Detailed information for compound 1624354

Basic information

Technical information
  • TDR Targets ID: 1624354
  • Name: 4-(2-oxo-2-phenylethoxy)chromen-2-one
  • MW: 280.275 | Formula: C17H12O4
  • H donors: 0 H acceptors: 2 LogP: 3.01 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=c1cc(OCC(=O)c2ccccc2)c2c(o1)cccc2
  • InChi: 1S/C17H12O4/c18-14(12-6-2-1-3-7-12)11-20-16-10-17(19)21-15-9-5-4-8-13(15)16/h1-10H,11H2
  • InChiKey: SNHRPWBRXQFXNV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(2-oxo-2-phenyl-ethoxy)chromen-2-one
  • 4-(2-oxo-2-phenylethoxy)-2-chromenone
  • 4-(2-keto-2-phenyl-ethoxy)coumarin
  • 4-(2-Oxo-2-phenylethoxy)-2H-1-benzopyran-2-one
  • 4-(2-Oxo-2-phenylethoxy)-2H-chromen-2-one
  • AIDS-147797
  • AIDS147797
  • NSC678029
  • NCI60_027900

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.1458 0.9498 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0094 0.0342 0.0213
Trichomonas vaginalis PIKK family atypical protein kinase 0.0786 0.4987 0.5074
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0094 0.0342 0.036
Echinococcus multilocularis survival motor neuron protein 1 0.0213 0.1142 0.1142
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0072 0.0197 0.0197
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0072 0.0197 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0787 0.4995 0.5082
Trichomonas vaginalis PIKK family atypical protein kinase 0.116 0.7495 0.7813
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0072 0.0197 0.0208
Loa Loa (eye worm) phosphatidylinositol 3 0.0489 0.2993 0.3151
Loa Loa (eye worm) hypothetical protein 0.0072 0.0197 0.0208
Schistosoma mansoni fkbp-rapamycin associated protein 0.0276 0.1562 0.1644
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0072 0.0197 0.5
Toxoplasma gondii FATC domain-containing protein 0.0276 0.1562 0.2009
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0489 0.2993 0.3151
Leishmania major phosphatidylinositol kinase, putative 0.0094 0.0342 0.036
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0276 0.1562 0.1644
Toxoplasma gondii target of rapamycin (TOR), putative 0.1084 0.699 1
Trichomonas vaginalis conserved hypothetical protein 0.0182 0.093 0.0642
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0094 0.0342 0.0213
Echinococcus multilocularis serine protein kinase ATM 0.0276 0.1562 0.1562
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0094 0.0342 0.036
Loa Loa (eye worm) jmjC domain-containing protein 0.0057 0.0091 0.0096
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0094 0.0342 0.0342
Loa Loa (eye worm) phosphatidylinositol 3 0.0094 0.0342 0.036
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0094 0.0342 0.036
Loa Loa (eye worm) hypothetical protein 0.0213 0.1142 0.1202
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0489 0.2993 0.3151
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.1458 0.9498 1
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0094 0.0342 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0094 0.0342 0.036
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0094 0.0342 0.036
Plasmodium vivax hypothetical protein, conserved 0.0094 0.0342 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.1458 0.9498 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.0094 0.0342 0.036
Schistosoma mansoni hypothetical protein 0.0094 0.0342 0.036
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0689 0.4339 0.4569
Loa Loa (eye worm) phosphatidylinositol 3 0.0094 0.0342 0.036
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0489 0.2993 0.3151
Loa Loa (eye worm) hypothetical protein 0.0297 0.1705 0.1795
Schistosoma mansoni hypothetical protein 0.0213 0.1142 0.1202
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0094 0.0342 0.036
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.1458 0.9498 1
Trypanosoma cruzi target of rapamycin kinase 3 0.1161 0.7503 0.79
Trichomonas vaginalis PIKK family atypical protein kinase 0.0391 0.2337 0.2178
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0094 0.0342 1
Loa Loa (eye worm) hypothetical protein 0.0213 0.1142 0.1202
Entamoeba histolytica protein kinase rad3, putative 0.0276 0.1562 0.1332
Brugia malayi jmjC domain containing protein 0.0057 0.0091 0.0096
Loa Loa (eye worm) phosphatidylinositol 3 0.0094 0.0342 0.036
Loa Loa (eye worm) hypothetical protein 0.0094 0.0342 0.036
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0043 0.0002 0.0003
Leishmania major hypothetical protein, conserved 0.0094 0.0342 0.036
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0094 0.0342 0.036
Schistosoma mansoni peptidase Clp (S14 family) 0.0072 0.0197 0.0208
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0094 0.0342 0.036
Giardia lamblia GTOR 0.1458 0.9498 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0094 0.0342 0.036
Trichomonas vaginalis PIKK family atypical protein kinase 0.116 0.7495 0.7813
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0094 0.0342 0.036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0276 0.1562 0.1332
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0094 0.0342 0.036
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0606 0.3776 0.3975
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0094 0.0342 0.036
Trichomonas vaginalis PIKK family atypical protein kinase 0.1084 0.699 0.7261
Trichomonas vaginalis PIKK family atypical protein kinase 0.0946 0.6064 0.625
Trichomonas vaginalis PIKK family atypical protein kinase 0.0786 0.4987 0.5074
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0091 0.0096
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0094 0.0342 0.036
Trichomonas vaginalis PIKK family atypical protein kinase 0.1084 0.699 0.7261
Trichomonas vaginalis PIKK family atypical protein kinase 0.1245 0.8067 0.8437
Echinococcus granulosus survival motor neuron protein 1 0.0213 0.1142 0.1202
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0072 0.0197 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.1084 0.699 0.7261
Trichomonas vaginalis PIKK family atypical protein kinase 0.1084 0.699 0.7261
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.0091 0.0091
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0276 0.1562 0.1644
Trichomonas vaginalis PIKK family atypical protein kinase 0.1084 0.699 0.7261
Brugia malayi jmjC domain containing protein 0.0057 0.0091 0.0096
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.0091 0.0096
Plasmodium vivax hypothetical protein 0.0094 0.0342 1
Echinococcus multilocularis Zinc finger, PHD finger 0.0094 0.0342 0.0342
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0094 0.0342 0.036
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0094 0.0342 0.0342
Trichomonas vaginalis PIKK family atypical protein kinase 0.1458 0.9498 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.1458 0.9498 1
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0307 0.1773 0.232
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.1458 0.9498 1
Brugia malayi Probable ClpP-like protease 0.0072 0.0197 0.0208
Trichomonas vaginalis conserved hypothetical protein 0.0213 0.1142 0.0873
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0094 0.0342 0.036
Onchocerca volvulus 0.0094 0.0342 1
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0094 0.0342 0.036
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0276 0.1562 0.1644
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0094 0.0342 0.036
Brugia malayi hypothetical protein 0.0213 0.1142 0.1202
Trichomonas vaginalis PIKK family atypical protein kinase 0.0871 0.5559 0.5698
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0094 0.0342 0.036
Brugia malayi FAT domain containing protein 0.0213 0.1142 0.1202
Onchocerca volvulus 0.0094 0.0342 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.1161 0.7503 0.79
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0094 0.0342 0.036
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0072 0.0197 0.5366
Trichomonas vaginalis PIKK family atypical protein kinase 0.0863 0.5501 0.5634
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0094 0.0342 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0787 0.4995 0.5082
Schistosoma mansoni survival motor neuron protein 0.0043 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0182 0.093 0.0979
Loa Loa (eye worm) phosphatidylinositol 3 0.0094 0.0342 0.036
Loa Loa (eye worm) hypothetical protein 0.0276 0.1562 0.1644
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0091 0.0096
Trichomonas vaginalis PIKK family atypical protein kinase 0.0787 0.4995 0.5082
Mycobacterium leprae conserved hypothetical protein 0.0094 0.0342 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0094 0.0342 0.0213
Trichomonas vaginalis PIKK family atypical protein kinase 0.1084 0.699 0.7261
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0094 0.0342 0.0342
Echinococcus granulosus peptidase Clp S14 family 0.0048 0.003 0.0031
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.1458 0.9498 1
Echinococcus granulosus serine protein kinase ATM 0.0276 0.1562 0.1644
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0094 0.0342 0.036
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0094 0.0342 0.036
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0276 0.1562 0.1644
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0094 0.0342 1
Loa Loa (eye worm) phosphatidylinositol kinase 0.0094 0.0342 0.036
Trichomonas vaginalis PIKK family atypical protein kinase 0.116 0.7495 0.7813
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0091 0.0096
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0094 0.0342 0.036
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0094 0.0342 0.036
Loa Loa (eye worm) hypothetical protein 0.0094 0.0342 0.036
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0094 0.0342 0.036
Leishmania major phosphatidylinositol 3-kinase, putative 0.0489 0.2993 0.3151
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0213 0.1142 0.1142
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0489 0.2993 0.3151
Trichomonas vaginalis PIKK family atypical protein kinase 0.1458 0.9498 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0489 0.2993 0.2895
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0094 0.0342 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.116 0.7495 0.7813
Trichomonas vaginalis PIKK family atypical protein kinase 0.0276 0.1562 0.1332
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0072 0.0197 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0489 0.2993 0.2895
Trichomonas vaginalis PIKK family atypical protein kinase 0.0276 0.1562 0.1332
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0489 0.2993 0.3151
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0489 0.2993 0.2993
Trichomonas vaginalis PIKK family atypical protein kinase 0.0871 0.5559 0.5698
Trichomonas vaginalis PIKK family atypical protein kinase 0.0489 0.2993 0.2895
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0094 0.0342 0.036
Entamoeba histolytica hypothetical protein 0.0276 0.1562 0.1332
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0094 0.0342 0.036
Trichomonas vaginalis PIKK family atypical protein kinase 0.1458 0.9498 1
Echinococcus multilocularis 0.0094 0.0342 0.0342
Loa Loa (eye worm) phosphatidylinositol 3 0.0094 0.0342 0.036
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0094 0.0342 0.036
Loa Loa (eye worm) hypothetical protein 0.0307 0.1773 0.1867
Echinococcus multilocularis peptidase Clp (S14 family) 0.0048 0.003 0.003
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.1458 0.9498 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.1458 0.9498 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0094 0.0342 0.036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0489 0.2993 0.2895
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0094 0.0342 0.0342
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.1458 0.9498 0.9498
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0276 0.1562 0.1644
Leishmania major phosphatidylinositol kinase related protein, putative 0.0094 0.0342 0.036
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0094 0.0342 0.036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0978 0.6276 0.6481
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0182 0.093 0.0979
Trichomonas vaginalis conserved hypothetical protein 0.0307 0.1773 0.1563
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0213 0.1142 0.1202
Schistosoma mansoni hypothetical protein 0.0043 0.0002 0.0003
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0489 0.2993 0.3151
Mycobacterium tuberculosis Conserved hypothetical protein 0.0094 0.0342 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0489 0.2993 0.2895
Leishmania major phosphatidylinositol 4-kinase, putative 0.0094 0.0342 0.036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0871 0.5559 0.5698
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.0091 0.0091
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0489 0.2993 0.3151
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0276 0.1562 0.1562
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0072 0.0197 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0787 0.4995 0.5082
Trypanosoma brucei target of rapamycin kinase 3, putative 0.1161 0.7503 0.79
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0276 0.1562 0.1332
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0094 0.0342 0.036
Leishmania major hypothetical protein, unknown function 0.0094 0.0342 0.036
Echinococcus granulosus lysine specific demethylase 5A 0.0057 0.0091 0.0096
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0094 0.0342 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0276 0.1562 0.1644
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0094 0.0342 1
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0276 0.1562 0.1644
Trichomonas vaginalis PIKK family atypical protein kinase 0.1084 0.699 0.7261
Trichomonas vaginalis PIKK family atypical protein kinase 0.0182 0.093 0.0642
Trichomonas vaginalis PIKK family atypical protein kinase 0.0863 0.5501 0.5634
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0094 0.0342 0.0213
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1458 0.9498 1
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0094 0.0342 0.036
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0094 0.0342 0.036
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0094 0.0342 0.036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0786 0.4987 0.5074
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0094 0.0342 0.036
Trichomonas vaginalis PIKK family atypical protein kinase 0.116 0.7495 0.7813
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0094 0.0342 0.0342
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0094 0.0342 0.036
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0094 0.0342 0.0342
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0094 0.0342 0.0213
Loa Loa (eye worm) phosphatidylinositol 3 0.1458 0.9498 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0489 0.2993 0.3151
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0094 0.0342 0.036
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.1458 0.9498 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0072 0.0197 0.5
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0094 0.0342 0.036
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0094 0.0342 0.036

Activities

Activity type Activity value Assay description Source Reference
FC (binding) = 1.98 Activation of Nrf2 in human HSC3-ARE9 cells assessed as increase of ARE-mediated luciferase expression at 50 uM after 24 hrs relative to control ChEMBL. 26519930
GI50 (functional) -5 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.778 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.704 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.667 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.598 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.328 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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