 0.0385
Echinococcus multilocularis histone deacetylase 3 0.0237 0.0438 0.0438
Echinococcus multilocularis Tubulin beta 2C chain 0.1563 0.3275 0.3275
Schistosoma mansoni biogenic amine (5HT) receptor 0.0921 0.1902 0.19
Loa Loa (eye worm) hypothetical protein 0.0921 0.1902 0.5807
Schistosoma mansoni hypothetical protein 0.0035 0.0007 0.0004
Loa Loa (eye worm) histone deacetylase 0.0213 0.0388 0.1184
Trypanosoma brucei glucose transporter 1E 0.0845 0.1741 0.5308
Echinococcus granulosus tm gpcr rhodopsin 0.0921 0.1902 0.1902
Leishmania major beta tubulin 0.1563 0.3275 1
Plasmodium falciparum hexose transporter 0.0845 0.1741 0.4685
Echinococcus multilocularis tubulin beta 1 chain 0.1563 0.3275 0.3275
Brugia malayi cytochrome P450 0.0035 0.0007 0.0005
Loa Loa (eye worm) CYP4Cod1 0.0055 0.005 0.0152
Leishmania major hypothetical protein, conserved 0.0845 0.1741 0.5304
Echinococcus multilocularis rhodopsin orphan GPCR 0.0921 0.1902 0.1902
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0921 0.1902 0.5807
Schistosoma mansoni cytochrome P450 0.0035 0.0007 0.0004
Schistosoma mansoni biogenic amine receptor 0.0921 0.1902 0.19
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0921 0.1902 0.19
Trypanosoma cruzi cytochrome P450, putative 0.0055 0.005 0.013
Echinococcus multilocularis beta tubulin 0.1563 0.3275 0.3275
Trichomonas vaginalis sugar transporter, putative 0.0845 0.1741 0.531
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0053 0.0044 0.0044
Loa Loa (eye worm) G-protein coupled receptor 0.0921 0.1902 0.5807
Trypanosoma brucei glucose transporter, putative 0.0845 0.1741 0.5308
Loa Loa (eye worm) hypothetical protein 0.0921 0.1902 0.5807
Loa Loa (eye worm) endoprotease bli-4 0.0142 0.0235 0.0718
Trichomonas vaginalis tubulin epsilon chain, putative 0.1563 0.3275 1
Schistosoma mansoni neuropeptide receptor 0.0921 0.1902 0.19
Echinococcus granulosus rhodopsin orphan GPCR 0.0921 0.1902 0.1902
Entamoeba histolytica histone deacetylase, putative 0.0237 0.0438 0.1338
Echinococcus granulosus rhodopsin orphan GPCR 0.0921 0.1902 0.1902
Brugia malayi Tachykinin-like peptides receptor 99D 0.0921 0.1902 0.215
Onchocerca volvulus 0.0845 0.1741 0.791
Echinococcus granulosus tubulin beta 4A class IVa 0.1563 0.3275 0.3275
Trichomonas vaginalis sugar transporter, putative 0.0845 0.1741 0.531
Onchocerca volvulus 0.0845 0.1741 0.791
Loa Loa (eye worm) SRC-1 0.0053 0.0044 0.0135
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0921 0.1902 0.215
Echinococcus multilocularis serotonin receptor 0.0921 0.1902 0.1902
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0921 0.1902 0.19
Trichomonas vaginalis conserved hypothetical protein 0.0845 0.1741 0.531
Schistosoma mansoni peptide (allatostatin)-like receptor 0.1057 0.2193 0.2191
Brugia malayi AKH receptor 0.0921 0.1902 0.215
Loa Loa (eye worm) hypothetical protein 0.0845 0.1741 0.5314
Toxoplasma gondii sugar transporter ST2 0.0845 0.1741 0.5304
Mycobacterium leprae Conserved hypothetical protein 0.0035 0.0007 0.5
Loa Loa (eye worm) BEN-1 protein 0.1563 0.3275 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0921 0.1902 0.215
Onchocerca volvulus 0.0845 0.1741 0.791
Leishmania major histone deacetylase, putative 0.0213 0.0388 0.1165
Loa Loa (eye worm) hypothetical protein 0.0921 0.1902 0.5807
Echinococcus granulosus g protein coupled receptor 0.0921 0.1902 0.1902
Trichomonas vaginalis sugar transporter, putative 0.0845 0.1741 0.531
Echinococcus multilocularis Tubulin beta 2C chain 0.1563 0.3275 0.3275
Loa Loa (eye worm) tubulin beta chain 0.1563 0.3275 1
Schistosoma mansoni biogenic amine receptor 0.0921 0.1902 0.19
Giardia lamblia Hexose transporter 0.0845 0.1741 0.525
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0053 0.0044 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0028 0.0071
Echinococcus multilocularis dna polymerase kappa 0.0045 0.0028 0.0028
Loa Loa (eye worm) tubulin beta-4 chain 0.1563 0.3275 1
Schistosoma mansoni histamine h1 receptor 0.0921 0.1902 0.19
Loa Loa (eye worm) hypothetical protein 0.0921 0.1902 0.5807
Loa Loa (eye worm) hypothetical protein 0.0921 0.1902 0.5807
Echinococcus granulosus histone deacetylase 6 0.0213 0.0388 0.0388
Echinococcus multilocularis Tubulin beta 2C chain 0.1563 0.3275 0.3275
Echinococcus granulosus dro:myosuppressin receptor 0.0921 0.1902 0.1902
Onchocerca volvulus 0.0845 0.1741 0.791
Schistosoma mansoni neuropeptide F-like receptor 0.0921 0.1902 0.19
Giardia lamblia Sugar-proton symporter 0.0845 0.1741 0.525
Loa Loa (eye worm) hypothetical protein 0.0845 0.1741 0.5314
Loa Loa (eye worm) cytochrome P450 family protein 0.0182 0.0322 0.0982
Echinococcus multilocularis solute carrier family 22 0.0845 0.1741 0.1741
Trypanosoma brucei glucose transporter, putative 0.0845 0.1741 0.5308
Trichomonas vaginalis sugar transporter, putative 0.0845 0.1741 0.531
Loa Loa (eye worm) hypothetical protein 0.0921 0.1902 0.5807
Schistosoma mansoni hypothetical protein 0.0845 0.1741 0.1738
Onchocerca volvulus 0.0921 0.1902 0.8655
Echinococcus multilocularis rhodopsin orphan GPCR 0.0921 0.1902 0.1902
Onchocerca volvulus 0.0921 0.1902 0.8655
Schistosoma mansoni adenoreceptor 0.0921 0.1902 0.19
Leishmania major myo-inositol/proton symporter (MIT) 0.0845 0.1741 0.5304
Loa Loa (eye worm) hypothetical protein 0.0921 0.1902 0.5807
Trypanosoma cruzi hexose transporter 0.0845 0.1741 0.5304
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0921 0.1902 0.19
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0028 0.0063
Trypanosoma brucei histone deacetylase 3 0.0213 0.0388 0.1172
Trichomonas vaginalis sugar transporter, putative 0.0845 0.1741 0.531
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0921 0.1902 0.5807
Loa Loa (eye worm) hypothetical protein 0.0921 0.1902 0.5807
Echinococcus granulosus synaptic vesicle 2 protein 0.0845 0.1741 0.1741
Brugia malayi RE15519p 0.0921 0.1902 0.215
Schistosoma mansoni tyrosine kinase 0.0053 0.0044 0.0042
Schistosoma mansoni serine/threonine protein kinase 0.0186 0.0329 0.0327
Brugia malayi hypothetical protein 0.0921 0.1902 0.215
Echinococcus multilocularis sex peptide receptor 0.0921 0.1902 0.1902
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0921 0.1902 0.1902
Echinococcus multilocularis tyrosine protein kinase csk 0.0034 0.0005 0.0005
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0012 0.0024
Trichomonas vaginalis sugar transporter, putative 0.0845 0.1741 0.531
Onchocerca volvulus 0.0845 0.1741 0.791
Schistosoma mansoni tubulin subunit beta 0.1563 0.3275 0.3273
Echinococcus multilocularis solute carrier family 22 0.0845 0.1741 0.1741
Trypanosoma cruzi histone deacetylase, putative 0.0213 0.0388 0.1165
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0921 0.1902 0.1902
Echinococcus granulosus rhodopsin orphan GPCR 0.0921 0.1902 0.1902
Toxoplasma gondii facilitative glucose transporter GT1 0.0845 0.1741 0.5304
Brugia malayi hypothetical protein 0.0921 0.1902 0.215
Schistosoma mansoni tyrosine kinase 0.0208 0.0377 0.0375
Echinococcus granulosus sodium channel protein 0.0199 0.0358 0.0358
Trichomonas vaginalis sugar transporter, putative 0.0845 0.1741 0.531
Echinococcus multilocularis neuropeptide Y receptor 0.0921 0.1902 0.1902
Echinococcus multilocularis solute carrier family 22 0.0845 0.1741 0.1741
Toxoplasma gondii sugar transporter ST1 0.0845 0.1741 0.5304
Schistosoma mansoni glucose transport protein 0.0845 0.1741 0.1738
Echinococcus granulosus tyrosine protein kinase Lyn 0.0053 0.0045 0.0045
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0042 0.0022 0.0022
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0921 0.1902 0.1902
Echinococcus multilocularis neuropeptide receptor 0.0921 0.1902 0.1902
Echinococcus granulosus neuropeptide s receptor 0.0921 0.1902 0.1902
Echinococcus multilocularis Tubulin beta 2C chain 0.1563 0.3275 0.3275
Loa Loa (eye worm) SH2 domain-containing protein 0.0042 0.0022 0.0066
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0142 0.0235 0.0232
Echinococcus multilocularis neuropeptides capa receptor 0.0921 0.1902 0.1902
Trypanosoma brucei glucose transporter, putative 0.0845 0.1741 0.5308
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0921 0.1902 0.1902
Brugia malayi G-protein coupled receptor 0.0921 0.1902 0.215
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0219 0.04 0.04
Loa Loa (eye worm) hypothetical protein 0.0102 0.0149 0.0456
Mycobacterium ulcerans DNA polymerase IV 0.0045 0.0028 0.0119
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0055 0.005 0.0246
Loa Loa (eye worm) hypothetical protein 0.0845 0.1741 0.5314
Schistosoma mansoni neuropeptide receptor 0.0921 0.1902 0.19
Brugia malayi Major Facilitator Superfamily protein 0.0845 0.1741 0.1967
Brugia malayi hypothetical protein 0.0845 0.1741 0.1967
Trypanosoma brucei cytochrome P450, putative 0.0055 0.005 0.0139
Trypanosoma brucei sugar transporter, putative 0.0845 0.1741 0.5308
Echinococcus granulosus rhodopsin orphan GPCR 0.0921 0.1902 0.1902
Schistosoma mansoni tyrosine kinase 0.0055 0.005 0.0047
Trypanosoma brucei glucose transporter, putative 0.0845 0.1741 0.5308
Brugia malayi Cytochrome P450 family protein 0.0035 0.0007 0.0005

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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