Detailed information for compound 1624358

Basic information

Technical information
  • TDR Targets ID: 1624358
  • Name: (3E)-N-phenethyl-3-[(2-pyridin-1-ium-1-ylacet yl)hydrazinylidene]butanamide chloride
  • MW: 374.865 | Formula: C19H23ClN4O2
  • H donors: 2 H acceptors: 2 LogP: 2.83 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C[n+]1ccccc1)N/N=C(/CC(=O)NCCc1ccccc1)\C.[Cl-]
  • InChi: 1S/C19H22N4O2.ClH/c1-16(21-22-19(25)15-23-12-6-3-7-13-23)14-18(24)20-11-10-17-8-4-2-5-9-17;/h2-9,12-13H,10-11,14-15H2,1H3,(H-,20,22,24,25);1H/b21-16+;
  • InChiKey: CBEVENLCBUQTCA-JEBHESKQSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-phenethyl-3-[(2-pyridin-1-ium-1-ylacetyl)hydrazinylidene]butanamide chloride
  • (3E)-N-phenethyl-3-[(2-pyridin-1-ium-1-ylacetyl)hydrazono]butanamide chloride
  • N-phenethyl-3-[(2-pyridin-1-ium-1-ylacetyl)hydrazono]butanamide chloride
  • (3E)-3-[[1-oxo-2-(1-pyridin-1-iumyl)ethyl]hydrazono]-N-phenethylbutanamide chloride
  • 3-[[1-oxo-2-(1-pyridin-1-iumyl)ethyl]hydrazono]-N-phenethylbutanamide chloride
  • (3E)-N-phenethyl-3-[(2-pyridin-1-ium-1-ylacetyl)hydrazono]butyramide chloride
  • N-phenethyl-3-[(2-pyridin-1-ium-1-ylacetyl)hydrazono]butyramide chloride
  • (3E)-N-phenethyl-3-(2-pyridin-1-ium-1-ylethanoylhydrazinylidene)butanamide chloride
  • N-phenethyl-3-(2-pyridin-1-ium-1-ylethanoylhydrazinylidene)butanamide chloride
  • NSC641847
  • 1-[2-((2E)-2-{1-Methyl-3-oxo-3-[(2-phenylethyl)amino]propylidene}hydrazino)-2-oxoethyl]pyridinium chloride
  • AIDS-015962
  • AIDS015962

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0708 0.3291 0.2895
Loa Loa (eye worm) hypothetical protein 0.0136 0.0557 0.0557
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.004 0.0717
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.2112 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2112 1 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0032 1
Plasmodium vivax hypothetical protein 0.0136 0.0557 1
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0136 0.0557 0.051
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0136 0.0557 0.0519
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0243 0.0195
Onchocerca volvulus 0.003 0.0049 0.0153
Schistosoma mansoni hypothetical protein 0.0136 0.0557 0.051
Trichomonas vaginalis PIKK family atypical protein kinase 0.1371 0.6459 0.625
Trichomonas vaginalis PIKK family atypical protein kinase 0.0708 0.3291 0.2895
Leishmania major hypothetical protein, unknown function 0.0136 0.0557 0.0527
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0136 0.0557 0.0527
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0399 0.1815 0.1789
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0136 0.0557 0.0527
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.2112 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0136 0.0557 0.0527
Loa Loa (eye worm) phosphatidylinositol 3 0.0136 0.0557 0.0557
Trichomonas vaginalis PIKK family atypical protein kinase 0.0708 0.3291 0.2895
Entamoeba histolytica hypothetical protein 0.0399 0.1815 0.1789
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0136 0.0557 0.051
Loa Loa (eye worm) phosphatidylinositol 3 0.0136 0.0557 0.0557
Trichomonas vaginalis PIKK family atypical protein kinase 0.114 0.5356 0.5082
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0999 0.4679 0.4658
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0136 0.0557 0.0519
Trichomonas vaginalis PIKK family atypical protein kinase 0.168 0.7935 0.7813
Brugia malayi hypothetical protein 0.0028 0.004 0.0008
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0032 1
Entamoeba histolytica hypothetical protein 0.0136 0.0557 0.0527
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0243 0.0195
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0136 0.0557 0.051
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0136 0.0557 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0 0.5
Trypanosoma brucei target of rapamycin kinase 3, putative 0.1681 0.7943 0.7935
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0399 0.1815 0.1774
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0136 0.0557 0.051
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0399 0.1815 0.1782
Trichomonas vaginalis PIKK family atypical protein kinase 0.168 0.7935 0.7813
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0136 0.0557 0.0527
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0136 0.0557 0.051
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0136 0.0557 0.0527
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.014 0.0576 0.053
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0065 0.0015
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0708 0.3291 0.3258
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0136 0.0557 0.0527
Trichomonas vaginalis PIKK family atypical protein kinase 0.168 0.7935 0.7813
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0032 1
Plasmodium vivax hypothetical protein, conserved 0.0136 0.0557 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0708 0.3291 0.3258
Onchocerca volvulus 0.003 0.0049 0.0153
Entamoeba histolytica hypothetical protein 0.0136 0.0557 0.0527
Echinococcus granulosus microtubule associated protein 2 0.0769 0.3583 0.3551
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0136 0.0557 0.051
Brugia malayi intermediate filament protein 0.003 0.0049 0.0017
Loa Loa (eye worm) TAR-binding protein 0.0071 0.0243 0.0243
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.2112 1 1
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0243 0.0195
Trichomonas vaginalis PIKK family atypical protein kinase 0.1262 0.5937 0.5698
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0708 0.3291 0.3264
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0136 0.0557 0.051
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0136 0.0557 0.051
Loa Loa (eye worm) phosphatidylinositol 3 0.2112 1 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0232 0.1015 0.1015
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0136 0.0557 0.051
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0032 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0032 0.0574
Echinococcus multilocularis thyroid hormone receptor alpha 0.0152 0.063 0.0584
Loa Loa (eye worm) RNA binding protein 0.0071 0.0243 0.0243
Loa Loa (eye worm) hypothetical protein 0.003 0.0049 0.0049
Brugia malayi Pre-SET motif family protein 0.0033 0.0065 0.0033
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.2112 1 1
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0708 0.3291 0.3264
Trichomonas vaginalis PIKK family atypical protein kinase 0.157 0.7413 0.7261
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0136 0.0557 0.051
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0136 0.0557 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.157 0.7413 1
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0136 0.0557 1
Leishmania major phosphatidylinositol kinase related protein, putative 0.0136 0.0557 0.0527
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0136 0.0557 0.0519
Trichomonas vaginalis PIKK family atypical protein kinase 0.157 0.7413 0.7261
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0136 0.0557 0.0527
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0136 0.0557 0.0519
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0399 0.1815 0.1789
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0136 0.0557 0.0701
Trichomonas vaginalis PIKK family atypical protein kinase 0.1416 0.6677 0.6481
Trichomonas vaginalis PIKK family atypical protein kinase 0.157 0.7413 0.7261
Echinococcus granulosus tar DNA binding protein 0.0071 0.0243 0.0195
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0708 0.3291 0.3264
Leishmania major phosphatidylinositol kinase, putative 0.0136 0.0557 0.0527
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0399 0.1815 0.1782
Schistosoma mansoni thyroid hormone receptor 0.0152 0.063 0.0584
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0136 0.0557 0.0701
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0136 0.0557 0.0519
Trichomonas vaginalis conserved hypothetical protein 0.0445 0.2033 0.1563
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0065 0.0015
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.2112 1 1
Entamoeba histolytica protein kinase rad3, putative 0.0399 0.1815 0.1789
Trichomonas vaginalis PIKK family atypical protein kinase 0.0708 0.3291 0.2895
Trichomonas vaginalis PIKK family atypical protein kinase 0.1138 0.5348 0.5074
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0136 0.0557 0.051
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0136 0.0557 0.0527
Brugia malayi RNA binding protein 0.0071 0.0243 0.0212
Trichomonas vaginalis PIKK family atypical protein kinase 0.114 0.5356 0.5082
Trichomonas vaginalis PIKK family atypical protein kinase 0.168 0.7935 0.7813
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0136 0.0557 0.0527
Echinococcus multilocularis serine protein kinase ATM 0.0399 0.1815 0.1774
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0136 0.0557 0.0557
Onchocerca volvulus 0.0055 0.0169 0.1208
Onchocerca volvulus 0.0136 0.0557 0.4621
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.004 0.0717
Trichomonas vaginalis PIKK family atypical protein kinase 0.0399 0.1815 0.1332
Trichomonas vaginalis PIKK family atypical protein kinase 0.157 0.7413 0.7261
Loa Loa (eye worm) hypothetical protein 0.0263 0.1164 0.1164
Loa Loa (eye worm) phosphatidylinositol kinase 0.0136 0.0557 0.0557
Leishmania major hypothetical protein, conserved 0.0028 0.004 0.0008
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0136 0.0557 0.0519
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0065 0.0015
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0065 0.0015
Entamoeba histolytica hypothetical protein 0.0136 0.0557 0.0527
Loa Loa (eye worm) hypothetical protein 0.0445 0.2033 0.2033
Echinococcus multilocularis tumor protein p63 0.0377 0.1706 0.1665
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0136 0.0557 0.0527
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0032 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0399 0.1815 0.1782
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0136 0.0557 0.051
Leishmania major phosphatidylinositol 3-kinase, putative 0.0708 0.3291 0.3269
Trichomonas vaginalis PIKK family atypical protein kinase 0.1249 0.5877 0.5634
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0065 0.0034
Loa Loa (eye worm) hypothetical protein 0.0026 0.0032 0.0032
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0445 0.2033 0.2703
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0263 0.1164 0.1128
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0309 0.1382 0.1339
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0071 0.0243 0.0243
Mycobacterium leprae conserved hypothetical protein 0.0136 0.0557 1
Loa Loa (eye worm) hypothetical protein 0.043 0.1963 0.1963
Trichomonas vaginalis PIKK family atypical protein kinase 0.114 0.5356 0.5082
Onchocerca volvulus 0.0264 0.1168 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.157 0.7413 0.7261
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0136 0.0557 0.0519
Toxoplasma gondii FATC domain-containing protein 0.0399 0.1815 0.2407
Trichomonas vaginalis PIKK family atypical protein kinase 0.168 0.7935 0.7813
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0136 0.0557 0.0527
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0136 0.0557 0.051
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.2112 1 1
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0708 0.3291 0.3258
Echinococcus multilocularis Zinc finger, PHD finger 0.0136 0.0557 0.051
Trichomonas vaginalis PIKK family atypical protein kinase 0.1803 0.8524 0.8437
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0136 0.0557 0.0527
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0065 0.0015
Leishmania major hypothetical protein, conserved 0.0136 0.0557 0.0527
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0136 0.0557 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0136 0.0557 0.0701
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.014 0.0576 0.053
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0136 0.0557 0.0519
Loa Loa (eye worm) phosphatidylinositol 3 0.0136 0.0557 0.0557
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0136 0.0557 0.0527
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0065 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.1249 0.5877 0.5634
Trichomonas vaginalis PIKK family atypical protein kinase 0.1138 0.5348 0.5074
Brugia malayi RNA recognition motif domain containing protein 0.0071 0.0243 0.0212
Schistosoma mansoni hypothetical protein 0.014 0.0576 0.053
Trichomonas vaginalis set domain proteins, putative 0.0264 0.1168 0.0647
Loa Loa (eye worm) hypothetical protein 0.0033 0.0065 0.0065
Echinococcus granulosus tumor protein p63 0.0377 0.1706 0.1665
Trichomonas vaginalis PIKK family atypical protein kinase 0.1262 0.5937 0.5698
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0309 0.1382 0.1339
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0136 0.0557 0.051
Schistosoma mansoni thyroid hormone receptor 0.0152 0.063 0.0584
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0136 0.0557 0.051
Loa Loa (eye worm) hypothetical protein 0.0136 0.0557 0.0557
Loa Loa (eye worm) hypothetical protein 0.0026 0.0032 0.0032
Brugia malayi Pre-SET motif family protein 0.0232 0.1015 0.0986
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0136 0.0557 0.051
Loa Loa (eye worm) intermediate filament protein 0.003 0.0049 0.0049
Echinococcus granulosus serine protein kinase ATM 0.0399 0.1815 0.1774
Trichomonas vaginalis conserved hypothetical protein 0.0263 0.1164 0.0642
Trichomonas vaginalis PIKK family atypical protein kinase 0.114 0.5356 0.5082
Echinococcus multilocularis tar DNA binding protein 0.0071 0.0243 0.0195
Trichomonas vaginalis PIKK family atypical protein kinase 0.157 0.7413 0.7261
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0049 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.2112 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2112 1 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0047 0.0047
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0399 0.1815 0.1774
Entamoeba histolytica hypothetical protein 0.0136 0.0557 0.0527
Trichomonas vaginalis PIKK family atypical protein kinase 0.0708 0.3291 0.2895
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0399 0.1815 0.1774
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0136 0.0557 0.051
Schistosoma mansoni hypothetical protein 0.0309 0.1382 0.1339
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0032 0.0574
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0049 0.0049
Brugia malayi TAR-binding protein 0.0071 0.0243 0.0212
Onchocerca volvulus 0.0136 0.0557 0.4621
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0136 0.0557 0.0519
Trichomonas vaginalis PIKK family atypical protein kinase 0.0567 0.2614 0.2178
Onchocerca volvulus 0.0033 0.0065 0.0288
Echinococcus multilocularis microtubule associated protein 2 0.0769 0.3583 0.3551
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0708 0.3291 0.3269
Mycobacterium ulcerans hypothetical protein 0.0026 0.0032 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0399 0.1815 0.1332
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0136 0.0557 1
Brugia malayi FAT domain containing protein 0.0309 0.1382 0.1354
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0399 0.1815 0.1789
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.004 0.0717
Plasmodium vivax SET domain protein, putative 0.0033 0.0065 0.1161
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.1681 0.7943 0.7936
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0136 0.0557 0.0527
Trichomonas vaginalis PIKK family atypical protein kinase 0.1262 0.5937 0.5698
Trichomonas vaginalis PIKK family atypical protein kinase 0.1138 0.5348 0.5074
Giardia lamblia GTOR 0.2112 1 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0136 0.0557 0.0701
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0136 0.0557 0.051
Loa Loa (eye worm) hypothetical protein 0.0399 0.1815 0.1815
Schistosoma mansoni microtubule-associated protein tau 0.0769 0.3583 0.3551
Loa Loa (eye worm) phosphatidylinositol 3 0.0136 0.0557 0.0557
Trichomonas vaginalis PIKK family atypical protein kinase 0.157 0.7413 0.7261
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0136 0.0557 0.0519
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0065 0.0015
Trypanosoma cruzi target of rapamycin kinase 3 0.1681 0.7943 0.7935
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0136 0.0557 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0032 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0399 0.1815 0.1332
Schistosoma mansoni cellular tumor antigen P53 0.0055 0.0169 0.012
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.2112 1 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0136 0.0557 0.051
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0032 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0136 0.0557 0.0701
Mycobacterium tuberculosis Conserved hypothetical protein 0.0136 0.0557 1
Echinococcus multilocularis 0.0136 0.0557 0.051
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.2112 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0136 0.0557 0.0527
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0708 0.3291 0.3269
Schistosoma mansoni fkbp-rapamycin associated protein 0.0399 0.1815 0.1774
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0136 0.0557 0.051
Leishmania major phosphatidylinositol 4-kinase, putative 0.0136 0.0557 0.0527
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.2112 1 1
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0136 0.0557 0.0519
Trichomonas vaginalis conserved hypothetical protein 0.0309 0.1382 0.0873
Loa Loa (eye worm) hypothetical protein 0.0055 0.0169 0.0169
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0136 0.0557 0.0519
Trichomonas vaginalis PIKK family atypical protein kinase 0.0263 0.1164 0.0642
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0243 0.0195
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0136 0.0557 1
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0243 0.0195
Loa Loa (eye worm) hypothetical protein 0.0309 0.1382 0.1382
Loa Loa (eye worm) phosphatidylinositol 3 0.0708 0.3291 0.3291
Loa Loa (eye worm) hypothetical protein 0.0028 0.004 0.004
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.2112 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0136 0.0557 0.0557
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0059 0.001
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0136 0.0557 0.0519
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0877 0.4098 0.4075
Leishmania major phosphatidylinositol 3-kinase, putative 0.0136 0.0557 0.0527
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0708 0.3291 0.3264
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0136 0.0557 0.0519
Loa Loa (eye worm) hypothetical protein 0.0026 0.0032 0.0032
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0136 0.0557 0.0527
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.2112 1 1
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0136 0.0557 0.051

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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